This is a Validated Antibody Database (VAD) review about mouse Socs3, based on 33 published articles (read how Labome selects the articles), using Socs3 antibody in all methods. It is aimed to help Labome visitors find the most suited Socs3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Socs3 synonym: Cis3; Cish3; EF-10; Ef10; SSI-3; Ssi3; suppressor of cytokine signaling 3; CIS-3; E2a-Pbx1 target gene in fibroblasts 10; STAT-induced STAT inhibitor 3; cytokine inducible SH2-containing protein 3

Knockout validation
Abcam
rabbit polyclonal
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 4d
In order to study the roles of STAT3 and SOCS3 in NG2 cell proliferation and differentiation after spinal cord injury, Abcam Socs3 antibody (Abcam, ab16030) was used in western blot knockout validation on mouse samples at 1:1000 (fig 4d). Neurobiol Dis (2016) ncbi
Abcam
rabbit polyclonal
  • western blot; mouse; fig 5
Abcam Socs3 antibody (Abcam, ab16030) was used in western blot on mouse samples (fig 5). Int J Obes (Lond) (2017) ncbi
rabbit polyclonal
  • western blot; human; fig 3g
In order to report that TrkC contributes to tumorigenicity, metastasis, and self-renewal traits of metastatic breast cancer, Abcam Socs3 antibody (Abcam, ab16030) was used in western blot on human samples (fig 3g). Sci Rep (2016) ncbi
rabbit polyclonal
  • flow cytometry; mouse; loading ...; fig 5d
Abcam Socs3 antibody (Abcam, ab16030) was used in flow cytometry on mouse samples (fig 5d). Oncotarget (2016) ncbi
rabbit polyclonal
  • western blot; rat; fig 3
Abcam Socs3 antibody (abcam, ab16030) was used in western blot on rat samples (fig 3). Int J Mol Sci (2016) ncbi
rabbit polyclonal
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 4d
In order to study the roles of STAT3 and SOCS3 in NG2 cell proliferation and differentiation after spinal cord injury, Abcam Socs3 antibody (Abcam, ab16030) was used in western blot knockout validation on mouse samples at 1:1000 (fig 4d). Neurobiol Dis (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig 3
Abcam Socs3 antibody (Abcam, 16030) was used in western blot on human samples at 1:1000 (fig 3). PLoS ONE (2015) ncbi
rabbit polyclonal
  • western blot; human; fig 5b
Abcam Socs3 antibody (AbCam, AB16030) was used in western blot on human samples (fig 5b). Int J Obes (Lond) (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; fig 7
In order to determine the correlation between neuronal caMKII-CREB and astroglial JAK2-STAT3 cascades in mice and how spinal IL-33/ST2 signaling contributes to neuropathic pain, Abcam Socs3 antibody (Abcam, ab16030) was used in western blot on mouse samples at 1:1000 (fig 7). Anesthesiology (2015) ncbi
rabbit polyclonal
  • immunoprecipitation; human; fig s7
Abcam Socs3 antibody (Abcam, ab3693) was used in immunoprecipitation on human samples (fig s7). Leukemia (2016) ncbi
rabbit polyclonal
  • western blot; human; fig s6
Abcam Socs3 antibody (Abcam, ab16030) was used in western blot on human samples (fig s6). Leukemia (2016) ncbi
rabbit polyclonal
  • immunohistochemistry; human; 1:100
Abcam Socs3 antibody (Abcam, ab16030) was used in immunohistochemistry on human samples at 1:100. PLoS ONE (2015) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3A
  • western blot; rat; 1:1000; loading ...; fig 3A
Abcam Socs3 antibody (Abcam, ab16030) was used in western blot on human samples at 1:1000 (fig 3A) and in western blot on rat samples at 1:1000 (fig 3A). Antioxid Redox Signal (2015) ncbi
rabbit polyclonal
  • immunocytochemistry; mouse; 1:100
Abcam Socs3 antibody (Abcam, ab16030) was used in immunocytochemistry on mouse samples at 1:100. Virus Res (2014) ncbi
rabbit polyclonal
  • immunocytochemistry; human; fig 1
Abcam Socs3 antibody (Abcam, ab16030) was used in immunocytochemistry on human samples (fig 1). Endocrinology (2013) ncbi
rabbit polyclonal
  • western blot; human; fig 1a
Abcam Socs3 antibody (Abcam, ab16030) was used in western blot on human samples (fig 1a). Mol Med (2012) ncbi
Invitrogen
mouse monoclonal (1B2)
  • flow cytometry; human; 1:500; fig 6
  • western blot; human; 3 ug/ml; fig 6
In order to assess the effects of diethyldithiophosphat on human CD4+ T lymphocytes, Invitrogen Socs3 antibody (Invitrogen, 37-7200) was used in flow cytometry on human samples at 1:500 (fig 6) and in western blot on human samples at 3 ug/ml (fig 6). Toxicol Appl Pharmacol (2010) ncbi
R&D Systems
mouse monoclonal (516919)
  • immunohistochemistry - paraffin section; human
  • western blot; human; fig s3
R&D Systems Socs3 antibody (R&D Systems, 516919) was used in immunohistochemistry - paraffin section on human samples and in western blot on human samples (fig s3). Clin Exp Immunol (2014) ncbi
Cell Signaling Technology
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig s8b
Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923) was used in western blot on mouse samples at 1:1000 (fig s8b). Proc Natl Acad Sci U S A (2018) ncbi
rabbit polyclonal
  • western blot; mouse; fig 2c
Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923) was used in western blot on mouse samples (fig 2c). Nature (2018) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig s5d
Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923S) was used in western blot on mouse samples (fig s5d). J Clin Invest (2017) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 5a
Cell Signaling Technology Socs3 antibody (Cell signaling, 2923) was used in western blot on mouse samples (fig 5a). Mol Biol Cell (2017) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig st2
Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923) was used in western blot on mouse samples at 1:1000 (fig st2). Brain Behav Immun (2017) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 3a
In order to show that the MEK1/2 pathway is a key regulator of macrophage reparative properties, Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923) was used in western blot on mouse samples (fig 3a). J Immunol (2017) ncbi
rabbit polyclonal
  • western blot; human; fig s6a
In order to study the mechanisms driving uterine leiomyoma growth and survival via aberrant activation of AKT, Cell Signaling Technology Socs3 antibody (Cell signaling, 2932) was used in western blot on human samples (fig s6a). Sci Adv (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology Socs3 antibody (Cell Signaling, 2932) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 4
In order to investigate the effect of a microtubule inhibitor, MPT0B098, on STAT3 signaling in oral squamous cell carcinoma, Cell Signaling Technology Socs3 antibody (Cell Signaling, 2932) was used in western blot on human samples (fig 4). PLoS ONE (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; fig 4
Cell Signaling Technology Socs3 antibody (Cell signaling, 2923) was used in western blot on mouse samples at 1:1000 (fig 4). Sci Rep (2016) ncbi
rabbit polyclonal
  • western blot; cow; 1:1000; fig 2
In order to study how the IL6R/STAT3 signaling pathway regulates IL-8 production by primary endometrial cells in response to lipopolysaccharide treatment, Cell Signaling Technology Socs3 antibody (Cell Signaling, 2932) was used in western blot on cow samples at 1:1000 (fig 2). Mucosal Immunol (2016) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig s3b
Cell Signaling Technology Socs3 antibody (Cell Signaling, 2932) was used in western blot on mouse samples (fig s3b). Cell Death Differ (2016) ncbi
rabbit polyclonal
  • other; mouse; 1:1000; fig s1
In order to identify host signaling dynamics upon Burkholderia spp. infection by a reverse-phase protein microarray-based screen, Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923) was used in other on mouse samples at 1:1000 (fig s1). Front Microbiol (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; fig 6
In order to show that impaired SOCS3 feedback leads to permissive IL10/STAT3 signaling that promotes alternative macrophage activation and pathological neovascularization in the eyes, Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923) was used in western blot on mouse samples at 1:1000 (fig 6). Nat Commun (2015) ncbi
rabbit polyclonal
  • western blot; mouse
In order to identify DUBA as a suppressor of IL-17 production in T cells, Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923) was used in western blot on mouse samples . Nature (2015) ncbi
rabbit polyclonal
  • western blot; mouse
Cell Signaling Technology Socs3 antibody (Cell Signaling Technologies, 2923) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
EMD Millipore
mouse monoclonal (1B2)
  • reverse phase protein lysate microarray; mouse; 1:500; fig 4
In order to elucidate a 7-month cigarette smoke inhalation study in C57BL/6 mice through system biology analysis, EMD Millipore Socs3 antibody (Millipore, 04004) was used in reverse phase protein lysate microarray on mouse samples at 1:500 (fig 4). Sci Data (2016) ncbi
Articles Reviewed
  1. Giurisato E, Xu Q, Lonardi S, Telfer B, Russo I, Pearson A, et al. Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition. Proc Natl Acad Sci U S A. 2018;115:E2801-E2810 pubmed publisher
  2. Shen Q, Zhang Q, Shi Y, Shi Q, Jiang Y, Gu Y, et al. Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation. Nature. 2018;554:123-127 pubmed publisher
  3. Li B, Wang X, Choi I, Wang Y, Liu S, Pham A, et al. miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. J Clin Invest. 2017;127:3702-3716 pubmed publisher
  4. Chaudhari A, Gupta R, Patel S, Velingkaar N, Kondratov R. Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation. Mol Biol Cell. 2017;28:834-842 pubmed publisher
  5. Liu W, Liu J, Xia J, Xue X, Wang H, Qi Z, et al. Leptin receptor knockout-induced depression-like behaviors and attenuated antidepressant effects of exercise are associated with STAT3/SOCS3 signaling. Brain Behav Immun. 2017;61:297-305 pubmed publisher
  6. Long M, Eddy W, Gong K, Lovelace Macon L, McMahan R, Charron J, et al. MEK1/2 Inhibition Promotes Macrophage Reparative Properties. J Immunol. 2017;198:862-872 pubmed publisher
  7. Hwang M, Go Y, Park J, Shin S, Song S, Oh B, et al. Epac2a-null mice exhibit obesity-prone nature more susceptible to leptin resistance. Int J Obes (Lond). 2017;41:279-288 pubmed publisher
  8. Vidimar V, Gius D, Chakravarti D, Bulun S, Wei J, Kim J. Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas. Sci Adv. 2016;2:e1601132 pubmed
  9. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  10. Kim M, Jeong J, Seo J, Kim H, Kim S, Jin W. Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer. Sci Rep. 2016;6:33899 pubmed publisher
  11. Chen W, Gao L, Wang J, Wang Y, Dong Z, Zhao J, et al. Conditional ablation of HDAC3 in islet beta cells results in glucose intolerance and enhanced susceptibility to STZ-induced diabetes. Oncotarget. 2016;7:57485-57497 pubmed publisher
  12. Peng H, Cheng Y, Hsu Y, Wu G, Kuo C, Liou J, et al. MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma. PLoS ONE. 2016;11:e0158440 pubmed publisher
  13. Dinger K, Kasper P, Hucklenbruch Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher
  14. Huang Y, Chen C, Tang K, Sheen J, Tiao M, Tain Y, et al. Postnatal High-Fat Diet Increases Liver Steatosis and Apoptosis Threatened by Prenatal Dexamethasone through the Oxidative Effect. Int J Mol Sci. 2016;17:369 pubmed publisher
  15. Cronin J, Kanamarlapudi V, Thornton C, Sheldon I. Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunol. 2016;9:1125-36 pubmed publisher
  16. Hackett A, Lee D, Dawood A, Rodriguez M, Funk L, Tsoulfas P, et al. STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury. Neurobiol Dis. 2016;89:10-22 pubmed publisher
  17. Ansari S, Baumer K, Boué S, Dijon S, Dulize R, Ekroos K, et al. Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice. Sci Data. 2016;3:150077 pubmed publisher
  18. Jackson E, Rendina Ruedy E, Smith B, Lacombe V. Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet. PLoS ONE. 2015;10:e0142077 pubmed publisher
  19. Trierweiler C, Hockenjos B, Zatloukal K, Thimme R, Blum H, Wagner E, et al. The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice. Cell Death Differ. 2016;23:576-82 pubmed publisher
  20. Singh P, Sharma P, Sahakyan K, Davison D, Sert Kuniyoshi F, Romero Corral A, et al. Differential effects of leptin on adiponectin expression with weight gain versus obesity. Int J Obes (Lond). 2016;40:266-74 pubmed publisher
  21. Liu S, Mi W, Li Q, Zhang M, Han P, Hu S, et al. Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII-CREB and Astroglial JAK2-STAT3 Cascades in Mice. Anesthesiology. 2015;123:1154-69 pubmed publisher
  22. Chiang C, Uzoma I, Lane D, Memišević V, Alem F, Yao K, et al. A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection. Front Microbiol. 2015;6:683 pubmed publisher
  23. Nakamura R, Sene A, Santeford A, Gdoura A, Kubota S, Zapata N, et al. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun. 2015;6:7847 pubmed publisher
  24. Roncero A, López Nieva P, Cobos Fernández M, Villa Morales M, González Sánchez L, López Lorenzo J, et al. Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development. Leukemia. 2016;30:94-103 pubmed publisher
  25. Kim M, Kim M, Kim W, Kang M, Cacalano N, Kang S, et al. Suppressor of cytokine signaling (SOCS) genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells. PLoS ONE. 2015;10:e0123133 pubmed publisher
  26. Zhang X, Zhang J, Chen X, Hu Q, Wang M, Jin R, et al. Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. Antioxid Redox Signal. 2015;22:848-70 pubmed publisher
  27. Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed publisher
  28. Vartoukian S, Tilakaratne W, Seoudi N, Bombardieri M, Bergmeier L, Tappuni A, et al. Dysregulation of the suppressor of cytokine signalling 3-signal transducer and activator of transcription-3 pathway in the aetiopathogenesis of Sjögren's syndrome. Clin Exp Immunol. 2014;177:618-29 pubmed publisher
  29. Sriram U, Xu J, Chain R, Varghese L, Chakhtoura M, Bennett H, et al. IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells. PLoS ONE. 2014;9:e87668 pubmed publisher
  30. Low Calle A, Prada Arismendy J, Castellanos J. Study of interferon-? antiviral activity against Herpes simplex virus type 1 in neuron-enriched trigeminal ganglia cultures. Virus Res. 2014;180:49-58 pubmed publisher
  31. Zhao Y, Park S, Bagchi M, Taylor R, Katzenellenbogen B. The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization. Endocrinology. 2013;154:1349-60 pubmed publisher
  32. Li Y, Deuring J, Peppelenbosch M, Kuipers E, de Haar C, van der Woude C. STAT1, STAT6 and adenosine 3',5'-cyclic monophosphate (cAMP) signaling drive SOCS3 expression in inactive ulcerative colitis. Mol Med. 2012;18:1412-9 pubmed publisher
  33. Esquivel Sentíes M, Barrera I, Ortega A, Vega L. Organophosphorous pesticide metabolite (DEDTP) induces changes in the activation status of human lymphocytes by modulating the interleukin 2 receptor signal transduction pathway. Toxicol Appl Pharmacol. 2010;248:122-33 pubmed publisher