This is a Validated Antibody Database (VAD) review about mouse Xrcc6, based on 19 published articles (read how Labome selects the articles), using Xrcc6 antibody in all methods. It is aimed to help Labome visitors find the most suited Xrcc6 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Xrcc6 synonym: 70kDa; G22p1; Ku70

Knockout validation
Invitrogen
mouse monoclonal (N3H10)
  • western blot knockout validation; mouse; 1:500; fig 3
In order to test if Bax-mediated apoptosis contributes to the premature death of ku70 knockout mice, Invitrogen Xrcc6 antibody (NeoMarkers, N3H10) was used in western blot knockout validation on mouse samples at 1:500 (fig 3). Cell Death Dis (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D10A7)
  • western blot knockout validation; mouse; fig s1
Cell Signaling Technology Xrcc6 antibody (Cell Signaling, 4588) was used in western blot knockout validation on mouse samples (fig s1). Nat Struct Mol Biol (2015) ncbi
Invitrogen
mouse monoclonal (N3H10)
  • western blot; mouse; loading ...; fig s4c
Invitrogen Xrcc6 antibody (Thermo Fisher, N3H10) was used in western blot on mouse samples (fig s4c). iScience (2020) ncbi
mouse monoclonal (N3H10)
  • western blot; human; 1:1000; loading ...; fig 3e
Invitrogen Xrcc6 antibody (Thermo Fisher Scientific, MA5-13110) was used in western blot on human samples at 1:1000 (fig 3e). Cell Rep (2018) ncbi
mouse monoclonal (N3H10)
  • western blot; human; 1:500; loading ...; fig 5d
In order to explore the role of chromodomain helicase DNA-binding protein 7 in CHARGE syndrome, Invitrogen Xrcc6 antibody (ThermoFisher, MA5-13110) was used in western blot on human samples at 1:500 (fig 5d). Nat Commun (2017) ncbi
mouse monoclonal (N3H10)
  • RNA immunoprecipitation; human; fig 3
  • western blot; human; fig 3
In order to study regulation of repair of DNA double-strand breaks in triple-negative breast cancer by long noncoding RNA LINP1, Invitrogen Xrcc6 antibody (Thermo, MA5-13110) was used in RNA immunoprecipitation on human samples (fig 3) and in western blot on human samples (fig 3). Nat Struct Mol Biol (2016) ncbi
mouse monoclonal (N3H10)
  • western blot; human; fig 1
In order to study correlation between early onset chronic erosive polyarthritis and LRBA deficiency with autoimmunity, Invitrogen Xrcc6 antibody (Thermo scientific, MA5-13110) was used in western blot on human samples (fig 1). Clin Immunol (2016) ncbi
mouse monoclonal (N3H10)
  • immunoprecipitation; human; fig 1a
  • western blot; human; fig 1c
In order to investigate the role of phospho-Ku70 in DNA repair, Invitrogen Xrcc6 antibody (Thermo Scientific, N3H10) was used in immunoprecipitation on human samples (fig 1a) and in western blot on human samples (fig 1c). Oncotarget (2015) ncbi
mouse monoclonal (N3H10)
  • immunoprecipitation; human; 1:5000; fig 7
In order to study the role of autophagy factors in cancer progression and treatment response, Invitrogen Xrcc6 antibody (Thermo-fisher, ab-4) was used in immunoprecipitation on human samples at 1:5000 (fig 7). Nat Commun (2015) ncbi
mouse monoclonal (N3H10)
  • western blot; bovine; fig 1
  • western blot; human; fig 1
In order to characterize cattle XLF for focus formation at DNA damage sites after irradiation and dynamic changes in subcellular localization during cell cycle, Invitrogen Xrcc6 antibody (NeoMarkers, N3H10) was used in western blot on bovine samples (fig 1) and in western blot on human samples (fig 1). J Vet Med Sci (2015) ncbi
mouse monoclonal (N3H10)
  • western blot knockout validation; mouse; 1:500; fig 3
In order to test if Bax-mediated apoptosis contributes to the premature death of ku70 knockout mice, Invitrogen Xrcc6 antibody (NeoMarkers, N3H10) was used in western blot knockout validation on mouse samples at 1:500 (fig 3). Cell Death Dis (2015) ncbi
mouse monoclonal (N3H10)
  • western blot; human; fig 5
In order to analyze effective tumor control in human lung cancer cells by the combination of heavy-ion irradiation and Hsp90 inhibitor 17AAG, Invitrogen Xrcc6 antibody (Thermo Scientific, N3H10) was used in western blot on human samples (fig 5). Cancer Med (2015) ncbi
mouse monoclonal (N3H10)
  • western blot; mouse; fig 2a
In order to explore the effects of aging on the intrinsic properties of satellite cells, Invitrogen Xrcc6 antibody (Neomarkers, MS-329-P) was used in western blot on mouse samples (fig 2a). PLoS ONE (2013) ncbi
mouse monoclonal (N3H10)
  • western blot; human; fig 2
In order to identify the effect of DNA-dependent protein kinase on cisplatin treatment, Invitrogen Xrcc6 antibody (Neomarkers, N3H10) was used in western blot on human samples (fig 2). Mol Cancer (2011) ncbi
mouse monoclonal (N3H10)
  • western blot; human; tbl 1
In order to test if over-expression of DNA repair genes enhances the invasive behavior of tumor cells, Invitrogen Xrcc6 antibody (Neomarkers, MS 329- P0) was used in western blot on human samples (tbl 1). PLoS ONE (2011) ncbi
Santa Cruz Biotechnology
mouse monoclonal (E-5)
  • western blot; human; 1:500; loading ...; fig 3b
Santa Cruz Biotechnology Xrcc6 antibody (Santa, sc-17789) was used in western blot on human samples at 1:500 (fig 3b). Nat Commun (2018) ncbi
mouse monoclonal (N3H10)
  • western blot; Xenopus laevis; fig 3
Santa Cruz Biotechnology Xrcc6 antibody (Santa Cruz Biotechnology, SC-56129) was used in western blot on Xenopus laevis samples (fig 3). J Cell Biol (2016) ncbi
mouse monoclonal (E-5)
  • western blot; human; fig 1
In order to elucidate how microphthalmia-associated transcription factor regulates transcription, Santa Cruz Biotechnology Xrcc6 antibody (Santa Cruz Biotechnology, sc-17789) was used in western blot on human samples (fig 1). elife (2015) ncbi
mouse monoclonal (E-5)
  • western blot; human
Santa Cruz Biotechnology Xrcc6 antibody (Santa Cruz Biotechnology Inc, sc-17789) was used in western blot on human samples . Mol Cell Proteomics (2014) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D10A7)
  • western blot; mouse; 1:3000; fig 4
Cell Signaling Technology Xrcc6 antibody (Cell Signaling, 4588) was used in western blot on mouse samples at 1:3000 (fig 4). Nat Commun (2015) ncbi
domestic rabbit monoclonal (D10A7)
  • western blot knockout validation; mouse; fig s1
Cell Signaling Technology Xrcc6 antibody (Cell Signaling, 4588) was used in western blot knockout validation on mouse samples (fig s1). Nat Struct Mol Biol (2015) ncbi
BD Biosciences
  • immunoprecipitation; mouse; fig 4
BD Biosciences Xrcc6 antibody (BD Biosciences, 611892) was used in immunoprecipitation on mouse samples (fig 4). Nat Commun (2015) ncbi
Articles Reviewed
  1. Chu S, Chabon J, Matovina C, Minehart J, Chen B, Zhang J, et al. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience. 2020;23:100941 pubmed publisher
  2. Craxton A, Munnur D, Jukes Jones R, Skalka G, Langlais C, Cain K, et al. PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair. Nat Commun. 2018;9:3877 pubmed publisher
  3. Tay L, Krishnan V, Sankar H, Chong Y, Chuang L, Tan T, et al. RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair. Cell Rep. 2018;24:1747-1755 pubmed publisher
  4. Feng W, Kawauchi D, Körkel Qu H, Deng H, Serger E, Sieber L, et al. Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme. Nat Commun. 2017;8:14758 pubmed publisher
  5. Zhang Y, He Q, Hu Z, Feng Y, Fan L, Tang Z, et al. Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat Struct Mol Biol. 2016;23:522-30 pubmed publisher
  6. Levy E, Stolzenberg M, Bruneau J, Breton S, Neven B, Sauvion S, et al. LRBA deficiency with autoimmunity and early onset chronic erosive polyarthritis. Clin Immunol. 2016;168:88-93 pubmed publisher
  7. Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol. 2016;212:399-408 pubmed publisher
  8. Liu X, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs R, et al. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun. 2015;6:8325 pubmed publisher
  9. Bouley J, Saad L, Grall R, Schellenbauer A, Biard D, Paget V, et al. A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines. Oncotarget. 2015;6:27980-8000 pubmed publisher
  10. Hartlerode A, Morgan M, Wu Y, Buis J, Ferguson D. Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors. Nat Struct Mol Biol. 2015;22:736-43 pubmed publisher
  11. He S, Zhao Z, Yang Y, O Connell D, Zhang X, Oh S, et al. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015;6:7839 pubmed publisher
  12. Koike M, Yutoku Y, Koike A. Dynamic changes in subcellular localization of cattle XLF during cell cycle, and focus formation of cattle XLF at DNA damage sites immediately after irradiation. J Vet Med Sci. 2015;77:1109-14 pubmed publisher
  13. Ngo J, Matsuyama M, Kim C, Poventud Fuentes I, Bates A, Siedlak S, et al. Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases. Cell Death Dis. 2015;6:e1706 pubmed publisher
  14. Laurette P, Strub T, Koludrovic D, Keime C, Le Gras S, Seberg H, et al. Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells. elife. 2015;4: pubmed publisher
  15. Hirakawa H, Fujisawa H, Masaoka A, Noguchi M, Hirayama R, Takahashi M, et al. The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells. Cancer Med. 2015;4:426-36 pubmed publisher
  16. Dutta B, Yan R, Lim S, Tam J, Sze S. Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis. Mol Cell Proteomics. 2014;13:3236-49 pubmed publisher
  17. Cousin W, Ho M, Desai R, Tham A, Chen R, Kung S, et al. Regenerative capacity of old muscle stem cells declines without significant accumulation of DNA damage. PLoS ONE. 2013;8:e63528 pubmed publisher
  18. Sand Dejmek J, Adelmant G, Sobhian B, Calkins A, Marto J, Iglehart D, et al. Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin. Mol Cancer. 2011;10:74 pubmed publisher
  19. Martinez Marignac V, Rodrigue A, Davidson D, Couillard M, Al Moustafa A, Abramovitz M, et al. The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells. PLoS ONE. 2011;6:e16394 pubmed publisher