This is a Validated Antibody Database (VAD) review about mouse Scn8a, based on 27 published articles (read how Labome selects the articles), using Scn8a antibody in all methods. It is aimed to help Labome visitors find the most suited Scn8a antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Scn8a synonym: AI853486; C630029C19Rik; NaCh6; Nav1.6; dmu; med; mnd-2; mnd2; nmf2; nmf335; nmf58; nur14; seal

Alomone Labs
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 6c
Alomone Labs Scn8a antibody (Alomone, ASC-009) was used in immunohistochemistry - frozen section on mouse samples at 1:500 (fig 6c). Nat Commun (2022) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; loading ...; fig 5d
Alomone Labs Scn8a antibody (Alomone, ASC-009) was used in immunohistochemistry - frozen section on mouse samples (fig 5d). Neural Dev (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - free floating section; mouse; 1:300; loading ...; fig 5e
Alomone Labs Scn8a antibody (Alomone, ASC-009) was used in immunohistochemistry - free floating section on mouse samples at 1:300 (fig 5e). PLoS Biol (2019) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; 1:500; loading ...; fig f2s3b
Alomone Labs Scn8a antibody (alomonelabs, ASC-009) was used in immunohistochemistry on mouse samples at 1:500 (fig f2s3b). elife (2019) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 1n
In order to identify factors that trigger central nervous system myelination, Alomone Labs Scn8a antibody (Alomone Labs, ASC-009) was used in immunohistochemistry - paraffin section on mouse samples at 1:500 (fig 1n). Nat Neurosci (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:300; fig 8
Alomone Labs Scn8a antibody (Alomone Labs, ASC-009) was used in immunohistochemistry - frozen section on mouse samples at 1:300 (fig 8). Front Cell Neurosci (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (W-78)
  • western blot; mouse
In order to investigate the effect of amyloid precursor protein on Nav1.6 sodium channel cell surface expression, Santa Cruz Biotechnology Scn8a antibody (Santa Cruz, sc-81884) was used in western blot on mouse samples . J Biol Chem (2015) ncbi
Abcam
domestic rabbit polyclonal
  • immunocytochemistry; mouse; fig 5
  • western blot; mouse; fig 4
Abcam Scn8a antibody (Abcam, ab65166) was used in immunocytochemistry on mouse samples (fig 5) and in western blot on mouse samples (fig 4). Front Neurosci (2016) ncbi
MilliporeSigma
mouse monoclonal (K58/35)
  • immunohistochemistry; rat; 1:200; fig 8o
MilliporeSigma Scn8a antibody (Sigma-Aldrich, S8809) was used in immunohistochemistry on rat samples at 1:200 (fig 8o). Sci Adv (2022) ncbi
mouse monoclonal (K58/35)
  • immunocytochemistry; mouse; 1:100; fig 3c
MilliporeSigma Scn8a antibody (Sigma-Aldrich, S8809-.1MG) was used in immunocytochemistry on mouse samples at 1:100 (fig 3c). Development (2022) ncbi
mouse monoclonal (K58/35)
  • immunocytochemistry; human; fig 6h
MilliporeSigma Scn8a antibody (Sigma-Aldrich, S8809) was used in immunocytochemistry on human samples (fig 6h). Cell Rep Med (2021) ncbi
mouse monoclonal (K58/35)
  • immunohistochemistry; mouse; 1:400; loading ...; fig 5b
MilliporeSigma Scn8a antibody (Sigma?CAldrich, K58/35) was used in immunohistochemistry on mouse samples at 1:400 (fig 5b). Commun Biol (2020) ncbi
mouse monoclonal (K58/35)
  • western blot; human; 1:2000; loading ...; fig 2a
MilliporeSigma Scn8a antibody (Sigma Aldrich, S8809) was used in western blot on human samples at 1:2000 (fig 2a). elife (2020) ncbi
mouse monoclonal (K58/35)
  • immunocytochemistry; rat; 1:100; loading ...; fig 3a
MilliporeSigma Scn8a antibody (Sigma-Aldrich, S8809) was used in immunocytochemistry on rat samples at 1:100 (fig 3a). Cell Death Differ (2019) ncbi
mouse monoclonal (K58/35)
  • immunocytochemistry; rat; 1:1000; loading ...; fig 1a
MilliporeSigma Scn8a antibody (Sigma, S8809) was used in immunocytochemistry on rat samples at 1:1000 (fig 1a). Front Cell Neurosci (2019) ncbi
mouse monoclonal (K58/35)
  • western blot; rat; 1:200; loading ...; fig 8
In order to demonstrate that fibroblast growth factor 14 affects KCNQ channel function and localization, MilliporeSigma Scn8a antibody (Sigma, K58/35) was used in western blot on rat samples at 1:200 (fig 8). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (K58/35)
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...; fig 4d
In order to examine the role of Opalin in mammalian myelination, MilliporeSigma Scn8a antibody (Sigma, S8809) was used in immunohistochemistry - frozen section on mouse samples at 1:250 (fig 4d). PLoS ONE (2016) ncbi
mouse monoclonal (K58/35)
  • western blot; mouse; fig 1
MilliporeSigma Scn8a antibody (Sigma Aldrich, K58/35) was used in western blot on mouse samples (fig 1). Nat Commun (2016) ncbi
mouse monoclonal (K58/35)
  • immunohistochemistry - frozen section; rat; 1:100; loading ...; fig 2a
MilliporeSigma Scn8a antibody (Sigma-Aldrich, S8809) was used in immunohistochemistry - frozen section on rat samples at 1:100 (fig 2a). J Comp Neurol (2017) ncbi
mouse monoclonal (K58/35)
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 5a
  • immunoprecipitation; mouse; 1:200; loading ...; fig 4a
MilliporeSigma Scn8a antibody (Sigma-Aldrich, S8809) was used in immunohistochemistry - frozen section on mouse samples at 1:200 (fig 5a) and in immunoprecipitation on mouse samples at 1:200 (fig 4a). J Neurosci (2016) ncbi
mouse monoclonal (K58/35)
  • immunohistochemistry - frozen section; mouse; 1:300; fig s7
MilliporeSigma Scn8a antibody (Sigma, S8809) was used in immunohistochemistry - frozen section on mouse samples at 1:300 (fig s7). Front Cell Neurosci (2016) ncbi
mouse monoclonal (K58/35)
  • immunoprecipitation; mouse; fig 6
  • western blot; mouse; 1:1000; fig 1
In order to study native cerebellar iFGF14 complexes by proteomic analysis, MilliporeSigma Scn8a antibody (Sigma, S8809) was used in immunoprecipitation on mouse samples (fig 6) and in western blot on mouse samples at 1:1000 (fig 1). Channels (Austin) (2016) ncbi
mouse monoclonal (K58/35)
  • western blot; guinea pig; 1:800; fig 6
MilliporeSigma Scn8a antibody (Sigma-Aldrich, S8809) was used in western blot on guinea pig samples at 1:800 (fig 6). PLoS ONE (2016) ncbi
mouse monoclonal (K58/35)
  • western blot; mouse
In order to examine the effects of Kidins220 ablation on neuronal excitability, MilliporeSigma Scn8a antibody (Sigma Aldrich, S8809) was used in western blot on mouse samples . J Biol Chem (2015) ncbi
mouse monoclonal (K58/35)
  • western blot; human; fig s6
MilliporeSigma Scn8a antibody (Sigma, S8809) was used in western blot on human samples (fig s6). PLoS ONE (2015) ncbi
mouse monoclonal (K58/35)
  • immunocytochemistry; rat; loading ...; fig 2e
MilliporeSigma Scn8a antibody (Sigma-Aldrich, S8809) was used in immunocytochemistry on rat samples (fig 2e). J Cell Biol (2015) ncbi
mouse monoclonal (K58/35)
  • immunocytochemistry; rat; 1:100; fig 6
MilliporeSigma Scn8a antibody (Sigma, S8809) was used in immunocytochemistry on rat samples at 1:100 (fig 6). J Neurosci (2015) ncbi
mouse monoclonal (K58/35)
  • immunohistochemistry; mouse; 1:100
In order to use multicolor labeling technology to simultaneously individual oligodendrocytes in the postnatal mouse optic nerve, MilliporeSigma Scn8a antibody (Sigma, S8809) was used in immunohistochemistry on mouse samples at 1:100. Glia (2015) ncbi
Articles Reviewed
  1. Dorrego Rivas A, Ezan J, Moreau M, Poirault Chassac S, Aubailly N, De Neve J, et al. The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling. Sci Adv. 2022;8:eabo6333 pubmed publisher
  2. Meschkat M, Steyer A, Weil M, Kusch K, Jahn O, Piepkorn L, et al. White matter integrity in mice requires continuous myelin synthesis at the inner tongue. Nat Commun. 2022;13:1163 pubmed publisher
  3. Tian T, Quintana Urzainqui I, Kozi x107 Z, Pratt T, Price D. Pax6 loss alters the morphological and electrophysiological development of mouse prethalamic neurons. Development. 2022;149: pubmed publisher
  4. Hay C, Jackson S, Mitew S, Scott D, Koenning M, Bensen A, et al. The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination. Neural Dev. 2021;16:6 pubmed publisher
  5. Clark A, Kugathasan U, Baskozos G, Priestman D, Fugger N, Lone M, et al. An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions. Cell Rep Med. 2021;2:100345 pubmed publisher
  6. Otani Y, Ohno N, Cui J, Yamaguchi Y, Baba H. Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice. Commun Biol. 2020;3:121 pubmed publisher
  7. Yang H, Pérez Hernández M, Sanchez Alonso J, Shevchuk A, Gorelik J, Rothenberg E, et al. Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc. elife. 2020;9: pubmed publisher
  8. Zhang Q, Zhu W, Xu F, Dai X, Shi L, Cai W, et al. The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury. PLoS Biol. 2019;17:e3000330 pubmed publisher
  9. Aprile D, Fruscione F, Baldassari S, Fadda M, Ferrante D, Falace A, et al. TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons. Cell Death Differ. 2019;: pubmed publisher
  10. Alpizar S, BAKER A, Gulledge A, Hoppa M. Loss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment. Front Cell Neurosci. 2019;13:1 pubmed publisher
  11. Erwig M, Patzig J, Steyer A, Dibaj P, Heilmann M, Heilmann I, et al. Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin. elife. 2019;8: pubmed publisher
  12. Pablo J, Pitt G. FGF14 is a regulator of KCNQ2/3 channels. Proc Natl Acad Sci U S A. 2017;114:154-159 pubmed publisher
  13. Yoshikawa F, Sato Y, Tohyama K, Akagi T, Furuse T, Sadakata T, et al. Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments. PLoS ONE. 2016;11:e0166732 pubmed publisher
  14. Goebbels S, Wieser G, Pieper A, Spitzer S, Weege B, Yan K, et al. A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nat Neurosci. 2017;20:10-15 pubmed publisher
  15. Dover K, Marra C, Solinas S, Popovic M, Subramaniyam S, Zecevic D, et al. FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon. Nat Commun. 2016;7:12895 pubmed publisher
  16. Serwanski D, Jukkola P, Nishiyama A. Heterogeneity of astrocyte and NG2 cell insertion at the node of ranvier. J Comp Neurol. 2017;525:535-552 pubmed publisher
  17. Kruger L, O Malley H, Hull J, Kleeman A, Patino G, Isom L. ?1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function. J Neurosci. 2016;36:6213-24 pubmed publisher
  18. Wang X, Zhang X, Zhou T, Li N, Jang C, Xiao Z, et al. Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ1-42. Front Neurosci. 2016;10:94 pubmed publisher
  19. Alshammari M, Alshammari T, Laezza F. Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment. Front Cell Neurosci. 2016;10:5 pubmed publisher
  20. Bosch M, Nerbonne J, Townsend R, Miyazaki H, Nukina N, Ornitz D, et al. Proteomic analysis of native cerebellar iFGF14 complexes. Channels (Austin). 2016;10:297-312 pubmed publisher
  21. Nassal D, Wan X, Liu H, Deschenes I. Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role. PLoS ONE. 2016;11:e0146561 pubmed publisher
  22. Cesca F, Satapathy A, Ferrea E, Nieus T, Benfenati F, Scholz Starke J. Functional Interaction between the Scaffold Protein Kidins220/ARMS and Neuronal Voltage-Gated Na+ Channels. J Biol Chem. 2015;290:18045-55 pubmed publisher
  23. Koenig J, Werdehausen R, Linley J, Habib A, Vernon J, Lolignier S, et al. Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia. PLoS ONE. 2015;10:e0128830 pubmed publisher
  24. Liu C, Tan F, Xiao Z, Dawe G. Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression. J Biol Chem. 2015;290:12048-57 pubmed publisher
  25. Colombelli C, Palmisano M, Eshed Eisenbach Y, Zambroni D, Pavoni E, Ferri C, et al. Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin. J Cell Biol. 2015;208:313-29 pubmed publisher
  26. Chand A, Galliano E, Chesters R, Grubb M. A distinct subtype of dopaminergic interneuron displays inverted structural plasticity at the axon initial segment. J Neurosci. 2015;35:1573-90 pubmed publisher
  27. Dumas L, Heitz Marchaland C, Fouquet S, Suter U, Livet J, Moreau Fauvarque C, et al. Multicolor analysis of oligodendrocyte morphology, interactions, and development with Brainbow. Glia. 2015;63:699-717 pubmed publisher