This is a Validated Antibody Database (VAD) review about mouse Syt1, based on 35 published articles (read how Labome selects the articles), using Syt1 antibody in all methods. It is aimed to help Labome visitors find the most suited Syt1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Syt1 synonym: AW124717; G630098F17Rik; SytI

Synaptic Systems
mouse monoclonal (41.1)
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2f
  • western blot; mouse; loading ...; fig 2d
Synaptic Systems Syt1 antibody (Synaptic Systems, 105011) was used in immunohistochemistry - frozen section on mouse samples (fig 2f) and in western blot on mouse samples (fig 2d). JCI Insight (2021) ncbi
mouse monoclonal (41.1)
  • immunohistochemistry; human; 1:500; loading ...; fig 1j
Synaptic Systems Syt1 antibody (Synaptic Systems, 105011) was used in immunohistochemistry on human samples at 1:500 (fig 1j). Brain Commun (2021) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; rat; loading ...
Synaptic Systems Syt1 antibody (Synaptic Systems, 105103C5) was used in immunocytochemistry on rat samples . Sci Adv (2021) ncbi
mouse monoclonal (41.1)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1b
Synaptic Systems Syt1 antibody (Synaptic Systems, 105011) was used in immunohistochemistry on mouse samples at 1:500 (fig 1b). elife (2020) ncbi
mouse monoclonal (41.1)
  • immunohistochemistry - frozen section; mouse; loading ...; fig s1f
  • western blot; mouse; loading ...; fig s6b
Synaptic Systems Syt1 antibody (Synaptic Systems, 105 011C5) was used in immunohistochemistry - frozen section on mouse samples (fig s1f) and in western blot on mouse samples (fig s6b). Neuron (2021) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; loading ...; fig s6c
Synaptic Systems Syt1 antibody (Synaptic Systems, 105 103C3) was used in immunocytochemistry on mouse samples (fig s6c). Neuron (2021) ncbi
guinea-pigs polyclonal
  • immunohistochemistry; mouse; 1:1000; loading ...
Synaptic Systems Syt1 antibody (Synaptic Systems, 105 105) was used in immunohistochemistry on mouse samples at 1:1000. Physiol Rep (2020) ncbi
mouse monoclonal (41.1)
  • western blot; mouse; 1:1000; loading ...; fig 5b
Synaptic Systems Syt1 antibody (Synaptic Systems, 105011) was used in western blot on mouse samples at 1:1000 (fig 5b). elife (2020) ncbi
mouse monoclonal (41.1)
  • immunocytochemistry; human; loading ...; fig s1e
Synaptic Systems Syt1 antibody (Synaptic Systems, 105 011C2) was used in immunocytochemistry on human samples (fig s1e). Cell (2019) ncbi
mouse monoclonal (41.1)
  • immunohistochemistry - free floating section; mouse; 1:200; loading ...; fig 2d
Synaptic Systems Syt1 antibody (Synaptic Systems, 105011) was used in immunohistochemistry - free floating section on mouse samples at 1:200 (fig 2d). J Neurosci (2017) ncbi
mouse monoclonal (41.1)
  • western blot; bovine; fig s1
Synaptic Systems Syt1 antibody (Synaptic Systems, 41.1) was used in western blot on bovine samples (fig s1). Sci Rep (2017) ncbi
mouse monoclonal (41.1)
  • western blot; mouse; loading ...; tbl 1
In order to elucidate the contribution of the Sac phosphatase domain of Synaptojanin 1 to neurological symptoms, Synaptic Systems Syt1 antibody (Synaptic Systems, 105 011) was used in western blot on mouse samples (tbl 1). Neuron (2017) ncbi
mouse monoclonal (41.1)
  • immunocytochemistry; mouse; 1:100; loading ...; fig 2a
In order to characterize synaptic vesicle endocytosis, Synaptic Systems Syt1 antibody (SySy, 105 011) was used in immunocytochemistry on mouse samples at 1:100 (fig 2a). Neuron (2017) ncbi
mouse monoclonal (41.1)
  • western blot; mouse; 1:5000; loading ...; fig 1a
In order to evaluate the application of CRISPR/Cas9 system in postmitotic cells, Synaptic Systems Syt1 antibody (Synaptic Systems, 105 011) was used in western blot on mouse samples at 1:5000 (fig 1a). J Neurosci Methods (2017) ncbi
guinea-pigs polyclonal
  • western blot; rat; 1:500; loading ...; fig 5b
In order to develop methods to study vesicle-associated proteins and exocytosis in stellate astrocytes, Synaptic Systems Syt1 antibody (Synaptic Systems, 105105) was used in western blot on rat samples at 1:500 (fig 5b). J Gen Physiol (2017) ncbi
mouse monoclonal (41.1)
  • western blot; rat; 1:1000; loading ...; fig 5b
In order to develop methods to study vesicle-associated proteins and exocytosis in stellate astrocytes, Synaptic Systems Syt1 antibody (Synaptic Systems, 105011) was used in western blot on rat samples at 1:1000 (fig 5b). J Gen Physiol (2017) ncbi
mouse monoclonal (41.1)
  • western blot; mouse; fig 2
Synaptic Systems Syt1 antibody (Synaptic Systems, 105011) was used in western blot on mouse samples (fig 2). Sci Rep (2016) ncbi
mouse monoclonal (41.1)
  • western blot; rat; loading ...; fig 6a
In order to investigate mechanisms involved in Rab35-mediated axonal elongation, Synaptic Systems Syt1 antibody (Synaptic Systems, 105 011) was used in western blot on rat samples (fig 6a). J Neurosci (2016) ncbi
mouse monoclonal (41.1)
  • western blot; mouse; 1:1000; loading ...; fig 3a
In order to investigate the function of extended synaptotagmins in knock out mice, Synaptic Systems Syt1 antibody (Synaptic systems, 41.1) was used in western blot on mouse samples at 1:1000 (fig 3a). PLoS ONE (2016) ncbi
mouse monoclonal (41.1)
  • immunohistochemistry; mouse; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 2b
Synaptic Systems Syt1 antibody (Synaptic Systems, 105011) was used in immunohistochemistry on mouse samples (fig 4a) and in western blot on mouse samples (fig 2b). EBioMedicine (2016) ncbi
mouse monoclonal (41.1)
  • western blot; mouse; 1:300; fig 5
In order to characterize induced human neurons harboring alleles of four disease-associated single nucleotide polymorphisms in MIR137, Synaptic Systems Syt1 antibody (Synaptic Systems, 105 011) was used in western blot on mouse samples at 1:300 (fig 5). Nat Neurosci (2015) ncbi
mouse monoclonal (41.1)
  • western blot; rat
In order to examine the biotinylation of vesicular transporters as a tool for the study of presynaptic function, Synaptic Systems Syt1 antibody (Synaptic Systems, 105 011) was used in western blot on rat samples . J Neurosci (2013) ncbi
Abcam
mouse monoclonal (ASV30)
  • western blot; mouse; loading ...; fig 4p
Abcam Syt1 antibody (Abcam, ab13259) was used in western blot on mouse samples (fig 4p). EBioMedicine (2022) ncbi
mouse monoclonal (ASV30)
  • immunocytochemistry; rat; loading ...
Abcam Syt1 antibody (Abcam, ab13259) was used in immunocytochemistry on rat samples . Sci Adv (2021) ncbi
mouse monoclonal (ASV30)
  • western blot; rat; 1:1000; loading ...; fig 2f
Abcam Syt1 antibody (Abcam, ab13259) was used in western blot on rat samples at 1:1000 (fig 2f). Aging Cell (2020) ncbi
mouse monoclonal (ASV30)
  • immunocytochemistry; mouse; 1:500; loading ...; fig 2b
Abcam Syt1 antibody (Abcam, ab13259) was used in immunocytochemistry on mouse samples at 1:500 (fig 2b). J Immunol Methods (2017) ncbi
mouse monoclonal (ASV30)
  • immunohistochemistry; rat; 1:100; fig 5
In order to utilize a system for neuromuscular junction development and maintenance to study mechanisms, Abcam Syt1 antibody (Abcam, ab13259) was used in immunohistochemistry on rat samples at 1:100 (fig 5). Development (2016) ncbi
Invitrogen
mouse monoclonal (ASV30)
  • immunoprecipitation; mouse; fig 4b
  • western blot; mouse; fig 3b
In order to study the activity-driven interaction between presenilin 1 and synaptotagmin 1 and links to calcium, amyloid beta, and synapse, Invitrogen Syt1 antibody (Pierce, MA125568) was used in immunoprecipitation on mouse samples (fig 4b) and in western blot on mouse samples (fig 3b). BMC Biol (2016) ncbi
mouse monoclonal (ASV30)
  • western blot; hamsters; 1:1000; fig 2
  • immunocytochemistry; rat; fig 3
In order to assess the interaction of APP with synaptotagmins that promotes A-beta generation, Invitrogen Syt1 antibody (Thermo Fisher, ASV30) was used in western blot on hamsters samples at 1:1000 (fig 2) and in immunocytochemistry on rat samples (fig 3). Mol Neurodegener (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (41)
  • western blot; human; loading ...; fig 2a
Santa Cruz Biotechnology Syt1 antibody (Santa Cruz, sc-136088) was used in western blot on human samples (fig 2a). Toxicol Lett (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D33B7)
  • western blot; mouse; loading ...; fig 8c
Cell Signaling Technology Syt1 antibody (Cell Signaling Technology, 14558) was used in western blot on mouse samples (fig 8c). Sci Adv (2022) ncbi
domestic rabbit monoclonal (D33B7)
  • western blot; mouse; loading ...; fig 3b
Cell Signaling Technology Syt1 antibody (CST, 14558) was used in western blot on mouse samples (fig 3b). Theranostics (2020) ncbi
domestic rabbit monoclonal (D33B7)
  • western blot; mouse; 1:500; loading ...; fig 4c
In order to find that complex 1 -deficient Ndufs4-/- mice present with acute vision loss around p30, and this vision loss is coincident with an 'inflammatory wave', Cell Signaling Technology Syt1 antibody (Cell signaling, 14558) was used in western blot on mouse samples at 1:500 (fig 4c). Brain Res (2017) ncbi
Developmental Studies Hybridoma Bank
mouse monoclonal (3H2 2D7)
  • immunohistochemistry; fruit fly ; 1:500; fig 6b
Developmental Studies Hybridoma Bank Syt1 antibody (Developmental Studies Hybridoma Bank, 3H2 2D7) was used in immunohistochemistry on fruit fly samples at 1:500 (fig 6b). elife (2021) ncbi
mouse monoclonal (mAB 30 (asv30))
  • western blot; mouse; 1:50; loading ...; fig s6a
Developmental Studies Hybridoma Bank Syt1 antibody (DSHB, mAB30) was used in western blot on mouse samples at 1:50 (fig s6a). Proc Natl Acad Sci U S A (2018) ncbi
mouse monoclonal (mAB 30 (asv30))
  • immunohistochemistry; mouse; 1:100; fig 8
Developmental Studies Hybridoma Bank Syt1 antibody (DSHB, 30) was used in immunohistochemistry on mouse samples at 1:100 (fig 8). Nat Commun (2015) ncbi
mouse monoclonal (3H2 2D7)
  • immunocytochemistry; fruit fly ; 1:100
In order to elucidate the molecular pathways downstream of Liprin-alpha in Drosophila brains, Developmental Studies Hybridoma Bank Syt1 antibody (Developmental Studies Hybridoma Bank, 3H2 2D7) was used in immunocytochemistry on fruit fly samples at 1:100. J Neurosci (2014) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • immunocytochemistry; rat; loading ...; fig 3
In order to study the role of astrocytes to Alzheimer's disease, MilliporeSigma Syt1 antibody (Sigma, SAB4502907) was used in immunocytochemistry on rat samples (fig 3). J Alzheimers Dis (2016) ncbi
Articles Reviewed
  1. Singh N, Das B, Zhou J, Hu X, Yan R. Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance. Sci Adv. 2022;8:eabo3610 pubmed publisher
  2. Zhou Q, Li S, Li M, Ke D, Wang Q, Yang Y, et al. Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration. EBioMedicine. 2022;78:103970 pubmed publisher
  3. Chen H, Zhang Brotzge X, Morozov Y, Li Y, Wang S, Zhang H, et al. Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. JCI Insight. 2021;6: pubmed publisher
  4. Haytural H, Jordà Siquier T, Winblad B, Mulle C, Tjernberg L, Granholm A, et al. Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease. Brain Commun. 2021;3:fcab079 pubmed publisher
  5. Ivanova D, Dobson K, Gajbhiye A, Davenport E, Hacker D, Ultanir S, et al. Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes. Sci Adv. 2021;7: pubmed publisher
  6. Kohrs F, Daumann I, Pavlović B, Jin E, Kiral F, Lin S, et al. Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies. elife. 2021;10: pubmed publisher
  7. Turecek J, Regehr W. Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters. elife. 2020;9: pubmed publisher
  8. Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht M, et al. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron. 2021;109:299-313.e9 pubmed publisher
  9. Arias Hervert E, Xu N, Njus M, Murphy G, Hou Y, Williams J, et al. Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission. Physiol Rep. 2020;8:e14428 pubmed publisher
  10. Zhang W, Zhou M, Lu W, Gong J, Gao F, Li Y, et al. CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes. Theranostics. 2020;10:3000-3021 pubmed publisher
  11. Sclip A, Sudhof T. LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses. elife. 2020;9: pubmed publisher
  12. Ye J, Yin Y, Liu H, Fang L, Tao X, Wei L, et al. Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation. Aging Cell. 2020;19:e13055 pubmed publisher
  13. Patzke C, Brockmann M, Dai J, Gan K, Grauel M, Fenske P, et al. Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell. 2019;179:498-513.e22 pubmed publisher
  14. Wang Y, Figueiredo D, Sun X, Dong Z, Chen W, Cui W, et al. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Proc Natl Acad Sci U S A. 2018;115:2508-2513 pubmed publisher
  15. Yadirgi G, Stickings P, Rajagopal S, Liu Y, Sesardic D. Immuno-detection of cleaved SNAP-25 from differentiated mouse embryonic stem cells provides a sensitive assay for determination of botulinum A toxin and antitoxin potency. J Immunol Methods. 2017;451:90-99 pubmed publisher
  16. Bouhours B, Gjoni E, Kochubey O, Schneggenburger R. Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons. J Neurosci. 2017;37:4604-4617 pubmed publisher
  17. Gümürdü A, Yildiz R, Eren E, Karakülah G, Unver T, Genc S, et al. MicroRNA exocytosis by large dense-core vesicle fusion. Sci Rep. 2017;7:45661 pubmed publisher
  18. Cao M, Wu Y, Ashrafi G, McCartney A, Wheeler H, Bushong E, et al. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron. 2017;93:882-896.e5 pubmed publisher
  19. Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, et al. Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly. Neuron. 2017;93:854-866.e4 pubmed publisher
  20. Song L, Yu A, Murray K, Cortopassi G. Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model. Brain Res. 2017;1657:232-244 pubmed publisher
  21. Horvath P, Kavalali E, Monteggia L. CRISPR/Cas9 system-mediated impairment of synaptobrevin/VAMP function in postmitotic hippocampal neurons. J Neurosci Methods. 2017;278:57-64 pubmed publisher
  22. Wolfes A, Ahmed S, Awasthi A, Stahlberg M, Rajput A, Magruder D, et al. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017;149:149-170 pubmed publisher
  23. Li Y, Chang L, Song Y, Gao X, Roselli F, Liu J, et al. Astrocytic GluN2A and GluN2B Oppose the Synaptotoxic Effects of Amyloid-?1-40 in Hippocampal Cells. J Alzheimers Dis. 2016;54:135-48 pubmed publisher
  24. Bodaleo F, Montenegro Venegas C, Henríquez D, Court F, Gonzalez Billault C. Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology. Sci Rep. 2016;6:30069 pubmed publisher
  25. Villarroel Campos D, Henríquez D, Bodaleo F, Oguchi M, Bronfman F, Fukuda M, et al. Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B. J Neurosci. 2016;36:7298-313 pubmed publisher
  26. Sclip A, Bacaj T, Giam L, Sudhof T. Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction. PLoS ONE. 2016;11:e0158295 pubmed publisher
  27. Emanuele M, Esposito A, Camerini S, Antonucci F, Ferrara S, Seghezza S, et al. Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts. EBioMedicine. 2016;7:191-204 pubmed publisher
  28. Vilmont V, Cadot B, Ouanounou G, Gomes E. A system for studying mechanisms of neuromuscular junction development and maintenance. Development. 2016;143:2464-77 pubmed publisher
  29. Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed publisher
  30. Gautam V, D Avanzo C, Berezovska O, Tanzi R, Kovacs D. Synaptotagmins interact with APP and promote Aβ generation. Mol Neurodegener. 2015;10:31 pubmed publisher
  31. Chiou Y, Liou S, Wong R, Chen C, Lee H. Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression. Toxicol Lett. 2015;237:46-54 pubmed publisher
  32. Siegert S, Seo J, Kwon E, Rudenko A, Cho S, Wang W, et al. The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nat Neurosci. 2015;18:1008-16 pubmed publisher
  33. Adams K, Rousso D, Umbach J, Novitch B. Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells. Nat Commun. 2015;6:6778 pubmed publisher
  34. Li L, Tian X, Zhu M, Bulgari D, Böhme M, Goettfert F, et al. Drosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons. J Neurosci. 2014;34:8474-87 pubmed publisher
  35. Xu W, Tse Y, Dobie F, Baudry M, Craig A, Wong T, et al. Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression. J Neurosci. 2013;33:5867-5877 pubmed publisher