This is a Validated Antibody Database (VAD) review about mouse Nr1h3, based on 15 published articles (read how Labome selects the articles), using Nr1h3 antibody in all methods. It is aimed to help Labome visitors find the most suited Nr1h3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Nr1h3 synonym: AU018371; LXR; RLD1; Unr1; oxysterols receptor LXR-alpha; LXR alpha; liver X receptor alpha; ubiquitously-expressed nuclear receptor 1

Abcam
mouse monoclonal (PPZ0412)
  • western blot; human; fig 3j
Abcam Nr1h3 antibody (Abcam, ab41902) was used in western blot on human samples (fig 3j). Sci Rep (2017) ncbi
mouse monoclonal (PPZ0412)
  • chromatin immunoprecipitation; mouse; loading ...; fig s3a
In order to investigate the contribution of liver receptor homolog 1 SUMOylation to nonalcoholic fatty liver disease development, Abcam Nr1h3 antibody (Abcam, ab41902) was used in chromatin immunoprecipitation on mouse samples (fig s3a). J Clin Invest (2017) ncbi
rabbit monoclonal (EPR6508(N))
  • western blot; mouse; loading ...; fig 5a
Abcam Nr1h3 antibody (Abcam, ab176323) was used in western blot on mouse samples (fig 5a). Int J Mol Med (2016) ncbi
mouse monoclonal (PPZ0412)
  • chromatin immunoprecipitation; mouse; loading ...; fig 5h, i
Abcam Nr1h3 antibody (Abcam, ab41902) was used in chromatin immunoprecipitation on mouse samples (fig 5h, i). Sci Rep (2016) ncbi
mouse monoclonal (PPZ0412)
  • immunoprecipitation; mouse; loading ...; fig 4b
In order to describe the ubiquitination and degradation of liver X receptor, Abcam Nr1h3 antibody (Abcam, PPZ0412) was used in immunoprecipitation on mouse samples (fig 4b). Nature (2016) ncbi
mouse monoclonal (PPZ0412)
  • chromatin immunoprecipitation; mouse; fig s3
Abcam Nr1h3 antibody (Abcam, PPZ0412) was used in chromatin immunoprecipitation on mouse samples (fig s3). Nature (2016) ncbi
mouse monoclonal (PPZ0412)
  • western blot; mouse; 1:1000; fig 7
Abcam Nr1h3 antibody (Abcam, ab41902) was used in western blot on mouse samples at 1:1000 (fig 7). Sci Rep (2016) ncbi
mouse monoclonal (PPZ0412)
  • western blot; human; loading ...; fig 3d
Abcam Nr1h3 antibody (Abcam, ab41902) was used in western blot on human samples (fig 3d). PLoS ONE (2016) ncbi
mouse monoclonal (PPZ0412)
  • chromatin immunoprecipitation; human; 1:500
  • western blot; human
In order to show that Ajuba is a novel coactivator for liver X receptors, Abcam Nr1h3 antibody (Abcam, ab41902) was used in chromatin immunoprecipitation on human samples at 1:500 and in western blot on human samples . Mol Endocrinol (2015) ncbi
mouse monoclonal (PPZ0412)
  • western blot; mouse; 1:1000; loading ...; fig 2d
Abcam Nr1h3 antibody (Abcam, ab41902) was used in western blot on mouse samples at 1:1000 (fig 2d). PLoS ONE (2015) ncbi
mouse monoclonal (PPZ0412)
  • western blot; mouse
Abcam Nr1h3 antibody (Abcam, ab41902) was used in western blot on mouse samples . J Biol Chem (2014) ncbi
mouse monoclonal (PPZ0412)
  • western blot; rat; 1:1000
  • western blot; human; 1:1000
Abcam Nr1h3 antibody (Abcam, ab41902) was used in western blot on rat samples at 1:1000 and in western blot on human samples at 1:1000. Br J Pharmacol (2013) ncbi
mouse monoclonal (PPZ0412)
  • western blot; mouse
Abcam Nr1h3 antibody (Abcam, ab41902) was used in western blot on mouse samples . Circulation (2013) ncbi
Santa Cruz Biotechnology
mouse monoclonal (H-7)
  • immunohistochemistry; human; 1:100; loading ...; fig 1b
Santa Cruz Biotechnology Nr1h3 antibody (Santa Cruz, sc-377260) was used in immunohistochemistry on human samples at 1:100 (fig 1b). PLoS ONE (2016) ncbi
MilliporeSigma
rabbit polyclonal
  • immunocytochemistry; human
MilliporeSigma Nr1h3 antibody (Sigma-Aldrich, L5044) was used in immunocytochemistry on human samples . J Steroid Biochem Mol Biol (2015) ncbi
Articles Reviewed
  1. Kim H. The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages. Sci Rep. 2017;7:7591 pubmed publisher
  2. Stein S, Lemos V, Xu P, Demagny H, Wang X, Ryu D, et al. Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. J Clin Invest. 2017;127:583-592 pubmed publisher
  3. Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X, et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 2016;38:1715-1726 pubmed publisher
  4. Wang J, Dong X, Wu H, Wu N, Zhang X, Wang X, et al. Relationship of Liver X Receptors α and Endoglin Levels in Serum and Placenta with Preeclampsia. PLoS ONE. 2016;11:e0163742 pubmed publisher
  5. Kim S, Lim E, Yoon Y, Ahn Y, Park E, Kim H, et al. Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages. Sci Rep. 2016;6:29673 pubmed publisher
  6. Hsieh J, Koseki M, Molusky M, Yakushiji E, Ichi I, Westerterp M, et al. TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature. 2016;535:303-7 pubmed publisher
  7. Sallam T, Jones M, Gilliland T, Zhang L, Wu X, Eskin A, et al. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. Nature. 2016;534:124-8 pubmed publisher
  8. Zhao Y, Xu L, Qiao Z, Gao L, Ding S, Ying X, et al. YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor α. Sci Rep. 2016;6:23025 pubmed publisher
  9. Sharma M, Tuaine J, McLaren B, Waters D, Black K, Jones L, et al. Chemotherapy Agents Alter Plasma Lipids in Breast Cancer Patients and Show Differential Effects on Lipid Metabolism Genes in Liver Cells. PLoS ONE. 2016;11:e0148049 pubmed publisher
  10. Fan H, Dong W, Li Q, Zou X, Zhang Y, Wang J, et al. Ajuba Preferentially Binds LXRα/RXRγ Heterodimer to Enhance LXR Target Gene Expression in Liver Cells. Mol Endocrinol. 2015;29:1608-18 pubmed publisher
  11. Hussein M, Shrestha E, Ouimet M, Barrett T, Leone S, Moore K, et al. LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2. PLoS ONE. 2015;10:e0135218 pubmed publisher
  12. Sakurabashi A, Wada Hiraike O, Hirano M, Fu H, Isono W, Fukuda T, et al. CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase. J Steroid Biochem Mol Biol. 2015;149:80-8 pubmed publisher
  13. Zhao J, Fu Y, Liu C, Shinohara M, Nielsen H, Dong Q, et al. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. J Biol Chem. 2014;289:11282-92 pubmed publisher
  14. Wang W, Wang C, Ding X, Pan Y, Gu T, Wang M, et al. Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats. Br J Pharmacol. 2013;169:1352-71 pubmed publisher
  15. Khan O, Akula M, Skålén K, Karlsson C, Ståhlman M, Young S, et al. Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice. Circulation. 2013;127:782-90 pubmed publisher