This is a Validated Antibody Database (VAD) review about mouse Ldha, based on 27 published articles (read how Labome selects the articles), using Ldha antibody in all methods. It is aimed to help Labome visitors find the most suited Ldha antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Ldha synonym: Ldh1; Ldhm; l7R2

Knockout validation
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig s3a
In order to study the activation of TAK1 by interleukin-1 and TRAF6, Cell Signaling Technology Ldha antibody (Cell Signaling, 2012) was used in western blot knockout validation on human samples (fig s3a). Biochem J (2017) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig s1b
Cell Signaling Technology Ldha antibody (Cell Signaling, 2012S) was used in western blot knockout validation on mouse samples (fig s1b). Science (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (E-9)
  • immunocytochemistry; human; loading ...
  • immunohistochemistry; human; loading ...
Santa Cruz Biotechnology Ldha antibody (Santa Cruz Biotechnology, sc-137243) was used in immunocytochemistry on human samples and in immunohistochemistry on human samples . Cell Mol Life Sci (2022) ncbi
mouse monoclonal (E-9)
  • immunocytochemistry; human; loading ...; fig 3m
  • western blot; human; loading ...; fig 3j, 3l, 5c
Santa Cruz Biotechnology Ldha antibody (Santa Cruz, sc-137243) was used in immunocytochemistry on human samples (fig 3m) and in western blot on human samples (fig 3j, 3l, 5c). Oncogene (2021) ncbi
mouse monoclonal (E-9)
  • western blot; human; loading ...; fig 2b
Santa Cruz Biotechnology Ldha antibody (Santa, sc-137243) was used in western blot on human samples (fig 2b). Autophagy (2019) ncbi
mouse monoclonal (E-9)
  • western blot; human
Santa Cruz Biotechnology Ldha antibody (Santa Cruz, sc-137243) was used in western blot on human samples . PLoS ONE (2015) ncbi
mouse monoclonal (E-9)
  • immunohistochemistry; human; 1:400
Santa Cruz Biotechnology Ldha antibody (Santa Cruz Biotechnology, sc-137243) was used in immunohistochemistry on human samples at 1:400. Lung Cancer (2014) ncbi
Abcam
domestic rabbit monoclonal (EPR1564)
  • western blot; human; 1:5000; loading ...; fig 4d
Abcam Ldha antibody (Abcam, ab101562) was used in western blot on human samples at 1:5000 (fig 4d). Oncol Lett (2021) ncbi
domestic rabbit monoclonal (EPR1564)
  • immunohistochemistry - paraffin section; human; loading ...; fig 6j
  • western blot; human; loading ...; fig 1k
Abcam Ldha antibody (Abcam, ab101562) was used in immunohistochemistry - paraffin section on human samples (fig 6j) and in western blot on human samples (fig 1k). Cell Death Dis (2020) ncbi
domestic rabbit monoclonal (EPR1564)
  • western blot; mouse; loading ...; fig 7a
Abcam Ldha antibody (Abcam, ab101562) was used in western blot on mouse samples (fig 7a). Biosci Rep (2020) ncbi
domestic rabbit monoclonal (EPR1564)
  • immunohistochemistry - frozen section; rat; 1:250; fig 5
Abcam Ldha antibody (Abcam, ab101562) was used in immunohistochemistry - frozen section on rat samples at 1:250 (fig 5). Neuroimage (2016) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; rat; 1:1000; fig 5a
Invitrogen Ldha antibody (Invitrogen, PA5-27406) was used in western blot on rat samples at 1:1000 (fig 5a). Diseases (2021) ncbi
domestic rabbit polyclonal
  • other; human; 1:100; loading ...; fig 4a
In order to determine if cytosolic lactate is metabolized by the mitochondria of fermenting mammalian cells, Invitrogen Ldha antibody (Thermo Scientific, PA5-17183) was used in other on human samples at 1:100 (fig 4a). Nat Chem Biol (2016) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 2b
Cell Signaling Technology Ldha antibody (CST, 8176) was used in western blot on mouse samples at 1:1000 (fig 2b). Nat Commun (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 2b
Cell Signaling Technology Ldha antibody (CST, 2012) was used in western blot on mouse samples at 1:1000 (fig 2b). Nat Commun (2022) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s4b, s4c
Cell Signaling Technology Ldha antibody (CST, 2012S) was used in western blot on human samples (fig s4b, s4c). J Exp Clin Cancer Res (2022) ncbi
domestic rabbit polyclonal
  • western blot; human; fig e5a, e6a
Cell Signaling Technology Ldha antibody (Cell Signaling, 2012S) was used in western blot on human samples (fig e5a, e6a). Nat Metab (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4c
Cell Signaling Technology Ldha antibody (Cell signaling technology, 8176S) was used in western blot on human samples (fig 4c). Biochim Biophys Acta Gen Subj (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4j
Cell Signaling Technology Ldha antibody (CST, 2012) was used in western blot on human samples (fig 4j). Sci Adv (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2k
Cell Signaling Technology Ldha antibody (Cell Signaling Technology, 2012S) was used in western blot on human samples (fig 2k). Nature (2019) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig s3a
In order to study the activation of TAK1 by interleukin-1 and TRAF6, Cell Signaling Technology Ldha antibody (Cell Signaling, 2012) was used in western blot knockout validation on human samples (fig s3a). Biochem J (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; human; 1:200; fig 7a
  • western blot; human; loading ...; fig 2a
In order to report that lactate dehydrogenase A phosphorylation results in pro-invasive, anti-anoikis, and pro-metastatic advantages to cancer cells, Cell Signaling Technology Ldha antibody (Cell Signaling Technology, 8176) was used in immunohistochemistry on human samples at 1:200 (fig 7a) and in western blot on human samples (fig 2a). Oncogene (2017) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig s1b
Cell Signaling Technology Ldha antibody (Cell Signaling, 2012S) was used in western blot knockout validation on mouse samples (fig s1b). Science (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:200; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology Ldha antibody (Cell Signaling, 2012) was used in western blot on human samples at 1:200 (fig st1). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 3
In order to study the reprogramming of glucose metabolism in cancer cells by ROS-mediated stabilization of HIF1alpha via the immunoregulatory protein B7-H3, Cell Signaling Technology Ldha antibody (Cell Signaling Technology, 2012) was used in western blot on human samples (fig 3). Cancer Res (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 4
In order to investigate protection of ovarian cancer-associated fibroblasts against oxidative stress by autophagy, Cell Signaling Technology Ldha antibody (Cell Signaling Technology, 2012) was used in western blot on human samples (fig 4). Cell Cycle (2016) ncbi
domestic rabbit monoclonal (C28H7)
  • immunohistochemistry - paraffin section; human; 1:250; fig 2
Cell Signaling Technology Ldha antibody (Cell Signaling, 3558) was used in immunohistochemistry - paraffin section on human samples at 1:250 (fig 2). PLoS ONE (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 4
Cell Signaling Technology Ldha antibody (Cell Signaling Technology, 2012) was used in western blot on human samples (fig 4). Mol Cancer Res (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 4g
  • western blot; mouse; 1:1000; fig 6l
Cell Signaling Technology Ldha antibody (Cell Signaling Technology, 2012) was used in western blot on human samples at 1:1000 (fig 4g) and in western blot on mouse samples at 1:1000 (fig 6l). FASEB J (2016) ncbi
domestic rabbit monoclonal (C28H7)
  • western blot; human; fig 1f
Cell Signaling Technology Ldha antibody (Cell Signaling Technology, 3558) was used in western blot on human samples (fig 1f). Oncogene (2015) ncbi
Articles Reviewed
  1. Queiroz A, Dantas E, Ramsamooj S, Murthy A, Ahmed M, Zunica E, et al. Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer. Nat Commun. 2022;13:4633 pubmed publisher
  2. Deng H, Gao Y, Trappetti V, Hertig D, Karatkevich D, Losmanová T, et al. Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. Cell Mol Life Sci. 2022;79:445 pubmed publisher
  3. Ma L, Xue X, Zhang X, Yu K, Xu X, Tian X, et al. The essential roles of m6A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma. J Exp Clin Cancer Res. 2022;41:36 pubmed publisher
  4. Singh L, Devi T. Potential Combination Drug Therapy to Prevent Redox Stress and Mitophagy Dysregulation in Retinal Müller Cells under High Glucose Conditions: Implications for Diabetic Retinopathy. Diseases. 2021;9: pubmed publisher
  5. Wu Q, Zhang W, Liu Y, Huang Y, Wu H, Ma C. Histone deacetylase 1 facilitates aerobic glycolysis and growth of endometrial cancer. Oncol Lett. 2021;22:721 pubmed publisher
  6. Mart xed nez Ordo xf1 ez A, Seoane S, Avila L, Eiró N, Mac xed a M, Arias E, et al. POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation. Oncogene. 2021;40:2725-2740 pubmed publisher
  7. Choi J, Sebastian C, Ferrer C, Lewis C, Sade Feldman M, LaSalle T, et al. A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma. Nat Metab. 2021;3:182-195 pubmed publisher
  8. Wang F, Zhang J, Zhou G. HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus. Biochim Biophys Acta Gen Subj. 2020;1864:129602 pubmed publisher
  9. Zhou Y, Huang Y, Hu K, Zhang Z, Yang J, Wang Z. HIF1A activates the transcription of lncRNA RAET1K to modulate hypoxia-induced glycolysis in hepatocellular carcinoma cells via miR-100-5p. Cell Death Dis. 2020;11:176 pubmed publisher
  10. Aldonza M, Ku J, Hong J, Kim D, Yu S, Lee M, et al. Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Sci Adv. 2020;6:eaav7416 pubmed publisher
  11. Liu W, Yang L, Liu Y, Yuan D, Zhao Z, Wang Q, et al. Dynamic characterization of intestinal metaplasia in the gastric corpus mucosa of Atp4a-deficient mice. Biosci Rep. 2020;40: pubmed publisher
  12. Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, et al. Metabolic regulation of gene expression by histone lactylation. Nature. 2019;574:575-580 pubmed publisher
  13. Huang X, Gan G, Wang X, Xu T, Xie W. The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance. Autophagy. 2019;15:1258-1279 pubmed publisher
  14. Zhang J, MacArtney T, Peggie M, Cohen P. Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3. Biochem J. 2017;474:2235-2248 pubmed publisher
  15. Jin L, Chun J, Pan C, Alesi G, Li D, Magliocca K, et al. Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis. Oncogene. 2017;36:3797-3806 pubmed publisher
  16. Peng M, Yin N, Chhangawala S, Xu K, Leslie C, Li M. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science. 2016;354:481-484 pubmed
  17. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  18. Chen Y, Mahieu N, Huang X, Singh M, Crawford P, Johnson S, et al. Lactate metabolism is associated with mammalian mitochondria. Nat Chem Biol. 2016;12:937-943 pubmed publisher
  19. Lim S, Liu H, Madeira da Silva L, Arora R, Liu Z, Phillips J, et al. Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1?. Cancer Res. 2016;76:2231-42 pubmed publisher
  20. Wang Q, Xue L, Zhang X, Bu S, Zhu X, Lai D. Autophagy protects ovarian cancer-associated fibroblasts against oxidative stress. Cell Cycle. 2016;15:1376-85 pubmed publisher
  21. Mohammad G, Olde Damink S, Malago M, Dhar D, Pereira S. Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome. PLoS ONE. 2016;11:e0151635 pubmed publisher
  22. Backes H, Walberer M, Ladwig A, Rueger M, Neumaier B, Endepols H, et al. Glucose consumption of inflammatory cells masks metabolic deficits in the brain. Neuroimage. 2016;128:54-62 pubmed publisher
  23. Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed publisher
  24. Sharma B, Kolhe R, Black S, Keller J, Mivechi N, Satyanarayana A. Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells. FASEB J. 2016;30:262-75 pubmed publisher
  25. Yang X, Zheng K, Lin K, Zheng G, Zou H, Wang J, et al. Energy Metabolism Disorder as a Contributing Factor of Rheumatoid Arthritis: A Comparative Proteomic and Metabolomic Study. PLoS ONE. 2015;10:e0132695 pubmed publisher
  26. Liu X, Yao J, Tripathi D, Ding Z, Xu Y, Sun M, et al. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene. 2015;34:2450-60 pubmed publisher
  27. Nair V, Gevaert O, Davidzon G, Plevritis S, West R. NF-κB protein expression associates with (18)F-FDG PET tumor uptake in non-small cell lung cancer: a radiogenomics validation study to understand tumor metabolism. Lung Cancer. 2014;83:189-96 pubmed publisher