This is a Validated Antibody Database (VAD) review about mouse Xiap, based on 27 published articles (read how Labome selects the articles), using Xiap antibody in all methods. It is aimed to help Labome visitors find the most suited Xiap antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Xiap synonym: 1110015C02Rik; Aipa; Api3; Birc4; IAP3; ILP-1; MIHA

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (E-2)
  • western blot; mouse; loading ...; fig 4b
  • western blot knockout validation; human; loading ...; fig 3c
  • immunohistochemistry - paraffin section; human; loading ...; fig 1a, 1b
  • immunocytochemistry; human; loading ...; fig s3a, s3b
Santa Cruz Biotechnology Xiap antibody (Santa, sc-55551) was used in western blot on mouse samples (fig 4b), in western blot knockout validation on human samples (fig 3c), in immunohistochemistry - paraffin section on human samples (fig 1a, 1b) and in immunocytochemistry on human samples (fig s3a, s3b). Oncogene (2019) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4d
Abcam Xiap antibody (Abcam, ab21278) was used in western blot on human samples (fig 4d). Cells (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4b
Abcam Xiap antibody (Abcam, ab21278) was used in western blot on human samples (fig 4b). Biosci Rep (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 1b
Abcam Xiap antibody (Abcam, ab21278) was used in western blot on mouse samples (fig 1b). Proc Natl Acad Sci U S A (2019) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:400; fig 6
  • western blot; human; 1:2000; fig 1
Abcam Xiap antibody (abcam, ab21278) was used in immunohistochemistry - paraffin section on human samples at 1:400 (fig 6) and in western blot on human samples at 1:2000 (fig 1). Int J Oncol (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; fig 3
Abcam Xiap antibody (Abcam, ab21278) was used in immunohistochemistry - paraffin section on human samples (fig 3). BMC Cancer (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 5
Abcam Xiap antibody (Abcam, ab21278) was used in western blot on human samples (fig 5). J Cancer (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (A-7)
  • western blot; human; loading ...; fig 10
Santa Cruz Biotechnology Xiap antibody (Santa Cruz Biotechnology, sc-55550) was used in western blot on human samples (fig 10). Biomolecules (2019) ncbi
mouse monoclonal (E-2)
  • western blot; mouse; loading ...; fig 4b
  • western blot knockout validation; human; loading ...; fig 3c
  • immunohistochemistry - paraffin section; human; loading ...; fig 1a, 1b
  • immunocytochemistry; human; loading ...; fig s3a, s3b
Santa Cruz Biotechnology Xiap antibody (Santa, sc-55551) was used in western blot on mouse samples (fig 4b), in western blot knockout validation on human samples (fig 3c), in immunohistochemistry - paraffin section on human samples (fig 1a, 1b) and in immunocytochemistry on human samples (fig s3a, s3b). Oncogene (2019) ncbi
mouse monoclonal (E-2)
  • western blot; mouse; loading ...; fig 4a, 4b
  • western blot; human; loading ...; fig 4b
Santa Cruz Biotechnology Xiap antibody (Santa Cruz, E-2) was used in western blot on mouse samples (fig 4a, 4b) and in western blot on human samples (fig 4b). Oncogene (2018) ncbi
mouse monoclonal (E-2)
  • immunocytochemistry; human; fig 1
Santa Cruz Biotechnology Xiap antibody (Santa Cruz Biotechnology, sc-55551) was used in immunocytochemistry on human samples (fig 1). J Biol Chem (2015) ncbi
mouse monoclonal (E-2)
  • western blot; mouse; fig 4
Santa Cruz Biotechnology Xiap antibody (Santa, sc-55551) was used in western blot on mouse samples (fig 4). Endocrinology (2012) ncbi
R&D Systems
domestic goat polyclonal
  • western blot; human; fig 3
R&D Systems Xiap antibody (R&D systems, AF8221) was used in western blot on human samples (fig 3). Onco Targets Ther (2016) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 8d
Cell Signaling Technology Xiap antibody (CST, 2042) was used in western blot on mouse samples at 1:1000 (fig 8d). Nat Commun (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:100; loading ...; fig 3a
Cell Signaling Technology Xiap antibody (CST, 2042) was used in western blot on mouse samples at 1:100 (fig 3a). Mol Brain (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s6a
Cell Signaling Technology Xiap antibody (Cell Signaling, 2042) was used in western blot on human samples (fig s6a). Sci Adv (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 3d
Cell Signaling Technology Xiap antibody (Cell Signaling, 2042) was used in western blot on human samples (fig 3d). Mol Cell (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4a
Cell Signaling Technology Xiap antibody (CST, 2042) was used in western blot on human samples (fig 4a). BMC Cancer (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 4c
Cell Signaling Technology Xiap antibody (Cell signaling technology, 2042) was used in western blot on mouse samples at 1:1000 (fig 4c). Nat Commun (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:5000; loading ...; fig 4f
Cell Signaling Technology Xiap antibody (Cell Signaling, 2042) was used in western blot on human samples at 1:5000 (fig 4f). Nat Commun (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 5
In order to elucidate a mutually regulatory relationship between signal transducer and activator of transcription 5 and nucleophosmin, Cell Signaling Technology Xiap antibody (Cell Signaling, 2042) was used in western blot on human samples (fig 5). Cell Death Dis (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 5b
In order to examine the effects of curcumin treatment on myeloid leukemia cells, Cell Signaling Technology Xiap antibody (Cell Signaling, 2042) was used in western blot on human samples (fig 5b). PLoS ONE (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 3a
In order to explore the role of the S100A7 in oral squamous cell carcinoma, Cell Signaling Technology Xiap antibody (Cell Signaling, 2042) was used in western blot on human samples (fig 3a). Cancer Gene Ther (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...
Cell Signaling Technology Xiap antibody (Cell Signaling, 2042) was used in western blot on human samples . Cell Microbiol (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 6
Cell Signaling Technology Xiap antibody (Cell Signaling Technology, 2042) was used in western blot on human samples (fig 6). Sci Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 5
Cell Signaling Technology Xiap antibody (Cell Signaling, 2042) was used in western blot on human samples (fig 5). Oncotarget (2016) ncbi
MBL International
mouse monoclonal (2F1)
  • western blot; mouse; 1:1000; loading ...; fig 1d
MBL International Xiap antibody (MBL, M044-3) was used in western blot on mouse samples at 1:1000 (fig 1d). Immunity (2022) ncbi
mouse monoclonal (2F1)
  • western blot; human; loading ...; fig 1c
MBL International Xiap antibody (MBL, M044-3) was used in western blot on human samples (fig 1c). Cell Death Differ (2017) ncbi
Articles Reviewed
  1. Simpson D, Pang J, Weir A, Kong I, Fritsch M, Rashidi M, et al. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity. 2022;55:423-441.e9 pubmed publisher
  2. Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella J, et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12:2482 pubmed publisher
  3. Sowa A, Popova T, Harmuth T, Weber J, Pereira Sena P, Schmidt J, et al. Neurodegenerative phosphoprotein signaling landscape in models of SCA3. Mol Brain. 2021;14:57 pubmed publisher
  4. Kitamura Y, Kanaya N, Moleirinho S, Du W, Reinshagen C, Attia N, et al. Anti-EGFR VHH-armed death receptor ligand-engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Sci Adv. 2021;7: pubmed publisher
  5. Ali R, Alabdullah M, Miligy I, Normatova M, Babaei Jadidi R, Nateri A, et al. ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity. Cells. 2019;8: pubmed publisher
  6. Thangaraj K, Balasubramanian B, Park S, Natesan K, Liu W, Manju V. Orientin Induces G0/G1 Cell Cycle Arrest and Mitochondria Mediated Intrinsic Apoptosis in Human Colorectal Carcinoma HT29 Cells. Biomolecules. 2019;9: pubmed publisher
  7. Fang D, Wang H, Li M, Wei W. α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3. Biosci Rep. 2019;39: pubmed publisher
  8. Lee S, Mayr C. Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. Mol Cell. 2019;: pubmed publisher
  9. Gennaro V, Wedegaertner H, McMahon S. Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC. BMC Cancer. 2019;19:258 pubmed publisher
  10. Baranov S, Baranova O, Yablonska S, Suofu Y, Vazquez A, Kozai T, et al. Mitochondria modulate programmed neuritic retraction. Proc Natl Acad Sci U S A. 2019;116:650-659 pubmed publisher
  11. Panda S, Gekara N. The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Nat Commun. 2018;9:4654 pubmed publisher
  12. Huang X, Wang X, Yuan X, Wu W, Lobie P, Wu Z. XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation. Oncogene. 2019;38:1448-1460 pubmed publisher
  13. Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny Geier G, et al. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018;9:3839 pubmed publisher
  14. Comiskey D, Jacob A, Sanford B, Montes M, Goodwin A, Steiner H, et al. A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo. Oncogene. 2018;37:95-106 pubmed publisher
  15. Tanzer M, Khan N, Rickard J, Etemadi N, Lalaoui N, Spall S, et al. Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways. Cell Death Differ. 2017;24:481-491 pubmed publisher
  16. Ren Z, Aerts J, Vandenplas H, Wang J, Gorbenko O, Chen J, et al. Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2. Cell Death Dis. 2016;7:e2560 pubmed publisher
  17. Martínez Castillo M, Bonilla Moreno R, Alemán Lazarini L, Meraz Rios M, Orozco L, Cedillo Barron L, et al. A Subpopulation of the K562 Cells Are Killed by Curcumin Treatment after G2/M Arrest and Mitotic Catastrophe. PLoS ONE. 2016;11:e0165971 pubmed publisher
  18. Dey K, Bharti R, Dey G, Pal I, Rajesh Y, Chavan S, et al. S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway. Cancer Gene Ther. 2016;23:382-391 pubmed publisher
  19. Qin S, Yang C, Zhang B, Li X, Sun X, Li G, et al. XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC. Int J Oncol. 2016;49:1289-96 pubmed publisher
  20. Wang C, Ma Y, Hu Q, Xie T, Wu J, Zeng F, et al. Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors. BMC Cancer. 2016;16:545 pubmed publisher
  21. Lin K, Cheng S, Tsai S, Tsai J, Lin C, Cheung C. Delivery of a survivin promoter-driven antisense survivin-expressing plasmid DNA as a cancer therapeutic: a proof-of-concept study. Onco Targets Ther. 2016;9:2601-13 pubmed publisher
  22. Zeng W, Liu Q, Chen Z, Wu X, Zhong Y, Wu J. Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-?B Pathway. J Cancer. 2016;7:746-57 pubmed publisher
  23. Waguia Kontchou C, Tzivelekidis T, Gentle I, Hacker G. Infection of epithelial cells with Chlamydia trachomatis inhibits TNF-induced apoptosis at the level of receptor internalization while leaving non-apoptotic TNF-signalling intact. Cell Microbiol. 2016;18:1583-1595 pubmed publisher
  24. Afsar T, Trembley J, Salomon C, Razak S, Khan M, Ahmed K. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. Sci Rep. 2016;6:23077 pubmed publisher
  25. Cousin F, Jouan Lanhouet S, Théret N, Brenner C, Jouan E, Le Moigne Muller G, et al. The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer. Oncotarget. 2016;7:7161-78 pubmed publisher
  26. Hamacher Brady A, Brady N. Bax/Bak-dependent, Drp1-independent Targeting of X-linked Inhibitor of Apoptosis Protein (XIAP) into Inner Mitochondrial Compartments Counteracts Smac/DIABLO-dependent Effector Caspase Activation. J Biol Chem. 2015;290:22005-18 pubmed publisher
  27. Lejonklou M, Barbu A, Stalberg P, Skogseid B. Accelerated proliferation and differential global gene expression in pancreatic islets of five-week-old heterozygous Men1 mice: Men1 is a haploinsufficient suppressor. Endocrinology. 2012;153:2588-98 pubmed publisher