This is a Validated Antibody Database (VAD) review about mouse Shc1, based on 15 published articles (read how Labome selects the articles), using Shc1 antibody in all methods. It is aimed to help Labome visitors find the most suited Shc1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Shc1 synonym: Shc; ShcA; p66; p66shc

Santa Cruz Biotechnology
mouse monoclonal (PG-797)
  • western blot; rat; loading ...; fig 1e
Santa Cruz Biotechnology Shc1 antibody (Santa Cruz Biotechnology, SC-967) was used in western blot on rat samples (fig 1e). PLoS ONE (2016) ncbi
mouse monoclonal (PG-797)
  • immunoprecipitation; human; fig 2
In order to show that fatty acylated cav-2 is a IR tyrosine kinase substrate during insulin signaling, Santa Cruz Biotechnology Shc1 antibody (santa cruz, sc-967) was used in immunoprecipitation on human samples (fig 2). Biochim Biophys Acta (2015) ncbi
mouse monoclonal (6E10)
  • immunoprecipitation; human
  • western blot; human
Santa Cruz Biotechnology Shc1 antibody (Santa Cruz Biotechnology, sc-81520) was used in immunoprecipitation on human samples and in western blot on human samples . Mol Biol Cell (2014) ncbi
Abcam
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 4a
  • immunohistochemistry; human; 1:100; loading ...; fig 1d
In order to evaluate the ability of Chrdl1 to suppress bone morphogenetic protein-induced increases in breast cancer cell migration and invasion, Abcam Shc1 antibody (Abcam, ab24787) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 4a) and in immunohistochemistry on human samples at 1:100 (fig 1d). Mol Cell Biol (2016) ncbi
domestic rabbit monoclonal (EP332Y)
  • western blot; rat; 1:500
Abcam Shc1 antibody (Abcam, ab33770) was used in western blot on rat samples at 1:500. J Cell Physiol (2016) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 1b
Cell Signaling Technology Shc1 antibody (Cell Signaling, 2432) was used in western blot on rat samples (fig 1b). Cell (2019) ncbi
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 1b
Cell Signaling Technology Shc1 antibody (Cell Signaling, 2431) was used in western blot on rat samples (fig 1b). Cell (2019) ncbi
domestic rabbit polyclonal
  • other; human; loading ...; fig 4c
Cell Signaling Technology Shc1 antibody (Cell Signaling, 2431) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4a
Cell Signaling Technology Shc1 antibody (Cell Signaling, 2434) was used in western blot on human samples (fig 4a). Mol Oncol (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; fig 7e
Cell Signaling Technology Shc1 antibody (Cell Signaling, 2434) was used in western blot on mouse samples at 1:500 (fig 7e). Nat Commun (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; fig 7e
Cell Signaling Technology Shc1 antibody (Cell Signaling, 2432) was used in western blot on mouse samples at 1:500 (fig 7e). Nat Commun (2017) ncbi
domestic rabbit polyclonal
  • reverse phase protein lysate microarray; human; loading ...; fig st6
In order to characterize the molecular identity of uterine carcinosarcomas., Cell Signaling Technology Shc1 antibody (CST, 2431) was used in reverse phase protein lysate microarray on human samples (fig st6). Cancer Cell (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 6
Cell Signaling Technology Shc1 antibody (Cell Signaling, CS2434) was used in western blot on human samples at 1:1000 (fig 6). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 6
  • western blot; mouse; 1:1000; fig 6
Cell Signaling Technology Shc1 antibody (Cell Signaling, CS2432) was used in western blot on human samples at 1:1000 (fig 6) and in western blot on mouse samples at 1:1000 (fig 6). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 2s2
In order to analyze Src homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases by time-resolved multimodal analysis, Cell Signaling Technology Shc1 antibody (Cell Signaling Technology, 2431) was used in western blot on human samples (fig 2s2). elife (2016) ncbi
BD Biosciences
mouse monoclonal (30/SHC)
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 1b, 1d
BD Biosciences Shc1 antibody (BD Transduction, 610878) was used in immunocytochemistry on mouse samples at 1:1000 (fig 1b, 1d). Cell Death Dis (2021) ncbi
mouse monoclonal (30/SHC)
  • western blot; mouse; 1:500; loading ...; fig s1b
BD Biosciences Shc1 antibody (BD Biosciences, 610879) was used in western blot on mouse samples at 1:500 (fig s1b). Stem Cells Dev (2018) ncbi
mouse monoclonal (30/SHC)
  • western blot; mouse; fig 1
In order to analyze how p66Shc activation can occur by cJun N-terminal kinase (JNK) phosphorylation of serine 36, BD Biosciences Shc1 antibody (BD Biosciences, 610879) was used in western blot on mouse samples (fig 1). Sci Rep (2016) ncbi
Articles Reviewed
  1. Baxter P, Márkus N, Dando O, He X, Al Mubarak B, Qiu J, et al. Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation. Cell Death Dis. 2021;12:218 pubmed publisher
  2. Lundby A, Franciosa G, Emdal K, Refsgaard J, Gnosa S, Bekker Jensen D, et al. Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Cell. 2019;179:543-560.e26 pubmed publisher
  3. Edwards N, Watson A, Betts D. Knockdown of p66Shc alters lineage-associated transcription factor expression in mouse blastocysts. Stem Cells Dev. 2018;: pubmed publisher
  4. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  5. Baumann C, Ullrich A, Torka R. GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance. Mol Oncol. 2017;11:1430-1447 pubmed publisher
  6. Cai W, Sakaguchi M, Kleinridders A, Gonzalez Del Pino G, Dreyfuss J, O Neill B, et al. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun. 2017;8:14892 pubmed publisher
  7. Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  8. Stucky A, Bakshi K, Friedman E, Wang H. Prenatal Cocaine Exposure Upregulates BDNF-TrkB Signaling. PLoS ONE. 2016;11:e0160585 pubmed publisher
  9. Barrow McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche B, et al. Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nat Commun. 2016;7:11942 pubmed publisher
  10. Jadwin J, Oh D, Curran T, Ogiue Ikeda M, Jia L, White F, et al. Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases. elife. 2016;5:e11835 pubmed publisher
  11. Cyr Depauw C, Northey J, Tabariès S, Annis M, Dong Z, Cory S, et al. Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion. Mol Cell Biol. 2016;36:1509-25 pubmed publisher
  12. Khalid S, Drasche A, Thurner M, Hermann M, Ashraf M, Fresser F, et al. cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation. Sci Rep. 2016;6:20930 pubmed publisher
  13. Tang N, Lyu D, Liu T, Chen F, Jing S, Hao T, et al. Different Effects of p52SHC1 and p52SHC3 on the Cell Cycle of Neurons and Neural Stem Cells. J Cell Physiol. 2016;231:172-80 pubmed publisher
  14. Kwon H, Lee J, Jeong K, Jang D, Pak Y. Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation. Biochim Biophys Acta. 2015;1853:1022-34 pubmed publisher
  15. Miyazawa M, Tsuji Y. Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene. Mol Biol Cell. 2014;25:2116-27 pubmed publisher