This is a Validated Antibody Database (VAD) review about mouse Map3k5, based on 15 published articles (read how Labome selects the articles), using Map3k5 antibody in all methods. It is aimed to help Labome visitors find the most suited Map3k5 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Map3k5 synonym: 7420452D20Rik; ASK; ASK1; MAPKKK5; Mekk5

Knockout validation
Abcam
domestic rabbit monoclonal (EP553Y)
  • western blot knockout validation; mouse; 1:10,000; fig 1
In order to elucidate regulation of brown and beige adipocyte function via ASK1 signaling, Abcam Map3k5 antibody (Abcam, ab45178) was used in western blot knockout validation on mouse samples at 1:10,000 (fig 1). Nat Commun (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D11C9)
  • western blot knockout validation; mouse; loading ...; fig 8a
  • immunoprecipitation; mouse; loading ...; fig 6f
Cell Signaling Technology Map3k5 antibody (Cell signaling, 8662) was used in western blot knockout validation on mouse samples (fig 8a) and in immunoprecipitation on mouse samples (fig 6f). elife (2016) ncbi
Abcam
domestic rabbit monoclonal (EP553Y)
  • western blot; human; loading ...; fig 6a
Abcam Map3k5 antibody (Abcam, ab45178) was used in western blot on human samples (fig 6a). Cell Death Dis (2021) ncbi
domestic rabbit monoclonal (EP553Y)
  • western blot knockout validation; mouse; 1:10,000; fig 1
In order to elucidate regulation of brown and beige adipocyte function via ASK1 signaling, Abcam Map3k5 antibody (Abcam, ab45178) was used in western blot knockout validation on mouse samples at 1:10,000 (fig 1). Nat Commun (2016) ncbi
domestic rabbit monoclonal (EP553Y)
  • immunocytochemistry; human
In order to identify QARS (encoding glutaminyl-tRNA synthetase [QARS]) mutations in two unrelated families affected by progressive microcephaly, Abcam Map3k5 antibody (Abcam, ab45178) was used in immunocytochemistry on human samples . Am J Hum Genet (2014) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 6a
Cell Signaling Technology Map3k5 antibody (Cell signaling technology, 3765) was used in western blot on human samples (fig 6a). Cell Death Dis (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 1a
Cell Signaling Technology Map3k5 antibody (Cell Signaling, 3765) was used in western blot on human samples (fig 1a). Sci Adv (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig s10
Cell Signaling Technology Map3k5 antibody (cell signalling, 3765) was used in western blot on mouse samples (fig s10). Cell Death Dis (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 3d
Cell Signaling Technology Map3k5 antibody (Cell Signaling, 3765) was used in western blot on human samples at 1:1000 (fig 3d). Front Pharmacol (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 5b
  • western blot; mouse; fig 5b
Cell Signaling Technology Map3k5 antibody (Cell Signalling, 3765) was used in western blot on human samples (fig 5b) and in western blot on mouse samples (fig 5b). Oncogene (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4c
Cell Signaling Technology Map3k5 antibody (Cell Signaling, 3764S) was used in western blot on human samples (fig 4c). Sci Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:100; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology Map3k5 antibody (Cell Signaling, 3765) was used in western blot on human samples at 1:100 (fig st1). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 5a
In order to elucidate how syndecan-1 contributes to multiple myeloma, Cell Signaling Technology Map3k5 antibody (Cell Signaling, 3764S) was used in western blot on human samples (fig 5a). Cancer Res (2016) ncbi
domestic rabbit monoclonal (D11C9)
  • immunoprecipitation; human; loading ...; fig 5a
In order to elucidate how syndecan-1 contributes to multiple myeloma, Cell Signaling Technology Map3k5 antibody (Cell Signaling, D11C9) was used in immunoprecipitation on human samples (fig 5a). Cancer Res (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 5a
In order to elucidate how syndecan-1 contributes to multiple myeloma, Cell Signaling Technology Map3k5 antibody (Cell Signaling, 3765S) was used in western blot on human samples (fig 5a). Cancer Res (2016) ncbi
domestic rabbit monoclonal (D11C9)
  • western blot; human; fig 6
In order to determine the promotion of genomic and phenotypic changes in glioblastoma cells by temozolomide, Cell Signaling Technology Map3k5 antibody (Cell Signaling, 8662) was used in western blot on human samples (fig 6). Cancer Cell Int (2016) ncbi
domestic rabbit monoclonal (D11C9)
  • western blot knockout validation; mouse; loading ...; fig 8a
  • immunoprecipitation; mouse; loading ...; fig 6f
Cell Signaling Technology Map3k5 antibody (Cell signaling, 8662) was used in western blot knockout validation on mouse samples (fig 8a) and in immunoprecipitation on mouse samples (fig 6f). elife (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 7c
Cell Signaling Technology Map3k5 antibody (Cell signaling, 3765) was used in western blot on mouse samples (fig 7c). elife (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:750; fig s4
In order to characterize the response to electrophile stress by assembly stoichiometry and dynamics of the apoptosis signal-regulating kinase (ASK) signalosome, Cell Signaling Technology Map3k5 antibody (Cell Signaling, 3765S) was used in western blot on human samples at 1:750 (fig s4). Mol Cell Proteomics (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 3a
In order to present liposomal c8 ceramide as a potent anti-hepatocellular carcinoma agent, Cell Signaling Technology Map3k5 antibody (Cell Signaling, 3765) was used in western blot on human samples (fig 3a). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (D11C9)
  • western blot; human
Cell Signaling Technology Map3k5 antibody (Cell Signaling Technology, 8662) was used in western blot on human samples . Biochim Biophys Acta (2014) ncbi
Articles Reviewed
  1. Chen X, Ma W, Yao Y, Zhang Q, Li J, Wu X, et al. Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways. Cell Death Dis. 2021;12:425 pubmed publisher
  2. Park H, Shin D, Sim J, Aum S, Lee M. IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv. 2020;6:eaax9914 pubmed publisher
  3. Wassermann Dozorets R, Rubinstein M. C/EBPβ LIP augments cell death by inducing osteoglycin. Cell Death Dis. 2017;8:e2733 pubmed publisher
  4. Lin C, Lin W, Cho R, Wang C, Hsiao L, Yang C. TNF-?-Induced cPLA2 Expression via NADPH Oxidase/Reactive Oxygen Species-Dependent NF-?B Cascade on Human Pulmonary Alveolar Epithelial Cells. Front Pharmacol. 2016;7:447 pubmed
  5. Dunnill C, Ibraheem K, Mohamed A, Southgate J, Georgopoulos N. A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis. Oncogene. 2017;36:2515-2528 pubmed publisher
  6. Wang C, Zhang F, Cao Y, Zhang M, Wang A, Xu M, et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep. 2016;6:34330 pubmed publisher
  7. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  8. Beauvais D, Jung O, Yang Y, Sanderson R, Rapraeger A. Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth. Cancer Res. 2016;76:4981-93 pubmed publisher
  9. Stepanenko A, Andreieva S, Korets K, Mykytenko D, Baklaushev V, Huleyuk N, et al. Temozolomide promotes genomic and phenotypic changes in glioblastoma cells. Cancer Cell Int. 2016;16:36 pubmed publisher
  10. Yu Z, Chen T, Li X, Yang M, Tang S, Zhu X, et al. Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. elife. 2016;5: pubmed publisher
  11. Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, et al. ASK1 signalling regulates brown and beige adipocyte function. Nat Commun. 2016;7:11158 pubmed publisher
  12. Federspiel J, Codreanu S, Palubinsky A, Winland A, Betanzos C, McLaughlin B, et al. Assembly Dynamics and Stoichiometry of the Apoptosis Signal-regulating Kinase (ASK) Signalosome in Response to Electrophile Stress. Mol Cell Proteomics. 2016;15:1947-61 pubmed publisher
  13. Lv H, Zhang Z, Wu X, Wang Y, Li C, Gong W, et al. Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent. PLoS ONE. 2016;11:e0145195 pubmed publisher
  14. Ishaq M, Evans M, Ostrikov K. Atmospheric pressure gas plasma-induced colorectal cancer cell death is mediated by Nox2-ASK1 apoptosis pathways and oxidative stress is mitigated by Srx-Nrf2 anti-oxidant system. Biochim Biophys Acta. 2014;1843:2827-37 pubmed publisher
  15. Zhang X, Ling J, Barcia G, Jing L, Wu J, Barry B, et al. Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet. 2014;94:547-58 pubmed publisher