This is a Validated Antibody Database (VAD) review about mouse Il12b, based on 37 published articles (read how Labome selects the articles), using Il12b antibody in all methods. It is aimed to help Labome visitors find the most suited Il12b antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Il12b synonym: Il-12b; Il-12p40; Il12p40; p40

BioLegend
rat monoclonal (C17.8)
  • flow cytometry; mouse; 1:200; loading ...
BioLegend Il12b antibody (BioLegend, C17.8) was used in flow cytometry on mouse samples at 1:200. J Immunother Cancer (2021) ncbi
rat monoclonal (C18.2)
  • mass cytometry; mouse; loading ...; fig 5c
BioLegend Il12b antibody (Biolegend, 511802) was used in mass cytometry on mouse samples (fig 5c). Nat Commun (2021) ncbi
rat monoclonal (C15.6)
  • flow cytometry; mouse; loading ...; fig 11a
BioLegend Il12b antibody (BioLegend, 505205) was used in flow cytometry on mouse samples (fig 11a). Cell Mol Gastroenterol Hepatol (2021) ncbi
rat monoclonal (C15.6)
  • flow cytometry; mouse; fig 3c, 3d
BioLegend Il12b antibody (Biolegend, 505204) was used in flow cytometry on mouse samples (fig 3c, 3d). Diabetes (2021) ncbi
rat monoclonal (C15.6)
  • flow cytometry; human; loading ...; fig 2b
In order to elucidate the mechanisms by which DRibbles induce T-cell activation, BioLegend Il12b antibody (Biolegend, 505203) was used in flow cytometry on human samples (fig 2b). Cell Death Dis (2016) ncbi
rat monoclonal (C17.8)
  • blocking or activating experiments; mouse; 10 ug/ml; loading ...
In order to investigate how dopamine receptor D3 signaling affects the balance of effector T cells, BioLegend Il12b antibody (BioLegend, C17.8) was used in blocking or activating experiments on mouse samples at 10 ug/ml. J Immunol (2016) ncbi
rat monoclonal (C15.6)
  • flow cytometry; mouse; fig 5
BioLegend Il12b antibody (BioLegend, C15.6) was used in flow cytometry on mouse samples (fig 5). J Immunol (2015) ncbi
rat monoclonal (C17.8)
  • ELISA; mouse; fig 6
BioLegend Il12b antibody (Biolegend, C17.8) was used in ELISA on mouse samples (fig 6). Eur J Immunol (2015) ncbi
rat monoclonal (C15.6)
  • ELISA; mouse; fig 6
BioLegend Il12b antibody (Biolegend, C15.6) was used in ELISA on mouse samples (fig 6). Eur J Immunol (2015) ncbi
rat monoclonal (C17.8)
  • blocking or activating experiments; mouse; 10 ug/ml
BioLegend Il12b antibody (BioLegend, C17.8) was used in blocking or activating experiments on mouse samples at 10 ug/ml. J Clin Invest (2014) ncbi
Invitrogen
rat monoclonal (C15.6)
  • ELISA; mouse; 1 ug/ml; loading ...; fig 1e
Invitrogen Il12b antibody (eBioscience, 14-7125-81) was used in ELISA on mouse samples at 1 ug/ml (fig 1e). elife (2019) ncbi
rat monoclonal (C17.8)
  • ELISA; mouse; loading ...; fig 1e
Invitrogen Il12b antibody (eBiosciences, 13-7123-85) was used in ELISA on mouse samples (fig 1e). elife (2019) ncbi
rat monoclonal (C15.6)
  • ELISA; mouse; fig 1c
Invitrogen Il12b antibody (eBioscience, C15.6) was used in ELISA on mouse samples (fig 1c). J Immunol (2018) ncbi
rat monoclonal (C17-8)
  • flow cytometry; mouse; loading ...; fig s5d
In order to assess the contribution of viral infection to the development of celiac disease, Invitrogen Il12b antibody (eBioscience, C17.8) was used in flow cytometry on mouse samples (fig s5d). Science (2017) ncbi
rat monoclonal (C17-8)
  • flow cytometry; mouse; loading ...; fig 2b
In order to study the ability of lymphocyte-derived microparticles to modulate the gene expression pattern of angiogenesis-related factors in macrophages, Invitrogen Il12b antibody (eBioscience, C17.8) was used in flow cytometry on mouse samples (fig 2b). Sci Rep (2016) ncbi
rat monoclonal (C17.8)
  • flow cytometry; mouse; fig 8
In order to identify CD11b(+) classical dendritic cells as the source of IL-23 in C. rodentium infected mice, Invitrogen Il12b antibody (eBioscience, C17.8) was used in flow cytometry on mouse samples (fig 8). Nat Immunol (2013) ncbi
rat monoclonal (C17-8)
  • ELISA; mouse; 0.5 ug/ml; tbl 2
In order to assess the influence of alcohol consumption on antigen-presenting cell populations and cytokine production in type 1 cell-mediated adaptive immune responses, Invitrogen Il12b antibody (Caltag, C17.8) was used in ELISA on mouse samples at 0.5 ug/ml (tbl 2). Alcohol Clin Exp Res (2007) ncbi
rat monoclonal (9A5)
  • immunohistochemistry; mouse; fig 6
In order to show that EtxB can block diabetes, Invitrogen Il12b antibody (Biosource, C15.6) was used in immunohistochemistry on mouse samples (fig 6). Immunology (2006) ncbi
rat monoclonal (C17-8)
  • ELISA; mouse
In order to describe the mechanisms by which tumor-infiltrating macrophages and dendritic cells can be redirected to become potent effectors and activators of the innate and adaptive immunity, Invitrogen Il12b antibody (Endogen, C17-8) was used in ELISA on mouse samples . Cancer Res (2005) ncbi
rat monoclonal (9A5)
  • immunohistochemistry - paraffin section; mouse
  • ELISA; mouse
In order to describe the mechanisms by which tumor-infiltrating macrophages and dendritic cells can be redirected to become potent effectors and activators of the innate and adaptive immunity, Invitrogen Il12b antibody (Endogen, 9A5) was used in immunohistochemistry - paraffin section on mouse samples and in ELISA on mouse samples . Cancer Res (2005) ncbi
rat monoclonal (C17-8)
  • ELISA; mouse; 0.5 ug/ml
In order to examine the influence of collagenase and trypsin on murine resident and oil-induced peritoneal macrophages, Invitrogen Il12b antibody (Endogen, C17.8) was used in ELISA on mouse samples at 0.5 ug/ml. Inflammation (2003) ncbi
rat monoclonal (C17-8)
  • flow cytometry; mouse
  • ELISA; mouse
In order to report that the strength of TCR signaling directs Th cell development by regulating CD40L expression on T cells which determines production of IL-12p40 from DC via CD40, Invitrogen Il12b antibody (Caltag, C17.8) was used in flow cytometry on mouse samples and in ELISA on mouse samples . Microbiol Immunol (2003) ncbi
Bio X Cell
rat monoclonal (C17.8)
  • blocking or activating experiments; mouse; fig s3a
Bio X Cell Il12b antibody (BioXcell, C17.8) was used in blocking or activating experiments on mouse samples (fig s3a). PLoS ONE (2020) ncbi
rat monoclonal (R1-5D9)
  • blocking or activating experiments; mouse; loading ...; fig 3c
Bio X Cell Il12b antibody (BioXcell, R1-5D9) was used in blocking or activating experiments on mouse samples (fig 3c). J Immunol (2016) ncbi
rat monoclonal (C17.8)
  • blocking or activating experiments; mouse
Bio X Cell Il12b antibody (BioXcell, C17.8) was used in blocking or activating experiments on mouse samples . Infect Immun (2016) ncbi
rat monoclonal (C17.8)
  • blocking or activating experiments; mouse; loading ...; fig 4a
In order to propose that CCL7 is a driver of TNF-alpha-dependent T cell-mediated inflammation in lesional psoriatic skin, Bio X Cell Il12b antibody (BioXCel, C17.8) was used in blocking or activating experiments on mouse samples (fig 4a). Exp Dermatol (2015) ncbi
Santa Cruz Biotechnology
rat monoclonal (C17.8)
  • western blot; mouse; loading ...; fig 5e
Santa Cruz Biotechnology Il12b antibody (Santa Cruz Biotechnology, sc-57258) was used in western blot on mouse samples (fig 5e). PLoS Pathog (2018) ncbi
rat monoclonal (C17.8)
  • immunohistochemistry; mouse; fig 5
Santa Cruz Biotechnology Il12b antibody (Santa Cruz Biotechnology, sc-57258) was used in immunohistochemistry on mouse samples (fig 5). Int J Mol Med (2016) ncbi
rat monoclonal (C17.8)
  • immunohistochemistry; mouse; fig 6
Santa Cruz Biotechnology Il12b antibody (Santa Cruz, sc-57258) was used in immunohistochemistry on mouse samples (fig 6). PLoS ONE (2015) ncbi
BD Biosciences
rat monoclonal (C15.6)
  • flow cytometry; mouse; 1:50; loading ...; fig s4a
BD Biosciences Il12b antibody (BD Biosciences, 560564) was used in flow cytometry on mouse samples at 1:50 (fig s4a). Front Immunol (2021) ncbi
rat monoclonal (C15.6)
  • flow cytometry; mouse; 1:100; loading ...; fig 3a
BD Biosciences Il12b antibody (BD, C15.6) was used in flow cytometry on mouse samples at 1:100 (fig 3a). Nat Commun (2021) ncbi
rat monoclonal (C17.8)
  • ELISA; mouse; 1:500; loading ...; fig 1d
BD Biosciences Il12b antibody (BD Biosciences, 554476) was used in ELISA on mouse samples at 1:500 (fig 1d). Cancer Res (2021) ncbi
rat monoclonal (9A5)
  • ELISA; mouse; 1:500; loading ...; fig 1d
BD Biosciences Il12b antibody (BD Biosciences, 554658) was used in ELISA on mouse samples at 1:500 (fig 1d). Cancer Res (2021) ncbi
rat monoclonal (C15.6)
  • flow cytometry; mouse; loading ...; fig 6c
BD Biosciences Il12b antibody (BD Biosciences, 562038) was used in flow cytometry on mouse samples (fig 6c). Cell Rep (2019) ncbi
rat monoclonal (C15.6)
  • flow cytometry; mouse; loading ...; fig 3k
BD Biosciences Il12b antibody (BD, 560564) was used in flow cytometry on mouse samples (fig 3k). Cancer Res (2018) ncbi
rat monoclonal (C17.8)
  • blocking or activating experiments; mouse; loading ...
In order to assess the role of p38 signaling in limiting regulatory T cell induction, BD Biosciences Il12b antibody (BD, C17.8) was used in blocking or activating experiments on mouse samples . J Biol Chem (2017) ncbi
rat monoclonal (C15.6)
  • ELISA; mouse; fig 5b
BD Biosciences Il12b antibody (BD Biosciences, 551219) was used in ELISA on mouse samples (fig 5b). Cell (2016) ncbi
rat monoclonal (C17.8)
  • ELISA; mouse; fig 5b
BD Biosciences Il12b antibody (BD Biosciences, 554476) was used in ELISA on mouse samples (fig 5b). Cell (2016) ncbi
rat monoclonal (C17.8)
  • blocking or activating experiments; mouse; 10 ug/ml; fig s6c
In order to investigate allergic responses to food allergens in WASP-deficient animals, BD Biosciences Il12b antibody (BD Pharmingen, C17.8) was used in blocking or activating experiments on mouse samples at 10 ug/ml (fig s6c). J Clin Invest (2016) ncbi
rat monoclonal (C15.6)
  • flow cytometry; mouse; fig 5
In order to study dendritic cells in Sirt6 knock out mice, BD Biosciences Il12b antibody (Becton Dickinson, C15.6) was used in flow cytometry on mouse samples (fig 5). Aging (Albany NY) (2016) ncbi
rat monoclonal (C15.6)
  • flow cytometry; mouse; loading ...; fig 8A
In order to determine that Th2 cell responses, alternative macrophage activation, and immunoglobulin class switching to IgG1, are enhanced in Batf3(-/-) mice responding to helminth parasites, BD Biosciences Il12b antibody (BD, C15.6) was used in flow cytometry on mouse samples (fig 8A). J Exp Med (2016) ncbi
rat monoclonal (C15.6)
  • flow cytometry; mouse
BD Biosciences Il12b antibody (Becton Dickinson, C15.6) was used in flow cytometry on mouse samples . J Immunother (2012) ncbi
Articles Reviewed
  1. Liu H, Pedros C, Kong K, Canonigo Balancio A, Xue W, Altman A. Leveraging the Treg-intrinsic CTLA4-PKCη signaling pathway for cancer immunotherapy. J Immunother Cancer. 2021;9: pubmed publisher
  2. Okamura T, Hashimoto Y, Mori J, Yamaguchi M, Majima S, Senmaru T, et al. ILC2s Improve Glucose Metabolism Through the Control of Saturated Fatty Acid Absorption Within Visceral Fat. Front Immunol. 2021;12:669629 pubmed publisher
  3. Lin Q, Rong L, Jia X, Li R, Yu B, Hu J, et al. IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella. Nat Commun. 2021;12:2537 pubmed publisher
  4. Mao F, Lv Y, Hao C, Teng Y, Liu Y, Cheng P, et al. Helicobacter pylori-Induced Rev-erbα Fosters Gastric Bacteria Colonization by Impairing Host Innate and Adaptive Defense. Cell Mol Gastroenterol Hepatol. 2021;12:395-425 pubmed publisher
  5. Yin H, Zhang X, Yang P, Zhang X, Peng Y, Li D, et al. RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming. Nat Commun. 2021;12:1394 pubmed publisher
  6. Kharkwal S, Johndrow C, Veerapen N, Kharkwal H, Saavedra Avila N, Carreño L, et al. Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T-cell Engagers Generates Antitumor Immunity While Avoiding Anergy. Cancer Res. 2021;81:1788-1801 pubmed publisher
  7. Antony A, Lian Z, Perrard X, Perrard J, Liu H, Cox A, et al. Deficiency of Stat1 in CD11c+ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed a High-Fat Diet. Diabetes. 2021;70:720-732 pubmed publisher
  8. Wang R, Graham S, Sun N, McCarthy D, Peng R, Erickson J, et al. CRISPR/Cas9-targeting of CD40 in hematopoietic stem cells limits immune activation mediated by anti-CD40. PLoS ONE. 2020;15:e0228221 pubmed publisher
  9. Leylek R, Alcántara Hernández M, Lanzar Z, Lüdtke A, Perez O, Reizis B, et al. Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population. Cell Rep. 2019;29:3736-3750.e8 pubmed publisher
  10. Roberts A, Popov L, Mitchell G, Ching K, Licht D, Golovkine G, et al. Cas9+ conditionally-immortalized macrophages as a tool for bacterial pathogenesis and beyond. elife. 2019;8: pubmed publisher
  11. Tan B, Shi X, Zhang J, Qin J, Zhang N, Ren H, et al. Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization. Cancer Res. 2018;78:4929-4942 pubmed publisher
  12. Napolitano A, van der Veen A, Bunyan M, Borg A, Frith D, Howell S, et al. Cysteine-Reactive Free ISG15 Generates IL-1β-Producing CD8α+ Dendritic Cells at the Site of Infection. J Immunol. 2018;201:604-614 pubmed publisher
  13. Gounder A, Yokoyama C, Jarjour N, Bricker T, Edelson B, Boon A. Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimer. PLoS Pathog. 2018;14:e1007001 pubmed publisher
  14. Bouziat R, Hinterleitner R, Brown J, Stencel Baerenwald J, Ikizler M, Mayassi T, et al. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017;356:44-50 pubmed publisher
  15. Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani R, Jiménez Andrade G, et al. Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem. 2017;292:1762-1772 pubmed publisher
  16. Moroishi T, Hayashi T, Pan W, Fujita Y, Holt M, Qin J, et al. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016;167:1525-1539.e17 pubmed publisher
  17. Tahiri H, Omri S, Yang C, Duhamel F, Samarani S, Ahmad A, et al. Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization. Sci Rep. 2016;6:37391 pubmed publisher
  18. Lexmond W, Goettel J, Lyons J, Jacobse J, Deken M, Lawrence M, et al. FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J Clin Invest. 2016;126:4030-4044 pubmed publisher
  19. Le Gars M, Haustant M, Klezovich Bénard M, Paget C, Trottein F, Goossens P, et al. Mechanisms of Invariant NKT Cell Activity in Restraining Bacillus anthracis Systemic Dissemination. J Immunol. 2016;197:3225-3232 pubmed
  20. Xing Y, Cao R, Hu H. TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles). Cell Death Dis. 2016;7:e2322 pubmed publisher
  21. Contreras F, Prado C, Gonzalez H, Franz D, Osorio Barrios F, Osorio F, et al. Dopamine Receptor D3 Signaling on CD4+ T Cells Favors Th1- and Th17-Mediated Immunity. J Immunol. 2016;196:4143-9 pubmed publisher
  22. Seo J, Bang M, Kim G, Cho S, Park D. Erythronium japonicum attenuates histopathological lung abnormalities in a mouse model of ovalbumin-induced asthma. Int J Mol Med. 2016;37:1221-8 pubmed publisher
  23. Lasigliè D, Boero S, Bauer I, Morando S, Damonte P, Cea M, et al. Sirt6 regulates dendritic cell differentiation, maturation, and function. Aging (Albany NY). 2016;8:34-49 pubmed
  24. Everts B, Tussiwand R, Dreesen L, Fairfax K, Huang S, Smith A, et al. Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12. J Exp Med. 2016;213:35-51 pubmed publisher
  25. Villegas Mendez A, Shaw T, Inkson C, Strangward P, de Souza J, Couper K. Parasite-Specific CD4+ IFN-γ+ IL-10+ T Cells Distribute within Both Lymphoid and Nonlymphoid Compartments and Are Controlled Systemically by Interleukin-27 and ICOS during Blood-Stage Malaria Infection. Infect Immun. 2016;84:34-46 pubmed publisher
  26. Sharma S, Chintala N, Vadrevu S, Patel J, Karbowniczek M, Markiewski M. Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs. J Immunol. 2015;194:5529-38 pubmed publisher
  27. Brunner P, Glitzner E, Reininger B, Klein I, Stary G, Mildner M, et al. CCL7 contributes to the TNF-alpha-dependent inflammation of lesional psoriatic skin. Exp Dermatol. 2015;24:522-8 pubmed publisher
  28. Bang M, Seo J, Seo J, Jo G, Jung S, Yu R, et al. Bacillus subtilis KCTC 11782BP-produced alginate oligosaccharide effectively suppresses asthma via T-helper cell type 2-related cytokines. PLoS ONE. 2015;10:e0117524 pubmed publisher
  29. Li J, Liu D, Mou Z, Ihedioha O, Blanchard A, Jia P, et al. Deficiency of prolactin-inducible protein leads to impaired Th1 immune response and susceptibility to Leishmania major in mice. Eur J Immunol. 2015;45:1082-91 pubmed publisher
  30. Koga T, Hedrich C, Mizui M, Yoshida N, Otomo K, Lieberman L, et al. CaMK4-dependent activation of AKT/mTOR and CREM-? underlies autoimmunity-associated Th17 imbalance. J Clin Invest. 2014;124:2234-45 pubmed publisher
  31. Satpathy A, Briseño C, Lee J, Ng D, Manieri N, Kc W, et al. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol. 2013;14:937-48 pubmed publisher
  32. Przewoznik M, Hömberg N, Naujoks M, Pötzl J, Münchmeier N, Brenner C, et al. Recruitment of natural killer cells in advanced stages of endogenously arising B-cell lymphoma: implications for therapeutic cell transfer. J Immunother. 2012;35:217-22 pubmed publisher
  33. Heinz R, Waltenbaugh C. Ethanol consumption modifies dendritic cell antigen presentation in mice. Alcohol Clin Exp Res. 2007;31:1759-71 pubmed
  34. Ola T, Williams N. Protection of non-obese diabetic mice from autoimmune diabetes by Escherichia coli heat-labile enterotoxin B subunit. Immunology. 2006;117:262-70 pubmed
  35. Guiducci C, Vicari A, Sangaletti S, Trinchieri G, Colombo M. Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res. 2005;65:3437-46 pubmed
  36. Bryniarski K, Maresz K, Szczepanik M, Ptak M, Ptak W. Modulation of macrophage activity by proteolytic enzymes. Differential regulation of IL-6 and reactive oxygen intermediates (ROIs) synthesis as a possible homeostatic mechanism in the control of inflammation. Inflammation. 2003;27:333-40 pubmed
  37. Fujimoto N, Ishida H, Nakamura I, Ogasawara K, Itoh Y. Quantities of interleukin-12p40 in mature CD8alpha negative dendritic cells correlate with strength of TCR signal and determine Th cell development. Microbiol Immunol. 2003;47:1017-24 pubmed