This is a Validated Antibody Database (VAD) review about mouse Trem2, based on 13 published articles (read how Labome selects the articles), using Trem2 antibody in all methods. It is aimed to help Labome visitors find the most suited Trem2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Trem2 synonym: TREM-2; Trem2a; Trem2b; Trem2c

R&D Systems
domestic sheep polyclonal
  • immunohistochemistry; mouse; 1:150; fig 8c
R&D Systems Trem2 antibody (R&D Systems, AF1729) was used in immunohistochemistry on mouse samples at 1:150 (fig 8c). Acta Neuropathol Commun (2021) ncbi
domestic sheep polyclonal
  • immunohistochemistry; mouse; loading ...; fig 4j
R&D Systems Trem2 antibody (R&D, AF1729) was used in immunohistochemistry on mouse samples (fig 4j). Sci Adv (2021) ncbi
domestic sheep polyclonal
  • western blot; mouse; 1:400; loading ...; fig 6b
R&D Systems Trem2 antibody (R&D Systems, AF1729) was used in western blot on mouse samples at 1:400 (fig 6b). Acta Neuropathol Commun (2021) ncbi
domestic sheep polyclonal
  • immunohistochemistry; human; 1:50; loading ...; fig 1d
R&D Systems Trem2 antibody (R&D systems, BAF 1729) was used in immunohistochemistry on human samples at 1:50 (fig 1d). Nat Immunol (2021) ncbi
domestic sheep polyclonal
  • immunohistochemistry; human; 1:200; loading ...; fig 1d
R&D Systems Trem2 antibody (R&D systems, AF1729) was used in immunohistochemistry on human samples at 1:200 (fig 1d). Nat Immunol (2021) ncbi
domestic sheep polyclonal
  • western blot; mouse; fig 4a
R&D Systems Trem2 antibody (R&D, AF-1729) was used in western blot on mouse samples (fig 4a). Alzheimers Res Ther (2021) ncbi
domestic sheep polyclonal
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 2d
R&D Systems Trem2 antibody (R&D, AF1729) was used in immunohistochemistry - frozen section on mouse samples at 1:1000 (fig 2d). Aging (Albany NY) (2020) ncbi
domestic sheep polyclonal
  • ELISA; mouse; 1:3000; loading ...; fig 6b, s2b
R&D Systems Trem2 antibody (R&D Systems, BAF1729) was used in ELISA on mouse samples at 1:3000 (fig 6b, s2b). Nat Commun (2019) ncbi
domestic sheep polyclonal
  • immunocytochemistry; mouse; loading ...; fig 3d
R&D Systems Trem2 antibody (R&D Systems, AF1729) was used in immunocytochemistry on mouse samples (fig 3d). Neuron (2018) ncbi
domestic sheep polyclonal
  • ELISA; mouse; loading ...; fig 1a
In order to quantify soluble triggering receptor expressed on myeloid cells 2 and amyloid levels in Alzheimer's disease mouse model brains, R&D Systems Trem2 antibody (R&D Systems, BAF1729) was used in ELISA on mouse samples (fig 1a). Front Aging Neurosci (2017) ncbi
Abcam
rat monoclonal (RM0139-5J46)
  • western blot; mouse; 1:100
Abcam Trem2 antibody (Abcam, ab86491) was used in western blot on mouse samples at 1:100. Sci Adv (2022) ncbi
rat monoclonal (RM0139-5J46)
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig ex8a
Abcam Trem2 antibody (Abcam, ab86491) was used in immunohistochemistry - frozen section on mouse samples at 1:200 (fig ex8a). Nature (2019) ncbi
rat monoclonal (6E9)
  • western blot; mouse; loading ...; fig 8c
Abcam Trem2 antibody (Abcam, ab125117) was used in western blot on mouse samples (fig 8c). Front Immunol (2018) ncbi
Invitrogen
domestic rabbit polyclonal
  • proximity ligation assay; human; fig 5g
Invitrogen Trem2 antibody (Thermo Fisher, PA5-87933) was used in proximity ligation assay on human samples (fig 5g). Mol Neurodegener (2022) ncbi
Articles Reviewed
  1. Singh N, Das B, Zhou J, Hu X, Yan R. Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance. Sci Adv. 2022;8:eabo3610 pubmed publisher
  2. Zhao P, Xu Y, Jiang L, Fan X, Ku Z, Li L, et al. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Mol Neurodegener. 2022;17:44 pubmed publisher
  3. Pankiewicz J, Lizińczyk A, Franco L, Díaz J, Martá Ariza M, Sadowski M. Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype. Acta Neuropathol Commun. 2021;9:157 pubmed publisher
  4. Cheng J, Dong Y, Ma J, Pan R, Liao Y, Kong X, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology. Sci Adv. 2021;7: pubmed publisher
  5. Emre C, Do K, Jun B, Hjorth E, Alcalde S, Kautzmann M, et al. Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:116 pubmed publisher
  6. Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed publisher
  7. Pons V, Lévesque P, Plante M, Rivest S. Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease. Alzheimers Res Ther. 2021;13:8 pubmed publisher
  8. Wang Y, Lin Y, Wang L, Zhan H, Luo X, Zeng Y, et al. TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice. Aging (Albany NY). 2020;12:20862-20879 pubmed publisher
  9. Culemann S, Grüneboom A, Nicolás Ávila J, Weidner D, Lämmle K, Rothe T, et al. Locally renewing resident synovial macrophages provide a protective barrier for the joint. Nature. 2019;572:670-675 pubmed publisher
  10. Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, et al. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nat Commun. 2019;10:1365 pubmed publisher
  11. Qu W, Wang Y, Wu Y, Liu Y, Chen K, Liu X, et al. Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis. Front Immunol. 2018;9:1121 pubmed publisher
  12. Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher
  13. Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, et al. Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis. Front Aging Neurosci. 2017;9:8 pubmed publisher