This is a Validated Antibody Database (VAD) review about mouse Ptpn6, based on 21 published articles (read how Labome selects the articles), using Ptpn6 antibody in all methods. It is aimed to help Labome visitors find the most suited Ptpn6 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Ptpn6 synonym: 70Z-SHP; Hcph; PTPTY-42; Ptp1C; SH-PTP1; SHP-1; hcp; me

Abcam
domestic rabbit monoclonal (Y476)
  • western blot; mouse; loading ...; fig 2b
Abcam Ptpn6 antibody (Abcam, Y476) was used in western blot on mouse samples (fig 2b). Front Immunol (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig 6c
In order to investigate the impact of a cancer-specific MUC1 glycoform, Abcam Ptpn6 antibody (Abcam, Ab51171) was used in western blot on human samples at 1:500 (fig 6c). Nat Immunol (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:50; fig s5d
Abcam Ptpn6 antibody (Abcam, ab131500) was used in immunohistochemistry - frozen section on mouse samples at 1:50 (fig s5d). Nature (2016) ncbi
domestic rabbit monoclonal (Y476)
  • immunoprecipitation; rat
Abcam Ptpn6 antibody (Abcam, ab32559) was used in immunoprecipitation on rat samples . J Mol Med (Berl) (2014) ncbi
Santa Cruz Biotechnology
mouse monoclonal (D-11)
  • western blot; human; loading ...; fig 5a
Santa Cruz Biotechnology Ptpn6 antibody (Santa Cruz biotechnology, sc-7289) was used in western blot on human samples (fig 5a). Cell Rep (2019) ncbi
mouse monoclonal (D-11)
  • western blot; human; loading ...; fig 4b
Santa Cruz Biotechnology Ptpn6 antibody (SantaCruz, sc-7289) was used in western blot on human samples (fig 4b). Mol Cell Biol (2016) ncbi
mouse monoclonal (D-11)
  • immunoprecipitation; human; fig s2
In order to determine the contribution of low molecular weight protein tyrosine phosphatase to colorectal cancer, Santa Cruz Biotechnology Ptpn6 antibody (santa Cruz, sc-7289) was used in immunoprecipitation on human samples (fig s2). Oncotarget (2015) ncbi
mouse monoclonal (D-11)
  • immunoprecipitation; human
  • western blot; human; fig 6
Santa Cruz Biotechnology Ptpn6 antibody (Santa Cruz Biotechnology, SC-7289) was used in immunoprecipitation on human samples and in western blot on human samples (fig 6). PLoS ONE (2014) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C14H6)
  • western blot; human; 1:1000; loading ...; fig 4j
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, 3759S) was used in western blot on human samples at 1:1000 (fig 4j). Mol Neurodegener (2022) ncbi
domestic rabbit monoclonal (D11G5)
  • western blot; human; 1:1000; loading ...; fig 4j
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, 8849S) was used in western blot on human samples at 1:1000 (fig 4j). Mol Neurodegener (2022) ncbi
domestic rabbit monoclonal (C14H6)
  • western blot; mouse; loading ...; fig 6a
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, 3759) was used in western blot on mouse samples (fig 6a). J Biomed Sci (2021) ncbi
domestic rabbit monoclonal (D11G5)
  • western blot; mouse; 1:1000; loading ...; fig 4a
Cell Signaling Technology Ptpn6 antibody (CST, 8849) was used in western blot on mouse samples at 1:1000 (fig 4a). JCI Insight (2020) ncbi
domestic rabbit monoclonal (D11G5)
  • western blot; mouse; 1:5000; loading ...; fig s1
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, D11G5) was used in western blot on mouse samples at 1:5000 (fig s1). Nature (2019) ncbi
domestic rabbit monoclonal (C14H6)
  • western blot; mouse; 1:10,000; loading ...; fig s1
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, C14H6) was used in western blot on mouse samples at 1:10,000 (fig s1). Nature (2019) ncbi
domestic rabbit monoclonal (C14H6)
  • western blot; mouse; loading ...; fig s4g
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, 3759) was used in western blot on mouse samples (fig s4g). Cell (2018) ncbi
domestic rabbit monoclonal (C14H6)
  • western blot; human; 1:1000; loading ...
Cell Signaling Technology Ptpn6 antibody (cell Signaling, 3759) was used in western blot on human samples at 1:1000. Nature (2018) ncbi
domestic rabbit monoclonal (D11G5)
  • western blot; human; fig 7f
Cell Signaling Technology Ptpn6 antibody (Cell signaling, 8849S) was used in western blot on human samples (fig 7f). Nat Commun (2018) ncbi
domestic rabbit monoclonal (C14H6)
  • western blot; mouse; 1:1000; fig 1
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, 3759) was used in western blot on mouse samples at 1:1000 (fig 1). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D11G5)
  • western blot; mouse; fig 6
In order to determine the response threshold of immunoreceptor tyrosine-based activation motifs, Cell Signaling Technology Ptpn6 antibody (Cell Signaling, 8849) was used in western blot on mouse samples (fig 6). elife (2015) ncbi
domestic rabbit monoclonal (D11G5)
  • western blot; mouse
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, D11G5) was used in western blot on mouse samples . Nature (2015) ncbi
domestic rabbit monoclonal (C14H6)
  • immunohistochemistry - frozen section; rat; 1:1500
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, C14H6) was used in immunohistochemistry - frozen section on rat samples at 1:1500. Nature (2015) ncbi
BD Biosciences
mouse monoclonal (52/PTP1C/SHP1)
  • western blot; human; loading ...; fig 5c
BD Biosciences Ptpn6 antibody (BD, 610125) was used in western blot on human samples (fig 5c). J Biol Chem (2017) ncbi
mouse monoclonal (52/PTP1C/SHP1)
  • western blot; human; loading ...; fig 5b
  • western blot; mouse; loading ...; fig 8b
BD Biosciences Ptpn6 antibody (BD Biosciences, 610126) was used in western blot on human samples (fig 5b) and in western blot on mouse samples (fig 8b). Redox Biol (2017) ncbi
mouse monoclonal (52/PTP1C/SHP1)
  • western blot; human; fig 3
BD Biosciences Ptpn6 antibody (BD Biosciences, 610126) was used in western blot on human samples (fig 3). Am J Physiol Renal Physiol (2013) ncbi
Articles Reviewed
  1. Zhao P, Xu Y, Jiang L, Fan X, Ku Z, Li L, et al. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Mol Neurodegener. 2022;17:44 pubmed publisher
  2. Hsu Y, Hsu F, Chiang M, Tsai D, Li F, Angata T, et al. Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation. J Biomed Sci. 2021;28:5 pubmed publisher
  3. Myers D, Abram C, Wildes D, Belwafa A, Welsh A, Schulze C, et al. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020;11:576310 pubmed publisher
  4. Liu B, Cao Q, Zhao X, Liu H, Zhang Y. Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia. JCI Insight. 2020;5: pubmed publisher
  5. Celis Gutierrez J, Blattmann P, Zhai Y, Jarmuzynski N, Ruminski K, Gregoire C, et al. Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy. Cell Rep. 2019;27:3315-3330.e7 pubmed publisher
  6. Pluvinage J, Haney M, Smith B, Sun J, Iram T, Bonanno L, et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature. 2019;568:187-192 pubmed publisher
  7. Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher
  8. Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature. 2018;562:605-609 pubmed publisher
  9. Zhao X, Sankaran S, Yap J, Too C, Ho Z, Dolton G, et al. Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nat Commun. 2018;9:2716 pubmed publisher
  10. Juhasz A, Markel S, Gaur S, Liu H, Lu J, Jiang G, et al. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction. J Biol Chem. 2017;292:7866-7887 pubmed publisher
  11. Chattopadhyay R, Raghavan S, Rao G. Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function. Redox Biol. 2017;12:438-455 pubmed publisher
  12. Sauer M, Herbst J, Diekmann U, Rudd C, Kardinal C. SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells. Mol Cell Biol. 2016;36:3113-3127 pubmed
  13. Beatson R, Tajadura Ortega V, Achkova D, Picco G, Tsourouktsoglou T, Klausing S, et al. The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9. Nat Immunol. 2016;17:1273-1281 pubmed publisher
  14. Kojima Y, Volkmer J, McKenna K, Civelek M, Lusis A, Miller C, et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016;536:86-90 pubmed
  15. Uto T, Fukaya T, Takagi H, Arimura K, Nakamura T, Kojima N, et al. Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity. Nat Commun. 2016;7:11273 pubmed publisher
  16. Freedman T, Tan Y, Skrzypczynska K, Manz B, Sjaastad F, Goodridge H, et al. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. elife. 2015;4: pubmed publisher
  17. Hoekstra E, Kodach L, Das A, Ruela de Sousa R, Ferreira C, Hardwick J, et al. Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer. Oncotarget. 2015;6:8300-12 pubmed
  18. Chen Z, Shojaee S, Buchner M, Geng H, Lee J, Klemm L, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015;521:357-61 pubmed publisher
  19. Buschmann I, Hackbusch D, Gatzke N, Dülsner A, Trappiel M, Dagnell M, et al. Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats. J Mol Med (Berl). 2014;92:983-94 pubmed publisher
  20. Nagao T, Kurosu T, Umezawa Y, Nogami A, Oshikawa G, Tohda S, et al. Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera. PLoS ONE. 2014;9:e84746 pubmed publisher
  21. Zhou X, Wang H, Burg M, Ferraris J. High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1. Am J Physiol Renal Physiol. 2013;305:F362-9 pubmed publisher