This is a Validated Antibody Database (VAD) review about mouse Wrn, based on 4 published articles (read how Labome selects the articles), using Wrn antibody in all methods. It is aimed to help Labome visitors find the most suited Wrn antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Wrn synonym: AI846146; Werner syndrome ATP-dependent helicase homolog; Werner syndrome homolog; exonuclease WRN

Abcam
rabbit polyclonal
  • western blot; human; loading ...; fig 2a
Abcam Wrn antibody (Abcam, ab200) was used in western blot on human samples (fig 2a). Genes Dev (2017) ncbi
Cell Signaling Technology
mouse monoclonal (8H3)
  • western blot; human; 1:1000; loading ...; fig 2a
Cell Signaling Technology Wrn antibody (Cell Signaling, 4666) was used in western blot on human samples at 1:1000 (fig 2a). elife (2019) ncbi
mouse monoclonal (8H3)
  • western blot; human; loading ...; fig 2s4
In order to investigate DNA repair in CD44+/CD24- cells, Cell Signaling Technology Wrn antibody (cell signalling, 4666) was used in western blot on human samples (fig 2s4). elife (2017) ncbi
mouse monoclonal (8H3)
  • western blot; human; loading ...; fig 3a
In order to study quinacrine-induced apoptosis, Cell Signaling Technology Wrn antibody (Cell Signaling, 4666) was used in western blot on human samples (fig 3a). Biochem Pharmacol (2016) ncbi
Articles Reviewed
  1. Lieb S, Blaha Ostermann S, Kamper E, Rippka J, Schwarz C, Ehrenhöfer Wölfer K, et al. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells. elife. 2019;8: pubmed publisher
  2. Gong Y, Handa N, Kowalczykowski S, de Lange T. PHF11 promotes DSB resection, ATR signaling, and HR. Genes Dev. 2017;31:46-58 pubmed publisher
  3. Pal D, Pertot A, Shirole N, Yao Z, Anaparthy N, Garvin T, et al. TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells. elife. 2017;6: pubmed publisher
  4. Preet R, Siddharth S, Satapathy S, Das S, Nayak A, Das D, et al. Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade. Biochem Pharmacol. 2016;105:23-33 pubmed publisher