This is a Validated Antibody Database (VAD) review about rat Cacna1c, based on 15 published articles (read how Labome selects the articles), using Cacna1c antibody in all methods. It is aimed to help Labome visitors find the most suited Cacna1c antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Cacna1c synonym: RATIVS302; voltage-dependent L-type calcium channel subunit alpha-1C; L-type calcium channel alpha-1 subunit; RBC; brain class C; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, L type, alpha 1C subunit; calcium channel, voltage-dependent, alpha 1C subunit; voltage-gated calcium channel subunit alpha Cav1.2

Alomone Labs
rabbit polyclonal
  • western blot; mouse; 1:200; loading ...; fig 2d
Alomone Labs Cacna1c antibody (Alomone, ACC-003) was used in western blot on mouse samples at 1:200 (fig 2d). elife (2019) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 1b
Alomone Labs Cacna1c antibody (Alomone Labs, ACC-003) was used in western blot on mouse samples (fig 1b). Science (2018) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:100; loading ...; fig 4a
  • western blot; human; 1:1000; loading ...; fig 7a
In order to propose that neonatal splice variant of CaV1.2 channels contribute to heart disease, Alomone Labs Cacna1c antibody (Alomone, ACC-003) was used in immunocytochemistry on human samples at 1:100 (fig 4a) and in western blot on human samples at 1:1000 (fig 7a). Sci Rep (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig 2c
In order to discuss how mutations in sarcomere genes may result in altered calcium signaling and heart defects, Alomone Labs Cacna1c antibody (Alomone Labs, ACC-003) was used in western blot on human samples at 1:500 (fig 2c). Circulation (2016) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; Domestic guinea pig; 1:50; fig 6
Alomone Labs Cacna1c antibody (Alomone, ACC-003) was used in immunohistochemistry - paraffin section on Domestic guinea pig samples at 1:50 (fig 6). Mediators Inflamm (2016) ncbi
rabbit polyclonal
  • western blot; rat; fig 2
In order to study the effects of ascending aortic banding on calcium handling in rat isolated atrial myocytes, Alomone Labs Cacna1c antibody (Alomone, ACC-003) was used in western blot on rat samples (fig 2). PLoS ONE (2015) ncbi
rabbit polyclonal
  • western blot; rat; fig 2c
In order to study t-tubule function during cardiac failure, Alomone Labs Cacna1c antibody (Alomone, ACC-003) was used in western blot on rat samples (fig 2c). J Mol Cell Cardiol (2015) ncbi
rabbit polyclonal
  • immunoprecipitation; human; 1:200; loading ...; fig 3a
  • western blot; human; 1:200; loading ...; fig 2a
Alomone Labs Cacna1c antibody (Alomone, ACC003) was used in immunoprecipitation on human samples at 1:200 (fig 3a) and in western blot on human samples at 1:200 (fig 2a). Pflugers Arch (2015) ncbi
rabbit polyclonal
  • immunocytochemistry; rat
In order to study the effect of regional t-tubule density during cardiomyocyte Ca(2+) homeostasis, Alomone Labs Cacna1c antibody (Alomone Labs, ACC-003) was used in immunocytochemistry on rat samples . Am J Physiol Heart Circ Physiol (2014) ncbi
rabbit polyclonal
  • immunocytochemistry; rat; 1:100
Alomone Labs Cacna1c antibody (Alomone Lab, ACC-003) was used in immunocytochemistry on rat samples at 1:100. Am J Physiol Cell Physiol (2014) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; rat; 1:400
Alomone Labs Cacna1c antibody (Alomone, ACC-003) was used in immunohistochemistry - paraffin section on rat samples at 1:400. J Comp Neurol (2012) ncbi
Abcam
rabbit polyclonal
  • western blot; chicken
Abcam Cacna1c antibody (Abcam, ab58552) was used in western blot on chicken samples . Biosci Biotechnol Biochem (2015) ncbi
Sigma-Aldrich
rabbit polyclonal
  • immunocytochemistry; rat; 1:400; loading ...; fig s5b
Sigma-Aldrich Cacna1c antibody (Sigma-Aldrich, C1603) was used in immunocytochemistry on rat samples at 1:400 (fig s5b). Nat Commun (2017) ncbi
rabbit polyclonal
  • western blot; mouse; fig 5
Sigma-Aldrich Cacna1c antibody (Sigma, C1603) was used in western blot on mouse samples (fig 5). J Physiol (2012) ncbi
Neuromab
mouse monoclonal (N263/31)
  • western blot; Domestic guinea pig; 1:500; fig 5
Neuromab Cacna1c antibody (UC Davis NeuroMab, 75-C257) was used in western blot on Domestic guinea pig samples at 1:500 (fig 5). PLoS ONE (2016) ncbi
Articles Reviewed
  1. Dai W, Laforest B, Tyan L, Shen K, Nadadur R, Alvarado F, et al. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. elife. 2019;8: pubmed publisher
  2. Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, et al. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018;362: pubmed publisher
  3. Axelsson A, Mahdi T, Nenonen H, Singh T, Hänzelmann S, Wendt A, et al. Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes. Nat Commun. 2017;8:15652 pubmed publisher
  4. Hu Z, Wang J, Yu D, Soon J, de Kleijn D, Foo R, et al. Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac Hypertrophy. Sci Rep. 2016;6:35247 pubmed publisher
  5. Helms A, Alvarado F, Yob J, Tang V, Pagani F, Russell M, et al. Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy. Circulation. 2016;134:1738-1748 pubmed
  6. Reyes García J, Flores Soto E, Solís Chagoyán H, Sommer B, Díaz Hernández V, García Hernández L, et al. Tumor Necrosis Factor Alpha Inhibits L-Type Ca(2+) Channels in Sensitized Guinea Pig Airway Smooth Muscle through ERK 1/2 Pathway. Mediators Inflamm. 2016;2016:5972302 pubmed publisher
  7. Nassal D, Wan X, Liu H, Deschenes I. Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role. PLoS ONE. 2016;11:e0146561 pubmed publisher
  8. Zhang H, Cannell M, Kim S, Watson J, Norman R, Calaghan S, et al. Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload. PLoS ONE. 2015;10:e0144309 pubmed publisher
  9. Ueda S, Kokaji Y, Simizu S, Honda K, Yoshino K, Kamisoyama H, et al. Chicken heat shock protein HSPB1 increases and interacts with αB-crystallin in aged skeletal muscle. Biosci Biotechnol Biochem. 2015;79:1867-75 pubmed publisher
  10. Bryant S, Kong C, Watson J, Cannell M, James A, Orchard C. Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts. J Mol Cell Cardiol. 2015;86:23-31 pubmed publisher
  11. Rougier J, Albesa M, Syam N, Halet G, Abriel H, Viard P. Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels. Pflugers Arch. 2015;467:1919-29 pubmed publisher
  12. Frisk M, Koivumäki J, Norseng P, Maleckar M, Sejersted O, Louch W. Variable t-tubule organization and Ca2+ homeostasis across the atria. Am J Physiol Heart Circ Physiol. 2014;307:H609-20 pubmed publisher
  13. Mizutani H, Yamamura H, Muramatsu M, Kiyota K, Nishimura K, Suzuki Y, et al. Spontaneous and nicotine-induced Ca2+ oscillations mediated by Ca2+ influx in rat pinealocytes. Am J Physiol Cell Physiol. 2014;306:C1008-16 pubmed publisher
  14. Kato H, Kassai H, Watabe A, Aiba A, Manabe T. Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells. J Physiol. 2012;590:3019-34 pubmed publisher
  15. Huang C, Chu D, Hwang W, Tsaur M. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. J Comp Neurol. 2012;520:3650-72 pubmed publisher