This is a Validated Antibody Database (VAD) review about mouse Insr, based on 64 published articles (read how Labome selects the articles), using Insr antibody in all methods. It is aimed to help Labome visitors find the most suited Insr antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Insr synonym: 4932439J01Rik; CD220; D630014A15Rik; IR; IR-A; IR-B

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (4B8)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 2a, 2c
Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in western blot knockout validation on mouse samples at 1:1000 (fig 2a, 2c). Nat Commun (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (4B8)
  • western blot knockout validation; mouse; fig 2
Cell Signaling Technology Insr antibody (Cell signaling, 3025) was used in western blot knockout validation on mouse samples (fig 2). Endocrinology (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (10C3)
  • western blot; mouse; 1:500; loading ...; fig 4f
Santa Cruz Biotechnology Insr antibody (Santa Cruz Biotechnology, sc-81500) was used in western blot on mouse samples at 1:500 (fig 4f). elife (2020) ncbi
mouse monoclonal (11B6)
  • western blot; mouse; loading ...; fig 8b
In order to show that PTI-125 therapeutically alters filamin A and reverses proteopathy, Santa Cruz Biotechnology Insr antibody (SantaCruz, SC-81465) was used in western blot on mouse samples (fig 8b). Neurobiol Aging (2017) ncbi
mouse monoclonal (10C3)
  • western blot; rat; 1:500; loading ...; fig 2c
Santa Cruz Biotechnology Insr antibody (Santa Cruz, sc-81500) was used in western blot on rat samples at 1:500 (fig 2c). Mol Med Rep (2017) ncbi
mouse monoclonal (46)
  • western blot; Spodoptera litura; fig 3a
Santa Cruz Biotechnology Insr antibody (SantaCruz, sc-135949) was used in western blot on Spodoptera litura samples (fig 3a). Sci Rep (2016) ncbi
mouse monoclonal (29B4)
  • immunohistochemistry; rat; 1:100; fig 2
Santa Cruz Biotechnology Insr antibody (Santa Cruz, sc-09) was used in immunohistochemistry on rat samples at 1:100 (fig 2). Nat Commun (2015) ncbi
mouse monoclonal (CT-3)
  • immunohistochemistry; rat; 1:100; fig 2
Santa Cruz Biotechnology Insr antibody (Santa Cruz, sc-57342) was used in immunohistochemistry on rat samples at 1:100 (fig 2). Nat Commun (2015) ncbi
mouse monoclonal (11B6)
  • western blot; human; loading ...; fig 3b
In order to quantify proteins involved in mitochondrial oxidation and glucose and lipid metabolism in skeletal muscle of trained and untrained middle-aged men, Santa Cruz Biotechnology Insr antibody (Santa Cruz, sc-81465) was used in western blot on human samples (fig 3b). Physiol Res (2016) ncbi
mouse monoclonal (10C3)
  • immunoprecipitation; human
  • western blot; human
Santa Cruz Biotechnology Insr antibody (Santa Cruz Biotechnology, sc-81500) was used in immunoprecipitation on human samples and in western blot on human samples . Nucleic Acids Res (2015) ncbi
mouse monoclonal (10C3)
  • western blot; mouse; fig 3b
In order to test the effects of high fat diet using a mouse model of familial Alzheimer disease, Santa Cruz Biotechnology Insr antibody (Santa Cruz, Sc-81500) was used in western blot on mouse samples (fig 3b). Biochim Biophys Acta (2015) ncbi
mouse monoclonal (46)
  • western blot; human
Santa Cruz Biotechnology Insr antibody (Santa Cruz Biotechnology, SC-135949) was used in western blot on human samples . J Diabetes (2016) ncbi
mouse monoclonal (10C3)
  • western blot; human
Santa Cruz Biotechnology Insr antibody (Santa Cruz Biotechnology, SC-81500) was used in western blot on human samples . J Diabetes (2016) ncbi
mouse monoclonal (29B4)
  • western blot; human; 1:1000
Santa Cruz Biotechnology Insr antibody (Santa Cruz Biotechnology, sc-09) was used in western blot on human samples at 1:1000. Tumour Biol (2015) ncbi
mouse monoclonal (29B4)
  • western blot; African green monkey
Santa Cruz Biotechnology Insr antibody (Santa Cruz Biotechnology, 29B4) was used in western blot on African green monkey samples . J Biol Chem (2002) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 8b
In order to show that PTI-125 therapeutically alters filamin A and reverses proteopathy, Invitrogen Insr antibody (Invitrogen, 44-800G) was used in western blot on mouse samples (fig 8b). Neurobiol Aging (2017) ncbi
mouse monoclonal (CT-3)
  • immunohistochemistry - paraffin section; mouse; fig 2
In order to find novel biomarkers associated with bladder cancer progression, Invitrogen Insr antibody (Invitrogen, AHR0271) was used in immunohistochemistry - paraffin section on mouse samples (fig 2). J Pathol (2017) ncbi
domestic rabbit polyclonal
  • flow cytometry; human; loading ...; fig s1a
In order to generate and characterize an antibody that is specific for the insulin receptor and evaluate its effect on diabetic pathogenesis, Invitrogen Insr antibody (Invitrogen, 44-809G) was used in flow cytometry on human samples (fig s1a). Diabetes (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 6a
In order to generate and characterize an antibody that is specific for the insulin receptor and evaluate its effect on diabetic pathogenesis, Invitrogen Insr antibody (Novex Life Technologies, 44-800G) was used in western blot on human samples (fig 6a). Diabetes (2017) ncbi
domestic rabbit polyclonal
  • other; human; fig 7
In order to research a novel method of differential ligand activation and phosphatase-mediated deactivation of insulin receptor tyrosine-specific phosphorylation, Invitrogen Insr antibody (Invitrogen, 44-809G) was used in other on human samples (fig 7). Cell Signal (2016) ncbi
domestic rabbit polyclonal
  • other; human; fig 7
In order to research a novel method of differential ligand activation and phosphatase-mediated deactivation of insulin receptor tyrosine-specific phosphorylation, Invitrogen Insr antibody (Novex (Life Technologies), 44- 800G) was used in other on human samples (fig 7). Cell Signal (2016) ncbi
domestic rabbit polyclonal
In order to investigate the effect of heat shock on glucose metabolism by skeletal muscles, Invitrogen Insr antibody (Life Technologies, 44-806G) was used . Physiol Rep (2015) ncbi
domestic rabbit polyclonal
In order to develop an ELISA method to quantitatively measure activated hybrid receptors comprised of Insulin Receptor and the Insulin-like Growth Factor 1 Receptor, Invitrogen Insr antibody (BioSource, 44-809G) was used . Sci Rep (2015) ncbi
domestic rabbit polyclonal
In order to elucidate the role of farnesylation in burn-induced metabolic aberration, Invitrogen Insr antibody (Life Technologies, 44-800G) was used . PLoS ONE (2015) ncbi
mouse monoclonal (CT-3)
  • immunohistochemistry - frozen section; rat; 4 ug/ml; fig 8
In order to study the role of insulin in olfactory function, Invitrogen Insr antibody (Invitrogen, #AHR0271) was used in immunohistochemistry - frozen section on rat samples at 4 ug/ml (fig 8). PLoS ONE (2012) ncbi
mouse monoclonal (CT-3)
  • western blot; rat
In order to examine the effect of Akt2 phosphorylation on on glucose uptake in skeletal muscle, Invitrogen Insr antibody (Invitrogen, AHR0271) was used in western blot on rat samples . Biochim Biophys Acta (2012) ncbi
mouse monoclonal (CT-3)
  • western blot; rat; 1:1000; fig 3
In order to examine the insulin signaling pathway in isolated epitrochlearis and soleus muscles of old rats, Invitrogen Insr antibody (Invitrogen, AHR0271) was used in western blot on rat samples at 1:1000 (fig 3). J Gerontol A Biol Sci Med Sci (2012) ncbi
mouse monoclonal (CT-3)
  • western blot; mouse; fig 2
In order to measure the effects of exercise on glucose uptake by type I (slow-twitch) muscle from old rats, Invitrogen Insr antibody (Invitrogen, AHR0271) was used in western blot on mouse samples (fig 2). Age (Dordr) (2013) ncbi
mouse monoclonal (CT-3)
  • western blot; human; fig 2
In order to test if the insulin receptor undergoes presenilin/gamma-secretase-dependent processing, Invitrogen Insr antibody (NeoMarkers, CT-3) was used in western blot on human samples (fig 2). Biochem Biophys Res Commun (2007) ncbi
mouse monoclonal (CT-3)
  • ELISA; human; 0.75 ug/ml
In order to study the in vivo antitumor activity of a potent and selective IGF-1 receptor kinase inhibitor, Invitrogen Insr antibody (Neomarkers, Ab6) was used in ELISA on human samples at 0.75 ug/ml. Cancer Cell (2004) ncbi
Abcam
mouse monoclonal (C18C4)
  • immunohistochemistry - free floating section; rat; 1:500; loading ...; fig 5a
  • western blot; rat; 1:1000; loading ...; fig 3a
Abcam Insr antibody (Abcam, ab69508) was used in immunohistochemistry - free floating section on rat samples at 1:500 (fig 5a) and in western blot on rat samples at 1:1000 (fig 3a). Aging Cell (2020) ncbi
mouse monoclonal (C18C4)
  • western blot; human; fig 3
In order to utilize a novel targe for type 2 diabetes and regulate the effects of GPR21, Abcam Insr antibody (Abcam, ab69508) was used in western blot on human samples (fig 3). Sci Rep (2016) ncbi
mouse monoclonal (C18C4)
  • western blot; human; 1:200; loading ...; fig 1b
In order to demonstrate that receptor tyrosine kinase-like orphan receptor 1 is a scaffold for cavin-1 and caveolin-1, Abcam Insr antibody (Abcam, ab69508) was used in western blot on human samples at 1:200 (fig 1b). Nat Commun (2016) ncbi
domestic rabbit monoclonal (EPR2334(2))
  • immunohistochemistry - frozen section; mouse; 1:10
In order to elucidate the factors that mediate radiation-induced endothelial dysfunction, Abcam Insr antibody (abcam, ab172965) was used in immunohistochemistry - frozen section on mouse samples at 1:10. J Proteome Res (2015) ncbi
Novus Biologicals
domestic rabbit polyclonal
  • western blot; rhesus macaque; 1:1000; loading ...; fig s6d
  • western blot; human; 1:1000; loading ...; fig s6d
Novus Biologicals Insr antibody (Novus, NBP2-12793) was used in western blot on rhesus macaque samples at 1:1000 (fig s6d) and in western blot on human samples at 1:1000 (fig s6d). Cell (2019) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (4B8)
  • western blot; mouse; loading ...; fig 5c
Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in western blot on mouse samples (fig 5c). iScience (2021) ncbi
domestic rabbit monoclonal (4B8)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 2a, 2c
Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in western blot knockout validation on mouse samples at 1:1000 (fig 2a, 2c). Nat Commun (2021) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; 1:1000; loading ...
Cell Signaling Technology Insr antibody (Cell Signalling Technology, 3025) was used in western blot on mouse samples at 1:1000. elife (2021) ncbi
mouse monoclonal (L55B10)
  • western blot; mouse; 1:1000; loading ...; fig 4j
Cell Signaling Technology Insr antibody (Cell Signaling, 3020) was used in western blot on mouse samples at 1:1000 (fig 4j). Int J Mol Sci (2021) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; loading ...; fig 3d
Cell Signaling Technology Insr antibody (Cell Signaling Technology, 3025) was used in western blot on mouse samples (fig 3d). Sci Rep (2020) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; loading ...; fig 1g
Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in western blot on mouse samples (fig 1g). elife (2020) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; 1:1000; loading ...; fig 4d
Cell Signaling Technology Insr antibody (Cell Signaling, 3025S) was used in western blot on mouse samples at 1:1000 (fig 4d). elife (2020) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; 1:1000; loading ...; fig 5e, 5f, 5g
Cell Signaling Technology Insr antibody (Cell Signaling, 3025S) was used in western blot on mouse samples at 1:1000 (fig 5e, 5f, 5g). elife (2019) ncbi
domestic rabbit monoclonal (4B8)
  • immunoprecipitation; mouse; loading ...; fig s2b
Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in immunoprecipitation on mouse samples (fig s2b). Cell (2019) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; human; loading ...; fig 2h
Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in western blot on human samples (fig 2h). J Appl Physiol (1985) (2019) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; rat; 1:1000; loading ...; fig 4f, 5f
Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in western blot on rat samples at 1:1000 (fig 4f, 5f). Br J Pharmacol (2019) ncbi
domestic rabbit monoclonal (4B8)
  • other; human; loading ...; fig 4c
Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; loading ...; fig 3a
Cell Signaling Technology Insr antibody (Cell Signaling, 3025S) was used in western blot on mouse samples (fig 3a). Biochem Biophys Res Commun (2017) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; pigs ; loading ...; fig 5b
Cell Signaling Technology Insr antibody (Cell Signal, 3025) was used in western blot on pigs samples (fig 5b). Oncotarget (2017) ncbi
mouse monoclonal (L55B10)
  • western blot; mouse; loading ...; fig s7a
In order to report that the Myomixer-Myomaker interaction regulates myofiber formation during muscle development, Cell Signaling Technology Insr antibody (Cell Signaling, 3020) was used in western blot on mouse samples (fig s7a). Science (2017) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; fig s3d
  • western blot; human; fig 1a
Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in western blot on mouse samples (fig s3d) and in western blot on human samples (fig 1a). Nature (2017) ncbi
domestic rabbit monoclonal (4B8)
  • flow cytometry; mouse; loading ...; fig 5b
In order to determine a physiological role for IL-1beta and insulin in the regulation of both metabolism and immunity, Cell Signaling Technology Insr antibody (Cell Signaling, 3025S) was used in flow cytometry on mouse samples (fig 5b). Nat Immunol (2017) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; human; loading ...; fig 6a
In order to generate and characterize an antibody that is specific for the insulin receptor and evaluate its effect on diabetic pathogenesis, Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in western blot on human samples (fig 6a). Diabetes (2017) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; human; loading ...; fig 4a
In order to identify autophagy-inducing phytochemicals, Cell Signaling Technology Insr antibody (Cell Signaling Technology, 3025) was used in western blot on human samples (fig 4a). Autophagy (2017) ncbi
domestic rabbit monoclonal (4B8)
  • western blot knockout validation; mouse; fig 2
Cell Signaling Technology Insr antibody (Cell signaling, 3025) was used in western blot knockout validation on mouse samples (fig 2). Endocrinology (2016) ncbi
  • western blot; mouse; loading ...; fig s8i
Cell Signaling Technology Insr antibody (Cell signalling, 3015) was used in western blot on mouse samples (fig s8i). Cell Rep (2016) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; 1:1000; fig 6
Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in western blot on mouse samples at 1:1000 (fig 6). Sci Rep (2016) ncbi
mouse monoclonal (L55B10)
  • immunoprecipitation; mouse; fig 3
  • immunocytochemistry; mouse; fig 1
  • western blot; mouse; fig 3
Cell Signaling Technology Insr antibody (Cell Signaling Technology, 3020S) was used in immunoprecipitation on mouse samples (fig 3), in immunocytochemistry on mouse samples (fig 1) and in western blot on mouse samples (fig 3). Mol Metab (2016) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; 1:1000; fig 6
Cell Signaling Technology Insr antibody (Cell signaling, 3025) was used in western blot on mouse samples at 1:1000 (fig 6). Sci Rep (2016) ncbi
mouse monoclonal (L55B10)
  • western blot; human; fig 8
In order to study attenuation of AKT signaling to promote internal ribosome entry site-dependent translation and expression of c-MYC by the human papillomavirus 16 E7 oncoprotein, Cell Signaling Technology Insr antibody (Cell Signaling, 3020) was used in western blot on human samples (fig 8). J Virol (2016) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; rat; fig 6
Cell Signaling Technology Insr antibody (Cell signaling, 3025) was used in western blot on rat samples (fig 6). Mol Metab (2016) ncbi
mouse monoclonal (L55B10)
  • western blot; mouse; 1:1000; fig 3
Cell Signaling Technology Insr antibody (Cell signaling, 3020) was used in western blot on mouse samples at 1:1000 (fig 3). Free Radic Biol Med (2016) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; fig 3
Cell Signaling Technology Insr antibody (Cell Signaling Tech, 3025) was used in western blot on mouse samples (fig 3). Drug Des Devel Ther (2015) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; fig 3E
Cell Signaling Technology Insr antibody (Cell Signaling Technology, 3025) was used in western blot on mouse samples (fig 3E). Sci Rep (2015) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; human; 1:1000
In order to study the insulin/IGF1 signaling pathway in human astrocytes, Cell Signaling Technology Insr antibody (Cell Signalling Technology, 3025) was used in western blot on human samples at 1:1000. Mol Brain (2015) ncbi
mouse monoclonal (L55B10)
  • western blot; human; loading ...; fig 4a
Cell Signaling Technology Insr antibody (Cell signaling, L55B10) was used in western blot on human samples (fig 4a). Mar Drugs (2015) ncbi
domestic rabbit monoclonal (4B8)
  • immunohistochemistry; mouse
  • western blot; mouse
Cell Signaling Technology Insr antibody (Cell Signaling Technology, 3025) was used in immunohistochemistry on mouse samples and in western blot on mouse samples . Mol Neurodegener (2015) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; human; fig 5
In order to investigate how loss of RE-1 Silencing Transcription Factor affects breast cancer, Cell Signaling Technology Insr antibody (cell signaling, 3025) was used in western blot on human samples (fig 5). Mol Cell Biol (2015) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; human; loading ...; fig 1c
In order to study mechanisms that confer resistance to therapeutic interventions in the insulin-like growth factor receptor pathway, Cell Signaling Technology Insr antibody (cst, 3025) was used in western blot on human samples (fig 1c). Mol Cancer (2015) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; mouse; fig 2
In order to examine the role of prolyl endopeptidase in glucose metabolism and pancreatic function, Cell Signaling Technology Insr antibody (Cell Signaling, 3025) was used in western blot on mouse samples (fig 2). Proc Natl Acad Sci U S A (2014) ncbi
domestic rabbit monoclonal (4B8)
  • western blot; human
Cell Signaling Technology Insr antibody (Cell signaling, 3025) was used in western blot on human samples . Biochem Biophys Res Commun (2014) ncbi
mouse monoclonal (L55B10)
  • western blot; mouse; 1:1000
Cell Signaling Technology Insr antibody (Cell Signaling, 3020S) was used in western blot on mouse samples at 1:1000. J Biol Chem (2014) ncbi
Articles Reviewed
  1. Takaoka S, Yanagiya A, Mohamed H, Higa R, Abe T, Inoue K, et al. Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis. iScience. 2021;24:103151 pubmed publisher
  2. Bruce J, Sánchez Alvarez R, Sans M, Sugden S, Qi N, James A, et al. Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps. Nat Commun. 2021;12:4386 pubmed publisher
  3. Kearney A, Norris D, Ghomlaghi M, Kin Lok Wong M, Humphrey S, Carroll L, et al. Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. elife. 2021;10: pubmed publisher
  4. López Gambero A, Rosell Valle C, Medina Vera D, Navarro J, Vargas A, Rivera P, et al. A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer's Disease, the 5XFAD Mouse. Int J Mol Sci. 2021;22: pubmed publisher
  5. Ow J, Cadez M, Zafer G, Foo J, Li H, Ghosh S, et al. Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division. elife. 2020;9: pubmed publisher
  6. Grundmann S, Schutkowski A, Berger C, Baur A, König B, Stangl G. High-phosphorus diets reduce aortic lesions and cardiomyocyte size and modify lipid metabolism in Ldl receptor knockout mice. Sci Rep. 2020;10:20748 pubmed publisher
  7. Frazier H, Anderson K, Ghoweri A, Lin R, Hawkinson T, Popa G, et al. Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats. Aging Cell. 2020;19:e13220 pubmed publisher
  8. Ruiz Velasco A, Zi M, Hille S, Azam T, Kaur N, Jiang J, et al. Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure. elife. 2020;9: pubmed publisher
  9. Shen H, Gan P, Wang K, Darehzereshki A, Wang K, Kumar S, et al. Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling. elife. 2020;9: pubmed publisher
  10. Helsley R, Varadharajan V, Brown A, Gromovsky A, Schugar R, Ramachandiran I, et al. Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. elife. 2019;8: pubmed publisher
  11. Hancock M, Meyer R, Mistry M, Khetani R, Wagschal A, Shin T, et al. Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression. Cell. 2019;177:722-736.e22 pubmed publisher
  12. Pollen A, Bhaduri A, Andrews M, Nowakowski T, Meyerson O, Mostajo Radji M, et al. Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution. Cell. 2019;176:743-756.e17 pubmed publisher
  13. Riis S, Christensen B, Nellemann B, Møller A, Husted A, Pedersen S, et al. Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males. J Appl Physiol (1985). 2019;126:569-577 pubmed publisher
  14. Zhou X, Zhang R, Zou Z, Shen X, Xie T, Xu C, et al. Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat. Br J Pharmacol. 2019;176:478-490 pubmed publisher
  15. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  16. Wei X, Guo L, Liu Y, Zhou S, Liu Y, Dou X, et al. Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin sensitivity by decreasing copper levels in adipocytes. Biochem Biophys Res Commun. 2017;491:814-820 pubmed publisher
  17. Wang H, Lee K, Pei Z, Khan A, Bakshi K, Burns L. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017;55:99-114 pubmed publisher
  18. Cai C, Qian L, Jiang S, Sun Y, Wang Q, Ma D, et al. Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs. Oncotarget. 2017;8:34911-34922 pubmed publisher
  19. Bi P, Ramirez Martinez A, Li H, Cannavino J, McAnally J, Shelton J, et al. Control of muscle formation by the fusogenic micropeptide myomixer. Science. 2017;356:323-327 pubmed publisher
  20. Roudnicky F, Dieterich L, Poyet C, Buser L, Wild P, Tang D, et al. High expression of insulin receptor on tumour-associated blood vessels in invasive bladder cancer predicts poor overall and progression-free survival. J Pathol. 2017;242:193-205 pubmed publisher
  21. Chan L, Chen Z, Braas D, Lee J, Xiao G, Geng H, et al. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017;542:479-483 pubmed publisher
  22. Dror E, Dalmas E, Meier D, Wueest S, Thévenet J, Thienel C, et al. Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat Immunol. 2017;18:283-292 pubmed publisher
  23. Yan H, Gao Y, Zhang Y. Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease. Mol Med Rep. 2017;15:180-186 pubmed publisher
  24. Cieniewicz A, Kirchner T, Hinke S, Nanjunda R, D AQUINO K, Boayke K, et al. Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance. Diabetes. 2017;66:206-217 pubmed publisher
  25. Fan Y, Wang N, Rocchi A, Zhang W, Vassar R, Zhou Y, et al. Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy. 2017;13:41-56 pubmed publisher
  26. Shao X, Lai D, Zhang L, Xu H. Induction of Autophagy and Apoptosis via PI3K/AKT/TOR Pathways by Azadirachtin A in Spodoptera litura Cells. Sci Rep. 2016;6:35482 pubmed publisher
  27. Li Z, Frey J, Wong G, Faugere M, Wolfgang M, Kim J, et al. Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts. Endocrinology. 2016;157:4094-4103 pubmed
  28. Tsai S, Rodriguez A, Dastidar S, Del Greco E, Carr K, Sitzmann J, et al. Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice. Cell Rep. 2016;16:1903-14 pubmed publisher
  29. Leonard S, Kinsella G, Benetti E, Findlay J. Regulating the effects of GPR21, a novel target for type 2 diabetes. Sci Rep. 2016;6:27002 pubmed publisher
  30. Wang K, Cao P, Wang H, Tang Z, Wang N, Wang J, et al. Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice. Sci Rep. 2016;6:26229 pubmed publisher
  31. Cieniewicz A, Cooper P, MCGEHEE J, Lingham R, Kihm A. Novel method demonstrates differential ligand activation and phosphatase-mediated deactivation of insulin receptor tyrosine-specific phosphorylation. Cell Signal. 2016;28:1037-47 pubmed publisher
  32. Boothe T, Lim G, Cen H, Skovsø S, Piske M, Li S, et al. Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells. Mol Metab. 2016;5:366-378 pubmed publisher
  33. Dinger K, Kasper P, Hucklenbruch Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher
  34. Strickland S, Vande Pol S. The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC. J Virol. 2016;90:5611-5621 pubmed publisher
  35. de Castro Barbosa T, Ingerslev L, Alm P, Versteyhe S, Massart J, Rasmussen M, et al. High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Mol Metab. 2016;5:184-197 pubmed publisher
  36. Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, et al. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun. 2016;7:10060 pubmed publisher
  37. Barone E, Di Domenico F, Cassano T, Arena A, Tramutola A, Lavecchia M, et al. Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. Free Radic Biol Med. 2016;91:127-42 pubmed publisher
  38. Sun J, Fu X, Liu Y, Wang Y, Huo B, Guo Y, et al. Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice. Drug Des Devel Ther. 2015;9:6327-42 pubmed publisher
  39. Ni Y, Nagashimada M, Zhuge F, Zhan L, Nagata N, Tsutsui A, et al. Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E. Sci Rep. 2015;5:17192 pubmed publisher
  40. Goto A, Egawa T, Sakon I, Oshima R, Ito K, Serizawa Y, et al. Heat stress acutely activates insulin-independent glucose transport and 5'-AMP-activated protein kinase prior to an increase in HSP72 protein in rat skeletal muscle. Physiol Rep. 2015;3: pubmed publisher
  41. Stouffer M, Woods C, Patel J, Lee C, Witkovsky P, Bao L, et al. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun. 2015;6:8543 pubmed publisher
  42. Vigelso A, Prats C, Ploug T, Dela F, Helge J. Higher muscle content of perilipin 5 and endothelial lipase protein in trained than untrained middle-aged men. Physiol Res. 2016;65:293-302 pubmed
  43. Garwood C, Ratcliffe L, Morgan S, Simpson J, Owens H, Vazquez Villaseñor I, et al. Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Mol Brain. 2015;8:51 pubmed publisher
  44. Yunn N, Koh A, Han S, Lim J, Park S, Lee J, et al. Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation. Nucleic Acids Res. 2015;43:7688-701 pubmed publisher
  45. Luo J, Wu N, Jiang B, Wang L, Wang S, Li X, et al. Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition. Mar Drugs. 2015;13:4452-69 pubmed publisher
  46. Tan X, Xue Y, Ma T, Wang X, Li J, Lan L, et al. Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment. Mol Neurodegener. 2015;10:24 pubmed publisher
  47. Meyer K, Albaugh B, Schoenike B, Roopra A. Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST. Mol Cell Biol. 2015;35:2991-3004 pubmed publisher
  48. Min H, Yun H, Lee J, Lee H, Cho J, Jang H, et al. Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer. Mol Cancer. 2015;14:113 pubmed publisher
  49. Petrov D, Pedrós I, Artiach G, Sureda F, Barroso E, Pallas M, et al. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents. Biochim Biophys Acta. 2015;1852:1687-99 pubmed publisher
  50. Slaaby R. Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin. Sci Rep. 2015;5:7911 pubmed publisher
  51. Yoo J, Kim T, Kong S, Lee J, Choi W, Kim K, et al. Role of Mig-6 in hepatic glucose metabolism. J Diabetes. 2016;8:86-97 pubmed publisher
  52. Nakazawa H, Yamada M, Tanaka T, Kramer J, Yu Y, Fischman A, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS ONE. 2015;10:e0116633 pubmed publisher
  53. Azimzadeh O, Sievert W, Sarioglu H, Merl Pham J, Yentrapalli R, Bakshi M, et al. Integrative proteomics and targeted transcriptomics analyses in cardiac endothelial cells unravel mechanisms of long-term radiation-induced vascular dysfunction. J Proteome Res. 2015;14:1203-19 pubmed publisher
  54. Kim E, Kim S, Jin X, Ham S, Kim J, Park J, et al. Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1. Tumour Biol. 2015;36:2921-8 pubmed publisher
  55. Kim J, Toda C, D Agostino G, Zeiss C, DiLeone R, Elsworth J, et al. Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Proc Natl Acad Sci U S A. 2014;111:11876-81 pubmed publisher
  56. Kim K, Lee S, Ryu S, Han D. Efficient isolation and elution of cellular proteins using aptamer-mediated protein precipitation assay. Biochem Biophys Res Commun. 2014;448:114-9 pubmed publisher
  57. Ziegler A, Chidambaram S, Forbes B, Wood T, Levison S. Insulin-like growth factor-II (IGF-II) and IGF-II analogs with enhanced insulin receptor-a binding affinity promote neural stem cell expansion. J Biol Chem. 2014;289:4626-33 pubmed publisher
  58. Aimé P, Hegoburu C, Jaillard T, Degletagne C, Garcia S, Messaoudi B, et al. A physiological increase of insulin in the olfactory bulb decreases detection of a learned aversive odor and abolishes food odor-induced sniffing behavior in rats. PLoS ONE. 2012;7:e51227 pubmed publisher
  59. Sharma N, Arias E, Sequea D, Cartee G. Preventing the calorie restriction-induced increase in insulin-stimulated Akt2 phosphorylation eliminates calorie restriction's effect on glucose uptake in skeletal muscle. Biochim Biophys Acta. 2012;1822:1735-40 pubmed publisher
  60. Sequea D, Sharma N, Arias E, Cartee G. Calorie restriction enhances insulin-stimulated glucose uptake and Akt phosphorylation in both fast-twitch and slow-twitch skeletal muscle of 24-month-old rats. J Gerontol A Biol Sci Med Sci. 2012;67:1279-85 pubmed publisher
  61. Xiao Y, Sharma N, Arias E, Castorena C, Cartee G. A persistent increase in insulin-stimulated glucose uptake by both fast-twitch and slow-twitch skeletal muscles after a single exercise session by old rats. Age (Dordr). 2013;35:573-82 pubmed
  62. Kasuga K, Kaneko H, Nishizawa M, Onodera O, Ikeuchi T. Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase. Biochem Biophys Res Commun. 2007;360:90-6 pubmed
  63. Garcia Echeverria C, Pearson M, Marti A, Meyer T, Mestan J, Zimmermann J, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004;5:231-9 pubmed
  64. Wu J, Guidotti G. Construction and characterization of a monomeric insulin receptor. J Biol Chem. 2002;277:27809-17 pubmed