This is a Validated Antibody Database (VAD) review about mouse Lrp6, based on 28 published articles (read how Labome selects the articles), using Lrp6 antibody in all methods. It is aimed to help Labome visitors find the most suited Lrp6 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Lrp6 synonym: C030016K15Rik; ska26; ska; skax26; low-density lipoprotein receptor-related protein 6; LRP-6; crooked; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6

Knockout validation
Cell Signaling Technology
rabbit monoclonal (C47E12)
  • western blot knockout validation; human; 1:1000; loading ...; fig 6f
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 3395) was used in western blot knockout validation on human samples at 1:1000 (fig 6f). Cell Rep (2019) ncbi
Santa Cruz Biotechnology
mouse monoclonal (C-10)
  • western blot; human; loading ...; fig s3i
Santa Cruz Biotechnology Lrp6 antibody (SantaCruz, sc-25317) was used in western blot on human samples (fig s3i). Nature (2017) ncbi
mouse monoclonal (C-10)
  • immunocytochemistry; human; 1:500; loading ...; fig s6f
  • immunoprecipitation; mouse; loading ...; fig 5c
  • immunohistochemistry; mouse; 1:50; loading ...; fig s6e
  • western blot; mouse; 1:500; loading ...; fig s7b
In order to demonstrate that actin-binding protein filamin A interacts with actin-nucleating protein formin 2, Santa Cruz Biotechnology Lrp6 antibody (Santa Cruz, Sc-25317) was used in immunocytochemistry on human samples at 1:500 (fig s6f), in immunoprecipitation on mouse samples (fig 5c), in immunohistochemistry on mouse samples at 1:50 (fig s6e) and in western blot on mouse samples at 1:500 (fig s7b). Development (2016) ncbi
mouse monoclonal (C-10)
  • western blot; human; fig 2
Santa Cruz Biotechnology Lrp6 antibody (Santa Cruz, sc-25317) was used in western blot on human samples (fig 2). Int J Mol Sci (2016) ncbi
mouse monoclonal
  • western blot; human; 1:500; tbl 1
In order to research the expression and the functions of cancer/testis-antigens in seminomas, Santa Cruz Biotechnology Lrp6 antibody (Santa Cruz, C10) was used in western blot on human samples at 1:500 (tbl 1). Br J Cancer (2016) ncbi
mouse monoclonal
  • immunohistochemistry; mouse; loading ...; fig s2a
  • immunohistochemistry; human; loading ...; fig s2c
In order to research the atheroprotective effect of OCT4 in smooth muscle cells, Santa Cruz Biotechnology Lrp6 antibody (Santa-Cruz, C10) was used in immunohistochemistry on mouse samples (fig s2a) and in immunohistochemistry on human samples (fig s2c). Nat Med (2016) ncbi
mouse monoclonal (C-10)
  • western blot; human; fig s2
Santa Cruz Biotechnology Lrp6 antibody (Santa Cruz, sc-25317) was used in western blot on human samples (fig s2). Int J Mol Sci (2016) ncbi
Abcam
rabbit monoclonal (EPR2423(2))
  • flow cytometry; mouse; 1:600; loading ...; fig 5e
  • western blot; mouse; 1:500; loading ...; fig 5d
Abcam Lrp6 antibody (Abcam, ab134146) was used in flow cytometry on mouse samples at 1:600 (fig 5e) and in western blot on mouse samples at 1:500 (fig 5d). Bone Res (2018) ncbi
rabbit monoclonal (EPR2423(2))
  • western blot; rat; loading ...; fig 5
Abcam Lrp6 antibody (Abcam, EPR2423(2)) was used in western blot on rat samples (fig 5). Biomed Pharmacother (2018) ncbi
rabbit monoclonal (EPR2423(2))
  • immunohistochemistry; mouse; 1:100; loading ...; fig s6e
  • western blot; mouse; 1:1000; loading ...; fig s7b
  • immunocytochemistry; human; 1:100; loading ...; fig s6f
In order to demonstrate that actin-binding protein filamin A interacts with actin-nucleating protein formin 2, Abcam Lrp6 antibody (Abcam, ab134146) was used in immunohistochemistry on mouse samples at 1:100 (fig s6e), in western blot on mouse samples at 1:1000 (fig s7b) and in immunocytochemistry on human samples at 1:100 (fig s6f). Development (2016) ncbi
Cell Signaling Technology
rabbit monoclonal (C47E12)
  • western blot knockout validation; human; 1:1000; loading ...; fig 6f
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 3395) was used in western blot knockout validation on human samples at 1:1000 (fig 6f). Cell Rep (2019) ncbi
rabbit polyclonal
  • other; human; loading ...; fig 4c
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 2568) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig s6g
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 2568) was used in western blot on human samples (fig s6g). Nature (2017) ncbi
rabbit monoclonal (C47E12)
  • western blot; human; loading ...; fig s6g
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 3395) was used in western blot on human samples (fig s6g). Nature (2017) ncbi
rabbit monoclonal (C47E12)
  • western blot; human; loading ...; fig 4a
Cell Signaling Technology Lrp6 antibody (Cell Signaling, C47E12) was used in western blot on human samples (fig 4a). Proc Natl Acad Sci U S A (2017) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 1b
In order to describe the dual roles of TbetaRIII/betaglycan, Cell Signaling Technology Lrp6 antibody (Cell signaling, 2568) was used in western blot on human samples (fig 1b). J Biol Chem (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:2500; loading ...; fig 1c
Cell Signaling Technology Lrp6 antibody (Cell signaling, 2568) was used in western blot on human samples at 1:2500 (fig 1c). J Cell Sci (2016) ncbi
rabbit monoclonal (C47E12)
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology Lrp6 antibody (Cell Signaling, 3395) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:200; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology Lrp6 antibody (Cell Signaling, 2568) was used in western blot on human samples at 1:200 (fig st1). Nat Commun (2016) ncbi
rabbit monoclonal (C47E12)
  • western blot; mouse; fig 2
In order to determine maintenance of mouse embryonic stem cell identity by a myc-driven self-reinforcing regulatory network, Cell Signaling Technology Lrp6 antibody (Cell Signalling, 3395) was used in western blot on mouse samples (fig 2). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; mouse; fig 2
In order to determine maintenance of mouse embryonic stem cell identity by a myc-driven self-reinforcing regulatory network, Cell Signaling Technology Lrp6 antibody (Cell Signalling, 2568) was used in western blot on mouse samples (fig 2). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; mouse; fig 6
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 2568) was used in western blot on mouse samples (fig 6). PLoS Genet (2016) ncbi
rabbit monoclonal (C47E12)
  • western blot; mouse; fig 1
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 3395S) was used in western blot on mouse samples (fig 1). PLoS Genet (2016) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 3f
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 2568S) was used in western blot on human samples (fig 3f). Proc Natl Acad Sci U S A (2016) ncbi
rabbit monoclonal (C47E12)
  • western blot; human; loading ...; fig 3f
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 3395S) was used in western blot on human samples (fig 3f). Proc Natl Acad Sci U S A (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig 6
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 2568) was used in western blot on human samples at 1:1000 (fig 6). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig s1d
Cell Signaling Technology Lrp6 antibody (Cell Signaling Technology, 2568) was used in western blot on human samples at 1:1000 (fig s1d). Sci Rep (2016) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 2568) was used in western blot on human samples . Mol Med Rep (2015) ncbi
rabbit monoclonal (C47E12)
  • western blot; mouse
Cell Signaling Technology Lrp6 antibody (Cell Signaling Technology, 3395) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
rabbit polyclonal
  • western blot; mouse
Cell Signaling Technology Lrp6 antibody (Cell Signaling Technology, 2568) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
rabbit polyclonal
  • western blot; rat; loading ...; fig 3
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 2568) was used in western blot on rat samples (fig 3). Biomed Res Int (2014) ncbi
rabbit monoclonal (C47E12)
  • western blot; human; fig 5
Cell Signaling Technology Lrp6 antibody (Cell Signaling Technology, C47E12) was used in western blot on human samples (fig 5). Cell (2014) ncbi
rabbit polyclonal
  • western blot; mouse; fig s3
In order to investigate the role of mTOR and Wnt signaling proteins to c-Met TKI resistance in melanoma cell lines, Cell Signaling Technology Lrp6 antibody (Cell Signaling Technology, 2568) was used in western blot on mouse samples (fig s3). Cancer Biol Ther (2014) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology Lrp6 antibody (CST, 2568) was used in western blot on human samples . FEBS Lett (2014) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology Lrp6 antibody (Cell Signaling, 2568) was used in western blot on human samples . J Biol Chem (2014) ncbi
rabbit polyclonal
  • western blot; mouse; fig 3
In order to investigate the contribution of Rspo/Wnt on gene expression, Cell Signaling Technology Lrp6 antibody (Cell Signaling Technology, 2568) was used in western blot on mouse samples (fig 3). PLoS ONE (2012) ncbi
Articles Reviewed
  1. Agajanian M, Walker M, Axtman A, Ruela de Sousa R, Serafin D, Rabinowitz A, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019;26:79-93.e8 pubmed publisher
  2. Wang L, Chai Y, Li C, Liu H, Su W, Liu X, et al. Oxidized phospholipids are ligands for LRP6. Bone Res. 2018;6:22 pubmed publisher
  3. Chen Z, Li Y, Jiang G, Yang C, Wang Y, Wang X, et al. Knockdown of LRP6 activates Drp1 to inhibit survival of cardiomyocytes during glucose deprivation. Biomed Pharmacother. 2018;103:1408-1414 pubmed publisher
  4. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  5. Wang H, Nicolay B, Chick J, Gao X, Geng Y, Ren H, et al. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature. 2017;546:426-430 pubmed publisher
  6. Janda C, Dang L, You C, Chang J, de Lau W, Zhong Z, et al. Surrogate Wnt agonists that phenocopy canonical Wnt and ?-catenin signalling. Nature. 2017;545:234-237 pubmed publisher
  7. van Andel H, Ren Z, Koopmans I, Joosten S, Kocemba K, de Lau W, et al. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins. Proc Natl Acad Sci U S A. 2017;114:376-381 pubmed publisher
  8. Lian G, Dettenhofer M, Lu J, Downing M, Chenn A, Wong T, et al. Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway. Development. 2016;143:4509-4520 pubmed
  9. JENKINS L, Singh P, Varadaraj A, Lee N, Shah S, Flores H, et al. Altering the Proteoglycan State of Transforming Growth Factor ? Type III Receptor (T?RIII)/Betaglycan Modulates Canonical Wnt/?-Catenin Signaling. J Biol Chem. 2016;291:25716-25728 pubmed
  10. Gammons M, Rutherford T, Steinhart Z, Angers S, Bienz M. Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay. J Cell Sci. 2016;129:3892-3902 pubmed
  11. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  12. Guo J, Li Y, Ren Y, Sun Z, Dong J, Yan H, et al. Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease. Int J Mol Sci. 2016;17: pubmed publisher
  13. Nettersheim D, Arndt I, Sharma R, Riesenberg S, Jostes S, Schneider S, et al. The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas. Br J Cancer. 2016;115:454-64 pubmed publisher
  14. Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun. 2016;7:11903 pubmed publisher
  15. Zeng L, Cai C, Li S, Wang W, Li Y, Chen J, et al. Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells. PLoS Genet. 2016;12:e1006055 pubmed publisher
  16. Cherepanova O, Gomez D, Shankman L, Swiatlowska P, Williams J, Sarmento O, et al. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. Nat Med. 2016;22:657-65 pubmed publisher
  17. Madan B, Walker M, Young R, Quick L, Orgel K, Ryan M, et al. USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. Proc Natl Acad Sci U S A. 2016;113:E2945-54 pubmed publisher
  18. Yang E, Tacchelly Benites O, Wang Z, Randall M, Tian A, Benchabane H, et al. Wnt pathway activation by ADP-ribosylation. Nat Commun. 2016;7:11430 pubmed publisher
  19. Ozeki N, Mogi M, Hase N, Hiyama T, Yamaguchi H, Kawai R, et al. Wnt16 Signaling Is Required for IL-1β-Induced Matrix Metalloproteinase-13-Regulated Proliferation of Human Stem Cell-Derived Osteoblastic Cells. Int J Mol Sci. 2016;17:221 pubmed publisher
  20. Chen Y, Statt S, Wu R, Chang H, Liao J, Wang C, et al. High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells. Sci Rep. 2016;6:18815 pubmed publisher
  21. Yu J, Kong C, Zhang Z, Zhan B, Jiang Z. Aplasia Ras homolog member I expression induces apoptosis in renal cancer cells via the β-catenin signaling pathway. Mol Med Rep. 2015;11:475-81 pubmed publisher
  22. Willis C, Klüppel M. Chondroitin sulfate-E is a negative regulator of a pro-tumorigenic Wnt/beta-catenin-Collagen 1 axis in breast cancer cells. PLoS ONE. 2014;9:e103966 pubmed publisher
  23. Bañón Maneus E, Rovira J, Ramírez Bajo M, Moya Rull D, Hierro Garcia N, Takenaka S, et al. Wnt pathway activation in long term remnant rat model. Biomed Res Int. 2014;2014:324713 pubmed publisher
  24. Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the ?-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed publisher
  25. Etnyre D, Stone A, Fong J, Jacobs R, Uppada S, Botting G, et al. Targeting c-Met in melanoma: mechanism of resistance and efficacy of novel combinatorial inhibitor therapy. Cancer Biol Ther. 2014;15:1129-41 pubmed publisher
  26. Li S, Song W, Jiang M, Zeng L, Zhu X, Chen J. Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation. FEBS Lett. 2014;588:1989-96 pubmed publisher
  27. Kriz V, Pospichalova V, Masek J, Kilander M, Slavík J, Tanneberger K, et al. ?-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein. J Biol Chem. 2014;289:1128-41 pubmed publisher
  28. Baljinnyam B, Klauzinska M, Saffo S, Callahan R, Rubin J. Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells. PLoS ONE. 2012;7:e29455 pubmed publisher