This is a Validated Antibody Database (VAD) review about mouse Prkn, based on 89 published articles (read how Labome selects the articles), using Prkn antibody in all methods. It is aimed to help Labome visitors find the most suited Prkn antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Prkn synonym: Park2

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (PRK8)
  • western blot knockout validation; human; loading ...; fig 2h, s3g
  • western blot; mouse; loading ...; fig 2h
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in western blot knockout validation on human samples (fig 2h, s3g) and in western blot on mouse samples (fig 2h). Stem Cell Reports (2020) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig s2e, s3c
Cell Signaling Technology Prkn antibody (Cell Signaling, 2132) was used in western blot knockout validation on mouse samples (fig s2e, s3c). Nat Commun (2022) ncbi
Cell Signaling Technology
mouse monoclonal (PRK8)
  • western blot knockout validation; human; fig 6a
Cell Signaling Technology Prkn antibody (Cell Signaling Technology, 4211) was used in western blot knockout validation on human samples (fig 6a). Front Mol Neurosci (2019) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; rat; 1:1000; fig 1a
Cell Signaling Technology Prkn antibody (Cell Signaling, 2132) was used in western blot knockout validation on rat samples at 1:1000 (fig 1a). Sci Rep (2018) ncbi
Cell Signaling Technology
mouse monoclonal (PRK8)
  • western blot knockout validation; rat; 1:1000; fig 1a
Cell Signaling Technology Prkn antibody (Cell Signaling, 4211S) was used in western blot knockout validation on rat samples at 1:1000 (fig 1a). Sci Rep (2018) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; 1:400; loading ...; fig 4a
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 4b
Cell Signaling Technology Prkn antibody (Cell Signaling, 2132S) was used in immunohistochemistry knockout validation on mouse samples at 1:400 (fig 4a) and in western blot knockout validation on mouse samples at 1:1000 (fig 4b). Autophagy (2017) ncbi
Cell Signaling Technology
mouse monoclonal (PRK8)
  • immunohistochemistry knockout validation; mouse; fig 3
  • western blot knockout validation; mouse; fig 3
Cell Signaling Technology Prkn antibody (Cell Signaling Tech, 4211) was used in immunohistochemistry knockout validation on mouse samples (fig 3) and in western blot knockout validation on mouse samples (fig 3). Autophagy (2014) ncbi
Santa Cruz Biotechnology
mouse monoclonal (PRK8)
  • immunocytochemistry; human; loading ...; fig s6b
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in immunocytochemistry on human samples (fig s6b). Sci Adv (2022) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; loading ...; fig 5c
Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, sc-32282) was used in western blot on mouse samples (fig 5c). Aging (Albany NY) (2021) ncbi
mouse monoclonal (D-1)
  • western blot; rat; 1:200; loading ...; fig 4a
Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, sc-133167) was used in western blot on rat samples at 1:200 (fig 4a). Signal Transduct Target Ther (2021) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; human; loading ...; fig 1a
  • western blot; human; loading ...; fig 1c
Santa Cruz Biotechnology Prkn antibody (Santa-Cruz Biotechnology, sc-32282) was used in immunocytochemistry on human samples (fig 1a) and in western blot on human samples (fig 1c). Sci Rep (2020) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:250; loading ...
Santa Cruz Biotechnology Prkn antibody (Santa-Cruz, sc32282) was used in western blot on human samples at 1:250. Life Sci Alliance (2020) ncbi
mouse monoclonal (PRK8)
  • western blot; rat; 1:500; loading ...; fig 4a
Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, sc-32282) was used in western blot on rat samples at 1:500 (fig 4a). Neurobiol Dis (2020) ncbi
mouse monoclonal (PRK8)
  • western blot knockout validation; human; loading ...; fig 2h, s3g
  • western blot; mouse; loading ...; fig 2h
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in western blot knockout validation on human samples (fig 2h, s3g) and in western blot on mouse samples (fig 2h). Stem Cell Reports (2020) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; mouse; 1:200; loading ...; fig 3h
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in immunocytochemistry on mouse samples at 1:200 (fig 3h). Nat Commun (2019) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:100; loading ...; fig 3a
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in western blot on mouse samples at 1:100 (fig 3a). Nature (2019) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:1000; loading ...; fig 2a
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in western blot on human samples at 1:1000 (fig 2a). PLoS ONE (2019) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:200; loading ...; fig 5f
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in western blot on mouse samples at 1:200 (fig 5f). Cardiovasc Res (2018) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:1000; loading ...; fig 7a
Santa Cruz Biotechnology Prkn antibody (Santa, Prk8) was used in western blot on human samples at 1:1000 (fig 7a). BMC Biol (2018) ncbi
mouse monoclonal
  • western blot; human; 1:1000; loading ...; fig 7a
Santa Cruz Biotechnology Prkn antibody (Santa, Prk8) was used in western blot on human samples at 1:1000 (fig 7a). BMC Biol (2018) ncbi
mouse monoclonal (PRK8)
  • western blot; human; loading ...; fig 2a, 4a
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in western blot on human samples (fig 2a, 4a). Mol Cell (2017) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; human; 1:500; loading ...; fig 7d
In order to analyze the impact of alpha-synuclein on mitochondrial responses to oxidative stress in neural cells, Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, sc-32282) was used in immunocytochemistry on human samples at 1:500 (fig 7d). Sci Rep (2017) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:1000; loading ...; fig 6a
In order to characterize muscle biopsy specimens derived from patients with spinal and bulbar muscular atrophy, Santa Cruz Biotechnology Prkn antibody (Santa Cruz, Sc-32282) was used in western blot on human samples at 1:1000 (fig 6a). Hum Mol Genet (2017) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; human; loading ...; fig 3b
  • western blot; human; loading ...; fig 3a
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in immunocytochemistry on human samples (fig 3b) and in western blot on human samples (fig 3a). Oncotarget (2017) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; mouse; 1:100; fig 6C
In order to show that follicle-stimulating hormone promotes granulosa cell survival by suppressing oxidative stress-induced mitophagy, Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in immunocytochemistry on mouse samples at 1:100 (fig 6C). Sci Rep (2016) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; rat; 1:500; loading ...; fig 2b
In order to study the role of Miro phosphorylation in Parkin-dependent mitochondrial arrest, Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, SC-32282) was used in immunocytochemistry on rat samples at 1:500 (fig 2b). Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:1000; loading ...; fig s7g
Santa Cruz Biotechnology Prkn antibody (SantaCruz, sc-32282) was used in western blot on human samples at 1:1000 (fig s7g). Nat Commun (2016) ncbi
mouse monoclonal (PRK8)
  • western blot; African green monkey; loading ...; fig 3b
  • western blot; mouse; loading ...; fig 1b
In order to show that syntaxin-17 is required for the delivery of stress-induced PINK1/parkin-dependent mitochondrial-derived vesicles to the late endosome/lysosome, Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in western blot on African green monkey samples (fig 3b) and in western blot on mouse samples (fig 1b). J Cell Biol (2016) ncbi
mouse monoclonal (PRK8)
  • western blot; human; loading ...; fig 1c
In order to investigate the contribution of PINK1 and PARKIN to cell death, Santa Cruz Biotechnology Prkn antibody (Santa Cruz, PRK8) was used in western blot on human samples (fig 1c). J Biol Chem (2016) ncbi
mouse monoclonal (PRK8)
  • proximity ligation assay; human; 1:200; fig 2
  • immunohistochemistry - paraffin section; human; fig 5
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 1
In order to study how Parkin is responsible for polyubiquitination of apurinic/apyrimidinic endonuclease 1, Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in proximity ligation assay on human samples at 1:200 (fig 2), in immunohistochemistry - paraffin section on human samples (fig 5), in immunoprecipitation on human samples (fig 2) and in western blot on human samples (fig 1). Mol Carcinog (2017) ncbi
mouse monoclonal (PRK8)
  • western blot; rat; fig 5
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, 32282) was used in western blot on rat samples (fig 5). J Biol Chem (2016) ncbi
mouse monoclonal (PRK8)
  • western blot; human; fig s1c
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in western blot on human samples (fig s1c). J Cell Biol (2016) ncbi
mouse monoclonal (PRK8)
  • western blot; human; fig 3
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in western blot on human samples (fig 3). Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (PRK8)
  • western blot; human; fig 1d
Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, PRK8) was used in western blot on human samples (fig 1d). Nat Commun (2015) ncbi
mouse monoclonal (PRK8)
  • western blot; human; fig s4c
Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, PRK8) was used in western blot on human samples (fig s4c). J Cell Biol (2015) ncbi
mouse monoclonal (PRK8)
  • immunohistochemistry; human; fig 12
  • western blot; human; fig 8
In order to investigate the contribution of the Trib3 signaling pathway to neuron death, Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, sc-32282) was used in immunohistochemistry on human samples (fig 12) and in western blot on human samples (fig 8). J Neurosci (2015) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; human; 1:1000; fig 4
  • western blot; human; 1:5000; fig 2
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in immunocytochemistry on human samples at 1:1000 (fig 4) and in western blot on human samples at 1:5000 (fig 2). EMBO Rep (2015) ncbi
mouse monoclonal (PRK8)
  • western blot; rat; 1:1000; fig 1
In order to study alpha-synuclein tetramers, Santa Cruz Biotechnology Prkn antibody (Santa Cruz, PRK8) was used in western blot on rat samples at 1:1000 (fig 1). Nat Commun (2015) ncbi
mouse monoclonal (PRK8)
  • western blot; rhesus macaque
Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, sc-32282) was used in western blot on rhesus macaque samples . J Neurosci (2015) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse
In order to study the effect of parkin deletion and acute knockdown on acetaminophen-induced mitophagy and liver injury in mice, Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, SC-32282) was used in western blot on mouse samples . J Biol Chem (2015) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:250; loading ...; fig 4d
Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, sc32282) was used in western blot on mouse samples at 1:250 (fig 4d). Sci Rep (2015) ncbi
mouse monoclonal (PRK8)
  • western blot; human; fig 7
Santa Cruz Biotechnology Prkn antibody (santa Cruz, sc-32282) was used in western blot on human samples (fig 7). Autophagy (2015) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; rat; 1:20
  • western blot; rat; 1:200
Santa Cruz Biotechnology Prkn antibody (Santa Cruz, sc-32282) was used in immunocytochemistry on rat samples at 1:20 and in western blot on rat samples at 1:200. Neurobiol Dis (2015) ncbi
mouse monoclonal (PRK8)
  • western blot; human
In order to explore the parkin-dependent regulation of apoptosis and the turnover of damaged mitochondria in various cell types, Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, sc-32282) was used in western blot on human samples . Cell Death Dis (2014) ncbi
mouse monoclonal (PRK8)
  • western blot; human; fig 4
Santa Cruz Biotechnology Prkn antibody (Santa Cruz Biotechnology, sc32282) was used in western blot on human samples (fig 4). FASEB J (2014) ncbi
mouse monoclonal (PRK8)
  • western blot; rat
  • western blot; human; fig 2
In order to study the existance of alpha- and beta-synuclein predomonantly as oligomers in normal neuronal and non-neuronal cells, Santa Cruz Biotechnology Prkn antibody (Santa Cruz, PRK8) was used in western blot on rat samples and in western blot on human samples (fig 2). J Biol Chem (2013) ncbi
Abcam
mouse monoclonal (PRK8)
  • western blot; mouse; 1:500-1:2000; loading ...; fig 5c
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on mouse samples at 1:500-1:2000 (fig 5c). Redox Biol (2021) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:1000; loading ...; fig 3g
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on mouse samples at 1:1000 (fig 3g). Front Cell Dev Biol (2021) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:500; loading ...; fig 8c
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on mouse samples at 1:500 (fig 8c). Oxid Med Cell Longev (2021) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:1000; fig 8c
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on mouse samples at 1:1000 (fig 8c). Mol Metab (2021) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:3000; loading ...; fig 3f
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on human samples at 1:3000 (fig 3f). Nat Commun (2021) ncbi
mouse monoclonal (PRK8)
  • western blot; rat; 1:1000; loading ...; fig 5c
Abcam Prkn antibody (Abcam, PRK8, ab77924) was used in western blot on rat samples at 1:1000 (fig 5c). PLoS ONE (2020) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:1000; loading ...; fig 6a
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on mouse samples at 1:1000 (fig 6a). Antioxidants (Basel) (2020) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:1000; loading ...; fig 2a
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on mouse samples at 1:1000 (fig 2a). J Transl Med (2020) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:1000; loading ...; fig 5b
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on human samples at 1:1000 (fig 5b). Autophagy (2020) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:1000; loading ...; fig 5f
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on mouse samples at 1:1000 (fig 5f). J Neuroinflammation (2020) ncbi
mouse monoclonal (PRK8)
  • immunohistochemistry - paraffin section; rat; loading ...; fig 2a
  • western blot; human; loading ...; fig 3d
Abcam Prkn antibody (Abcam, ab77924) was used in immunohistochemistry - paraffin section on rat samples (fig 2a) and in western blot on human samples (fig 3d). J Clin Med (2019) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:1000; loading ...; fig e10a
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on human samples at 1:1000 (fig e10a). Nature (2019) ncbi
mouse monoclonal (PRK8)
  • western blot; human; loading ...; fig 7b
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on human samples (fig 7b). Cell Syst (2017) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; human; 1:500; fig 5
Abcam Prkn antibody (Abcam, ab77924) was used in immunocytochemistry on human samples at 1:500 (fig 5). Sci Rep (2016) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; loading ...; fig 3a
Abcam Prkn antibody (Abcam, ab77924) was used in western blot on mouse samples (fig 3a). J Gerontol A Biol Sci Med Sci (2017) ncbi
mouse monoclonal (PRK8)
  • immunoprecipitation; human; fig 2b
  • western blot; human; 1:1000; fig 1c
In order to report and characterize the interaction between BECN1 and PARK2, Abcam Prkn antibody (Abcam, ab77924) was used in immunoprecipitation on human samples (fig 2b) and in western blot on human samples at 1:1000 (fig 1c). Autophagy (2014) ncbi
mouse monoclonal (PRK8)
  • immunoprecipitation; human
  • western blot; human
Abcam Prkn antibody (abcam, ab77924) was used in immunoprecipitation on human samples and in western blot on human samples . PLoS ONE (2014) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig s2e, s3c
Cell Signaling Technology Prkn antibody (Cell Signaling, 2132) was used in western blot knockout validation on mouse samples (fig s2e, s3c). Nat Commun (2022) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; loading ...; fig 2j
Cell Signaling Technology Prkn antibody (Cell Signaling, 4211) was used in western blot on mouse samples (fig 2j). Cell Death Dis (2022) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:500; fig sy5y
Cell Signaling Technology Prkn antibody (Cell Signaling Technology, 4211) was used in western blot on mouse samples at 1:500 (fig sy5y). EMBO J (2021) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; loading ...; fig 7b
Cell Signaling Technology Prkn antibody (CST, 4211) was used in western blot on mouse samples (fig 7b). Signal Transduct Target Ther (2021) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:1000; loading ...; fig 5c
Cell Signaling Technology Prkn antibody (CST, 4211) was used in western blot on mouse samples at 1:1000 (fig 5c). JCI Insight (2021) ncbi
mouse monoclonal (PRK8)
  • western blot; rat; fig 7f
Cell Signaling Technology Prkn antibody (CST, 4211) was used in western blot on rat samples (fig 7f). Oxid Med Cell Longev (2021) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:1000; loading ...; fig 4
Cell Signaling Technology Prkn antibody (Cell Signaling Technology, 4211) was used in western blot on human samples at 1:1000 (fig 4). NPJ Parkinsons Dis (2020) ncbi
mouse monoclonal (PRK8)
  • western blot; rat; 1:50; loading ...; fig 5c
Cell Signaling Technology Prkn antibody (Cell Signaling Technology, 4211) was used in western blot on rat samples at 1:50 (fig 5c). Aging (Albany NY) (2020) ncbi
mouse monoclonal (PRK8)
  • western blot; rat; loading ...; fig 5a
Cell Signaling Technology Prkn antibody (CST, 4211) was used in western blot on rat samples (fig 5a). Cells (2019) ncbi
mouse monoclonal (PRK8)
  • western blot knockout validation; human; fig 6a
Cell Signaling Technology Prkn antibody (Cell Signaling Technology, 4211) was used in western blot knockout validation on human samples (fig 6a). Front Mol Neurosci (2019) ncbi
mouse monoclonal (PRK8)
  • western blot knockout validation; rat; 1:1000; fig 1a
Cell Signaling Technology Prkn antibody (Cell Signaling, 4211S) was used in western blot knockout validation on rat samples at 1:1000 (fig 1a). Sci Rep (2018) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; rat; 1:1000; fig 1a
Cell Signaling Technology Prkn antibody (Cell Signaling, 2132) was used in western blot knockout validation on rat samples at 1:1000 (fig 1a). Sci Rep (2018) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:1000; fig 4
Cell Signaling Technology Prkn antibody (Cell Signaling Technology, PRK8) was used in western blot on human samples at 1:1000 (fig 4). Hum Mol Genet (2017) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:1000; loading ...; fig s6c
In order to elucidate the mechanism by which the I4895T mutation in the type 1 ryanodine receptor/Ca(2+) release channel results in disease, Cell Signaling Technology Prkn antibody (Cell Signaling, 4211) was used in western blot on mouse samples at 1:1000 (fig s6c). Nat Commun (2017) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; loading ...; fig 2a
In order to elucidate the contribution of the Sac phosphatase domain of Synaptojanin 1 to neurological symptoms, Cell Signaling Technology Prkn antibody (Cell Signaling, 4211) was used in western blot on mouse samples (fig 2a). Neuron (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; 1:400; loading ...; fig 4a
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 4b
Cell Signaling Technology Prkn antibody (Cell Signaling, 2132S) was used in immunohistochemistry knockout validation on mouse samples at 1:400 (fig 4a) and in western blot knockout validation on mouse samples at 1:1000 (fig 4b). Autophagy (2017) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; loading ...; fig 7a
Cell Signaling Technology Prkn antibody (Cell Signaling, 4211) was used in western blot on mouse samples (fig 7a). Neurobiol Dis (2017) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; fig 3a
In order to find that continued 26S proteasome dysfunction in mouse brain cortical neurons causes paranuclear accumulation of fragmented dysfunctional mitochondria, associated with earlier recruitment of Parkin and lysine 48-linked ubiquitination of mitochond, Cell Signaling Technology Prkn antibody (Cell Signaling, 4211) was used in western blot on mouse samples (fig 3a). Cell Death Dis (2017) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:1000; loading ...; fig 1b
In order to recognize the inner mitochondrial membrane protein, prohibitin 2, as a crucial mitophagy receptor involved in targeting mitochondria for autophagic degradation, Cell Signaling Technology Prkn antibody (Cell signaling, mAb4211) was used in western blot on human samples at 1:1000 (fig 1b). Cell (2017) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; human; 1:1000; fig 2a
In order to study the role of PEX13 in autophagy, Cell Signaling Technology Prkn antibody (Cell signaling, 4211) was used in immunocytochemistry on human samples at 1:1000 (fig 2a). EMBO Rep (2017) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:1000; loading ...; fig 2a
Cell Signaling Technology Prkn antibody (Cell Signaling Technology, 4211) was used in western blot on human samples at 1:1000 (fig 2a). Brain (2017) ncbi
mouse monoclonal (PRK8)
  • western blot; human; loading ...; fig 5b
In order to demonstrate that miR-181a inhibits mitophagy, Cell Signaling Technology Prkn antibody (Cell Signaling, 4211) was used in western blot on human samples (fig 5b). Oncotarget (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; human; fig 2
  • western blot; human; fig 2
Cell Signaling Technology Prkn antibody (Cell Signaling, 2132) was used in immunohistochemistry on human samples (fig 2) and in western blot on human samples (fig 2). J Immunol (2016) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; human; fig 1
  • western blot; human; fig 1
Cell Signaling Technology Prkn antibody (Cell signaling, 4211) was used in immunocytochemistry on human samples (fig 1) and in western blot on human samples (fig 1). Cell Death Dis (2015) ncbi
mouse monoclonal (PRK8)
  • immunoprecipitation; human
  • immunocytochemistry; human; fig 9
In order to investigate the contribution of the Trib3 signaling pathway to neuron death, Cell Signaling Technology Prkn antibody (Cell Signaling Technology, 4211) was used in immunoprecipitation on human samples and in immunocytochemistry on human samples (fig 9). J Neurosci (2015) ncbi
mouse monoclonal (PRK8)
Cell Signaling Technology Prkn antibody (Cell Signaling Tech, 4211S) was used . Sci Rep (2015) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:1000
In order to assess the effect of PINK1-deficiency on mitochondrial quality control in myocytes, Cell Signaling Technology Prkn antibody (Cell Signaling, 4211) was used in western blot on mouse samples at 1:1000. PLoS ONE (2015) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:1000; loading ...; fig 7
Cell Signaling Technology Prkn antibody (Cell Signaling, 4211) was used in western blot on human samples at 1:1000 (fig 7). Mol Neurodegener (2015) ncbi
mouse monoclonal (PRK8)
  • immunohistochemistry knockout validation; mouse; fig 3
  • western blot knockout validation; mouse; fig 3
Cell Signaling Technology Prkn antibody (Cell Signaling Tech, 4211) was used in immunohistochemistry knockout validation on mouse samples (fig 3) and in western blot knockout validation on mouse samples (fig 3). Autophagy (2014) ncbi
mouse monoclonal (PRK8)
  • western blot; rat; 1:1000
Cell Signaling Technology Prkn antibody (Cell Signaling, Prk8) was used in western blot on rat samples at 1:1000. J Neurochem (2014) ncbi
MilliporeSigma
mouse monoclonal (PRK8)
  • immunocytochemistry; human; fig 6
  • western blot; human; 1:2000; fig 7
In order to investigate how PINK1 recruits Parkin, MilliporeSigma Prkn antibody (Sigma-Aldrich, PRK8) was used in immunocytochemistry on human samples (fig 6) and in western blot on human samples at 1:2000 (fig 7). J Cell Biol (2015) ncbi
mouse monoclonal (PRK8)
  • immunocytochemistry; mouse; loading ...; fig 3b
  • western blot; mouse; loading ...; fig 2c
MilliporeSigma Prkn antibody (Sigma, P6248) was used in immunocytochemistry on mouse samples (fig 3b) and in western blot on mouse samples (fig 2c). Hum Mol Genet (2015) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse; 1:5000; fig 1
MilliporeSigma Prkn antibody (Sigma, PRK8) was used in western blot on mouse samples at 1:5000 (fig 1). Cell Res (2015) ncbi
mouse monoclonal (PRK8)
  • immunoprecipitation; human; 1:6000; fig 2
  • western blot; human; 1:6000; fig 2
  • immunoprecipitation; mouse; 1:6000; fig 2
  • western blot; mouse; 1:6000; fig 2
In order to elucidate how mutations in parkin result in autosomal recessive juvenile parkinsonism, MilliporeSigma Prkn antibody (Sigma, P6248) was used in immunoprecipitation on human samples at 1:6000 (fig 2), in western blot on human samples at 1:6000 (fig 2), in immunoprecipitation on mouse samples at 1:6000 (fig 2) and in western blot on mouse samples at 1:6000 (fig 2). Nat Commun (2014) ncbi
mouse monoclonal (PRK8)
  • western blot; human; 1:2000
In order to report PINK1 phosphorylates ubiquitin which results in parkin activation, MilliporeSigma Prkn antibody (Sigma, PRK8) was used in western blot on human samples at 1:2000. Nature (2014) ncbi
mouse monoclonal (PRK8)
  • western blot; mouse
  • immunocytochemistry; African green monkey
MilliporeSigma Prkn antibody (Sigma-Aldrich, PRK8) was used in western blot on mouse samples and in immunocytochemistry on African green monkey samples . J Biol Chem (2014) ncbi
Articles Reviewed
  1. Moore T, Cheng L, Wolf D, Ngo J, Segawa M, Zhu X, et al. Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes. Nat Commun. 2022;13:6661 pubmed publisher
  2. Chen P, Katsuyama E, Satyam A, Li H, Rubio J, Jung S, et al. CD38 reduces mitochondrial fitness and cytotoxic T cell response against viral infection in lupus patients by suppressing mitophagy. Sci Adv. 2022;8:eabo4271 pubmed publisher
  3. Jin Y, Liu Y, Xu L, Xu J, Xiong Y, Peng Y, et al. Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis. Cell Death Dis. 2022;13:512 pubmed publisher
  4. Chiang S, Braidy N, Maleki S, Lal S, Richardson D, Huang M. Mechanisms of impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation. Redox Biol. 2021;46:102038 pubmed publisher
  5. López Doménech G, Howden J, Covill Cooke C, Morfill C, Patel J, Bürli R, et al. Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response. EMBO J. 2021;40:e100715 pubmed publisher
  6. Gan L, Liu D, Liu J, Chen E, Chen C, Liu L, et al. CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice. Signal Transduct Target Ther. 2021;6:223 pubmed publisher
  7. Baik S, Selvaraji S, Fann D, Poh L, Jo D, Herr D, et al. Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging. Aging (Albany NY). 2021;13:14651-14674 pubmed publisher
  8. Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar K, et al. ECSIT is a critical limiting factor for cardiac function. JCI Insight. 2021;6: pubmed publisher
  9. Tian F, Zhang Y. Overexpression of SERCA2a Alleviates Cardiac Microvascular Ischemic Injury by Suppressing Mfn2-Mediated ER/Mitochondrial Calcium Tethering. Front Cell Dev Biol. 2021;9:636553 pubmed publisher
  10. Huo S, Shi W, Ma H, Yan D, Luo P, Guo J, et al. Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene. Oxid Med Cell Longev. 2021;2021:6699054 pubmed publisher
  11. Cheng Y, Liu M, Tang H, Chen B, Yang G, Zhao W, et al. iTRAQ-Based Quantitative Proteomics Indicated Nrf2/OPTN-Mediated Mitophagy Inhibits NLRP3 Inflammasome Activation after Intracerebral Hemorrhage. Oxid Med Cell Longev. 2021;2021:6630281 pubmed publisher
  12. Xu S, Tao H, Cao W, Cao L, Lin Y, Zhao S, et al. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduct Target Ther. 2021;6:54 pubmed publisher
  13. Sass F, Schlein C, Jaeckstein M, Pertzborn P, Schweizer M, Schinke T, et al. TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality. Mol Metab. 2021;47:101173 pubmed publisher
  14. Choi G, Lee H, Chae C, Cho J, Jung Y, Kim J, et al. BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects. Nat Commun. 2021;12:487 pubmed publisher
  15. Kano M, Takanashi M, Oyama G, Yoritaka A, Hatano T, Shiba Fukushima K, et al. Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations. NPJ Parkinsons Dis. 2020;6:33 pubmed publisher
  16. Uda M, Yoshihara T, Ichinoseki Sekine N, Baba T, Yoshioka T. Potential roles of neuronal nitric oxide synthase and the PTEN-induced kinase 1 (PINK1)/Parkin pathway for mitochondrial protein degradation in disuse-induced soleus muscle atrophy in adult rats. PLoS ONE. 2020;15:e0243660 pubmed publisher
  17. Xu Y, Zhi F, Mao J, Peng Y, Shao N, Balboni G, et al. δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy. Aging (Albany NY). 2020;12:25035-25059 pubmed publisher
  18. Hollville E, Joers V, Nakamura A, Swahari V, TANSEY M, Moy S, et al. Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease. Sci Rep. 2020;10:16886 pubmed publisher
  19. Rusilowicz Jones E, Jardine J, Kallinos A, Pinto Fernandez A, Guenther F, Giurrandino M, et al. USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation. Life Sci Alliance. 2020;3: pubmed publisher
  20. Meza Torres C, Hernández Camacho J, Cortés Rodríguez A, Fang L, Bui Thanh T, Rodríguez Bies E, et al. Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet. Antioxidants (Basel). 2020;9: pubmed publisher
  21. Gao Y, Dai X, Li Y, Li G, Lin X, Ai C, et al. Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury. J Transl Med. 2020;18:114 pubmed publisher
  22. Castro Gonzalez S, Shi Y, Colomer Lluch M, Song Y, Mowery K, Almodovar S, et al. HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner. Autophagy. 2020;:1-25 pubmed publisher
  23. Zhang S, Hu L, Jiang J, Li H, Wu Q, Ooi K, et al. HMGB1/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia. J Neuroinflammation. 2020;17:15 pubmed publisher
  24. Aimé P, Karuppagounder S, Rao A, Chen Y, Burke R, Ratan R, et al. The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease. Neurobiol Dis. 2020;136:104725 pubmed publisher
  25. Ahfeldt T, Ordureau A, Bell C, Sarrafha L, Sun C, Piccinotti S, et al. Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons. Stem Cell Reports. 2020;14:75-90 pubmed publisher
  26. Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher
  27. Shin H, Park H, Shin N, Kwon H, Yin Y, Hwang J, et al. Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis. J Clin Med. 2019;8: pubmed publisher
  28. Hoshino A, Wang W, Wada S, McDermott Roe C, Evans C, Gosis B, et al. The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature. 2019;575:375-379 pubmed publisher
  29. He Q, Li Z, Meng C, Wu J, Zhao Y, Zhao J. Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats. Cells. 2019;8: pubmed publisher
  30. Swatek K, Usher J, Kueck A, Gladkova C, Mevissen T, Pruneda J, et al. Insights into ubiquitin chain architecture using Ub-clipping. Nature. 2019;572:533-537 pubmed publisher
  31. Lee L, Seager R, Nakamura Y, Wilkinson K, Henley J. Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff). PLoS ONE. 2019;14:e0213116 pubmed publisher
  32. Park H, Chung K, An H, Gim J, Hong J, Woo H, et al. Parkin Promotes Mitophagic Cell Death in Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal. Front Mol Neurosci. 2019;12:46 pubmed publisher
  33. Zhang J, Sheng J, Dong L, Xu Y, Yu L, Liu Y, et al. Cardiomyocyte-specific loss of RMP causes myocardial dysfunction and heart failure. Cardiovasc Res. 2018;: pubmed publisher
  34. Zhu M, Cortese G, Waites C. Parkinson's disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons. BMC Biol. 2018;16:100 pubmed publisher
  35. Gemechu J, Sharma A, Yu D, Xie Y, Merkel O, Moszczynska A. Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats. Sci Rep. 2018;8:1517 pubmed publisher
  36. Malty R, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, et al. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. Cell Syst. 2017;5:564-577.e12 pubmed publisher
  37. Shiba Fukushima K, Ishikawa K, Inoshita T, Izawa N, Takanashi M, Sato S, et al. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum Mol Genet. 2017;26:3172-3185 pubmed publisher
  38. Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed publisher
  39. Gupta A, Anjomani Virmouni S, Koundouros N, Dimitriadi M, Choo Wing R, Valle A, et al. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Mol Cell. 2017;65:999-1013.e7 pubmed publisher
  40. Cao M, Wu Y, Ashrafi G, McCartney A, Wheeler H, Bushong E, et al. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron. 2017;93:882-896.e5 pubmed publisher
  41. Menges S, Minakaki G, Schaefer P, Meixner H, Prots I, Schlötzer Schrehardt U, et al. Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress. Sci Rep. 2017;7:42942 pubmed publisher
  42. Shen Z, Zheng Y, Wu J, Chen Y, Wu X, Zhou Y, et al. PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window. Autophagy. 2017;13:473-485 pubmed publisher
  43. Borgia D, Malena A, Spinazzi M, Desbats M, Salviati L, Russell A, et al. Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patients. Hum Mol Genet. 2017;26:1087-1103 pubmed publisher
  44. Upadhyay M, Agarwal S, Bhadauriya P, Ganesh S. Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models. Neurobiol Dis. 2017;100:39-51 pubmed publisher
  45. Li G, Fu R, Shen H, Zhou J, Hu X, Liu Y, et al. Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels. Oncotarget. 2017;8:10359-10374 pubmed publisher
  46. Ugun Klusek A, Tatham M, Elkharaz J, Constantin Teodosiu D, Lawler K, Mohamed H, et al. Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway. Cell Death Dis. 2017;8:e2531 pubmed publisher
  47. Wei Y, Chiang W, Sumpter R, Mishra P, Levine B. Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. Cell. 2017;168:224-238.e10 pubmed publisher
  48. Shen M, Jiang Y, Guan Z, Cao Y, Sun S, Liu H. FSH protects mouse granulosa cells from oxidative damage by repressing mitophagy. Sci Rep. 2016;6:38090 pubmed publisher
  49. Lee M, Sumpter R, Zou Z, Sirasanagandla S, Wei Y, Mishra P, et al. Peroxisomal protein PEX13 functions in selective autophagy. EMBO Rep. 2017;18:48-60 pubmed publisher
  50. Puschmann A, Fiesel F, Caulfield T, Hudec R, Ando M, Truban D, et al. Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism. Brain. 2017;140:98-117 pubmed publisher
  51. Shlevkov E, Kramer T, Schapansky J, LaVoie M, Schwarz T. Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility. Proc Natl Acad Sci U S A. 2016;113:E6097-E6106 pubmed
  52. Guo X, Sun X, Hu D, Wang Y, Fujioka H, Vyas R, et al. VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nat Commun. 2016;7:12646 pubmed publisher
  53. McLelland G, Lee S, McBride H, Fon E. Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system. J Cell Biol. 2016;214:275-91 pubmed publisher
  54. Akabane S, Matsuzaki K, Yamashita S, Arai K, Okatsu K, Kanki T, et al. Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy. J Biol Chem. 2016;291:16162-74 pubmed publisher
  55. Cheng M, Liu L, Lao Y, Liao W, Liao M, Luo X, et al. MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis. Oncotarget. 2016;7:42274-42287 pubmed publisher
  56. Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher
  57. Scott T, Wicker C, Suganya R, Dhar B, Pittman T, Horbinski C, et al. Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin. Mol Carcinog. 2017;56:325-336 pubmed publisher
  58. Qvit N, Joshi A, Cunningham A, Ferreira J, Mochly Rosen D. Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death. J Biol Chem. 2016;291:13608-21 pubmed publisher
  59. Pryde K, Smith H, Chau K, Schapira A. PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy. J Cell Biol. 2016;213:163-71 pubmed publisher
  60. Qi Y, Qiu Q, Gu X, Tian Y, Zhang Y. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts. Sci Rep. 2016;6:24700 pubmed publisher
  61. Tamura Y, Matsunaga Y, Kitaoka Y, Hatta H. Effects of Heat Stress Treatment on Age-dependent Unfolded Protein Response in Different Types of Skeletal Muscle. J Gerontol A Biol Sci Med Sci. 2017;72:299-308 pubmed publisher
  62. Richter B, Sliter D, Herhaus L, Stolz A, Wang C, Beli P, et al. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc Natl Acad Sci U S A. 2016;113:4039-44 pubmed publisher
  63. Shi J, Fung G, Deng H, Zhang J, Fiesel F, Springer W, et al. NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1. Cell Death Dis. 2015;6:e1943 pubmed publisher
  64. Phinney D, Di Giuseppe M, Njah J, Sala E, Shiva S, St Croix C, et al. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nat Commun. 2015;6:8472 pubmed publisher
  65. Nezich C, Wang C, Fogel A, Youle R. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol. 2015;210:435-50 pubmed publisher
  66. Aimé P, Sun X, Zareen N, Rao A, Berman Z, Volpicelli Daley L, et al. Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models. J Neurosci. 2015;35:10731-49 pubmed publisher
  67. Sargsyan A, Cai J, Fandino L, Labasky M, Forostyan T, Colosimo L, et al. Rapid parallel measurements of macroautophagy and mitophagy in mammalian cells using a single fluorescent biosensor. Sci Rep. 2015;5:12397 pubmed publisher
  68. Kazlauskaite A, Martínez Torres R, Wilkie S, Kumar A, Peltier J, González A, et al. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. EMBO Rep. 2015;16:939-54 pubmed publisher
  69. Kubli D, Cortez M, Moyzis A, Najor R, Lee Y, Gustafsson Ã. PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes. PLoS ONE. 2015;10:e0130707 pubmed publisher
  70. Van Rompuy A, Oliveras Salvá M, Van der Perren A, Corti O, Van den Haute C, Baekelandt V. Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration. Mol Neurodegener. 2015;10:23 pubmed publisher
  71. Dettmer U, Newman A, Soldner F, Luth E, Kim N, von Saucken V, et al. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015;6:7314 pubmed publisher
  72. Yang W, Wang G, Wang C, Guo X, Yin P, Gao J, et al. Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. J Neurosci. 2015;35:8345-58 pubmed publisher
  73. Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, et al. Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol. 2015;209:111-28 pubmed publisher
  74. Williams J, Ni H, Haynes A, Manley S, Li Y, Jaeschke H, et al. Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice. J Biol Chem. 2015;290:10934-46 pubmed publisher
  75. Gouspillou G, Scheede Bergdahl C, Spendiff S, Vuda M, Meehan B, Mlynarski H, et al. Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle. Sci Rep. 2015;5:8717 pubmed publisher
  76. Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11:253-70 pubmed publisher
  77. Corsetti V, Florenzano F, Atlante A, Bobba A, Ciotti M, Natale F, et al. NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease. Hum Mol Genet. 2015;24:3058-81 pubmed publisher
  78. Van Laar V, Roy N, Liu A, Rajprohat S, Arnold B, Dukes A, et al. Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy. Neurobiol Dis. 2015;74:180-93 pubmed publisher
  79. Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, et al. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell Res. 2015;25:394-7 pubmed publisher
  80. Maraschi A, Ciammola A, Folci A, Sassone F, Ronzitti G, Cappelletti G, et al. Parkin regulates kainate receptors by interacting with the GluK2 subunit. Nat Commun. 2014;5:5182 pubmed publisher
  81. Charan R, Johnson B, Zaganelli S, Nardozzi J, LaVoie M. Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin. Cell Death Dis. 2014;5:e1313 pubmed publisher
  82. Choubey V, Cagalinec M, Liiv J, Safiulina D, Hickey M, Kuum M, et al. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy. 2014;10:1105-19 pubmed publisher
  83. Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, et al. Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature. 2014;510:162-6 pubmed publisher
  84. Zou J, Yue F, Li W, Song K, Jiang X, Yi J, et al. Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin. PLoS ONE. 2014;9:e94903 pubmed publisher
  85. Furuya N, Ikeda S, Sato S, Soma S, Ezaki J, Oliva Trejo J, et al. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014;10:631-41 pubmed publisher
  86. Gouspillou G, Sgarioto N, Kapchinsky S, Purves Smith F, Norris B, Pion C, et al. Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans. FASEB J. 2014;28:1621-33 pubmed publisher
  87. Brot S, Auger C, Bentata R, Rogemond V, Ménigoz S, Chounlamountri N, et al. Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites. J Biol Chem. 2014;289:2261-76 pubmed publisher
  88. Killinger B, Shah M, Moszczynska A. Co-administration of betulinic acid and methamphetamine causes toxicity to dopaminergic and serotonergic nerve terminals in the striatum of late adolescent rats. J Neurochem. 2014;128:764-75 pubmed publisher
  89. Dettmer U, Newman A, Luth E, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of ?-synuclein and ?-synuclein in neurons and non-neural cells. J Biol Chem. 2013;288:6371-85 pubmed publisher