This is a Validated Antibody Database (VAD) review about mouse Sirt3, based on 28 published articles (read how Labome selects the articles), using Sirt3 antibody in all methods. It is aimed to help Labome visitors find the most suited Sirt3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Sirt3 synonym: 2310003L23Rik; AI848213; Sir2l3

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; mouse; loading ...; fig 3b
Cell Signaling Technology Sirt3 antibody (CST, 5490) was used in western blot knockout validation on mouse samples (fig 3b). Cell Death Dis (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D22A3)
  • immunocytochemistry knockout validation; mouse; loading ...; fig 5i
  • western blot knockout validation; mouse; loading ...; fig 5j
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490S) was used in immunocytochemistry knockout validation on mouse samples (fig 5i) and in western blot knockout validation on mouse samples (fig 5j). Biology (Basel) (2020) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 1a
Cell Signaling Technology Sirt3 antibody (Cell Signaling Technology, D22A3) was used in western blot knockout validation on mouse samples at 1:1000 (fig 1a). Antioxidants (Basel) (2020) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; human; loading ...; fig 1a
Cell Signaling Technology Sirt3 antibody (Cell Signaling Technology, 5490) was used in western blot knockout validation on human samples (fig 1a). Cell Rep (2018) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; mouse; loading ...; fig 6b
Cell Signaling Technology Sirt3 antibody (Cell signaling, 5490) was used in western blot knockout validation on mouse samples (fig 6b). J Mol Cell Cardiol (2017) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; mouse; loading ...; fig 1a
  • immunoprecipitation; mouse; loading ...; fig 5e
  • western blot; rat; fig 3d
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot knockout validation on mouse samples (fig 1a), in immunoprecipitation on mouse samples (fig 5e) and in western blot on rat samples (fig 3d). Oncotarget (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; mouse; fig 1
Cell Signaling Technology Sirt3 antibody (Cell signaling, 5490) was used in western blot knockout validation on mouse samples (fig 1). J Cell Mol Med (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; loading ...; fig 5a
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot on mouse samples (fig 5a). J Biol Chem (2022) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; mouse; loading ...; fig 3b
Cell Signaling Technology Sirt3 antibody (CST, 5490) was used in western blot knockout validation on mouse samples (fig 3b). Cell Death Dis (2021) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; 1:1000; loading ...; fig 3c
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot on mouse samples at 1:1000 (fig 3c). Aging Cell (2021) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; loading ...; fig 3a
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot on mouse samples (fig 3a). Nutrients (2021) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; 1:1000; loading ...; fig 6e
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot on mouse samples at 1:1000 (fig 6e). Commun Biol (2021) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; 1:2000; loading ...; fig 2j
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot on mouse samples at 1:2000 (fig 2j). elife (2020) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; loading ...; fig 3a
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490s) was used in western blot on mouse samples (fig 3a). Infect Immun (2021) ncbi
domestic rabbit monoclonal (D22A3)
  • immunocytochemistry knockout validation; mouse; loading ...; fig 5i
  • western blot knockout validation; mouse; loading ...; fig 5j
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490S) was used in immunocytochemistry knockout validation on mouse samples (fig 5i) and in western blot knockout validation on mouse samples (fig 5j). Biology (Basel) (2020) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; 1:1000; loading ...; fig 4a
Cell Signaling Technology Sirt3 antibody (CST, 5490) was used in western blot on mouse samples at 1:1000 (fig 4a). J Cell Mol Med (2020) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 1a
Cell Signaling Technology Sirt3 antibody (Cell Signaling Technology, D22A3) was used in western blot knockout validation on mouse samples at 1:1000 (fig 1a). Antioxidants (Basel) (2020) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; 1:1000; loading ...; fig 1e
Cell Signaling Technology Sirt3 antibody (Cell Signaling Technology, 5490S) was used in western blot on mouse samples at 1:1000 (fig 1e). Sci Rep (2019) ncbi
domestic rabbit monoclonal (D22A3)
  • immunohistochemistry; mouse; loading ...; fig 1b
  • western blot; mouse; fig 2d, 2e
Cell Signaling Technology Sirt3 antibody (Cell Signaling Technology, 5490) was used in immunohistochemistry on mouse samples (fig 1b) and in western blot on mouse samples (fig 2d, 2e). JCI Insight (2019) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; human; loading ...; fig 1a
Cell Signaling Technology Sirt3 antibody (Cell Signaling Technology, 5490) was used in western blot knockout validation on human samples (fig 1a). Cell Rep (2018) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; human; fig s5f
Cell Signaling Technology Sirt3 antibody (Cell Signaling Technology, 5490) was used in western blot on human samples (fig s5f). Cell (2018) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; 1:1000; loading ...; fig s3s5
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot on mouse samples at 1:1000 (fig s3s5). elife (2018) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; loading ...; fig 5a
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot on mouse samples (fig 5a). Proc Natl Acad Sci U S A (2018) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; mouse; loading ...; fig 6b
Cell Signaling Technology Sirt3 antibody (Cell signaling, 5490) was used in western blot knockout validation on mouse samples (fig 6b). J Mol Cell Cardiol (2017) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; 1:1000; fig 5a
In order to study the contribution of Id1 to brown adipose tissue thermogenesis and to the regulation of beige adipocytes in white adipose tissue, Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot on mouse samples at 1:1000 (fig 5a). Diabetes (2017) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; loading ...; fig 6
Cell Signaling Technology Sirt3 antibody (Cell Signaling, D22A3) was used in western blot on mouse samples (fig 6). Am J Physiol Endocrinol Metab (2017) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; mouse; loading ...; fig 1a
  • immunoprecipitation; mouse; loading ...; fig 5e
  • western blot; rat; fig 3d
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot knockout validation on mouse samples (fig 1a), in immunoprecipitation on mouse samples (fig 5e) and in western blot on rat samples (fig 3d). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; loading ...; fig 4a
Cell Signaling Technology Sirt3 antibody (Cell Signaling Technology, 5490) was used in western blot on mouse samples (fig 4a). J Exp Med (2016) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse; fig 4
Cell Signaling Technology Sirt3 antibody (Cell signaling, 5490) was used in western blot on mouse samples (fig 4). PLoS ONE (2015) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse
In order to test the requirement of AMP-activated protein kinase for exercise training-induced increases in skeletal muscle abundance of mitochondrial proteins, Cell Signaling Technology Sirt3 antibody (Cell Signaling, #5490S) was used in western blot on mouse samples . Front Physiol (2015) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot knockout validation; mouse; fig 1
Cell Signaling Technology Sirt3 antibody (Cell signaling, 5490) was used in western blot knockout validation on mouse samples (fig 1). J Cell Mol Med (2015) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; human; 1:1000
Cell Signaling Technology Sirt3 antibody (Cell Signaling Technology, 5490) was used in western blot on human samples at 1:1000. Biochim Biophys Acta (2015) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; mouse
In order to study the mechanism underlying the preventative effect of uridine against fenofibrate-induced fatty liver disease, Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
domestic rabbit monoclonal (D22A3)
  • western blot; human
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490) was used in western blot on human samples . Anal Chem (2013) ncbi
domestic rabbit monoclonal (D22A3)
  • immunocytochemistry; human; 1:50
  • western blot; human
Cell Signaling Technology Sirt3 antibody (Cell Signaling, 5490 s) was used in immunocytochemistry on human samples at 1:50 and in western blot on human samples . Age (Dordr) (2013) ncbi
Articles Reviewed
  1. Wang X, Xie C, Libby A, Ranjit S, Levi J, Myakala K, et al. The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice. J Biol Chem. 2022;298:102530 pubmed publisher
  2. Zhang Y, Wen P, Luo J, Ding H, Cao H, He W, et al. Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis. Cell Death Dis. 2021;12:847 pubmed publisher
  3. Wallace M, Aguirre N, Marcotte G, Marshall A, Baehr L, Hughes D, et al. The ketogenic diet preserves skeletal muscle with aging in mice. Aging Cell. 2021;20:e13322 pubmed publisher
  4. Akashi S, Morita A, Mochizuki Y, Shibuya F, Kamei Y, Miura S. Citrus hassaku Extract Powder Increases Mitochondrial Content and Oxidative Muscle Fibers by Upregulation of PGC-1α in Skeletal Muscle. Nutrients. 2021;13: pubmed publisher
  5. Stojakovic A, Trushin S, Sheu A, Khalili L, Chang S, Li X, et al. Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Commun Biol. 2021;4:61 pubmed publisher
  6. Ow J, Cadez M, Zafer G, Foo J, Li H, Ghosh S, et al. Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division. elife. 2020;9: pubmed publisher
  7. Zhao J, Liu X, Chen Y, Zhang L, Zhang Y, Ji D, et al. STAT3 Promotes Schistosome-Induced Liver Injury by Inflammation, Oxidative Stress, Proliferation, and Apoptosis Signal Pathway. Infect Immun. 2021;89: pubmed publisher
  8. Wang C, Chen C, Lin M, Su H, Ho M, Yeh J, et al. TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity. Biology (Basel). 2020;9: pubmed publisher
  9. Li M, Li C, Ye Z, Huang J, Li Y, Lai W, et al. Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice. J Cell Mol Med. 2020;24:5109-5121 pubmed publisher
  10. Pinterić M, Podgorski I, Hadžija M, Bujak I, Dekanic A, Bagarić R, et al. Role of Sirt3 in Differential Sex-Related Responses to a High-Fat Diet in Mice. Antioxidants (Basel). 2020;9: pubmed publisher
  11. Lin J, Lin J, Chen H, Chen T, Apte R. Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes. Sci Rep. 2019;9:3799 pubmed publisher
  12. Kurundkar D, Kurundkar A, Bone N, Becker E, Liu W, Chacko B, et al. SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. JCI Insight. 2019;4: pubmed publisher
  13. Peterson B, Campbell J, Ilkayeva O, Grimsrud P, Hirschey M, Newgard C. Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or ? Cell Metabolism in the Absence of Overnutrition. Cell Rep. 2018;24:209-223.e6 pubmed publisher
  14. Das A, Huang G, Bonkowski M, Longchamp A, Li C, Schultz M, et al. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018;173:74-89.e20 pubmed publisher
  15. Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta M, et al. SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. elife. 2018;7: pubmed publisher
  16. Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau D, Zavala E, et al. NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A. 2018;115:E1876-E1885 pubmed publisher
  17. He X, Zeng H, Chen S, Roman R, Aschner J, Didion S, et al. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. J Mol Cell Cardiol. 2017;112:104-113 pubmed publisher
  18. Patil M, Sharma B, Elattar S, Chang J, Kapil S, Yuan J, et al. Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning. Diabetes. 2017;66:1611-1625 pubmed publisher
  19. Gudiksen A, Bertholdt L, Vingborg M, Hansen H, Ringholm S, Pilegaard H. Muscle interleukin-6 and fasting-induced PDH regulation in mouse skeletal muscle. Am J Physiol Endocrinol Metab. 2017;312:E204-E214 pubmed publisher
  20. Li J, Chen T, Xiao M, Li N, Wang S, Su H, et al. Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1. Oncotarget. 2016;7:86648-86659 pubmed publisher
  21. Liu Y, Wang T, Zhang R, Fu W, Wang X, Wang F, et al. Calorie restriction protects against experimental abdominal aortic aneurysms in mice. J Exp Med. 2016;213:2473-2488 pubmed
  22. Gurt I, Artsi H, Cohen Kfir E, Hamdani G, Ben Shalom G, Feinstein B, et al. The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. PLoS ONE. 2015;10:e0134391 pubmed publisher
  23. Brandauer J, Andersen M, Kellezi H, Risis S, Frøsig C, Vienberg S, et al. AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD. Front Physiol. 2015;6:85 pubmed publisher
  24. Zeng H, Vaka V, He X, Booz G, Chen J. High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. J Cell Mol Med. 2015;19:1847-56 pubmed publisher
  25. Kim T, Kim H, Kang Y, Yoon S, Lee J, Choi W, et al. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta. 2015;1850:401-10 pubmed publisher
  26. Le T, Urasaki Y, Pizzorno G. Uridine prevents fenofibrate-induced fatty liver. PLoS ONE. 2014;9:e87179 pubmed publisher
  27. Kuo H, Deluca T, Miller W, Mrksich M. Profiling deacetylase activities in cell lysates with peptide arrays and SAMDI mass spectrometry. Anal Chem. 2013;85:10635-10642 pubmed publisher
  28. Zhang B, Cui S, Bai X, Zhuo L, Sun X, Hong Q, et al. SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway. Age (Dordr). 2013;35:2237-53 pubmed publisher