This is a Validated Antibody Database (VAD) review about mouse Six2, based on 16 published articles (read how Labome selects the articles), using Six2 antibody in all methods. It is aimed to help Labome visitors find the most suited Six2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Six2 synonym: homeobox protein SIX2; sine oculis homeobox homolog 2; sine oculis-related homeobox 2 homolog

Proteintech Group
rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig 1f
Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunohistochemistry on mouse samples (fig 1f). elife (2019) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:200; fig 4a
  • western blot; human; 1:600; fig s2
Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunocytochemistry on human samples at 1:200 (fig 4a) and in western blot on human samples at 1:600 (fig s2). PLoS ONE (2018) ncbi
rabbit polyclonal
  • immunohistochemistry; mouse; 1:300; fig 2
In order to investigate the roles of NF2, LATS1/2, and YAP in the branching morphogenesis of the mouse kidney, Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunohistochemistry on mouse samples at 1:300 (fig 2). Nat Commun (2016) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; fig 4d
  • western blot; mouse; loading ...; fig 2i
In order to determine the contributions of Osr1 and Wt1 during early nephrogenesis using transgenic mice, Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunohistochemistry - paraffin section on mouse samples (fig 4d) and in western blot on mouse samples (fig 2i). PLoS ONE (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; mouse; 1:200; fig 8a
In order to develop methods to culture mesothelial cells isolated from the mouse omentum and characterize the cells, Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunocytochemistry on mouse samples at 1:200 (fig 8a). PLoS ONE (2016) ncbi
rabbit polyclonal
  • immunohistochemistry; rat; 1:500; fig s13
Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunohistochemistry on rat samples at 1:500 (fig s13). Sci Rep (2016) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:100
Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunohistochemistry - paraffin section on human samples at 1:100. PLoS ONE (2015) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:300
In order to evaluate the kidney organoids from human iPS cells, Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunocytochemistry on human samples at 1:300. Nature (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:600
In order to study kidney development in Robo2 mouse mutants, Proteintech Group Six2 antibody (United Bioresearch Products, 11562-1-AP) was used in immunohistochemistry - paraffin section on mouse samples at 1:600. Dev Biol (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 2
  • western blot; mouse; 1:500; fig S4
Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunohistochemistry - paraffin section on mouse samples at 1:200 (fig 2) and in western blot on mouse samples at 1:500 (fig S4). Development (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:100
Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunohistochemistry - paraffin section on mouse samples at 1:100. PLoS ONE (2014) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:200
In order to investigate the role of Mdm2 in the nephrogenic niche, Proteintech Group Six2 antibody (Proteintech group, 11562-1-AP) was used in immunohistochemistry - paraffin section on mouse samples at 1:200. Dev Biol (2014) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:200; fig 3
In order to describe a protocol for pluripotent-stem-cell-based renal regeneration, Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunocytochemistry on human samples at 1:200 (fig 3). Nat Cell Biol (2014) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; fig 3
Proteintech Group Six2 antibody (Proteintech, 11562-1-AP) was used in immunohistochemistry - paraffin section on mouse samples (fig 3). PLoS Genet (2013) ncbi
Santa Cruz Biotechnology
mouse monoclonal (H-4)
  • immunohistochemistry - frozen section; mouse
In order to study the development of renal vasculature and the role played by Tbx18, Santa Cruz Biotechnology Six2 antibody (Santa Cruz, sc377193) was used in immunohistochemistry - frozen section on mouse samples . Dev Biol (2014) ncbi
Sigma-Aldrich
rabbit polyclonal
  • ChIP-Seq; rat; fig 6
  • immunohistochemistry; rat; fig 9
  • western blot; rat; fig 9
Sigma-Aldrich Six2 antibody (Sigma, SAB2103006) was used in ChIP-Seq on rat samples (fig 6), in immunohistochemistry on rat samples (fig 9) and in western blot on rat samples (fig 9). Cell Death Dis (2016) ncbi
Articles Reviewed
  1. Lawlor K, Zappia L, Lefevre J, Park J, Hamilton N, Oshlack A, et al. Nephron progenitor commitment is a stochastic process influenced by cell migration. elife. 2019;8: pubmed publisher
  2. Hsieh W, Ramadesikan S, FEKETE D, Aguilar R. Kidney-differentiated cells derived from Lowe Syndrome patient's iPSCs show ciliogenesis defects and Six2 retention at the Golgi complex. PLoS ONE. 2018;13:e0192635 pubmed publisher
  3. Reginensi A, Enderle L, Gregorieff A, Johnson R, Wrana J, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016;7:12309 pubmed publisher
  4. Xu J, Liu H, Chai O, Lan Y, Jiang R. Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis. PLoS ONE. 2016;11:e0159597 pubmed publisher
  5. Dauleh S, Santeramo I, Fielding C, Ward K, Herrmann A, Murray P, et al. Characterisation of Cultured Mesothelial Cells Derived from the Murine Adult Omentum. PLoS ONE. 2016;11:e0158997 pubmed publisher
  6. Kirita Y, Kami D, Ishida R, Adachi T, Tamagaki K, Matoba S, et al. Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates. Sci Rep. 2016;6:26792 pubmed publisher
  7. Gao J, Kang X, Sun S, Li L, Zhang B, Li Y, et al. Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression. Cell Death Dis. 2016;7:e2217 pubmed publisher
  8. Batchelder C, Martinez M, Tarantal A. Natural Scaffolds for Renal Differentiation of Human Embryonic Stem Cells for Kidney Tissue Engineering. PLoS ONE. 2015;10:e0143849 pubmed publisher
  9. Takasato M, Er P, Chiu H, Maier B, Baillie G, Ferguson C, et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature. 2015;526:564-8 pubmed publisher
  10. Wainwright E, Wilhelm D, Combes A, Little M, Koopman P. ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation. Dev Biol. 2015;404:88-102 pubmed publisher
  11. Kann M, Bae E, Lenz M, Li L, Trannguyen B, Schumacher V, et al. WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015;142:1254-66 pubmed publisher
  12. Xu J, Nie X, Cai X, Cai C, Xu P. Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney. Dev Biol. 2014;391:17-31 pubmed publisher
  13. Hum S, Rymer C, Schaefer C, Bushnell D, Sims Lucas S. Ablation of the renal stroma defines its critical role in nephron progenitor and vasculature patterning. PLoS ONE. 2014;9:e88400 pubmed publisher
  14. Hilliard S, Yao X, El Dahr S. Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol. 2014;387:1-14 pubmed publisher
  15. Takasato M, Er P, Becroft M, Vanslambrouck J, Stanley E, Elefanty A, et al. Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nat Cell Biol. 2014;16:118-26 pubmed publisher
  16. Reginensi A, Scott R, Gregorieff A, Bagherie Lachidan M, Chung C, Lim D, et al. Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet. 2013;9:e1003380 pubmed publisher