This is a Validated Antibody Database (VAD) review about mouse Mlh1, based on 17 published articles (read how Labome selects the articles), using Mlh1 antibody in all methods. It is aimed to help Labome visitors find the most suited Mlh1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Mlh1 synonym: 1110035C23Rik; AI317206; AI325952; AI561766

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (B-12)
  • western blot knockout validation; human; loading ...; fig 4a
Santa Cruz Biotechnology Mlh1 antibody (Santa Cruz, sc-271978) was used in western blot knockout validation on human samples (fig 4a). Cell Death Dis (2020) ncbi
Abcam
domestic rabbit monoclonal (EPR3894)
  • western blot; mouse; loading ...; fig s1b
Abcam Mlh1 antibody (Abcam, ab92312) was used in western blot on mouse samples (fig s1b). Front Genet (2022) ncbi
domestic rabbit monoclonal (EPR3894)
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5a
Abcam Mlh1 antibody (Abcam, ab92312) was used in immunohistochemistry on mouse samples at 1:200 (fig 5a). Front Cell Dev Biol (2021) ncbi
domestic rabbit monoclonal (EPR3894)
  • western blot; human; loading ...; fig s1
Abcam Mlh1 antibody (Abcam, ab92312) was used in western blot on human samples (fig s1). Aging (Albany NY) (2021) ncbi
domestic rabbit monoclonal (EPR3894)
  • immunohistochemistry; mouse; 1:500; loading ...
Abcam Mlh1 antibody (Abcam, ab92312) was used in immunohistochemistry on mouse samples at 1:500. JCI Insight (2020) ncbi
mouse monoclonal (G168-15)
  • immunocytochemistry; human; loading ...; fig 2b
Abcam Mlh1 antibody (Abcam, ab14206) was used in immunocytochemistry on human samples (fig 2b). J Biol Chem (2019) ncbi
domestic rabbit monoclonal (EPR3894)
  • immunohistochemistry - frozen section; mouse; 1:1500; loading ...; fig 1a
Abcam Mlh1 antibody (Abcam, ab92312) was used in immunohistochemistry - frozen section on mouse samples at 1:1500 (fig 1a). Carcinogenesis (2018) ncbi
domestic rabbit monoclonal (EPR3894)
  • western blot; mouse; fig s4c
Abcam Mlh1 antibody (Abcam, ab92312) was used in western blot on mouse samples (fig s4c). Cell (2018) ncbi
domestic rabbit monoclonal (EPR3894)
  • western blot; mouse; fig s4c
Abcam Mlh1 antibody (Abcam, ab92312) was used in western blot on mouse samples (fig s4c). Cell (2018) ncbi
domestic rabbit monoclonal (EPR3894)
  • immunohistochemistry - paraffin section; human; loading ...; fig s5e-h
  • western blot; human; loading ...; fig s3a-b
In order to investigate the oncogenic functions of CHD4, Abcam Mlh1 antibody (Abcam, ab92312) was used in immunohistochemistry - paraffin section on human samples (fig s5e-h) and in western blot on human samples (fig s3a-b). Cancer Cell (2017) ncbi
domestic rabbit monoclonal (EPR3894)
  • immunohistochemistry - paraffin section; rat; 1:1600; fig st11
In order to outline the protocols for antibodies used for immunohistochemical studies, Abcam Mlh1 antibody (Abcam, ab92312) was used in immunohistochemistry - paraffin section on rat samples at 1:1600 (fig st11). J Toxicol Pathol (2017) ncbi
mouse monoclonal (G168-15)
  • immunocytochemistry; mouse; 1:20; fig 1
Abcam Mlh1 antibody (Abcam, ab14206) was used in immunocytochemistry on mouse samples at 1:20 (fig 1). PLoS Genet (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (B-12)
  • western blot knockout validation; human; loading ...; fig 4a
Santa Cruz Biotechnology Mlh1 antibody (Santa Cruz, sc-271978) was used in western blot knockout validation on human samples (fig 4a). Cell Death Dis (2020) ncbi
BD Biosciences
mouse monoclonal (G168-728)
  • western blot; human; loading ...; fig 1s1c
BD Biosciences Mlh1 antibody (BD, 554073) was used in western blot on human samples (fig 1s1c). elife (2019) ncbi
mouse monoclonal (G168-728)
  • western blot; human; loading ...; fig s1
In order to characterize autophagy induction by thiopurines, BD Biosciences Mlh1 antibody (BD Pharmingen, 554073) was used in western blot on human samples (fig s1). Oncotarget (2016) ncbi
mouse monoclonal (G168-728)
  • immunohistochemistry; human; 1:400; fig s4b
In order to discuss mechanisms involved in the resistance of androgen receptor-targeted therapies, BD Biosciences Mlh1 antibody (Abcam, 554073) was used in immunohistochemistry on human samples at 1:400 (fig s4b). Nat Med (2016) ncbi
mouse monoclonal (G168-728)
  • immunohistochemistry; human; 1:100; loading ...
BD Biosciences Mlh1 antibody (BD Pharmingen, G168-728) was used in immunohistochemistry on human samples at 1:100. JAMA Oncol (2016) ncbi
mouse monoclonal (G168-728)
  • immunoprecipitation; human
  • western blot; human
BD Biosciences Mlh1 antibody (BD Biosciences, G168-728) was used in immunoprecipitation on human samples and in western blot on human samples . Mol Cancer (2014) ncbi
Articles Reviewed
  1. Ye K, Zhong W, Wang P, Chen Y, Chi P. PD-1 blockage combined with vaccine therapy can facilitate immune infiltration in tumor microenvironment of Lynch syndrome colon cancer. Front Genet. 2022;13:877833 pubmed publisher
  2. Mu X, Tu Z, Chen X, Hong Y, Geng Y, Zhang Y, et al. In utero Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice. Front Cell Dev Biol. 2021;9:669732 pubmed publisher
  3. Zhou Z, Tan F, Pei Q, Li C, Zhou Y, Li Y, et al. lncRNA SNHG4 modulates colorectal cancer cell cycle and cell proliferation through regulating miR-590-3p/CDK1 axis. Aging (Albany NY). 2021;13:9838-9858 pubmed publisher
  4. Li H, Lu C, Zhang H, Hu Q, Zhang J, Cuevas I, et al. A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response. JCI Insight. 2020;5: pubmed publisher
  5. Liu K, Wang Y, Zhu Q, Li P, Chen J, Tang Z, et al. Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells. Cell Death Dis. 2020;11:519 pubmed publisher
  6. Pech M, Fong L, Villalta J, Chan L, Kharbanda S, O Brien J, et al. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. elife. 2019;8: pubmed publisher
  7. Zhang M, Hu C, Moses N, Haakenson J, Xiang S, Quan D, et al. HDAC6 regulates DNA damage response via deacetylating MLH1. J Biol Chem. 2019;294:5813-5826 pubmed publisher
  8. Pussila M, Toronen P, Einarsdottir E, Katayama S, Krjutskov K, Holm L, et al. Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer. Carcinogenesis. 2018;39:788-797 pubmed publisher
  9. Garzia L, Kijima N, Morrissy A, De Antonellis P, Guerreiro Stucklin A, Holgado B, et al. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018;172:1050-1062.e14 pubmed publisher
  10. Hoshii T, Cifani P, Feng Z, Huang C, Koche R, Chen C, et al. A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response. Cell. 2018;172:1007-1021.e17 pubmed publisher
  11. Xia L, Huang W, Bellani M, Seidman M, Wu K, Fan D, et al. CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Cancer Cell. 2017;31:653-668.e7 pubmed publisher
  12. Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  13. Chaabane W, Appell M. Interconnections between apoptotic and autophagic pathways during thiopurine-induced toxicity in cancer cells: the role of reactive oxygen species. Oncotarget. 2016;7:75616-75634 pubmed publisher
  14. Balcova M, Faltusova B, Gergelits V, Bhattacharyya T, Mihola O, Trachtulec Z, et al. Hybrid Sterility Locus on Chromosome X Controls Meiotic Recombination Rate in Mouse. PLoS Genet. 2016;12:e1005906 pubmed publisher
  15. Beltran H, Prandi D, Mosquera J, Benelli M, Puca L, Cyrta J, et al. Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. Nat Med. 2016;22:298-305 pubmed publisher
  16. Taieb J, Zaanan A, Le Malicot K, Julie C, Blons H, Mineur L, et al. Prognostic Effect of BRAF and KRAS Mutations in Patients With Stage III Colon Cancer Treated With Leucovorin, Fluorouracil, and Oxaliplatin With or Without Cetuximab: A Post Hoc Analysis of the PETACC-8 Trial. JAMA Oncol. 2016;2:643-653 pubmed publisher
  17. Hinrichsen I, Ernst B, Nuber F, Passmann S, Schäfer D, Steinke V, et al. Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1. Mol Cancer. 2014;13:11 pubmed publisher