This is a Validated Antibody Database (VAD) review about mouse Syvn1, based on 7 published articles (read how Labome selects the articles), using Syvn1 antibody in all methods. It is aimed to help Labome visitors find the most suited Syvn1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Syvn1 synonym: 1200010C09Rik; AW211966; C85322; D530017H19Rik; Hrd1

Knockout validation
Abcam
domestic rabbit monoclonal (EP7459)
  • western blot knockout validation; mouse; fig s1
Abcam Syvn1 antibody (Abcam, EP7459) was used in western blot knockout validation on mouse samples (fig s1). Proc Natl Acad Sci U S A (2016) ncbi
Abcam
domestic rabbit monoclonal (EP7459)
  • western blot; human; loading ...; fig s7i
Abcam Syvn1 antibody (Abcam, ab170901) was used in western blot on human samples (fig s7i). Mol Cancer (2021) ncbi
domestic rabbit monoclonal (EP7459)
  • western blot; mouse; 1:1000; loading ...; fig 2d
Abcam Syvn1 antibody (Abcam, ab170901) was used in western blot on mouse samples at 1:1000 (fig 2d). Cell Death Discov (2021) ncbi
domestic rabbit monoclonal (EP7459)
  • western blot; human; loading ...; fig 1a
Abcam Syvn1 antibody (Abcam, ab170901) was used in western blot on human samples (fig 1a). Aging (Albany NY) (2020) ncbi
domestic rabbit monoclonal (EP7459)
  • immunohistochemistry; mouse; loading ...; fig 2
  • western blot; mouse; loading ...; fig 3
Abcam Syvn1 antibody (abcam, ab170901) was used in immunohistochemistry on mouse samples (fig 2) and in western blot on mouse samples (fig 3). Aging (Albany NY) (2020) ncbi
domestic rabbit monoclonal (EP7459)
  • western blot; human; loading ...; fig 1h
In order to discover that endoplasmic reticulum membrane-spanning ubiquitin ligase SYVN1/HRD1 enhances the degradation of the Z variant of SERPINA1 through the autophagy-lysosome pathway, Abcam Syvn1 antibody (Abcam, ab170901) was used in western blot on human samples (fig 1h). Autophagy (2017) ncbi
domestic rabbit monoclonal (EP7459)
  • western blot knockout validation; mouse; fig s1
Abcam Syvn1 antibody (Abcam, EP7459) was used in western blot knockout validation on mouse samples (fig s1). Proc Natl Acad Sci U S A (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal
  • immunohistochemistry; mouse; loading ...; fig 2
  • western blot; mouse; loading ...; fig 3
Santa Cruz Biotechnology Syvn1 antibody (Santa cruz, sc-293484) was used in immunohistochemistry on mouse samples (fig 2) and in western blot on mouse samples (fig 3). Aging (Albany NY) (2020) ncbi
Novus Biologicals
domestic rabbit polyclonal (Ubi-1)
Novus Biologicals Syvn1 antibody (Novus Biologicals, NB100-2526) was used . Nat Cell Biol (2015) ncbi
Articles Reviewed
  1. Liu Z, Wang T, She Y, Wu K, Gu S, Li L, et al. N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Mol Cancer. 2021;20:105 pubmed publisher
  2. Zhang J, Zhang J, Ni H, Wang Y, Katwal G, Zhao Y, et al. Downregulation of XBP1 protects kidney against ischemia-reperfusion injury via suppressing HRD1-mediated NRF2 ubiquitylation. Cell Death Discov. 2021;7:44 pubmed publisher
  3. Liu S, Tian Y, Zheng Y, Cheng Y, Zhang D, Jiang J, et al. TRIM27 acts as an oncogene and regulates cell proliferation and metastasis in non-small cell lung cancer through SIX3-β-catenin signaling. Aging (Albany NY). 2020;12:25564-25580 pubmed publisher
  4. Jin Y, Cheng X, Huang X, Ding F, Lee S, Wang F, et al. The role of Hrd1 in ultraviolet (UV) radiation induced photoaging. Aging (Albany NY). 2020;12:21273-21289 pubmed publisher
  5. Feng L, Zhang J, Zhu N, Ding Q, Zhang X, Yu J, et al. Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/?-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy. Autophagy. 2017;13:686-702 pubmed publisher
  6. Kong S, Yang Y, Xu Y, Wang Y, Zhang Y, Melo Cardenas J, et al. Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas. Proc Natl Acad Sci U S A. 2016;113:10394-9 pubmed publisher
  7. Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015;17:1546-55 pubmed publisher