This is a Validated Antibody Database (VAD) review about mouse Klrk1, based on 34 published articles (read how Labome selects the articles), using Klrk1 antibody in all methods. It is aimed to help Labome visitors find the most suited Klrk1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Klrk1 synonym: D6H12S2489E; NKG2-D; Nkg2d

Invitrogen
rat monoclonal (CX5)
  • flow cytometry; mouse; 1:100; loading ...; fig s1b
Invitrogen Klrk1 antibody (eBioscience, 25-5882-82) was used in flow cytometry on mouse samples at 1:100 (fig s1b). Nat Commun (2021) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; 1:100; fig 6f
Invitrogen Klrk1 antibody (hermo Fisher Scientific, 17-5882-81) was used in flow cytometry on mouse samples at 1:100 (fig 6f). Nat Commun (2021) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; loading ...; fig 5a
Invitrogen Klrk1 antibody (Invitrogen, CX5) was used in flow cytometry on mouse samples (fig 5a). Front Immunol (2019) ncbi
hamsters monoclonal (A10)
  • flow cytometry; mouse; loading ...; fig s1c
Invitrogen Klrk1 antibody (eBioscience, A10) was used in flow cytometry on mouse samples (fig s1c). Front Immunol (2018) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; loading ...; fig 2c
In order to examine the localization and function of FHL2 in natural killer cells, Invitrogen Klrk1 antibody (Affymetrix eBioscience, CX5) was used in flow cytometry on mouse samples (fig 2c). Front Immunol (2017) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; 1:50; loading ...; fig 2c
In order to find an alternative pathway of NK-cell development driven by IL-12, Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples at 1:50 (fig 2c). Nat Commun (2016) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; loading ...; fig 2
In order to determine the function of the SLAM family of proteins in natural killer cells, Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples (fig 2). J Exp Med (2016) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; fig 3b
In order to study mTOR signaling in gamma delta T cells, Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples (fig 3b). J Leukoc Biol (2016) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; 1:100; fig s4
In order to assess the role of NLRC5 to NK-T-cell crosstalk, Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples at 1:100 (fig s4). Nat Commun (2016) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; fig 3
In order to study how DNAM-1 controls NK cell-mediated cytotoxicity and cytokine production, Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples (fig 3). J Exp Med (2015) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; loading ...; fig 1e
Invitrogen Klrk1 antibody (Affymetrix/eBioscience, CX5) was used in flow cytometry on mouse samples (fig 1e). Oncoimmunology (2015) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; fig 1
Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples (fig 1). Nat Immunol (2015) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; fig 4
Invitrogen Klrk1 antibody (eBioscience, cx5) was used in flow cytometry on mouse samples (fig 4). Infect Immun (2015) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; fig 6
Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples (fig 6). PLoS Pathog (2015) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; loading ...; fig 3d
In order to investigate the ability of PTEN to regulate natural killer cell function, Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples (fig 3d). J Immunol (2015) ncbi
hamsters monoclonal (A10)
  • flow cytometry; mouse
Invitrogen Klrk1 antibody (eBioscience, A10) was used in flow cytometry on mouse samples . J Leukoc Biol (2015) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse
Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples . Eur J Immunol (2014) ncbi
hamsters monoclonal (A10)
  • flow cytometry; mouse; fig s1
Invitrogen Klrk1 antibody (Ebioscience, 12-5872) was used in flow cytometry on mouse samples (fig s1). PLoS Pathog (2014) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse
Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples . Blood (2010) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; fig 5
In order to study the role of liver NK cells in virus-induced severe viral hepatitis, Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples (fig 5). J Immunol (2010) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; fig s2
Invitrogen Klrk1 antibody (eBioscience, CX5) was used in flow cytometry on mouse samples (fig s2). Proc Natl Acad Sci U S A (2009) ncbi
rat monoclonal (CX5)
  • blocking or activating experiments; mouse
In order to study the impact of the caspase recruitment domain 9-Bcl10 complex on NK cell receptor signaling, Invitrogen Klrk1 antibody (eBioscience, CX5) was used in blocking or activating experiments on mouse samples . J Immunol (2008) ncbi
rat monoclonal (MI-6 (MI6))
  • flow cytometry; mouse; fig 2
In order to examine the role of T-bet in Valpha14i natural killer T cell function, Invitrogen Klrk1 antibody (eBioscience, MI-6) was used in flow cytometry on mouse samples (fig 2). Blood (2006) ncbi
BioLegend
rat monoclonal (CX5)
  • flow cytometry; mouse; 1:100; loading ...; fig 6a
BioLegend Klrk1 antibody (Biolegend, 130207) was used in flow cytometry on mouse samples at 1:100 (fig 6a). Nat Commun (2021) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; loading ...; fig s6a
BioLegend Klrk1 antibody (Biolegend, 130207) was used in flow cytometry on mouse samples (fig s6a). Cell (2019) ncbi
hamsters monoclonal (A10)
  • flow cytometry; mouse; loading ...; fig 5a
BioLegend Klrk1 antibody (BioLegend, A10) was used in flow cytometry on mouse samples (fig 5a). J Immunol Res (2018) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; loading ...; fig 3
BioLegend Klrk1 antibody (Biolegend, 130212) was used in flow cytometry on mouse samples (fig 3). Sci Rep (2017) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; 1:200; loading ...; fig 6b
In order to find genes that alter invariant natural killer T cell development, migration, or function, BioLegend Klrk1 antibody (BioLegend, CX5) was used in flow cytometry on mouse samples at 1:200 (fig 6b). Nat Commun (2016) ncbi
rat monoclonal (CX5)
  • blocking or activating experiments; mouse; 5 mg/ml; fig 4
  • flow cytometry; mouse
In order to study mTOR signaling in gamma delta T cells, BioLegend Klrk1 antibody (BioLegend, CX5) was used in blocking or activating experiments on mouse samples at 5 mg/ml (fig 4) and in flow cytometry on mouse samples . J Leukoc Biol (2016) ncbi
hamsters monoclonal (C7)
  • flow cytometry; mouse
BioLegend Klrk1 antibody (Biolegend, C7) was used in flow cytometry on mouse samples . Immunology (2014) ncbi
BD Biosciences
rat monoclonal (CX5)
  • flow cytometry; mouse; loading ...; fig 5b
In order to discuss the contribution of astrocytic IL-15 to postischemic brain damage, BD Biosciences Klrk1 antibody (BD Biosciences, Cx5) was used in flow cytometry on mouse samples (fig 5b). Proc Natl Acad Sci U S A (2017) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; fig 4
BD Biosciences Klrk1 antibody (BD Pharmingen, 558403) was used in flow cytometry on mouse samples (fig 4). Front Pharmacol (2016) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; fig 3
In order to study the functions of WASp knock out natural killer cells, BD Biosciences Klrk1 antibody (BD Biosciences, CX5) was used in flow cytometry on mouse samples (fig 3). Sci Rep (2016) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse; fig 4, 7
In order to determine how brain inflammation is recovered by neural stem cells that sustain natural killer cells, BD Biosciences Klrk1 antibody (BD Biosciences, 562347) was used in flow cytometry on mouse samples (fig 4, 7). Nat Neurosci (2016) ncbi
rat monoclonal (CX5)
  • flow cytometry; mouse
BD Biosciences Klrk1 antibody (BD Biosciences, CX5) was used in flow cytometry on mouse samples . PLoS ONE (2014) ncbi
Articles Reviewed
  1. Petley E, Koay H, Henderson M, Sek K, Todd K, Keam S, et al. MAIT cells regulate NK cell-mediated tumor immunity. Nat Commun. 2021;12:4746 pubmed publisher
  2. James O, Vandereyken M, Marchingo J, Singh F, Bray S, Wilson J, et al. IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes. Nat Commun. 2021;12:4290 pubmed publisher
  3. Lin Q, Rong L, Jia X, Li R, Yu B, Hu J, et al. IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella. Nat Commun. 2021;12:2537 pubmed publisher
  4. Sanz Ortega L, Rojas J, Portilla Y, Pérez Yagüe S, Barber D. Magnetic Nanoparticles Attached to the NK Cell Surface for Tumor Targeting in Adoptive Transfer Therapies Does Not Affect Cellular Effector Functions. Front Immunol. 2019;10:2073 pubmed publisher
  5. Davies A, Kim H, González Cano R, Choi J, Back S, Roh S, et al. Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell. 2019;176:716-728.e18 pubmed publisher
  6. Qu J, Li L, Xie H, Zhang X, Yang Q, Qiu H, et al. TLR3 Modulates the Response of NK Cells against Schistosoma japonicum. J Immunol Res. 2018;2018:7519856 pubmed publisher
  7. Abel A, Tiwari A, Gerbec Z, Siebert J, Yang C, Schloemer N, et al. IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells. Front Immunol. 2018;9:1168 pubmed publisher
  8. Glasner A, Isaacson B, Viukov S, Neuman T, Friedman N, Mandelboim M, et al. Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression. Sci Rep. 2017;7:13090 pubmed publisher
  9. Baranek T, Morello E, Valayer A, Aimar R, Bréa D, Henry C, et al. FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection. Front Immunol. 2017;8:123 pubmed publisher
  10. Li M, Li Z, Yao Y, Jin W, Wood K, Liu Q, et al. Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity. Proc Natl Acad Sci U S A. 2017;114:E396-E405 pubmed publisher
  11. Ohs I, Van Den Broek M, Nussbaum K, MUNZ C, Arnold S, Quezada S, et al. Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis. Nat Commun. 2016;7:13708 pubmed publisher
  12. Georgiev H, Ravens I, Benarafa C, Forster R, Bernhardt G. Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets. Nat Commun. 2016;7:13116 pubmed publisher
  13. Guo H, Cranert S, Lu Y, Zhong M, Zhang S, Chen J, et al. Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. J Exp Med. 2016;213:2187-207 pubmed publisher
  14. Huang Y, Li P, Wang J, Zhou H, Yang Z, Yang R, et al. Inhibition of Sophocarpine on Poly I: C/D-GalN-Induced Immunological Liver Injury in Mice. Front Pharmacol. 2016;7:256 pubmed publisher
  15. Kritikou J, Dahlberg C, Baptista M, Wagner A, Banerjee P, Gwalani L, et al. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep. 2016;6:30636 pubmed publisher
  16. Cao G, Wang Q, Li G, Meng Z, Liu H, Tong J, et al. mTOR inhibition potentiates cytotoxicity of V?4 ?? T cells via up-regulating NKG2D and TNF-?. J Leukoc Biol. 2016;100:1181-1189 pubmed
  17. Ludigs K, Jandus C, Utzschneider D, Staehli F, Bessoles S, Dang A, et al. NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nat Commun. 2016;7:10554 pubmed publisher
  18. Liu Q, Sanai N, Jin W, La Cava A, Van Kaer L, Shi F. Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Nat Neurosci. 2016;19:243-52 pubmed publisher
  19. Zhang Z, Wu N, Lu Y, Davidson D, Colonna M, Veillette A. DNAM-1 controls NK cell activation via an ITT-like motif. J Exp Med. 2015;212:2165-82 pubmed publisher
  20. Wilson K, Goding S, Neely H, Harris K, Antony P. Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells. Oncoimmunology. 2015;4:e1019196 pubmed
  21. Wensveen F, Jelenčić V, Valentić S, Šestan M, Wensveen T, Theurich S, et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015;16:376-85 pubmed publisher
  22. Zhan R, Han Q, Zhang C, Tian Z, Zhang J. Toll-Like receptor 2 (TLR2) and TLR9 play opposing roles in host innate immunity against Salmonella enterica serovar Typhimurium infection. Infect Immun. 2015;83:1641-9 pubmed publisher
  23. Sell S, Dietz M, Schneider A, Holtappels R, Mach M, Winkler T. Control of murine cytomegalovirus infection by γδ T cells. PLoS Pathog. 2015;11:e1004481 pubmed publisher
  24. Briercheck E, Trotta R, Chen L, Hartlage A, Cole J, Cole T, et al. PTEN is a negative regulator of NK cell cytolytic function. J Immunol. 2015;194:1832-40 pubmed publisher
  25. Spada R, Rojas J, Pérez Yagüe S, Mulens V, Cannata Ortiz P, Bragado R, et al. NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery. J Leukoc Biol. 2015;97:583-98 pubmed publisher
  26. Dang V, Tanabe K, Tanaka Y, Tokumoto N, Misumi T, Saeki Y, et al. Fasting enhances TRAIL-mediated liver natural killer cell activity via HSP70 upregulation. PLoS ONE. 2014;9:e110748 pubmed publisher
  27. Guttman O, Yossef R, Freixo Lima G, Rider P, Porgador A, Lewis E. α1-Antitrypsin modifies general NK cell interactions with dendritic cells and specific interactions with islet β-cells in favor of protection from autoimmune diabetes. Immunology. 2014;: pubmed publisher
  28. Wei H, Nash W, Makrigiannis A, Brown M. Impaired NK-cell education diminishes resistance to murine CMV infection. Eur J Immunol. 2014;44:3273-82 pubmed publisher
  29. Ataide M, Andrade W, Zamboni D, Wang D, Souza M, Franklin B, et al. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog. 2014;10:e1003885 pubmed publisher
  30. White D, Keppel C, Schneider S, Reese T, Coder J, Payton J, et al. Latent herpesvirus infection arms NK cells. Blood. 2010;115:4377-83 pubmed publisher
  31. Zou Y, Chen T, Han M, Wang H, Yan W, Song G, et al. Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure. J Immunol. 2010;184:466-75 pubmed publisher
  32. Cooper M, Elliott J, Keyel P, Yang L, Carrero J, Yokoyama W. Cytokine-induced memory-like natural killer cells. Proc Natl Acad Sci U S A. 2009;106:1915-9 pubmed publisher
  33. Hara H, Ishihara C, Takeuchi A, Xue L, Morris S, Penninger J, et al. Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9. J Immunol. 2008;181:918-30 pubmed
  34. Matsuda J, Zhang Q, Ndonye R, Richardson S, Howell A, Gapin L. T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells. Blood. 2006;107:2797-805 pubmed