This is a Validated Antibody Database (VAD) review about mouse Mnk1, based on 9 published articles (read how Labome selects the articles), using Mnk1 antibody in all methods. It is aimed to help Labome visitors find the most suited Mnk1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Mnk1 synonym: 2410048M24Rik; Mnk1

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (C4C1)
  • immunohistochemistry knockout validation; human; loading ...; fig 2b
  • western blot; human; loading ...; fig 4e
Cell Signaling Technology Mnk1 antibody (Cell Signaling, 2195S) was used in immunohistochemistry knockout validation on human samples (fig 2b) and in western blot on human samples (fig 4e). Cancer Res (2019) ncbi
Abnova
mouse monoclonal (2F12)
  • western blot; mouse; loading ...; fig 5b
Abnova Mnk1 antibody (Novus Biologicals, H00008569-M14) was used in western blot on mouse samples (fig 5b). PLoS ONE (2017) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C4C1)
  • immunohistochemistry knockout validation; human; loading ...; fig 2b
  • western blot; human; loading ...; fig 4e
Cell Signaling Technology Mnk1 antibody (Cell Signaling, 2195S) was used in immunohistochemistry knockout validation on human samples (fig 2b) and in western blot on human samples (fig 4e). Cancer Res (2019) ncbi
domestic rabbit monoclonal (C4C1)
  • other; human; loading ...; fig 4c
Cell Signaling Technology Mnk1 antibody (Cell Signaling, 2195) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
domestic rabbit monoclonal (C4C1)
  • immunocytochemistry; mouse; 1:100; loading ...; fig 4i
Cell Signaling Technology Mnk1 antibody (Cell Signaling, 2195S) was used in immunocytochemistry on mouse samples at 1:100 (fig 4i). Biol Reprod (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 1e
Cell Signaling Technology Mnk1 antibody (Cell Signaling, 2111) was used in western blot on human samples (fig 1e). J Clin Invest (2017) ncbi
domestic rabbit monoclonal (C4C1)
  • western blot; human; loading ...; fig 1e
Cell Signaling Technology Mnk1 antibody (Cell Signaling, 2195) was used in western blot on human samples (fig 1e). J Clin Invest (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 5b
Cell Signaling Technology Mnk1 antibody (CST, 2111) was used in western blot on mouse samples (fig 5b). PLoS ONE (2017) ncbi
domestic rabbit monoclonal (C4C1)
  • western blot; human; 1:200; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology Mnk1 antibody (Cell Signaling, 2195) was used in western blot on human samples at 1:200 (fig st1). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:200; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology Mnk1 antibody (Cell Signaling, 2111) was used in western blot on human samples at 1:200 (fig st1). Nat Commun (2016) ncbi
domestic rabbit monoclonal (C4C1)
  • western blot; human; fig 2
In order to analyze induction of the regression of NF1-mutant cancers by cotargeting MNK and MEK kinases, Cell Signaling Technology Mnk1 antibody (Cell signaling, 2195) was used in western blot on human samples (fig 2). J Clin Invest (2016) ncbi
domestic rabbit monoclonal (C4C1)
  • western blot; human; fig s2
Cell Signaling Technology Mnk1 antibody (Cell Signaling, 2195) was used in western blot on human samples (fig s2). Nat Immunol (2015) ncbi
domestic rabbit monoclonal (C4C1)
  • western blot; human; 1:1000; fig 7
Cell Signaling Technology Mnk1 antibody (Cell Signaling, 2195) was used in western blot on human samples at 1:1000 (fig 7). PLoS ONE (2015) ncbi
Articles Reviewed
  1. Guo Q, Li V, Nichol J, Huang F, Yang W, Preston S, et al. MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ. Cancer Res. 2019;79:1646-1657 pubmed publisher
  2. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  3. Hu J, Sun F, Handel M. Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice. Biol Reprod. 2018;98:102-114 pubmed publisher
  4. Zhan Y, Guo J, Yang W, Goncalves C, Rzymski T, Dreas A, et al. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. J Clin Invest. 2017;127:4179-4192 pubmed publisher
  5. Tormos A, Rius Pérez S, Jorques M, Rada P, Ramírez L, Valverde A, et al. p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. PLoS ONE. 2017;12:e0171738 pubmed publisher
  6. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  7. Lock R, Ingraham R, Maertens O, Miller A, Weledji N, Legius E, et al. Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers. J Clin Invest. 2016;126:2181-90 pubmed publisher
  8. Su X, Yu Y, Zhong Y, Giannopoulou E, Hu X, Liu H, et al. Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nat Immunol. 2015;16:838-849 pubmed publisher
  9. Martínez A, Sesé M, Losa J, Robichaud N, Sonenberg N, Aasen T, et al. Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. PLoS ONE. 2015;10:e0123352 pubmed publisher