This is a Validated Antibody Database (VAD) review about mouse Lig3, based on 10 published articles (read how Labome selects the articles), using Lig3 antibody in all methods. It is aimed to help Labome visitors find the most suited Lig3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Lig3 synonym: D11Wsu78e; DNA ligase 3; DNA ligase (ATP) 3; DNA ligase III; polydeoxyribonucleotide synthase [ATP] 3

Knockout validation
BD Biosciences
mouse monoclonal (7/DNA Ligase III)
  • western blot knockout validation; mouse; fig s2
BD Biosciences Lig3 antibody (BD Biosciences, 611876) was used in western blot knockout validation on mouse samples (fig s2). Proc Natl Acad Sci U S A (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (6G9)
  • western blot; human; loading ...; fig 1b
Santa Cruz Biotechnology Lig3 antibody (Santa Cruz, sc-56089) was used in western blot on human samples (fig 1b). Mol Cell (2017) ncbi
mouse monoclonal (6G9)
  • western blot; human; 1:100; loading ...; fig s2a
In order to screen for genes involved in mitochondrial DNA maintenance, Santa Cruz Biotechnology Lig3 antibody (Santa Cruz, sc-56089) was used in western blot on human samples at 1:100 (fig s2a). Nat Chem Biol (2016) ncbi
mouse monoclonal (6G9)
  • western blot; mouse; 1:500; fig s2
Santa Cruz Biotechnology Lig3 antibody (Santa Cruz, sc- 56089) was used in western blot on mouse samples at 1:500 (fig s2). Nat Commun (2016) ncbi
GeneTex
mouse monoclonal (1F3)
  • western blot; human; fig s2
In order to study the functional significance of the DNA polymerase-beta interaction with BRCA1, GeneTex Lig3 antibody (GeneTex, GTX70143) was used in western blot on human samples (fig s2). PLoS ONE (2013) ncbi
mouse monoclonal (1F3)
  • western blot; human; fig 4
GeneTex Lig3 antibody (Genetex, GTX70143) was used in western blot on human samples (fig 4). Mutat Res (2011) ncbi
BD Biosciences
mouse monoclonal (7/DNA Ligase III)
  • western blot; human; loading ...; fig s6a
In order to describe a unique replication-dependent repair pathway that leads to the mitochondrial common deletion, BD Biosciences Lig3 antibody (Becton Dickinson, 611877) was used in western blot on human samples (fig s6a). Mol Cell (2017) ncbi
mouse monoclonal (7/DNA Ligase III)
  • western blot knockout validation; mouse; fig s2
BD Biosciences Lig3 antibody (BD Biosciences, 611876) was used in western blot knockout validation on mouse samples (fig s2). Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (7/DNA Ligase III)
  • western blot; mouse; 1:1000; fig  4
BD Biosciences Lig3 antibody (BD Biosciences, 611876) was used in western blot on mouse samples at 1:1000 (fig  4). Neurobiol Aging (2015) ncbi
mouse monoclonal (7/DNA Ligase III)
  • western blot; human; fig s5
BD Biosciences Lig3 antibody (BD Transduction Labs, 611876) was used in western blot on human samples (fig s5). Nucleic Acids Res (2015) ncbi
mouse monoclonal (7/DNA Ligase III)
  • western blot; human
BD Biosciences Lig3 antibody (BD Transduction Laboratories, 611877) was used in western blot on human samples . DNA Repair (Amst) (2014) ncbi
Articles Reviewed
  1. Biehs R, Steinlage M, Barton O, Juhasz S, Künzel J, Spies J, et al. DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Mol Cell. 2017;65:671-684.e5 pubmed publisher
  2. Phillips A, Millet A, Tigano M, Dubois S, Crimmins H, Babin L, et al. Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion. Mol Cell. 2017;65:527-538.e6 pubmed publisher
  3. Wisnovsky S, Jean S, Kelley S. Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes. Nat Chem Biol. 2016;12:567-73 pubmed publisher
  4. Rai R, Chen Y, Lei M, Chang S. TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions. Nat Commun. 2016;7:10881 pubmed publisher
  5. Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, et al. Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining. Proc Natl Acad Sci U S A. 2016;113:1256-60 pubmed publisher
  6. Ghosh S, Canugovi C, Yoon J, Wilson D, Croteau D, Mattson M, et al. Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice. Neurobiol Aging. 2015;36:2319-2330 pubmed publisher
  7. Abdou I, Poirier G, Hendzel M, Weinfeld M. DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair. Nucleic Acids Res. 2015;43:875-92 pubmed publisher
  8. Akbari M, Keijzers G, Maynard S, Scheibye Knudsen M, Desler C, Hickson I, et al. Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair. DNA Repair (Amst). 2014;16:44-53 pubmed publisher
  9. Masaoka A, Gassman N, Horton J, Kedar P, Witt K, Hobbs C, et al. Interaction between DNA Polymerase ? and BRCA1. PLoS ONE. 2013;8:e66801 pubmed publisher
  10. Ebert F, Weiss A, Bültemeyer M, Hamann I, Hartwig A, Schwerdtle T. Arsenicals affect base excision repair by several mechanisms. Mutat Res. 2011;715:32-41 pubmed publisher