This is a Validated Antibody Database (VAD) review about mouse Slc6a3, based on 39 published articles (read how Labome selects the articles), using Slc6a3 antibody in all methods. It is aimed to help Labome visitors find the most suited Slc6a3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Slc6a3 synonym: DAT; Dat1; sodium-dependent dopamine transporter; DA transporter; dopamine transporter 1

Abcam
rat monoclonal (hDAT-NT)
  • immunocytochemistry; human; loading ...; fig 2
Abcam Slc6a3 antibody (Abcam, AB5990) was used in immunocytochemistry on human samples (fig 2). J Stem Cells Regen Med (2018) ncbi
rat monoclonal (hDAT-NT)
  • immunocytochemistry; mouse; fig s12
Abcam Slc6a3 antibody (Abcam, ab5990) was used in immunocytochemistry on mouse samples (fig s12). Nat Commun (2016) ncbi
rat monoclonal (hDAT-NT)
  • flow cytometry; mouse; fig s5
  • flow cytometry; human; fig s4
Abcam Slc6a3 antibody (Abcam, ab5990) was used in flow cytometry on mouse samples (fig s5) and in flow cytometry on human samples (fig s4). Lab Invest (2014) ncbi
Santa Cruz Biotechnology
rat monoclonal (6-5G10)
  • immunohistochemistry - paraffin section; mouse; 1:250
Santa Cruz Biotechnology Slc6a3 antibody (Santa Cruz, sc-32258) was used in immunohistochemistry - paraffin section on mouse samples at 1:250. PLoS Genet (2014) ncbi
Invitrogen
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 5a
In order to assess the role of prolyl oligopeptidase in the nigrostriatal dopaminergic and GABAergic systems of wild-type C57Bl/6 and prolyl oligopeptidase knockout mice, Invitrogen Slc6a3 antibody (Thermo Fisher Scientific, PA1-4656) was used in western blot on mouse samples at 1:1000 (fig 5a). Mol Neurobiol (2018) ncbi
EMD Millipore
rabbit polyclonal
  • immunohistochemistry; mouse; fig 2e
EMD Millipore Slc6a3 antibody (Millipore, AB1591p) was used in immunohistochemistry on mouse samples (fig 2e). Cell (2018) ncbi
rabbit polyclonal
  • western blot; mouse; 1:20,000; loading ...; fig 4c
EMD Millipore Slc6a3 antibody (Millipore, AB2231) was used in western blot on mouse samples at 1:20,000 (fig 4c). Neuropharmacology (2018) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry - frozen section; mouse; loading ...; tbl 1
In order to elucidate the contribution of the Sac phosphatase domain of Synaptojanin 1 to neurological symptoms, EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in immunohistochemistry - frozen section on mouse samples (tbl 1). Neuron (2017) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry - free floating section; mouse; 1:200; loading ...; fig 6k
EMD Millipore Slc6a3 antibody (Chemicon, MAB369) was used in immunohistochemistry - free floating section on mouse samples at 1:200 (fig 6k). PLoS ONE (2017) ncbi
rat monoclonal (DAT-Nt)
  • western blot; mouse; 1:1000; loading ...; fig 3e
In order to test if activin A has anti-inflammatory and neuroprotective effects in in vivo mouse models of Parkinson's disease, EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in western blot on mouse samples at 1:1000 (fig 3e). PLoS ONE (2017) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry; mouse; 1:1000; loading ...
EMD Millipore Slc6a3 antibody (Chemicon, MAB369) was used in immunohistochemistry on mouse samples at 1:1000. Front Neuroanat (2016) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 4c
In order to demonstrate the protective effects of an oligomer-specific single-chain variable fragment antibody in Parkinson's disease and Huntington's disease mouse models, EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in immunohistochemistry - paraffin section on mouse samples at 1:100 (fig 4c). Sci Rep (2016) ncbi
rat monoclonal (DAT-Nt)
  • western blot; mouse; loading ...; fig 7a
In order to examine the dopaminergic abnormalities in Histone deacetylase 6 knockout mice, EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in western blot on mouse samples (fig 7a). Neuropharmacology (2016) ncbi
rat monoclonal (DAT-Nt)
  • western blot; mouse; 1:5000; loading ...; fig 1a
EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in western blot on mouse samples at 1:5000 (fig 1a). J Neurosci (2016) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 2f
In order to demonstrate that sustained Lmx1a and Lmx1b expression is needed for the survival of adult midbrain dopaminergic neurons, EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in immunohistochemistry - frozen section on mouse samples at 1:1000 (fig 2f). Proc Natl Acad Sci U S A (2016) ncbi
rabbit polyclonal
  • western blot; rat; loading ...; fig 5b
In order to examine the effects of dietary calcium supplementation and the mesocorticolimbic dopaminergic reward system in obese rats, EMD Millipore Slc6a3 antibody (Millipore, B1591P) was used in western blot on rat samples (fig 5b). J Neuroendocrinol (2016) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry; mouse; 1:1000; fig 2
In order to utilize an in vitro cell culture modeling neurodegenerative diseases to learn about brain aggregates, EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in immunohistochemistry on mouse samples at 1:1000 (fig 2). J Neuropathol Exp Neurol (2016) ncbi
rat monoclonal (DAT-Nt)
  • western blot; mouse; 1:200; loading ...; fig s6a
EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in western blot on mouse samples at 1:200 (fig s6a). Nat Neurosci (2016) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry; mouse; 1:1000; fig 8
In order to characterize sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain by primary cilia, EMD Millipore Slc6a3 antibody (Millipore, AB369) was used in immunohistochemistry on mouse samples at 1:1000 (fig 8). Dev Biol (2016) ncbi
rat monoclonal (DAT-Nt)
  • western blot; mouse; loading ...; fig 8b
EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in western blot on mouse samples (fig 8b). Sci Rep (2015) ncbi
rabbit polyclonal
  • western blot; rat; 1:1000
EMD Millipore Slc6a3 antibody (Millipore, AB2231) was used in western blot on rat samples at 1:1000. Neuropsychopharmacology (2016) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry; mouse; 1:1000; fig 5
EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in immunohistochemistry on mouse samples at 1:1000 (fig 5). Nat Neurosci (2015) ncbi
rat monoclonal (DAT-Nt)
  • immunocytochemistry; mouse; 1:1000
EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in immunocytochemistry on mouse samples at 1:1000. J Neurosci (2015) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 5a
EMD Millipore Slc6a3 antibody (Merck Millipore, MAB369) was used in immunohistochemistry - frozen section on mouse samples at 1:1000 (fig 5a). PLoS ONE (2015) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry - free floating section; mouse; 1:1000
In order to assess the effects of peripherally administered Nrg1beta1 in a toxin-based mouse model of Parkinson's disease, EMD Millipore Slc6a3 antibody (Chemicon International, MAB369) was used in immunohistochemistry - free floating section on mouse samples at 1:1000. J Neurochem (2015) ncbi
rat monoclonal (DAT-Nt)
  • western blot; rat; 1:2000
EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in western blot on rat samples at 1:2000. Addict Biol (2016) ncbi
rat monoclonal (DAT-Nt)
  • immunocytochemistry; mouse; 1:500
In order to investigate their role Nurr1 in the generation of dopaminergic neurons, EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in immunocytochemistry on mouse samples at 1:500. Dev Neurobiol (2015) ncbi
rat monoclonal (DAT-Nt)
  • western blot; human; 1:1000
EMD Millipore Slc6a3 antibody (Chemicon International, MAB369) was used in western blot on human samples at 1:1000. Transl Psychiatry (2014) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry - frozen section; rat; 1:100
EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in immunohistochemistry - frozen section on rat samples at 1:100. BMC Complement Altern Med (2014) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry; mouse; 1:1,000
EMD Millipore Slc6a3 antibody (EMD Millipore, MAB369) was used in immunohistochemistry on mouse samples at 1:1,000. J Comp Neurol (2015) ncbi
rat monoclonal (DAT-Nt)
  • immunocytochemistry; mouse
EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in immunocytochemistry on mouse samples . J Neurosci (2014) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry - free floating section; mouse; 1:300
EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in immunohistochemistry - free floating section on mouse samples at 1:300. Front Behav Neurosci (2014) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry; human; 1:250
EMD Millipore Slc6a3 antibody (Millipore, MAB369) was used in immunohistochemistry on human samples at 1:250. J Psychiatry Neurosci (2014) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry; rat; 1:20,000
EMD Millipore Slc6a3 antibody (Chemicon, AB369) was used in immunohistochemistry on rat samples at 1:20,000. J Comp Neurol (2013) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; fig 5
In order to investigate the contribution of LPA1 receptors to drug abuse, EMD Millipore Slc6a3 antibody (Millipore, AB1591P) was used in western blot on mouse samples at 1:1000 (fig 5). Psychopharmacology (Berl) (2012) ncbi
rat monoclonal (DAT-Nt)
  • immunohistochemistry - frozen section; mouse; 1:300
EMD Millipore Slc6a3 antibody (Chemicon, MAB369) was used in immunohistochemistry - frozen section on mouse samples at 1:300. J Comp Neurol (2008) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 5b
In order to elucidate the effects of mutations in leucine-rich repeat kinase 2 on nigro0striatal dopamine neurons, Sigma-Aldrich Slc6a3 antibody (Sigma, D6944) was used in western blot on mouse samples at 1:1000 (fig 5b). Acta Neuropathol Commun (2017) ncbi
rabbit polyclonal
  • immunocytochemistry; human; loading ...; fig 3a
  • western blot; human; loading ...; fig 4a
In order to present the trophic and modulatory potential of statins in a dopaminergic cell line, Sigma-Aldrich Slc6a3 antibody (Sigma-Aldrich, D6944) was used in immunocytochemistry on human samples (fig 3a) and in western blot on human samples (fig 4a). Synapse (2016) ncbi
rabbit polyclonal
  • western blot; rat
In order to examine the p.G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) and it's role in Parkinson's disease, Sigma-Aldrich Slc6a3 antibody (Sigma, D6944) was used in western blot on rat samples . J Parkinsons Dis (2014) ncbi
Articles Reviewed
  1. Playne R, Jones K, Connor B. Generation of dopamine neuronal-like cells from induced neural precursors derived from adult human cells by non-viral expression of lineage factors. J Stem Cells Regen Med. 2018;14:34-44 pubmed
  2. Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser P. Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. Cell. 2018;172:706-718.e15 pubmed publisher
  3. Curry D, Young M, Tran A, Daoud G, Howell L. Separating the agony from ecstasy: R(-)-3,4-methylenedioxymethamphetamine has prosocial and therapeutic-like effects without signs of neurotoxicity in mice. Neuropharmacology. 2018;128:196-206 pubmed publisher
  4. Longo F, Mercatelli D, Novello S, Arcuri L, Brugnoli A, Vincenzi F, et al. Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. Acta Neuropathol Commun. 2017;5:22 pubmed publisher
  5. Cao M, Wu Y, Ashrafi G, McCartney A, Wheeler H, Bushong E, et al. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron. 2017;93:882-896.e5 pubmed publisher
  6. Stott S, Hayat S, Carnwath T, Garas S, Sleeman J, Barker R. CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease. PLoS ONE. 2017;12:e0171748 pubmed publisher
  7. Stayte S, Rentsch P, Tröscher A, Bamberger M, Li K, Vissel B. Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo. PLoS ONE. 2017;12:e0167211 pubmed publisher
  8. Cádiz Moretti B, Abellán Álvaro M, Pardo Bellver C, Martinez Garcia F, Lanuza E. Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice. Front Neuroanat. 2016;10:125 pubmed publisher
  9. Julku U, Panhelainen A, Tiilikainen S, Svarcbahs R, Tammimäki A, Piepponen T, et al. Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse. Mol Neurobiol. 2018;55:470-482 pubmed publisher
  10. Zha J, Liu X, Zhu J, Liu S, Lu S, Xu P, et al. A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses. Sci Rep. 2016;6:36631 pubmed publisher
  11. Fukada M, Nakayama A, Mamiya T, Yao T, Kawaguchi Y. Dopaminergic abnormalities in Hdac6-deficient mice. Neuropharmacology. 2016;110:470-479 pubmed publisher
  12. Cockerham R, Liu S, Cachope R, Kiyokage E, Cheer J, Shipley M, et al. Subsecond Regulation of Synaptically Released Dopamine by COMT in the Olfactory Bulb. J Neurosci. 2016;36:7779-85 pubmed publisher
  13. Doucet Beaupré H, Gilbert C, Profes M, Chabrat A, Pacelli C, Giguère N, et al. Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons. Proc Natl Acad Sci U S A. 2016;113:E4387-96 pubmed publisher
  14. Conceição E, Carvalho J, Manhães A, Guarda D, Figueiredo M, Quitete F, et al. Effect of Early Overfeeding on Palatable Food Preference and Brain Dopaminergic Reward System at Adulthood: Role of Calcium Supplementation. J Neuroendocrinol. 2016;28: pubmed publisher
  15. Ahn M, Kalume F, Pitstick R, Oehler A, Carlson G, Dearmond S. Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2016;75:256-62 pubmed publisher
  16. Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, et al. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun. 2016;7:10332 pubmed publisher
  17. Schmitt M, Dehay B, Bezard E, Garcia Ladona F. Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line. Synapse. 2016;70:71-86 pubmed publisher
  18. Ren W, Centeno M, Berger S, Wu Y, Na X, Liu X, et al. The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain. Nat Neurosci. 2016;19:220-2 pubmed publisher
  19. Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, et al. Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain. Dev Biol. 2016;409:55-71 pubmed publisher
  20. Dearborn J, Harmon S, Fowler S, O Malley K, Taylor G, Sands M, et al. Comprehensive functional characterization of murine infantile Batten disease including Parkinson-like behavior and dopaminergic markers. Sci Rep. 2015;5:12752 pubmed publisher
  21. Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, et al. Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids. Neuropsychopharmacology. 2016;41:811-21 pubmed publisher
  22. Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen J, et al. Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nat Neurosci. 2015;18:826-35 pubmed publisher
  23. Xenias H, Ibáñez Sandoval O, Koós T, Tepper J. Are striatal tyrosine hydroxylase interneurons dopaminergic?. J Neurosci. 2015;35:6584-99 pubmed publisher
  24. Stayte S, Rentsch P, Li K, Vissel B. Activin A protects midbrain neurons in the 6-hydroxydopamine mouse model of Parkinson's disease. PLoS ONE. 2015;10:e0124325 pubmed publisher
  25. Depboylu C, Rösler T, de Andrade A, Oertel W, Höglinger G. Systemically administered neuregulin-1β1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson's disease. J Neurochem. 2015;133:590-7 pubmed publisher
  26. García Pérez D, Núñez C, Laorden M, Milanés M. Regulation of dopaminergic markers expression in response to acute and chronic morphine and to morphine withdrawal. Addict Biol. 2016;21:374-86 pubmed publisher
  27. Bifsha P, Yang J, Fisher R, Drouin J. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS Genet. 2014;10:e1004863 pubmed publisher
  28. Vergaño Vera E, Díaz Guerra E, Rodríguez Traver E, Méndez Gómez H, Solís Ã, Pignatelli J, et al. Nurr1 blocks the mitogenic effect of FGF-2 and EGF, inducing olfactory bulb neural stem cells to adopt dopaminergic and dopaminergic-GABAergic neuronal phenotypes. Dev Neurobiol. 2015;75:823-41 pubmed publisher
  29. Bowton E, Saunders C, Reddy I, Campbell N, Hamilton P, Henry L, et al. SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl Psychiatry. 2014;4:e464 pubmed publisher
  30. Gao J, Tu S, Liu J, Zhang J, Huang Y, Han M, et al. An-jun-ning, a traditional herbal formula, attenuates spontaneous withdrawal symptoms via modulation of the dopamine system in morphine-dependent rats. BMC Complement Altern Med. 2014;14:308 pubmed publisher
  31. Quina L, Tempest L, Ng L, Harris J, Ferguson S, Jhou T, et al. Efferent pathways of the mouse lateral habenula. J Comp Neurol. 2015;523:32-60 pubmed publisher
  32. Postupna N, Keene C, Latimer C, Sherfield E, Van Gelder R, Ojemann J, et al. Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease. Lab Invest. 2014;94:1161-72 pubmed publisher
  33. Walker M, Volta M, Cataldi S, Dinelle K, Beccano Kelly D, Munsie L, et al. Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging. J Parkinsons Dis. 2014;4:483-98 pubmed publisher
  34. Montgomery T, Steinkellner T, Sucic S, Koban F, Schüchner S, Ogris E, et al. Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum. J Neurosci. 2014;34:6344-6351 pubmed publisher
  35. Ting J, Feng G. Recombineering strategies for developing next generation BAC transgenic tools for optogenetics and beyond. Front Behav Neurosci. 2014;8:111 pubmed publisher
  36. Kim H, Andreazza A, Yeung P, Isaacs Trepanier C, Young L. Oxidation and nitration in dopaminergic areas of the prefrontal cortex from patients with bipolar disorder and schizophrenia. J Psychiatry Neurosci. 2014;39:276-85 pubmed
  37. Garzón M, Pickel V. Somatodendritic targeting of M5 muscarinic receptor in the rat ventral tegmental area: implications for mesolimbic dopamine transmission. J Comp Neurol. 2013;521:2927-46 pubmed publisher
  38. Blanco E, Bilbao A, Luque Rojas M, Palomino A, Bermudez Silva F, Suarez J, et al. Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors. Psychopharmacology (Berl). 2012;220:27-42 pubmed publisher
  39. Witkovsky P, G briel R, Krizaj D. Anatomical and neurochemical characterization of dopaminergic interplexiform processes in mouse and rat retinas. J Comp Neurol. 2008;510:158-74 pubmed publisher