This is a Validated Antibody Database (VAD) review about mouse Prkdc, based on 20 published articles (read how Labome selects the articles), using Prkdc antibody in all methods. It is aimed to help Labome visitors find the most suited Prkdc antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Prkdc synonym: AI326420; AU019811; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC1; XRCC7; dxnph; p460; scid; slip

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal
  • western blot knockout validation; human; loading ...; fig 5a
Santa Cruz Biotechnology Prkdc antibody (Santa Cruz, G12) was used in western blot knockout validation on human samples (fig 5a). elife (2020) ncbi
Santa Cruz Biotechnology
mouse monoclonal (G-12)
  • western blot knockout validation; human; loading ...; fig 5a
Santa Cruz Biotechnology Prkdc antibody (Santa Cruz, G12) was used in western blot knockout validation on human samples (fig 5a). elife (2020) ncbi
Abcam
domestic rabbit monoclonal (Y393)
  • western blot; human; 1:1000; loading ...; fig 1f
Abcam Prkdc antibody (Abcam, ab32566) was used in western blot on human samples at 1:1000 (fig 1f). J Exp Clin Cancer Res (2021) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; loading ...; fig 4s2a
  • western blot; human; loading ...; fig 4g, 6b
Abcam Prkdc antibody (Abcam, ab18192) was used in immunocytochemistry on human samples (fig 4s2a) and in western blot on human samples (fig 4g, 6b). elife (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3e
Abcam Prkdc antibody (Abcam, ab70250) was used in western blot on human samples at 1:1000 (fig 3e). Cell Rep (2018) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; fig 6k
  • western blot; mouse; 1:100; loading ...; fig 6l
  • immunocytochemistry; human; loading ...; fig 2h, 4j
  • western blot; human; 1:100; loading ...; fig 2i, 4b, 6n
Abcam Prkdc antibody (Abcam, ab18192) was used in immunocytochemistry on mouse samples (fig 6k), in western blot on mouse samples at 1:100 (fig 6l), in immunocytochemistry on human samples (fig 2h, 4j) and in western blot on human samples at 1:100 (fig 2i, 4b, 6n). Nucleic Acids Res (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 3d
Abcam Prkdc antibody (Abcam, ab18192) was used in western blot on human samples (fig 3d). Nucleic Acids Res (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig s2
In order to describe a role for NIPBL in DNA damage repair, Abcam Prkdc antibody (Abcam, ab18192) was used in western blot on human samples at 1:1000 (fig s2). J Cell Sci (2017) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; 1:500; loading ...; fig 6c
In order to describe a role for APRIN in homologous recombination, Abcam Prkdc antibody (ABCAM, ab18192) was used in immunocytochemistry on human samples at 1:500 (fig 6c). Nucleic Acids Res (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 6c
In order to use knockout mice to determine if GRK6 contributes to hematopoiesis, Abcam Prkdc antibody (Abcam, ab70250) was used in western blot on human samples (fig 6c). Cell Death Dis (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 6c
In order to use knockout mice to determine if GRK6 contributes to hematopoiesis, Abcam Prkdc antibody (Abcam, ab18192) was used in western blot on human samples (fig 6c). Cell Death Dis (2016) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; loading ...; fig 5C
In order to investigate the role of the PTEN phosphatase in DNA interstrand crosslink repair, Abcam Prkdc antibody (Abcam, ab18192) was used in immunocytochemistry on human samples (fig 5C). Sci Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 6e
In order to identify genetic features regulating cell survival after exposure to radiation., Abcam Prkdc antibody (Abcam, 18192) was used in western blot on human samples at 1:1000 (fig 6e). Nat Commun (2016) ncbi
domestic rabbit monoclonal (Y393)
  • western blot; human; loading ...; fig 4c
In order to study the effect of cathepsin L on glioma stem cells both in vivo and in vitro, Abcam Prkdc antibody (Abcam, ab32566) was used in western blot on human samples (fig 4c). Cancer Lett (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:400; fig s6
Abcam Prkdc antibody (Abcam, ab18192) was used in western blot on human samples at 1:400 (fig s6). Nat Genet (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 4
Abcam Prkdc antibody (Abcam, ab18192) was used in western blot on human samples (fig 4). Nucleic Acids Res (2016) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; fig 2
In order to study how the Fanconi anemia pathway promotes homologous recombination at stalled replication forks, Abcam Prkdc antibody (Abcam, ab18192) was used in immunocytochemistry on human samples (fig 2). Nucleic Acids Res (2016) ncbi
domestic rabbit monoclonal (Y393)
  • western blot; human; 1:1000; fig 1g
In order to elucidate the function of TRIM29 in double stranded break repair, Abcam Prkdc antibody (Abcam, ab32566) was used in western blot on human samples at 1:1000 (fig 1g). Nat Commun (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal
  • western blot knockout validation; human; loading ...; fig 5a
Santa Cruz Biotechnology Prkdc antibody (Santa Cruz, G12) was used in western blot knockout validation on human samples (fig 5a). elife (2020) ncbi
mouse monoclonal (G-12)
  • western blot knockout validation; human; loading ...; fig 5a
Santa Cruz Biotechnology Prkdc antibody (Santa Cruz, G12) was used in western blot knockout validation on human samples (fig 5a). elife (2020) ncbi
mouse monoclonal (G-12)
  • western blot; human; loading ...; fig 1b
Santa Cruz Biotechnology Prkdc antibody (Santa Cruz, sc-390849) was used in western blot on human samples (fig 1b). elife (2020) ncbi
mouse monoclonal (E-6)
  • immunocytochemistry; human; loading ...; fig 6i
Santa Cruz Biotechnology Prkdc antibody (Santa Cruz, sc390698) was used in immunocytochemistry on human samples (fig 6i). J Cell Physiol (2017) ncbi
mouse monoclonal (E-3)
  • western blot; human; 1:500; loading ...; fig s6b
Santa Cruz Biotechnology Prkdc antibody (Santa Cruz, sc-390495) was used in western blot on human samples at 1:500 (fig s6b). PLoS ONE (2016) ncbi
mouse monoclonal (E-6)
  • immunocytochemistry; human; fig 4
Santa Cruz Biotechnology Prkdc antibody (SantaCruz, sc390698) was used in immunocytochemistry on human samples (fig 4). Oncotarget (2015) ncbi
Novus Biologicals
mouse monoclonal (3H6)
  • western blot; human; loading ...; fig 2a
Novus Biologicals Prkdc antibody (Novus Biologicals, NBP2-22128) was used in western blot on human samples (fig 2a). Mol Biol Cell (2017) ncbi
Articles Reviewed
  1. Lei X, Cao K, Chen Y, Shen H, Liu Z, Qin H, et al. Nuclear Transglutaminase 2 interacts with topoisomerase II⍺ to promote DNA damage repair in lung cancer cells. J Exp Clin Cancer Res. 2021;40:224 pubmed publisher
  2. Brunner A, Suryo Rahmanto A, Johansson H, Franco M, Viiliäinen J, Gazi M, et al. PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer. elife. 2020;9: pubmed publisher
  3. Zhu S, Paydar M, Wang F, Li Y, Wang L, Barrette B, et al. Kinesin Kif2C in regulation of DNA double strand break dynamics and repair. elife. 2020;9: pubmed publisher
  4. Tay L, Krishnan V, Sankar H, Chong Y, Chuang L, Tan T, et al. RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair. Cell Rep. 2018;24:1747-1755 pubmed publisher
  5. Kannan A, Bhatia K, Branzei D, Gangwani L. Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy. Nucleic Acids Res. 2018;46:8326-8346 pubmed publisher
  6. Li M, Yang X, LU X, Dai N, Zhang S, Cheng Y, et al. APE1 deficiency promotes cellular senescence and premature aging features. Nucleic Acids Res. 2018;46:5664-5677 pubmed publisher
  7. Bot C, Pfeiffer A, Giordano F, Manjeera D, Dantuma N, Ström L. Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage. J Cell Sci. 2017;130:1134-1146 pubmed publisher
  8. Squillaro T, Antonucci I, Alessio N, Esposito A, Cipollaro M, Melone M, et al. Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes. J Cell Physiol. 2017;232:3454-3467 pubmed publisher
  9. Fantini D, Huang S, Asara J, Bagchi S, Raychaudhuri P. Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. Mol Biol Cell. 2017;28:192-200 pubmed publisher
  10. Couturier A, Fleury H, Patenaude A, Bentley V, Rodrigue A, Coulombe Y, et al. Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction. Nucleic Acids Res. 2016;44:10879-10897 pubmed
  11. Zhang H, Sun L, Wang K, Wu D, Trappio M, Witting C, et al. Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome. PLoS ONE. 2016;11:e0167454 pubmed publisher
  12. Le Q, Yao W, Chen Y, Yan B, Liu C, Yuan M, et al. GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal. Cell Death Dis. 2016;7:e2478 pubmed publisher
  13. Vuono E, Mukherjee A, Vierra D, Adroved M, Hodson C, Deans A, et al. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. Sci Rep. 2016;6:36439 pubmed publisher
  14. Yard B, Adams D, Chie E, Tamayo P, Battaglia J, Gopal P, et al. A genetic basis for the variation in the vulnerability of cancer to DNA damage. Nat Commun. 2016;7:11428 pubmed publisher
  15. Wang W, Long L, Wang L, Tan C, Fei X, Chen L, et al. Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro. Cancer Lett. 2016;371:274-84 pubmed publisher
  16. Harley M, Murina O, Leitch A, Higgs M, Bicknell L, Yigit G, et al. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Nat Genet. 2016;48:36-43 pubmed publisher
  17. Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res. 2016;44:1161-78 pubmed publisher
  18. Renaud E, Barascu A, Rosselli F. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucleic Acids Res. 2016;44:648-56 pubmed publisher
  19. Masuda Y, Takahashi H, Sato S, Tomomori Sato C, Saraf A, Washburn M, et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat Commun. 2015;6:7299 pubmed publisher
  20. Alessio N, Del Gaudio S, Capasso S, Di Bernardo G, Cappabianca S, Cipollaro M, et al. Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process. Oncotarget. 2015;6:8155-66 pubmed