This is a Validated Antibody Database (VAD) review about rat Bak1, based on 21 published articles (read how Labome selects the articles), using Bak1 antibody in all methods. It is aimed to help Labome visitors find the most suited Bak1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Bak1 synonym: Bak

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D4E4)
  • western blot knockout validation; mouse; 1:1000; fig s1i
Cell Signaling Technology Bak1 antibody (Cell Signaling, 12105) was used in western blot knockout validation on mouse samples at 1:1000 (fig s1i). Nat Cell Biol (2017) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D4E4)
  • western blot knockout validation; human; fig 4
Cell Signaling Technology Bak1 antibody (Cell Signaling, 12105) was used in western blot knockout validation on human samples (fig 4). Nat Commun (2016) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3g
Cell Signaling Technology Bak1 antibody (Cell Signaling Technology, 3814) was used in western blot on human samples at 1:1000 (fig 3g). Theranostics (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 2a
Cell Signaling Technology Bak1 antibody (CST, 3814) was used in western blot on mouse samples (fig 2a). Sci Rep (2021) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot; human; loading ...
Cell Signaling Technology Bak1 antibody (Cell Signaling, 12105) was used in western blot on human samples . Cell Death Differ (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; loading ...; fig 6a
Cell Signaling Technology Bak1 antibody (Cell Signaling, 3814S) was used in western blot on mouse samples at 1:500 (fig 6a). J Biomed Sci (2020) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot; mouse; 1:1000; loading ...; fig 3g
Cell Signaling Technology Bak1 antibody (Cell signaling, 12105) was used in western blot on mouse samples at 1:1000 (fig 3g). Science (2019) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot; mouse; loading ...; fig 3a
Cell Signaling Technology Bak1 antibody (Cell Signaling, 12105) was used in western blot on mouse samples (fig 3a). Oxid Med Cell Longev (2019) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot; human; loading ...; fig 4f
Cell Signaling Technology Bak1 antibody (Cell Signaling, 12105) was used in western blot on human samples (fig 4f). J Clin Invest (2019) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot; mouse; loading ...; fig s3i
Cell Signaling Technology Bak1 antibody (Cell Signaling, 12105) was used in western blot on mouse samples (fig s3i). Science (2019) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot; human; loading ...; fig 4c
Cell Signaling Technology Bak1 antibody (Cell Signaling, 12105) was used in western blot on human samples (fig 4c). Cancer Cell Int (2019) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot knockout validation; mouse; 1:1000; fig s1i
Cell Signaling Technology Bak1 antibody (Cell Signaling, 12105) was used in western blot knockout validation on mouse samples at 1:1000 (fig s1i). Nat Cell Biol (2017) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot; human; 1:1000; loading ...; fig 8b
Cell Signaling Technology Bak1 antibody (cell signalling, 12105) was used in western blot on human samples at 1:1000 (fig 8b). Int J Oncol (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2b
Cell Signaling Technology Bak1 antibody (Cell Signaling, 3814) was used in western blot on human samples (fig 2b). Int J Biochem Cell Biol (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 5a
In order to elucidate the upstream mechanisms of apoptosis triggered by an anti-microtubule drug, ABT-751, Cell Signaling Technology Bak1 antibody (cell signalling, 3814) was used in western blot on human samples at 1:1000 (fig 5a). Toxicol Appl Pharmacol (2016) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot; human; loading ...; fig 5d
Cell Signaling Technology Bak1 antibody (Cell Signaling, 12105) was used in western blot on human samples (fig 5d). Cell Death Dis (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4a
Cell Signaling Technology Bak1 antibody (Cell Signaling, 3814) was used in western blot on human samples (fig 4a). Oncotarget (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 3
Cell Signaling Technology Bak1 antibody (Cell Signaling, 3814) was used in western blot on human samples (fig 3). Genes Dev (2016) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot; mouse; fig 2
Cell Signaling Technology Bak1 antibody (Cell Signaling Technolog, 12105) was used in western blot on mouse samples (fig 2). Cell Death Differ (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 1
Cell Signaling Technology Bak1 antibody (Cell Signaling Tech, 3814) was used in western blot on human samples (fig 1). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot; human; 1:1000; fig 1
In order to investigate the effect of Obatoclax in esophageal cancer cells, Cell Signaling Technology Bak1 antibody (Cell Signaling Tech, 12105) was used in western blot on human samples at 1:1000 (fig 1). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot knockout validation; human; fig 4
Cell Signaling Technology Bak1 antibody (Cell Signaling, 12105) was used in western blot knockout validation on human samples (fig 4). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D4E4)
  • western blot; human
Cell Signaling Technology Bak1 antibody (Cell Signaling, 12105) was used in western blot on human samples . Eur Respir J (2014) ncbi
Articles Reviewed
  1. Zheleznyak A, Mixdorf M, Marsala L, Prior J, Yang X, Cui G, et al. Orthogonal targeting of osteoclasts and myeloma cells for radionuclide stimulated dynamic therapy induces multidimensional cell death pathways. Theranostics. 2021;11:7735-7754 pubmed publisher
  2. Nozaki Y, Hikita H, Tanaka S, Fukumoto K, Urabe M, Sato K, et al. Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration. Sci Rep. 2021;11:3363 pubmed publisher
  3. Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, et al. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020;: pubmed publisher
  4. Modi J, Menzie Suderam J, Xu H, Trujillo P, Medley K, Marshall M, et al. Mode of action of granulocyte-colony stimulating factor (G-CSF) as a novel therapy for stroke in a mouse model. J Biomed Sci. 2020;27:19 pubmed publisher
  5. Kim J, Gupta R, Blanco L, Yang S, Shteinfer Kuzmine A, Wang K, et al. VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease. Science. 2019;366:1531-1536 pubmed publisher
  6. Sul O, Rajasekaran M, Park H, Suh J, Choi H. MicroRNA-29b Enhances Osteoclast Survival by Targeting BCL-2-Modifying Factor after Lipopolysaccharide Stimulation. Oxid Med Cell Longev. 2019;2019:6018180 pubmed publisher
  7. Pan C, Jin L, Wang X, Li Y, Chun J, Boese A, et al. Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. J Clin Invest. 2019;129:2431-2445 pubmed publisher
  8. He M, Chaurushiya M, Webster J, Kummerfeld S, Reja R, Chaudhuri S, et al. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science. 2019;364:283-285 pubmed publisher
  9. Liu Y, Wang X, Deng L, Ping L, Shi Y, Zheng W, et al. ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma. Cancer Cell Int. 2019;19:32 pubmed publisher
  10. Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, et al. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nat Cell Biol. 2017;19:1116-1129 pubmed publisher
  11. Yokoyama T, Kohn E, Brill E, Lee J. Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP. Int J Oncol. 2017;: pubmed publisher
  12. Park S, Jwa E, Shin S, Ju E, Park I, Pak J, et al. Ibulocydine sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis via calpain-mediated Bax cleavage. Int J Biochem Cell Biol. 2017;83:47-55 pubmed publisher
  13. Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed publisher
  14. Klingbeil O, Lesche R, Gelato K, Haendler B, Lejeune P. Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents. Cell Death Dis. 2016;7:e2365 pubmed publisher
  15. Zhao J, Niu X, Li X, Edwards H, Wang G, Wang Y, et al. Inhibition of CHK1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells. Oncotarget. 2016;7:34785-99 pubmed publisher
  16. O Neill K, Huang K, Zhang J, Chen Y, Luo X. Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane. Genes Dev. 2016;30:973-88 pubmed publisher
  17. Barroso González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher
  18. Gilormini M, Malesys C, Armandy E, Manas P, Guy J, Magne N, et al. Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC. Oncotarget. 2016;7:16731-44 pubmed publisher
  19. Yu L, Wu W, Gu C, Zhong D, Zhao X, Kong Y, et al. Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget. 2016;7:14693-707 pubmed publisher
  20. Lopez J, Bessou M, Riley J, Giampazolias E, Todt F, Rochegüe T, et al. Mito-priming as a method to engineer Bcl-2 addiction. Nat Commun. 2016;7:10538 pubmed publisher
  21. Sanders Y, Hagood J, Liu H, Zhang W, Ambalavanan N, Thannickal V. Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice. Eur Respir J. 2014;43:1448-58 pubmed publisher