This is a Validated Antibody Database (VAD) review about mouse Tardbp, based on 17 published articles (read how Labome selects the articles), using Tardbp antibody in all methods. It is aimed to help Labome visitors find the most suited Tardbp antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Tardbp synonym: 1190002A23Rik; C85084; TDP-43; Tdp43

Abcam
monoclonal
  • immunocytochemistry; rat; loading ...; fig s5d
  • western blot; rat; loading ...; fig s5c
Abcam Tardbp antibody (Abcam, 104223) was used in immunocytochemistry on rat samples (fig s5d) and in western blot on rat samples (fig s5c). Sci Adv (2019) ncbi
mouse monoclonal (2E2-D3)
  • western blot; Caenorhabditis elegans; fig 9d
Abcam Tardbp antibody (Abcam, ab57105) was used in western blot on Caenorhabditis elegans samples (fig 9d). Acta Neuropathol Commun (2019) ncbi
domestic rabbit monoclonal
  • western blot; mouse; 1:10,000; loading ...; fig s4g
Abcam Tardbp antibody (Abcam, Ab133547) was used in western blot on mouse samples at 1:10,000 (fig s4g). Nat Commun (2018) ncbi
mouse monoclonal (2E2-D3)
  • immunohistochemistry; human; loading ...; fig 3a
In order to research the effects of two familial ALS proteins on DNA damage repair, Abcam Tardbp antibody (Abcam, ab57105) was used in immunohistochemistry on human samples (fig 3a). Proc Natl Acad Sci U S A (2016) ncbi
monoclonal
  • flow cytometry; mouse; loading ...; fig 5a
In order to test if the NLRP3 inflammasome plays a role in valosin-containing protein-associated diseases, Abcam Tardbp antibody (Abcam, 3H8) was used in flow cytometry on mouse samples (fig 5a). Inflammation (2017) ncbi
mouse monoclonal (2E2-D3)
  • immunohistochemistry - frozen section; domestic rabbit; fig s1
In order to characterize the role of endolysosomes in skeletal muscle pathology observed in a model of Alzheimer's disease with a cholesterol-fed rabbit, Abcam Tardbp antibody (Abcam, ab57105) was used in immunohistochemistry - frozen section on domestic rabbit samples (fig s1). Front Aging Neurosci (2016) ncbi
monoclonal
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 6b
  • western blot; mouse; 1:2500; loading ...; fig 6a
Abcam Tardbp antibody (Abcam, ab104223) was used in immunocytochemistry on mouse samples at 1:1000 (fig 6b) and in western blot on mouse samples at 1:2500 (fig 6a). Mol Neurobiol (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - free floating section; mouse; 1:200; loading ...; fig 4b
In order to study cytosolic localization of Fox proteins in motor neurons of G93A SOD1 mice, Abcam Tardbp antibody (Abcam, ab41881) was used in immunohistochemistry - free floating section on mouse samples at 1:200 (fig 4b). Histochem Cell Biol (2016) ncbi
monoclonal
  • immunoprecipitation; mouse; fig 6
  • immunocytochemistry; mouse; fig 1
  • western blot; mouse; 1:1000; fig 1
In order to report that Tat-activating regulatory DNA-binding protein-43 regulates the synthesis of the interleukin-6 and -10 splicing activating compartment, Abcam Tardbp antibody (Abcam, ab104223) was used in immunoprecipitation on mouse samples (fig 6), in immunocytochemistry on mouse samples (fig 1) and in western blot on mouse samples at 1:1000 (fig 1). Nat Commun (2015) ncbi
Novus Biologicals
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:100; fig 5a
Novus Biologicals Tardbp antibody (Novus Biologicals, NB110-55376) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig 5a). Dis Model Mech (2017) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • immunohistochemistry; mouse; 1:1000; loading ...; fig s5c
  • western blot; mouse; 1:5000; loading ...; fig 3a
MilliporeSigma Tardbp antibody (Sigma, T1580) was used in immunohistochemistry on mouse samples at 1:1000 (fig s5c) and in western blot on mouse samples at 1:5000 (fig 3a). Nature (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; human; 1:500; loading ...; fig s3b
In order to show that expression of human TDP-43 impairs small interfering RNA silencing, the major post-transcriptional mechanism of retrotransposable element control in somatic tissue, MilliporeSigma Tardbp antibody (Sigma Aldrich, SAB4200223) was used in immunohistochemistry on human samples at 1:500 (fig s3b). PLoS Genet (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; fig 5g
  • immunocytochemistry; mouse; loading ...; fig 3a
  • western blot; mouse; loading ...; fig 4c
In order to describe the mechanisms affected in TDP-43 knockdown neurons., MilliporeSigma Tardbp antibody (Sigma, SAB4200006) was used in immunohistochemistry - paraffin section on human samples (fig 5g), in immunocytochemistry on mouse samples (fig 3a) and in western blot on mouse samples (fig 4c). EMBO J (2016) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; 1:50; fig 2
  • immunohistochemistry - frozen section; human; 1:50; fig 7
  • western blot; human; fig 3
MilliporeSigma Tardbp antibody (Sigma, T1580) was used in immunocytochemistry on mouse samples at 1:50 (fig 2), in immunohistochemistry - frozen section on human samples at 1:50 (fig 7) and in western blot on human samples (fig 3). J Neurosci Res (2016) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • immunocytochemistry; human; loading ...; fig 6d
Cell Signaling Technology Tardbp antibody (Cell signaling, 3448) was used in immunocytochemistry on human samples (fig 6d). Ann Neurol (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 4
Cell Signaling Technology Tardbp antibody (Cell Signaling, 3449S) was used in western blot on mouse samples (fig 4). EMBO J (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 1
Cell Signaling Technology Tardbp antibody (Cell signaling, 3448) was used in western blot on mouse samples (fig 1). Sci Rep (2016) ncbi
Articles Reviewed
  1. Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, et al. The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43. Sci Adv. 2019;5:eaay2670 pubmed publisher
  2. Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed publisher
  3. Luisier R, Tyzack G, Hall C, Mitchell J, Devine H, Taha D, et al. Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS. Nat Commun. 2018;9:2010 pubmed publisher
  4. Becker L, Huang B, Bieri G, Ma R, Knowles D, Jafar Nejad P, et al. Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice. Nature. 2017;544:367-371 pubmed publisher
  5. Krug L, Chatterjee N, Borges Monroy R, Hearn S, Liao W, Morrill K, et al. Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS. PLoS Genet. 2017;13:e1006635 pubmed publisher
  6. Kobayashi M, Chandrasekhar A, Cheng C, Martinez J, Ng H, de La Hoz C, et al. Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22. Dis Model Mech. 2017;10:215-224 pubmed publisher
  7. Hill S, Mordes D, Cameron L, Neuberg D, Landini S, Eggan K, et al. Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proc Natl Acad Sci U S A. 2016;113:E7701-E7709 pubmed
  8. Nalbandian A, Khan A, Srivastava R, Llewellyn K, Tan B, Shukr N, et al. Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy. Inflammation. 2017;40:21-41 pubmed publisher
  9. Schwenk B, Hartmann H, Serdaroglu A, Schludi M, Hornburg D, Meissner F, et al. TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons. EMBO J. 2016;35:2350-2370 pubmed
  10. Hu B, Arpag S, Zuchner S, Li J. A novel missense mutation of CMT2P alters transcription machinery. Ann Neurol. 2016;80:834-845 pubmed publisher
  11. Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed publisher
  12. Sellier C, Campanari M, Julie Corbier C, Gaucherot A, Kolb Cheynel I, Oulad Abdelghani M, et al. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. EMBO J. 2016;35:1276-97 pubmed publisher
  13. Maharjan N, Künzli C, Buthey K, Saxena S. C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress. Mol Neurobiol. 2017;54:3062-3077 pubmed publisher
  14. Lin P, Folorunso O, Taglialatela G, Pierce A. Overexpression of heat shock factor 1 maintains TAR DNA binding protein 43 solubility via induction of inducible heat shock protein 70 in cultured cells. J Neurosci Res. 2016;94:671-82 pubmed publisher
  15. Kitamura A, Nakayama Y, Shibasaki A, Taki A, Yuno S, Takeda K, et al. Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicity. Sci Rep. 2016;6:19230 pubmed publisher
  16. Ma X, Turnbull P, Crapper E, Wang H, Drannik A, Jiang F, et al. Cytosolic localization of Fox proteins in motor neurons of G93A SOD1 mice. Histochem Cell Biol. 2016;145:545-59 pubmed publisher
  17. Lee S, Lee T, Lee E, Kang S, Park A, Kim S, et al. Identification of a subnuclear body involved in sequence-specific cytokine RNA processing. Nat Commun. 2015;6:5791 pubmed publisher