This is a Validated Antibody Database (VAD) review about mouse Top2b, based on 7 published articles (read how Labome selects the articles), using Top2b antibody in all methods. It is aimed to help Labome visitors find the most suited Top2b antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Top2b synonym: D230016L12Rik; Top-2

Santa Cruz Biotechnology
mouse monoclonal (H-8)
  • immunohistochemistry; mouse; 1:300; loading ...; fig 4b
Santa Cruz Biotechnology Top2b antibody (Santa Cruz, sc-25330) was used in immunohistochemistry on mouse samples at 1:300 (fig 4b). J Neurosci Res (2017) ncbi
mouse monoclonal (H-8)
  • western blot; human; 1:1000
Santa Cruz Biotechnology Top2b antibody (Santa Cruz Biotechnology, sc-25330) was used in western blot on human samples at 1:1000. J Neuroimmunol (2014) ncbi
mouse monoclonal (H-8)
  • immunohistochemistry; mouse; fig 3
  • western blot; mouse; fig 3
  • immunohistochemistry; human; fig 3
  • western blot; human; fig 3
In order to study the roles of Top2-alpha and -beta in mitochondria and the effect on mitochondrial DNA supercoiling of Top1mt deletion, Santa Cruz Biotechnology Top2b antibody (Santa Cruz, sc-25330) was used in immunohistochemistry on mouse samples (fig 3), in western blot on mouse samples (fig 3), in immunohistochemistry on human samples (fig 3) and in western blot on human samples (fig 3). Nucleic Acids Res (2014) ncbi
mouse monoclonal (H-8)
  • western blot; mouse
Santa Cruz Biotechnology Top2b antibody (Santa Cruz, sc-25330) was used in western blot on mouse samples . Drug Discov Ther (2014) ncbi
R&D Systems
mouse monoclonal (681417)
  • other; mouse; 1:100; loading ...; fig 8j
  • western blot; mouse; 1:1000; loading ...; fig 8a
R&D Systems Top2b antibody (R&D Systems, MAB6348) was used in other on mouse samples at 1:100 (fig 8j) and in western blot on mouse samples at 1:1000 (fig 8a). Nat Commun (2018) ncbi
mouse monoclonal (681417)
  • immunocytochemistry; human; fig 3
R&D Systems Top2b antibody (R&D systems, MAB6348) was used in immunocytochemistry on human samples (fig 3). Biochem Pharmacol (2016) ncbi
Novus Biologicals
domestic rabbit polyclonal
  • ChIP-Seq; mouse; ; loading ...; fig 4a
  • chromatin immunoprecipitation; mouse; ; loading ...; fig 7d
Novus Biologicals Top2b antibody (NOVUS, NB100-40842) was used in ChIP-Seq on mouse samples at (fig 4a) and in chromatin immunoprecipitation on mouse samples at (fig 7d). Nat Commun (2020) ncbi
Articles Reviewed
  1. Alvarez Quilón A, Terron Bautista J, Delgado Sainz I, Serrano Benítez A, Romero Granados R, Martínez García P, et al. Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency. Nat Commun. 2020;11:910 pubmed publisher
  2. Hsu J, Xia W, Hsu Y, Chan L, Yu W, Cha J, et al. STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. Nat Commun. 2018;9:1908 pubmed publisher
  3. Li Y, Hao H, Swerdel M, Cho H, Lee K, Hart R, et al. Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network. J Neurosci Res. 2017;95:1951-1964 pubmed publisher
  4. Lee K, Bramley R, Cowell I, Jackson G, Austin C. Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II. Biochem Pharmacol. 2016;103:29-39 pubmed publisher
  5. Kong L, Wei J, Haider A, Liebelt B, Ling X, Conrad C, et al. Therapeutic targets in subependymoma. J Neuroimmunol. 2014;277:168-75 pubmed publisher
  6. Zhang H, Zhang Y, Yasukawa T, Dalla Rosa I, Khiati S, Pommier Y. Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases II? and II? in vertebrate mitochondria. Nucleic Acids Res. 2014;42:7259-67 pubmed publisher
  7. Wang R, Wang Y, Gao Z, Qu X. The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice. Drug Discov Ther. 2014;8:25-32 pubmed