This is a Validated Antibody Database (VAD) review about platanna xrcc6.L, based on 14 published articles (read how Labome selects the articles), using xrcc6.L antibody in all methods. It is aimed to help Labome visitors find the most suited xrcc6.L antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
xrcc6.L synonym: xrcc6; X-ray repair complementing defective repair in Chinese hamster cells 6 L homeolog; ATP-dependent DNA helicase 2 subunit 1

Knockout validation
Invitrogen
mouse monoclonal (N3H10)
  • western blot knockout validation; mouse; 1:500; fig 3
In order to test if Bax-mediated apoptosis contributes to the premature death of ku70 knockout mice, Invitrogen xrcc6.L antibody (NeoMarkers, N3H10) was used in western blot knockout validation on mouse samples at 1:500 (fig 3). Cell Death Dis (2015) ncbi
Invitrogen
mouse monoclonal (N3H10)
  • western blot; human; 1:500; loading ...; fig 5d
In order to explore the role of chromodomain helicase DNA-binding protein 7 in CHARGE syndrome, Invitrogen xrcc6.L antibody (ThermoFisher, MA5-13110) was used in western blot on human samples at 1:500 (fig 5d)Nat Commun (2017) ncbi
mouse monoclonal (162)
  • chromatin immunoprecipitation; mouse; loading ...; fig 5a
  • EMSA; mouse; loading ...; fig 5f
In order to assess the contributions of single-strand annealing factors HR Rad52 and translesion DNA polymerase q to CSR, Invitrogen xrcc6.L antibody (Thermo Fisher Scientific, MA1-21818) was used in chromatin immunoprecipitation on mouse samples (fig 5a) and in EMSA on mouse samples (fig 5f)Nat Commun (2017) ncbi
mouse monoclonal (N3H10)
  • RNA immunoprecipitation; human; fig 3
  • western blot; human; fig 3
In order to study regulation of repair of DNA double-strand breaks in triple-negative breast cancer by long noncoding RNA LINP1, Invitrogen xrcc6.L antibody (Thermo, MA5-13110) was used in RNA immunoprecipitation on human samples (fig 3) and in western blot on human samples (fig 3)Nat Struct Mol Biol (2016) ncbi
mouse monoclonal (N3H10)
  • western blot; human; fig 1
In order to study correlation between early onset chronic erosive polyarthritis and LRBA deficiency with autoimmunity, Invitrogen xrcc6.L antibody (Thermo scientific, MA5-13110) was used in western blot on human samples (fig 1)Clin Immunol (2016) ncbi
mouse monoclonal (N3H10)
  • immunoprecipitation; human; fig 1a
  • western blot; human; fig 1c
In order to investigate the role of phospho-Ku70 in DNA repair, Invitrogen xrcc6.L antibody (Thermo Scientific, N3H10) was used in immunoprecipitation on human samples (fig 1a) and in western blot on human samples (fig 1c)Oncotarget (2015) ncbi
mouse monoclonal (N3H10)
  • immunoprecipitation; human; 1:5000; fig 7
In order to study the role of autophagy factors in cancer progression and treatment response, Invitrogen xrcc6.L antibody (Thermo-fisher, ab-4) was used in immunoprecipitation on human samples at 1:5000 (fig 7)Nat Commun (2015) ncbi
mouse monoclonal (N3H10)
  • western blot; human; fig 1
  • western blot; cow; fig 1
In order to characterize cattle XLF for focus formation at DNA damage sites after irradiation and dynamic changes in subcellular localization during cell cycle, Invitrogen xrcc6.L antibody (NeoMarkers, N3H10) was used in western blot on human samples (fig 1) and in western blot on cow samples (fig 1)J Vet Med Sci (2015) ncbi
mouse monoclonal (162)
  • immunohistochemistry - paraffin section; human; 1:200; fig 6
  • immunocytochemistry; human; 1:200; fig 5
  • western blot; human; 1:1000; fig 5
In order to analyze chemotherapeutic agent treatment and the DNA damage/repair cascade in glioblastoma cell lines, Invitrogen xrcc6.L antibody (NeoMarkers, MS-286) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 6), in immunocytochemistry on human samples at 1:200 (fig 5), and in western blot on human samples at 1:1000 (fig 5)Int J Oncol (2015) ncbi
mouse monoclonal (N3H10)
  • western blot knockout validation; mouse; 1:500; fig 3
In order to test if Bax-mediated apoptosis contributes to the premature death of ku70 knockout mice, Invitrogen xrcc6.L antibody (NeoMarkers, N3H10) was used in western blot knockout validation on mouse samples at 1:500 (fig 3)Cell Death Dis (2015) ncbi
mouse monoclonal (N3H10)
  • western blot; human; fig 5
In order to analyze effective tumor control in human lung cancer cells by the combination of heavy-ion irradiation and Hsp90 inhibitor 17AAG, Invitrogen xrcc6.L antibody (Thermo Scientific, N3H10) was used in western blot on human samples (fig 5)Cancer Med (2015) ncbi
mouse monoclonal (N3H10)
  • western blot; mouse; fig 2a
In order to explore the effects of aging on the intrinsic properties of satellite cells, Invitrogen xrcc6.L antibody (Neomarkers, MS-329-P) was used in western blot on mouse samples (fig 2a)PLoS ONE (2013) ncbi
mouse monoclonal (N3H10)
  • western blot; human; fig 2
In order to identify the effect of DNA-dependent protein kinase on cisplatin treatment, Invitrogen xrcc6.L antibody (Neomarkers, N3H10) was used in western blot on human samples (fig 2)Mol Cancer (2011) ncbi
mouse monoclonal (N3H10)
  • western blot; human; tbl 1
In order to test if over-expression of DNA repair genes enhances the invasive behavior of tumor cells, Invitrogen xrcc6.L antibody (Neomarkers, MS 329- P0) was used in western blot on human samples (tbl 1)PLoS ONE (2011) ncbi
mouse monoclonal (162)
  • immunoprecipitation; human; 10 ug
In order to investigate the role of TRF2/RAP1 and DNA-PK at telomeric fusion, Invitrogen xrcc6.L antibody (Thermo Scientific, Ab3-162) was used in immunoprecipitation on human samples at 10 ugEMBO J (2010) ncbi
Articles Reviewed
  1. Weijun Feng et al. (2017). "Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.".PMID 28317875
  2. Hong Zan et al. (2017). "Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination".PMID 28176781
  3. Youyou Zhang et al. (2016). "Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer".PMID 27111890
  4. Eva Levy et al. (2016). "LRBA deficiency with autoimmunity and early onset chronic erosive polyarthritis".PMID 27057999
  5. Julien Bouley et al. (2015). "A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines".PMID 26337656
  6. Shanshan He et al. (2015). "Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers".PMID 26234763
  7. Manabu Koike et al. (2015). "Dynamic changes in subcellular localization of cattle XLF during cell cycle, and focus formation of cattle XLF at DNA damage sites immediately after irradiation".PMID 25947322
  8. Laura Annovazzi et al. (2015). "The DNA damage/repair cascade in glioblastoma cell lines after chemotherapeutic agent treatment".PMID 25892134
  9. J Ngo et al. (2015). "Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases".PMID 25811803
  10. Hirokazu Hirakawa et al. (2015). "The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells".PMID 25582113
  11. Wendy Cousin et al. (2013). "Regenerative capacity of old muscle stem cells declines without significant accumulation of DNA damage".PMID 23704914
  12. Janna Sand-Dejmek et al. (2011). "Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin".PMID 21679440
  13. Veronica L Martinez-Marignac et al. (2011). "The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells".PMID 21283680
  14. Oriane Bombarde et al. (2010). "TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends".PMID 20407424