This is a Validated Antibody Database (VAD) review about mouse Ldlr, based on 28 published articles (read how Labome selects the articles), using Ldlr antibody in all methods. It is aimed to help Labome visitors find the most suited Ldlr antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Ldlr synonym: Hlb301

Knockout validation
Abcam
domestic rabbit monoclonal (EP1553Y)
  • western blot knockout validation; human; 1:2000; loading ...; fig 4b
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot knockout validation on human samples at 1:2000 (fig 4b). PLoS Genet (2021) ncbi
Abcam
domestic rabbit monoclonal (EP1553Y)
  • western blot knockout validation; human; loading ...; fig e4e
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot knockout validation on human samples (fig e4e). Nature (2019) ncbi
Abcam
domestic rabbit monoclonal (EP1553Y)
  • immunohistochemistry knockout validation; mouse; 1:1000; fig 4
  • western blot knockout validation; mouse; 1:1000; fig 2
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 6
Abcam Ldlr antibody (Novus Biologicals, EP1553Y) was used in immunohistochemistry knockout validation on mouse samples at 1:1000 (fig 4), in western blot knockout validation on mouse samples at 1:1000 (fig 2) and in immunohistochemistry - frozen section on mouse samples at 1:1000 (fig 6). J Lipid Res (2016) ncbi
Abcam
domestic rabbit monoclonal (EP1553Y)
  • western blot knockout validation; pigs ; fig 2
Abcam Ldlr antibody (Abcam, EP1553Y) was used in western blot knockout validation on pigs samples (fig 2). PLoS ONE (2014) ncbi
R&D Systems
domestic goat polyclonal
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 3b
R&D Systems Ldlr antibody (R&D, AF2255) was used in western blot knockout validation on mouse samples at 1:1000 (fig 3b). J Biol Chem (2021) ncbi
Abcam
domestic rabbit monoclonal (EP1553Y)
  • western blot; mouse; 1:1000; fig 7a
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot on mouse samples at 1:1000 (fig 7a). Cancer Res (2021) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot; human; 1.4 ug/ml; loading ...; fig 1d
  • western blot; mouse; 1.4 ug/ml; loading ...; fig 1e
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot on human samples at 1.4 ug/ml (fig 1d) and in western blot on mouse samples at 1.4 ug/ml (fig 1e). J Biol Chem (2021) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot knockout validation; human; 1:2000; loading ...; fig 4b
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot knockout validation on human samples at 1:2000 (fig 4b). PLoS Genet (2021) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot; human; 1:250; loading ...; fig 5g
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot on human samples at 1:250 (fig 5g). Nat Metab (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 8e
Abcam Ldlr antibody (Abcam, ab30532) was used in western blot on human samples (fig 8e). Toxicology (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4b
  • western blot; mouse; loading ...; fig 5c
Abcam Ldlr antibody (Abcam, ab30532) was used in western blot on human samples (fig 4b) and in western blot on mouse samples (fig 5c). Front Pharmacol (2019) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot; human; loading ...; fig 4g
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot on human samples (fig 4g). Nature (2019) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot knockout validation; human; loading ...; fig e4e
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot knockout validation on human samples (fig e4e). Nature (2019) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot; mouse; loading ...; fig 3a
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot on mouse samples (fig 3a). Mol Metab (2018) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot; mouse; loading ...; fig s5d
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot on mouse samples (fig s5d). PLoS Genet (2017) ncbi
domestic rabbit monoclonal (EP1553Y)
  • immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 4d
  • western blot; human; loading ...; fig 4c
Abcam Ldlr antibody (abcam, ab52818) was used in immunohistochemistry - paraffin section on human samples at 1:500 (fig 4d) and in western blot on human samples (fig 4c). Oncogene (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 1e
Abcam Ldlr antibody (Abcam, ab30532) was used in western blot on mouse samples (fig 1e). Sci Rep (2017) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot; human; 1:4000; loading ...; fig s1a
Abcam Ldlr antibody (Abcam, EP1553Y) was used in western blot on human samples at 1:4000 (fig s1a). PLoS ONE (2017) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot; mouse; 1:1000; loading ...; fig 3
In order to assess the effects of statins on Trypanosoma cruzi infection-induced myocarditis, Abcam Ldlr antibody (Abcam, AB52818) was used in western blot on mouse samples at 1:1000 (fig 3). Microbes Infect (2016) ncbi
domestic rabbit monoclonal (EP1553Y)
  • immunohistochemistry knockout validation; mouse; 1:1000; fig 4
  • western blot knockout validation; mouse; 1:1000; fig 2
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 6
Abcam Ldlr antibody (Novus Biologicals, EP1553Y) was used in immunohistochemistry knockout validation on mouse samples at 1:1000 (fig 4), in western blot knockout validation on mouse samples at 1:1000 (fig 2) and in immunohistochemistry - frozen section on mouse samples at 1:1000 (fig 6). J Lipid Res (2016) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot; human; 1:4000; fig 2
In order to examine the role of deubiquitylating enzymes in cholesterol metabolism, Abcam Ldlr antibody (Epitomics, EP1553Y) was used in western blot on human samples at 1:4000 (fig 2). J Biol Chem (2016) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot; human; fig 3
Abcam Ldlr antibody (abcam, ab52818) was used in western blot on human samples (fig 3). BMC Cancer (2015) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot; mouse; loading ...; fig 7B
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot on mouse samples (fig 7B). Sci Rep (2015) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot; human
Abcam Ldlr antibody (Abcam, ab52818) was used in western blot on human samples . Sci Rep (2015) ncbi
domestic rabbit monoclonal (EP1553Y)
  • western blot knockout validation; pigs ; fig 2
Abcam Ldlr antibody (Abcam, EP1553Y) was used in western blot knockout validation on pigs samples (fig 2). PLoS ONE (2014) ncbi
R&D Systems
domestic goat polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 5d
R&D Systems Ldlr antibody (R&D Systems, AF2255) was used in immunohistochemistry - paraffin section on mouse samples at 1:100 (fig 5d). Nat Commun (2022) ncbi
domestic goat polyclonal
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 3b
R&D Systems Ldlr antibody (R&D, AF2255) was used in western blot knockout validation on mouse samples at 1:1000 (fig 3b). J Biol Chem (2021) ncbi
domestic goat polyclonal
  • immunocytochemistry; mouse; loading ...; fig 7d
  • western blot; mouse; loading ...; fig 7b
R&D Systems Ldlr antibody (R&D, AF2255) was used in immunocytochemistry on mouse samples (fig 7d) and in western blot on mouse samples (fig 7b). Front Cell Dev Biol (2020) ncbi
Invitrogen
domestic rabbit recombinant (SJ0197)
  • western blot; mouse; loading ...; fig s6a
Invitrogen Ldlr antibody (Thermo Fisher, MA532075) was used in western blot on mouse samples (fig s6a). JCI Insight (2020) ncbi
Abnova
domestic rabbit polyclonal
  • immunocytochemistry; mouse; 1:200; fig 3
  • western blot; mouse; 1:1000; fig 2
In order to analyze how WASH- and CCC-mediated endosomal sorting of LDLr is needed for regular clearance of circulating LDL, Abnova Ldlr antibody (Abnova, PAB8804) was used in immunocytochemistry on mouse samples at 1:200 (fig 3) and in western blot on mouse samples at 1:1000 (fig 2). Nat Commun (2016) ncbi
BioVision
  • western blot; hamsters; loading ...; fig 4d
BioVision Ldlr antibody (BioVision, 3839-100) was used in western blot on hamsters samples (fig 4d). J Nutr Biochem (2017) ncbi
  • western blot; mouse; loading ...; fig 5d
In order to investigate how leoligin modulates cholesterol levels, BioVision Ldlr antibody (BioVision, 3939-100) was used in western blot on mouse samples (fig 5d). J Mol Cell Cardiol (2016) ncbi
  • western blot; rat; fig 3
BioVision Ldlr antibody (BioVision, 3839-100) was used in western blot on rat samples (fig 3). Physiol Rep (2016) ncbi
Articles Reviewed
  1. Lebeau P, Byun J, Platko K, Saliba P, Sguazzin M, Macdonald M, et al. Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance. Nat Commun. 2022;13:770 pubmed publisher
  2. Susan Resiga D, Girard E, Essalmani R, Roubtsova A, Marcinkiewicz J, Derbali R, et al. Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin. J Biol Chem. 2021;297:101177 pubmed publisher
  3. Kemp S, Carpenter E, Steele N, Donahue K, Nwosu Z, Pacheco A, et al. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1. Cancer Res. 2021;81:4305-4318 pubmed publisher
  4. Muramatsu M, Osawa T, Miyamura Y, Nakagawa S, Tanaka T, Kodama T, et al. Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background. J Biol Chem. 2021;296:100697 pubmed publisher
  5. Emmer B, Sherman E, Lascuna P, Graham S, Willer C, Ginsburg D. Genome-scale CRISPR screening for modifiers of cellular LDL uptake. PLoS Genet. 2021;17:e1009285 pubmed publisher
  6. Lv J, Wang H, Cui H, Liu Z, Zhang R, Lu M, et al. Blockade of Macrophage CD147 Protects Against Foam Cell Formation in Atherosclerosis. Front Cell Dev Biol. 2020;8:609090 pubmed publisher
  7. Nakayama A, Albarrán Juárez J, Liang G, Roquid K, Iring A, Tonack S, et al. Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. JCI Insight. 2020;5: pubmed publisher
  8. Aregger M, Lawson K, Billmann M, Costanzo M, Tong A, Chan K, et al. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Nat Metab. 2020;2:499-513 pubmed publisher
  9. Zhang G, Zhou J, Huang W, Fang M, Yu L, Wang H, et al. Prenatal ethanol exposure-induced a low level of foetal blood cholesterol and its mechanism of IGF1-related placental cholesterol transport dysfunction. Toxicology. 2019;:152237 pubmed publisher
  10. Xu F, Xiao H, Liu R, Yang Y, Zhang M, Chen L, et al. Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt. Front Pharmacol. 2019;10:261 pubmed publisher
  11. Jiang Y, Sun A, Zhao Y, Ying W, Sun H, Yang X, et al. Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma. Nature. 2019;567:257-261 pubmed publisher
  12. Garcia Bermudez J, Baudrier L, Bayraktar E, Shen Y, La K, Guarecuco R, et al. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. 2019;567:118-122 pubmed publisher
  13. Zhu L, Shi J, Luu T, Neuman J, Trefts E, Yu S, et al. Hepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding. Mol Metab. 2018;8:106-116 pubmed publisher
  14. Rocchi A, Yamamoto S, Ting T, Fan Y, SADLEIR K, Wang Y, et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet. 2017;13:e1006962 pubmed publisher
  15. Gallagher E, Zelenko Z, Neel B, Antoniou I, Rajan L, Kase N, et al. Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia. Oncogene. 2017;36:6462-6471 pubmed publisher
  16. Hirata H, Uto Kondo H, Ogura M, Ayaori M, Shiotani K, Ota A, et al. Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport. J Nutr Biochem. 2017;47:29-34 pubmed publisher
  17. Vienken H, Mabrouki N, Grabau K, Claas R, Rudowski A, Schömel N, et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage. Sci Rep. 2017;7:43575 pubmed publisher
  18. Cook E, Nelson J, Sorrentino V, Koenis D, Moeton M, Scheij S, et al. Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene. PLoS ONE. 2017;12:e0172721 pubmed publisher
  19. Scharinger B, Messner B, Türkcan A, Schuster D, Vuorinen A, Pitterl F, et al. Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice. J Mol Cell Cardiol. 2016;99:35-46 pubmed publisher
  20. Zhao D, Lizardo K, Cui M, Ambadipudi K, Lora J, Jelicks L, et al. Antagonistic effect of atorvastatin on high fat diet induced survival during acute Chagas disease. Microbes Infect. 2016;18:675-686 pubmed publisher
  21. Zinkhan E, Zalla J, Carpenter J, Yu B, Yu X, Chan G, et al. Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats. Physiol Rep. 2016;4: pubmed publisher
  22. Tao W, Moore R, Meng Y, Smith E, Xu X. Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol. J Lipid Res. 2016;57:809-17 pubmed publisher
  23. Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun. 2016;7:10961 pubmed publisher
  24. Nelson J, Cook E, Loregger A, Hoeksema M, Scheij S, Kovacevic I, et al. Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake. J Biol Chem. 2016;291:4813-25 pubmed publisher
  25. De Gonzalo Calvo D, López Vilaró L, Nasarre L, Pérez Olabarría M, Vázquez T, Escuin D, et al. Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study. BMC Cancer. 2015;15:460 pubmed publisher
  26. Zhong C, Sun W, Ma Y, Zhu H, Yang P, Wei H, et al. Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice. Sci Rep. 2015;5:10512 pubmed publisher
  27. Stöhr R, Mavilio M, Marino A, Casagrande V, Kappel B, Möllmann J, et al. ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice. Sci Rep. 2015;5:9023 pubmed publisher
  28. Davis B, Wang X, Rohret J, Struzynski J, Merricks E, Bellinger D, et al. Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs. PLoS ONE. 2014;9:e93457 pubmed publisher