This is a Validated Antibody Database (VAD) review about mouse Jak1, based on 32 published articles (read how Labome selects the articles), using Jak1 antibody in all methods. It is aimed to help Labome visitors find the most suited Jak1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Jak1 synonym: AA960307; BAP004; C130039L05Rik; tyrosine-protein kinase JAK1; JAK-1

R&D Systems
mouse monoclonal (452804)
  • western blot; mouse; loading ...; fig 3d
R&D Systems Jak1 antibody (R&D Systems, MAB42601-SP) was used in western blot on mouse samples (fig 3d). Cancer Discov (2019) ncbi
mouse monoclonal (452804)
  • western blot; mouse; 1:500
R&D Systems Jak1 antibody (R&D Systems, MAB42601) was used in western blot on mouse samples at 1:500. Virus Res (2014) ncbi
Invitrogen
rabbit polyclonal
  • western blot; human; fig 2
In order to examine the transforming potential of leukocyte tyrosine kinase, Invitrogen Jak1 antibody (Invitrogen, 44-422G) was used in western blot on human samples (fig 2). PLoS ONE (2012) ncbi
rabbit polyclonal
  • western blot; human
In order to determine the function of IL-6 in the epithelial-mesenchymal transition in head and neck tumor cells, Invitrogen Jak1 antibody (Invitrogen, 44422G) was used in western blot on human samples . Mol Cancer Res (2011) ncbi
rabbit polyclonal
  • western blot; human; fig 8
In order to study the assembly of full-length IL-2R at the surface of living lymphocytes, Invitrogen Jak1 antibody (Biosource, 44-422G) was used in western blot on human samples (fig 8). J Mol Biol (2010) ncbi
rabbit polyclonal
In order to elucidate how suppressor of cytokine signaling-1 regulates IFN-gamma receptor subunit 1 using a new mouse model, Invitrogen Jak1 antibody (Invitrogen, 44-422G) was used . J Immunol (2009) ncbi
rabbit polyclonal
In order to study the function of CaMK and Pyk2 downstream of ITAM-associated receptors in the regulation of cytokine-induced activation of Jak kinases and STAT transcription factors, Invitrogen Jak1 antibody (Biosource, 44-422G) was used . Nat Immunol (2008) ncbi
Santa Cruz Biotechnology
mouse monoclonal (73)
  • western blot; human
Santa Cruz Biotechnology Jak1 antibody (Santa Cruz Biotechnology, sc- 136225) was used in western blot on human samples . Viral Immunol (2014) ncbi
Abcam
rabbit polyclonal
  • western blot; rat
In order to investigate the role of ANGII in the regulation of latent and active MMP-2 in rat heart, Abcam Jak1 antibody (Abcam, ab125051) was used in western blot on rat samples . Basic Res Cardiol (2014) ncbi
MilliporeSigma
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; loading ...; fig 8
MilliporeSigma Jak1 antibody (Sigma, SAB4504446) was used in immunohistochemistry - paraffin section on human samples (fig 8). J Clin Invest (2016) ncbi
Cell Signaling Technology
rabbit monoclonal (6G4)
  • western blot; human; 1:1000; loading ...; fig 4a
Cell Signaling Technology Jak1 antibody (Cell Signaling, 6G4) was used in western blot on human samples at 1:1000 (fig 4a). Br J Cancer (2019) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 3d
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on mouse samples (fig 3d). Cancer Discov (2019) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 1f
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3332) was used in western blot on mouse samples (fig 1f). Cell (2018) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 1f
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on mouse samples (fig 1f). Cell (2018) ncbi
rabbit monoclonal (6G4)
  • western blot; mouse; 1:500; loading ...; fig 4e
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3344) was used in western blot on mouse samples at 1:500 (fig 4e). Nat Commun (2018) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 1b
Cell Signaling Technology Jak1 antibody (Cell Signaling Technologies, 3332) was used in western blot on human samples (fig 1b). Oncoimmunology (2018) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 9a
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on human samples (fig 9a). Nature (2017) ncbi
rabbit monoclonal (6G4)
  • western blot; human; loading ...; fig 3e
Cell Signaling Technology Jak1 antibody (Cell signaling, 3344) was used in western blot on human samples (fig 3e). Nat Commun (2017) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3a
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on human samples at 1:1000 (fig 3a). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 5a
Cell Signaling Technology Jak1 antibody (cell signalling, 3331) was used in western blot on human samples (fig 5a). PLoS Med (2016) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig s8
In order to find that that vascular endothelial growth factor 165b prevents activation of vascular endothelial growth factor receptor 1-STAT3 signaling by vascular endothelial growth factor 165a, Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on mouse samples (fig s8). Circ Res (2017) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 4
In order to study mouse models of dilated cardiomyopathy to study calcium signaling, Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on mouse samples (fig 4). PLoS ONE (2016) ncbi
rabbit monoclonal (6G4)
  • immunoprecipitation; mouse; loading ...; fig 4
  • western blot; mouse; loading ...; fig 4
In order to study mouse models of dilated cardiomyopathy to study calcium signaling, Cell Signaling Technology Jak1 antibody (Cell Signaling, 3344) was used in immunoprecipitation on mouse samples (fig 4) and in western blot on mouse samples (fig 4). PLoS ONE (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig s4
Cell Signaling Technology Jak1 antibody (cell signalling, 3332) was used in western blot on human samples at 1:500 (fig s4). Oncotarget (2017) ncbi
rabbit polyclonal
  • western blot; human; 1:200; loading ...; fig s4
Cell Signaling Technology Jak1 antibody (cell signalling, 3331) was used in western blot on human samples at 1:200 (fig s4). Oncotarget (2017) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 9a
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3331) was used in western blot on mouse samples at 1:1000 (fig 9a). Drug Des Devel Ther (2016) ncbi
rabbit monoclonal (6G4)
  • western blot; mouse; 1:2000; loading ...; fig 9a
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3344) was used in western blot on mouse samples at 1:2000 (fig 9a). Drug Des Devel Ther (2016) ncbi
rabbit monoclonal (6G4)
  • western blot; mouse; fig 6c
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 6G4) was used in western blot on mouse samples (fig 6c). J Exp Med (2016) ncbi
rabbit monoclonal (6G4)
  • western blot; human; loading ...; fig 4
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 6G4) was used in western blot on human samples (fig 4). Oncotarget (2016) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 3f
  • immunohistochemistry; mouse; loading ...; fig 3g
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on human samples (fig 3f) and in immunohistochemistry on mouse samples (fig 3g). J Clin Invest (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:500; loading ...; fig 7a
In order to demonstrate that Ndfip1/Ndfip2 regulate cross talk between T-cell receptor and cytokine signaling pathways, Cell Signaling Technology Jak1 antibody (Cell Signaling Technologies, 3332) was used in western blot on mouse samples at 1:500 (fig 7a). Nat Commun (2016) ncbi
rabbit monoclonal (6G4)
  • western blot; human; fig 4
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3344) was used in western blot on human samples (fig 4). Oncotarget (2015) ncbi
rabbit monoclonal (6G4)
  • western blot; human; 1:1000; fig 4
In order to analyze multidrug resistant human cancer cells and autocrime cytokine/JAK/STAT-signaling induces kynurenin synthesis, Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3344) was used in western blot on human samples at 1:1000 (fig 4). PLoS ONE (2015) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig 4
In order to analyze multidrug resistant human cancer cells and autocrime cytokine/JAK/STAT-signaling induces kynurenin synthesis, Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3331) was used in western blot on human samples at 1:1000 (fig 4). PLoS ONE (2015) ncbi
rabbit polyclonal
  • western blot; hamsters
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on hamsters samples . Front Cell Infect Microbiol (2014) ncbi
rabbit monoclonal (6G4)
  • western blot; human
In order to show that uPAR regulates nasopharyngeal carcinoma NPC progression, Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3344) was used in western blot on human samples . Cell Cycle (2014) ncbi
rabbit polyclonal
  • western blot; human; 1:300
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on human samples at 1:300. Cell Death Dis (2014) ncbi
BD Biosciences
mouse monoclonal (73/JAK1)
  • western blot; human; 1:1000; loading ...; fig 3a
BD Biosciences Jak1 antibody (BD Biosciences, 610231) was used in western blot on human samples at 1:1000 (fig 3a). Nat Commun (2016) ncbi
mouse monoclonal (73/JAK1)
  • western blot; mouse; loading ...; fig 3a
  • western blot; human; loading ...; fig 3f
BD Biosciences Jak1 antibody (BD Biosciences, 610231) was used in western blot on mouse samples (fig 3a) and in western blot on human samples (fig 3f). J Clin Invest (2016) ncbi
mouse monoclonal (73/JAK1)
  • western blot; human; 0.25 ug/mL
In order to evaluate the effect of JAK1/2 inhibitor AZD1480 on IL-6-induced experimental prostate cancer metastases formation, BD Biosciences Jak1 antibody (BD Biosciences, 610231) was used in western blot on human samples at 0.25 ug/mL. Mol Cancer Ther (2014) ncbi
EMD Millipore
rabbit polyclonal
  • western blot; human; loading ...; fig 4a
EMD Millipore Jak1 antibody (Millipore/Upstate, 06-272) was used in western blot on human samples (fig 4a). Mol Cancer Res (2017) ncbi
Articles Reviewed
  1. Martin V, Chiriaco C, Modica C, Acquadro A, Cortese M, Galimi F, et al. Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours. Br J Cancer. 2019;120:527-536 pubmed publisher
  2. Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher
  3. Xu X, Xu J, Wu J, Hu Y, Han Y, Gu Y, et al. Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response. Cell. 2018;175:1336-1351.e17 pubmed publisher
  4. Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, et al. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun. 2018;9:2789 pubmed publisher
  5. Luo N, Formisano L, Gonzalez Ericsson P, Sanchez V, Dean P, Opalenik S, et al. Melanoma response to anti-PD-L1 immunotherapy requires JAK1 signaling, but not JAK2. Oncoimmunology. 2018;7:e1438106 pubmed publisher
  6. Patel S, Sanjana N, Kishton R, Eidizadeh A, Vodnala S, Cam M, et al. Identification of essential genes for cancer immunotherapy. Nature. 2017;548:537-542 pubmed publisher
  7. Cayrol F, Praditsuktavorn P, Fernando T, Kwiatkowski N, Marullo R, Calvo Vidal M, et al. THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors. Nat Commun. 2017;8:14290 pubmed publisher
  8. Zhu F, Hwang B, Miyamoto S, Rui L. Nuclear Import of JAK1 Is Mediated by a Classical NLS and Is Required for Survival of Diffuse Large B-cell Lymphoma. Mol Cancer Res. 2017;15:348-357 pubmed publisher
  9. Eletto D, Burns S, Angulo I, Plagnol V, Gilmour K, Henriquez F, et al. Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection. Nat Commun. 2016;7:13992 pubmed publisher
  10. Li Y, Buijs Gladdines J, Canté Barrett K, Stubbs A, Vroegindeweij E, Smits W, et al. IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study. PLoS Med. 2016;13:e1002200 pubmed publisher
  11. Ganta V, Choi M, Kutateladze A, Annex B. VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease. Circ Res. 2017;120:282-295 pubmed publisher
  12. Ramratnam M, Salama G, Sharma R, Wang D, Smith S, Banerjee S, et al. Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization. PLoS ONE. 2016;11:e0167681 pubmed publisher
  13. Bonan S, Albrengues J, Grasset E, Kuzet S, Nottet N, Bourget I, et al. Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts. Oncotarget. 2017;8:1304-1320 pubmed publisher
  14. He Y, Yan Y, Zhang H, Lin Y, Chen Y, Yan Y, et al. Methyl salicylate 2-O-?-d-lactoside alleviates the pathological progression of pristane-induced systemic lupus erythematosus-like disease in mice via suppression of inflammatory response and signal transduction. Drug Des Devel Ther. 2016;10:3183-3196 pubmed
  15. Textor A, Schmidt K, Kloetzel P, Weißbrich B, Perez C, Charo J, et al. Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med. 2016;213:2333-2348 pubmed
  16. Ma Y, Chen L, Xie G, Zhou Y, Yue C, Yuan X, et al. Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3. Oncotarget. 2016;7:73003-73015 pubmed publisher
  17. Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, et al. Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis. J Clin Invest. 2016;126:2064-76 pubmed publisher
  18. O Leary C, Riling C, Spruce L, Ding H, Kumar S, Deng G, et al. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016;7:11226 pubmed publisher
  19. Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, et al. Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget. 2015;6:14796-813 pubmed
  20. Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, et al. An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells. PLoS ONE. 2015;10:e0126159 pubmed publisher
  21. Hall J, Sun J, Slade J, Kintner J, Bambino M, Whittimore J, et al. Host nectin-1 is required for efficient Chlamydia trachomatis serovar E development. Front Cell Infect Microbiol. 2014;4:158 pubmed publisher
  22. Kopaliani I, Martin M, Zatschler B, Bortlik K, Müller B, Deussen A. Cell-specific and endothelium-dependent regulations of matrix metalloproteinase-2 in rat aorta. Basic Res Cardiol. 2014;109:419 pubmed publisher
  23. Liu Y, Zhang Z, Zhao X, Yu R, Zhang X, Wu S, et al. Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression. Viral Immunol. 2014;27:267-76 pubmed publisher
  24. Bao Y, Cao X, Luo D, Sun R, Peng L, Wang L, et al. Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis. Cell Cycle. 2014;13:1958-69 pubmed publisher
  25. Gu L, Talati P, Vogiatzi P, Romero Weaver A, Abdulghani J, Liao Z, et al. Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation. Mol Cancer Ther. 2014;13:1246-58 pubmed publisher
  26. Mathieu M, Miles A, Ahmad M, Buczek M, Pockley A, Rees R, et al. The helicase HAGE prevents interferon-?-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1. Cell Death Dis. 2014;5:e1061 pubmed publisher
  27. Low Calle A, Prada Arismendy J, Castellanos J. Study of interferon-? antiviral activity against Herpes simplex virus type 1 in neuron-enriched trigeminal ganglia cultures. Virus Res. 2014;180:49-58 pubmed publisher
  28. Roll J, Reuther G. ALK-activating homologous mutations in LTK induce cellular transformation. PLoS ONE. 2012;7:e31733 pubmed publisher
  29. Yadav A, Kumar B, Datta J, Teknos T, Kumar P. IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway. Mol Cancer Res. 2011;9:1658-67 pubmed publisher
  30. Pillet A, Lavergne V, Pasquier V, Gesbert F, Theze J, Rose T. IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork. J Mol Biol. 2010;403:671-92 pubmed publisher
  31. Starr R, Fuchsberger M, Lau L, Uldrich A, Goradia A, Willson T, et al. SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo. J Immunol. 2009;183:4537-44 pubmed publisher
  32. Wang L, Tassiulas I, Park Min K, Reid A, Gil Henn H, Schlessinger J, et al. 'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages. Nat Immunol. 2008;9:186-93 pubmed