This is a Validated Antibody Database (VAD) review about mouse Lepr, based on 18 published articles (read how Labome selects the articles), using Lepr antibody in all methods. It is aimed to help Labome visitors find the most suited Lepr antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Lepr synonym: LEPROT; Leprb; Modb1; OB-RGRP; Obr; diabetes; obese-like; obl; leptin receptor; B219; LEP-R; OB receptor; leptin receptor gene-related protein

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (B-3)
  • immunohistochemistry knockout validation; mouse; 1:100; fig 1
Santa Cruz Biotechnology Lepr antibody (Santa Cruz Biotechnology, sc8391) was used in immunohistochemistry knockout validation on mouse samples at 1:100 (fig 1). Mol Metab (2014) ncbi
Santa Cruz Biotechnology
mouse monoclonal (B-3)
  • western blot; mouse; 1:1000; loading ...; fig 10
Santa Cruz Biotechnology Lepr antibody (SantaCruz, sc-8391) was used in western blot on mouse samples at 1:1000 (fig 10). Am J Physiol Regul Integr Comp Physiol (2017) ncbi
mouse monoclonal (B-3)
  • western blot; human; fig 2
Santa Cruz Biotechnology Lepr antibody (Santa Cruz Biotechnology, sc-8391) was used in western blot on human samples (fig 2). Arthritis Res Ther (2016) ncbi
mouse monoclonal (B-3)
  • immunoprecipitation; mouse; fig 7
  • western blot; mouse; 1:1000; fig 7
Santa Cruz Biotechnology Lepr antibody (Santa Cruz, sc-8391) was used in immunoprecipitation on mouse samples (fig 7) and in western blot on mouse samples at 1:1000 (fig 7). PLoS Genet (2016) ncbi
mouse monoclonal (B-3)
  • immunohistochemistry; human; 1:25; loading ...; fig 1b
  • western blot; human; 1:500; loading ...; fig 3
Santa Cruz Biotechnology Lepr antibody (Santa Cruz, sc-8391) was used in immunohistochemistry on human samples at 1:25 (fig 1b) and in western blot on human samples at 1:500 (fig 3). PLoS ONE (2015) ncbi
mouse monoclonal (B-3)
  • immunohistochemistry knockout validation; mouse; 1:100; fig 1
Santa Cruz Biotechnology Lepr antibody (Santa Cruz Biotechnology, sc8391) was used in immunohistochemistry knockout validation on mouse samples at 1:100 (fig 1). Mol Metab (2014) ncbi
mouse monoclonal (B-3)
  • immunohistochemistry; human; fig 2
Santa Cruz Biotechnology Lepr antibody (santa cruz, sc-8391) was used in immunohistochemistry on human samples (fig 2). Reprod Sci (2015) ncbi
R&D Systems
goat polyclonal
  • flow cytometry; mouse; 1:200; loading ...; fig s1
R&D Systems Lepr antibody (R&D, AF497) was used in flow cytometry on mouse samples at 1:200 (fig s1). elife (2019) ncbi
goat polyclonal
  • immunohistochemistry; mouse; loading ...; fig 3a
R&D Systems Lepr antibody (R&D Systems, BAF497) was used in immunohistochemistry on mouse samples (fig 3a). J Clin Invest (2018) ncbi
goat polyclonal
  • flow cytometry; mouse; 1:500; loading ...; fig s2a
R&D Systems Lepr antibody (R&D Systems, AF497) was used in flow cytometry on mouse samples at 1:500 (fig s2a). Bone Res (2018) ncbi
goat polyclonal
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1d
R&D Systems Lepr antibody (R&D Systems, AF497) was used in immunohistochemistry on mouse samples at 1:100 (fig 1d). Nat Cell Biol (2017) ncbi
goat polyclonal
  • flow cytometry; mouse; 1:200; loading ...; fig 3c
In order to investigate Hox expression and function in skeletal mesenchymal stromal cells, R&D Systems Lepr antibody (R&D, BAF497) was used in flow cytometry on mouse samples at 1:200 (fig 3c). Dev Cell (2016) ncbi
goat polyclonal
  • immunohistochemistry; mouse; 1:200; loading ...; fig 1f
R&D Systems Lepr antibody (R&D, BAF497) was used in immunohistochemistry on mouse samples at 1:200 (fig 1f). Nat Commun (2016) ncbi
goat polyclonal
  • flow cytometry; mouse; fig s4
R&D Systems Lepr antibody (R&D Systems, BAF497) was used in flow cytometry on mouse samples (fig s4). Stem Cell Reports (2015) ncbi
Abcam
rabbit polyclonal
  • western blot; human; 1:2000; fig 3
Abcam Lepr antibody (abcam, ab5593) was used in western blot on human samples at 1:2000 (fig 3). Cancer Chemother Pharmacol (2016) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig st3
In order to study the contribution of SFMBT2 to prostate cancer metastasis, Abcam Lepr antibody (Abcam, ab7212) was used in western blot on human samples (fig st3). Oncotarget (2016) ncbi
rabbit polyclonal
  • western blot; rat; fig 3
Abcam Lepr antibody (abcam, ab5593) was used in western blot on rat samples (fig 3). Int J Mol Sci (2016) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 6c
Abcam Lepr antibody (Abcam, ab5593) was used in immunohistochemistry - paraffin section on human samples at 1:1000 (fig 6c). PLoS ONE (2015) ncbi
Invitrogen
rabbit polyclonal
  • western blot; mouse
In order to study leptin and prolactin signaling pathways in an APPswe/PS1dE9 (APP/PS1) transgenic mice model of Alzheimer's disease, Invitrogen Lepr antibody (Thermo Scientific, PA1-28843) was used in western blot on mouse samples . J Nutr Health Aging (2015) ncbi
Articles Reviewed
  1. Shen B, Vardy K, Hughes P, Tasdogan A, Zhao Z, Yue R, et al. Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass. elife. 2019;8: pubmed publisher
  2. Li C, Xiao Y, Yang M, Su T, Sun X, Guo Q, et al. Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. J Clin Invest. 2018;128:5251-5266 pubmed publisher
  3. Wang L, Chai Y, Li C, Liu H, Su W, Liu X, et al. Oxidized phospholipids are ligands for LRP6. Bone Res. 2018;6:22 pubmed publisher
  4. Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez N, Birbrair A, et al. Differential cytokine contributions of perivascular haematopoietic stem cell niches. Nat Cell Biol. 2017;19:214-223 pubmed publisher
  5. Yi X, Gao H, Chen D, Tang D, Huang W, Li T, et al. Effects of obesity and exercise on testicular leptin signal transduction and testosterone biosynthesis in male mice. Am J Physiol Regul Integr Comp Physiol. 2017;312:R501-R510 pubmed publisher
  6. Rux D, Song J, Swinehart I, Pineault K, Schlientz A, Trulik K, et al. Regionally Restricted Hox Function in Adult Bone Marrow Multipotent Mesenchymal Stem/Stromal Cells. Dev Cell. 2016;39:653-666 pubmed publisher
  7. Malaise O, Relic B, Charlier E, Zeddou M, Neuville S, Deroyer C, et al. Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts. Arthritis Res Ther. 2016;18:219 pubmed
  8. Fiedor E, Gregoraszczuk E. The molecular mechanism of action of superactive human leptin antagonist (SHLA) and quadruple leptin mutein Lan-2 on human ovarian epithelial cell lines. Cancer Chemother Pharmacol. 2016;78:611-22 pubmed publisher
  9. Gwak J, Shin J, Lee K, Hong S, Oh S, Goh S, et al. SFMBT2 (Scm-like with four mbt domains 2) negatively regulates cell migration and invasion in prostate cancer cells. Oncotarget. 2016;7:48250-48264 pubmed publisher
  10. Li C, Zhen G, Chai Y, Xie L, Crane J, Farber E, et al. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix. Nat Commun. 2016;7:11455 pubmed publisher
  11. Huang Y, Chen C, Tang K, Sheen J, Tiao M, Tain Y, et al. Postnatal High-Fat Diet Increases Liver Steatosis and Apoptosis Threatened by Prenatal Dexamethasone through the Oxidative Effect. Int J Mol Sci. 2016;17:369 pubmed publisher
  12. Guo D, Cui H, Zhang Q, Morgan D, Thedens D, Nishimura D, et al. The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane. PLoS Genet. 2016;12:e1005890 pubmed publisher
  13. Ramirez H, Liang L, Pastar I, Rosa A, Stojadinovic O, Zwick T, et al. Comparative Genomic, MicroRNA, and Tissue Analyses Reveal Subtle Differences between Non-Diabetic and Diabetic Foot Skin. PLoS ONE. 2015;10:e0137133 pubmed publisher
  14. Choi E, Byeon S, Kim S, Lee H, Kwon H, Ahn H, et al. Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric Carcinomas. PLoS ONE. 2015;10:e0130839 pubmed publisher
  15. James S, Fox J, Afsari F, Lee J, Clough S, Knight C, et al. Multiparameter Analysis of Human Bone Marrow Stromal Cells Identifies Distinct Immunomodulatory and Differentiation-Competent Subtypes. Stem Cell Reports. 2015;4:1004-15 pubmed publisher
  16. Pedrós I, Petrov D, Artiach G, Abad S, Ramon Duaso C, Sureda F, et al. Adipokine pathways are altered in hippocampus of an experimental mouse model of Alzheimer's disease. J Nutr Health Aging. 2015;19:403-12 pubmed publisher
  17. de Lartigue G, Ronveaux C, Raybould H. Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity. Mol Metab. 2014;3:595-607 pubmed publisher
  18. Tsai P, Davis J, Bryant Greenwood G. Systemic and placental leptin and its receptors in pregnancies associated with obesity. Reprod Sci. 2015;22:189-97 pubmed publisher