This is a Validated Antibody Database (VAD) review about mouse Icosl, based on 27 published articles (read how Labome selects the articles), using Icosl antibody in all methods. It is aimed to help Labome visitors find the most suited Icosl antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Icosl synonym: AU044799; B7-H2; B7RP-1; B7h; BG071784; GI50; GL50; GL50-B; ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653

BioLegend
rat monoclonal (HK5.3)
  • flow cytometry; mouse; loading ...; fig 5e
BioLegend Icosl antibody (Biolegend, 107405) was used in flow cytometry on mouse samples (fig 5e). Mol Cancer (2021) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; loading ...; fig 1a, 1b
BioLegend Icosl antibody (Biolegend, HK5.3) was used in flow cytometry on mouse samples (fig 1a, 1b). elife (2021) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; loading ...; fig s15d
BioLegend Icosl antibody (Biolegend, HK5.3) was used in flow cytometry on mouse samples (fig s15d). Science (2019) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; loading ...; fig s1g
BioLegend Icosl antibody (Biolegend, 107405) was used in flow cytometry on mouse samples (fig s1g). Cell (2019) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; loading ...
In order to investigate the role of dopamine in B cell maturation in germinal centres, BioLegend Icosl antibody (BioLegend, HK5.3) was used in flow cytometry on mouse samples . Nature (2017) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; loading ...; fig s4e
In order to study T cell migration in inflammatory demyelinating lesions confined to optic nerves and spinal cord, BioLegend Icosl antibody (BioLegend, HK5.3) was used in flow cytometry on mouse samples (fig s4e). Proc Natl Acad Sci U S A (2016) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; loading ...; fig s1c
In order to explore the role of exhausted CD8 positive CXCR5 positive T cells in mice chronically infected with lymphocytic choriomeningitis virus, BioLegend Icosl antibody (Biolegend, HK5.3) was used in flow cytometry on mouse samples (fig s1c). Nature (2016) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; 1:200; loading ...; tbl s2
In order to identify and characterize follicular cytotoxic T cells, BioLegend Icosl antibody (Biolegend, HK5.3) was used in flow cytometry on mouse samples at 1:200 (tbl s2). Nat Immunol (2016) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; tbl s1
In order to study the role of ICOS in group 2 innate lymphoid cell responses, BioLegend Icosl antibody (BioLegend, HK5.3) was used in flow cytometry on mouse samples (tbl s1). Biochem Biophys Res Commun (2015) ncbi
rat monoclonal (HK5.3)
  • blocking or activating experiments; mouse; 20 ug/ml; fig 3
BioLegend Icosl antibody (Biolegend, HK5.3) was used in blocking or activating experiments on mouse samples at 20 ug/ml (fig 3). J Immunol (2015) ncbi
Invitrogen
rat monoclonal (HK5.3)
  • flow cytometry; mouse; loading ...
Invitrogen Icosl antibody (eBiosciences, 12-5985-82) was used in flow cytometry on mouse samples . Cell (2021) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; loading ...; fig s6
Invitrogen Icosl antibody (eBiosciences, HK5.3) was used in flow cytometry on mouse samples (fig s6). Cancer Cell (2018) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; loading ...; fig 5a
Invitrogen Icosl antibody (eBioscience, HK5.3) was used in flow cytometry on mouse samples (fig 5a). J Exp Med (2017) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; 1:200; loading ...; fig 1i
In order to evaluate the use of a recombinant Newcastle disease virus expressing ICOS ligand to treat cancer, Invitrogen Icosl antibody (eBioscience, 12-5985) was used in flow cytometry on mouse samples at 1:200 (fig 1i). Nat Commun (2017) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; fig 2
In order to test if a diet high in fats affects the development of respiratory tolerance, Invitrogen Icosl antibody (eBioscience, HK5.3) was used in flow cytometry on mouse samples (fig 2). PLoS ONE (2016) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; fig 2c
Invitrogen Icosl antibody (eBioscience, HK5.3) was used in flow cytometry on mouse samples (fig 2c). Immunity (2016) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; human; fig 3
Invitrogen Icosl antibody (eBioscience, HK5.3) was used in flow cytometry on human samples (fig 3). Cell Res (2015) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse
Invitrogen Icosl antibody (eBioscience, HK5.3) was used in flow cytometry on mouse samples . J Immunol (2014) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; fig 5
In order to test if upregulation of major histocompatibility complex class II and costimulatory molecules in the retina contributes to the regulation of CD4 T cells, Invitrogen Icosl antibody (eBiosciences, HK5.3) was used in flow cytometry on mouse samples (fig 5). Infect Immun (2010) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; fig 5b
In order to study the effect of Lactobacillus acidophilus strain L-92 on antigen-stimulated T cell responses in vitro and in vivo, Invitrogen Icosl antibody (e-Bioscience, HK5.3) was used in flow cytometry on mouse samples (fig 5b). Immunobiology (2008) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse; fig 1
In order to characterize and compare T helper 1 and 17 cells, Invitrogen Icosl antibody (eBiosciences, HK5.3) was used in flow cytometry on mouse samples (fig 1). J Leukoc Biol (2007) ncbi
rat monoclonal (HK5.3)
  • flow cytometry; mouse
In order to elucidate how Schistosoma mansoni suppresses T cell activation, Invitrogen Icosl antibody (eBiosciences, HK5.3) was used in flow cytometry on mouse samples . J Immunol (2004) ncbi
Bio X Cell
rat monoclonal (HK5.3)
  • blocking or activating experiments; mouse; fig 6l
Bio X Cell Icosl antibody (BioXcell, HK5.3) was used in blocking or activating experiments on mouse samples (fig 6l). elife (2020) ncbi
rat monoclonal (HK5.3)
  • blocking or activating experiments; mouse; loading ...; fig 7a
  • flow cytometry; mouse; loading ...; fig 5a
Bio X Cell Icosl antibody (Bio X cell, HK5.3) was used in blocking or activating experiments on mouse samples (fig 7a) and in flow cytometry on mouse samples (fig 5a). Front Immunol (2019) ncbi
rat monoclonal (HK5.3)
  • blocking or activating experiments; mouse; loading ...; fig s3b
Bio X Cell Icosl antibody (Bio-X-cell, HK5.3) was used in blocking or activating experiments on mouse samples (fig s3b). J Immunol (2018) ncbi
rat monoclonal (HK5.3)
  • blocking or activating experiments; mouse; loading ...; fig 3a
In order to explore the relationship between ICOS signaling and FOXO1 in T follicular helper cells, Bio X Cell Icosl antibody (BioXCell, HK5.3) was used in blocking or activating experiments on mouse samples (fig 3a). Immunity (2015) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; mouse; fig s1b
Abcam Icosl antibody (Abcam, ab138354) was used in western blot on mouse samples (fig s1b). Sci Rep (2019) ncbi
Articles Reviewed
  1. Yan C, Saleh N, Yang J, Nebhan C, Vilgelm A, Reddy E, et al. Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade. Mol Cancer. 2021;20:85 pubmed publisher
  2. Gangoso E, Southgate B, Bradley L, Rus S, Gálvez Cancino F, McGivern N, et al. Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion. Cell. 2021;184:2454-2470.e26 pubmed publisher
  3. Angulo G, Železnjak J, Martínez Vicente P, Puñet Ortiz J, Hengel H, Messerle M, et al. Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion. elife. 2021;10: pubmed publisher
  4. Canel M, Taggart D, Sims A, Lonergan D, Waizenegger I, Serrels A. T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity. elife. 2020;9: pubmed publisher
  5. Mizuno R, Sugiura D, Shimizu K, Maruhashi T, Watada M, Okazaki I, et al. PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation. Front Immunol. 2019;10:630 pubmed publisher
  6. Sugiura D, Maruhashi T, Okazaki I, Shimizu K, Maeda T, Takemoto T, et al. Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses. Science. 2019;364:558-566 pubmed publisher
  7. Knox T, Sahakian E, Banik D, Hadley M, Palmer E, Noonepalle S, et al. Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells. Sci Rep. 2019;9:6136 pubmed publisher
  8. Binnewies M, Mujal A, Pollack J, Combes A, Hardison E, Barry K, et al. Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity. Cell. 2019;177:556-571.e16 pubmed publisher
  9. Cortes J, Ambesi Impiombato A, Couronné L, Quinn S, Kim C, da Silva Almeida A, et al. RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis. Cancer Cell. 2018;33:259-273.e7 pubmed publisher
  10. Shi B, Geng J, Wang Y, Wei H, Walters B, Li W, et al. Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4. J Immunol. 2018;200:586-594 pubmed publisher
  11. Papa I, Saliba D, Ponzoni M, Bustamante S, Canete P, Gonzalez Figueroa P, et al. TFH-derived dopamine accelerates productive synapses in germinal centres. Nature. 2017;547:318-323 pubmed publisher
  12. Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T. The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help. J Exp Med. 2017;214:1181-1198 pubmed publisher
  13. Zamarin D, Holmgaard R, Ricca J, Plitt T, Palese P, Sharma P, et al. Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity. Nat Commun. 2017;8:14340 pubmed publisher
  14. Klotz L, Kuzmanov I, Hucke S, Gross C, Posevitz V, Dreykluft A, et al. B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity. Proc Natl Acad Sci U S A. 2016;113:E6182-E6191 pubmed
  15. He R, Hou S, Liu C, Zhang A, Bai Q, Han M, et al. Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection. Nature. 2016;537:412-428 pubmed publisher
  16. Leong Y, Chen Y, Ong H, Wu D, Man K, Deléage C, et al. CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol. 2016;17:1187-96 pubmed publisher
  17. Pizzolla A, Oh D, Luong S, Prickett S, Henstridge D, Febbraio M, et al. High Fat Diet Inhibits Dendritic Cell and T Cell Response to Allergens but Does Not Impair Inhalational Respiratory Tolerance. PLoS ONE. 2016;11:e0160407 pubmed publisher
  18. Wang S, Xia P, Chen Y, Huang G, Xiong Z, Liu J, et al. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection. Immunity. 2016;45:131-44 pubmed publisher
  19. Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S. ICOS promotes group 2 innate lymphoid cell activation in lungs. Biochem Biophys Res Commun. 2015;463:739-45 pubmed publisher
  20. Stone E, Pepper M, Katayama C, Kerdiles Y, Lai C, Emslie E, et al. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity. 2015;42:239-251 pubmed publisher
  21. Hannani D, Vétizou M, Enot D, Rusakiewicz S, Chaput N, Klatzmann D, et al. Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25. Cell Res. 2015;25:208-24 pubmed publisher
  22. Nelson M, Kundimi S, Bowers J, Rogers C, Huff L, Schwartz K, et al. The inducible costimulator augments Tc17 cell responses to self and tumor tissue. J Immunol. 2015;194:1737-47 pubmed publisher
  23. Mercadante A, Perobelli S, Alves A, Gonçalves Silva T, Mello W, Gomes Santos A, et al. Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance. J Immunol. 2014;192:1928-37 pubmed publisher
  24. Charles E, Joshi S, Ash J, Fox B, Farris A, Bzik D, et al. CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infect Immun. 2010;78:3484-92 pubmed publisher
  25. Kanzato H, Fujiwara S, Ise W, Kaminogawa S, Sato R, Hachimura S. Lactobacillus acidophilus strain L-92 induces apoptosis of antigen-stimulated T cells by modulating dendritic cell function. Immunobiology. 2008;213:399-408 pubmed publisher
  26. Nakae S, Iwakura Y, Suto H, Galli S. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol. 2007;81:1258-68 pubmed
  27. Smith P, Walsh C, Mangan N, Fallon R, Sayers J, McKenzie A, et al. Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages. J Immunol. 2004;173:1240-8 pubmed