This is a Validated Antibody Database (VAD) review about mouse Helios, based on 36 published articles (read how Labome selects the articles), using Helios antibody in all methods. It is aimed to help Labome visitors find the most suited Helios antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Helios synonym: A730095J18Rik; Helios; Zfpn1a2; Znfn1a2

Invitrogen
hamsters monoclonal (22F6)
  • flow cytometry; mouse; loading ...; fig 1b
Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on mouse samples (fig 1b). J Clin Invest (2019) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; human; loading ...; fig s3
Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on human samples (fig s3). Eur J Immunol (2019) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; loading ...; fig 1d
Invitrogen Helios antibody (eBiosciences, 22F6) was used in flow cytometry on mouse samples (fig 1d). J Exp Med (2019) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; human; loading ...; fig s2a
Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on human samples (fig s2a). Proc Natl Acad Sci U S A (2018) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; human; loading ...; fig s2a
Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on human samples (fig s2a). J Immunol (2018) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; loading ...; fig s4a
In order to study the role of hypercholesterolemia in T cell receptor signaling and regulatory T cell population, Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on mouse samples (fig s4a). Sci Rep (2017) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; human; loading ...; fig 4d
In order to detail MAIT cell responses to various microorganisms and cytokines, Invitrogen Helios antibody (eBiosciences, 22F6) was used in flow cytometry on human samples (fig 4d). Proc Natl Acad Sci U S A (2017) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; loading ...; fig 3a
Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on mouse samples (fig 3a). Immunology (2017) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; loading ...; fig 2b
In order to generate and characterize Treg-of-B cells, Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on mouse samples (fig 2b). Sci Rep (2017) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; fig s3e
In order to study the role of moesin during the generation of TGF-beta-induced T regulatory cells, Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on mouse samples (fig s3e). J Clin Invest (2017) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; 1:400; loading ...; fig 4a
In order to report a CD40-dependent mechanism capable of abrogating inducible T regulatory cell induction by dendritic cells, Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on mouse samples at 1:400 (fig 4a). Nat Commun (2017) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; loading ...; fig s4f
Invitrogen Helios antibody (eBiosciences, 12-9883-41) was used in flow cytometry on mouse samples (fig s4f). Nat Immunol (2016) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; loading ...; fig s1c
In order to explore the role of exhausted CD8 positive CXCR5 positive T cells in mice chronically infected with lymphocytic choriomeningitis virus, Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on mouse samples (fig s1c). Nature (2016) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; loading ...; fig s4
In order to report the effects of PD-L1 modulation of T cell function in graft-versus-host disease, Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on mouse samples (fig s4). J Clin Invest (2016) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; fig 4
Invitrogen Helios antibody (e-Bioscience, 17-9883) was used in flow cytometry on mouse samples (fig 4). Nat Commun (2016) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; fig 2
In order to establish that autophagy is essential for maintenance of a balanced CD4 positive intestinal T cell response, Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on mouse samples (fig 2). elife (2016) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; fig s4
Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on mouse samples (fig s4). Theranostics (2015) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; cat; loading ...; fig 4b
In order to investigate dendritic cell maturation and function and immune response dysregulation in feline FIV infection models, Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on cat samples (fig 4b). Comp Immunol Microbiol Infect Dis (2015) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; human; fig 2
In order to assess arming of MAIT cell cytolytic antimicrobial activity and induction by IL-7 and faulty in HIV-1 infection, Invitrogen Helios antibody (eBioscience, 22F6) was used in flow cytometry on human samples (fig 2). PLoS Pathog (2015) ncbi
BioLegend
hamsters monoclonal (22F6)
  • flow cytometry; mouse; loading ...; fig s6a
BioLegend Helios antibody (BioLegend, 137229) was used in flow cytometry on mouse samples (fig s6a). Immunity (2018) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; loading ...; fig 3b
BioLegend Helios antibody (BioLegend, 22F6) was used in flow cytometry on mouse samples (fig 3b). J Immunol (2018) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; human; loading ...; fig 1a
In order to develop a method to assess the capacity of human regulatory T cells to suppress IgM production from an immature human B cell line, BioLegend Helios antibody (Biolegend, 137216) was used in flow cytometry on human samples (fig 1a). J Immunol Methods (2017) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; human; loading ...; fig s7
BioLegend Helios antibody (Biolegend, 22F6) was used in flow cytometry on human samples (fig s7). Proc Natl Acad Sci U S A (2016) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; human; 1:100; fig st2
BioLegend Helios antibody (Biolegend, 137214) was used in flow cytometry on human samples at 1:100 (fig st2). Nat Commun (2016) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; fig s2
In order to describe a role for Nbn in skin homeostasis, BioLegend Helios antibody (Biolegend, 137206) was used in flow cytometry on mouse samples (fig s2). Oncotarget (2016) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; rhesus macaque; fig 3c
BioLegend Helios antibody (BioLegend, 22F6) was used in flow cytometry on rhesus macaque samples (fig 3c). J Immunol (2016) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse
In order to investigate the induction and role of Tregs during the early pre-patent larval stage of infection with Schistosoma mansoni, BioLegend Helios antibody (Biolegend, 22F6) was used in flow cytometry on mouse samples . Infect Immun (2015) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; human; fig 3
BioLegend Helios antibody (BioLegend, 22F6) was used in flow cytometry on human samples (fig 3). J Autoimmun (2015) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse
BioLegend Helios antibody (BioLegend, 22F6) was used in flow cytometry on mouse samples . Sci Rep (2015) ncbi
hamsters monoclonal (22F6)
  • immunocytochemistry; human
BioLegend Helios antibody (BioLegend, 22F6) was used in immunocytochemistry on human samples . Dev Comp Immunol (2015) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse
In order to examine the role of lymph node stromal cells in immune responses, BioLegend Helios antibody (Biolegend, 22F6) was used in flow cytometry on mouse samples . elife (2014) ncbi
hamsters monoclonal (22F6)
In order to study the role of CD93 molecule in mature dendritic cells and T cells, BioLegend Helios antibody (BioLegend, 22F6) was used . Immunobiology (2015) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse; fig 5
BioLegend Helios antibody (Biolegend, 22F6) was used in flow cytometry on mouse samples (fig 5). PLoS ONE (2014) ncbi
hamsters monoclonal (22F6)
BioLegend Helios antibody (BioLegend, 22F6) was used . Immunol Cell Biol (2014) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; human
BioLegend Helios antibody (Biolegend, clone 22F6) was used in flow cytometry on human samples . Mol Ther (2014) ncbi
hamsters monoclonal (22F6)
  • flow cytometry; mouse
BioLegend Helios antibody (BioLegend, 22F6) was used in flow cytometry on mouse samples . J Immunol (2014) ncbi
Articles Reviewed
  1. Visekruna A, Hartmann S, Sillke Y, Glauben R, Fischer F, Raifer H, et al. Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells. J Clin Invest. 2019;129:1972-1983 pubmed publisher
  2. Remmerswaal E, Hombrink P, Nota B, Pircher H, ten Berge I, van Lier R, et al. Expression of IL-7Rα and KLRG1 defines functionally distinct CD8+ T-cell populations in humans. Eur J Immunol. 2019;49:694-708 pubmed publisher
  3. Xing S, Gai K, Li X, Shao P, Zeng Z, Zhao X, et al. Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. J Exp Med. 2019;: pubmed publisher
  4. Dias J, Boulouis C, Gorin J, van den Biggelaar R, Lal K, Gibbs A, et al. The CD4-CD8- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool. Proc Natl Acad Sci U S A. 2018;115:E11513-E11522 pubmed publisher
  5. Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F, Liniany L, Knight D, et al. PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells. Immunity. 2018;49:247-263.e7 pubmed publisher
  6. Mittelstadt P, Taves M, Ashwell J. Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection. J Immunol. 2018;200:1988-1994 pubmed publisher
  7. Amodio D, Cotugno N, Macchiarulo G, Rocca S, Dimopoulos Y, Castrucci M, et al. Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination. J Immunol. 2018;200:538-550 pubmed publisher
  8. Mailer R, Gisterå A, Polyzos K, Ketelhuth D, Hansson G. Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. Sci Rep. 2017;7:15655 pubmed publisher
  9. Dias J, Leeansyah E, Sandberg J. Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines. Proc Natl Acad Sci U S A. 2017;114:E5434-E5443 pubmed publisher
  10. Meinicke H, Bremser A, Brack M, Akeus P, Pearson C, Bullers S, et al. Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Immunology. 2017;152:74-88 pubmed publisher
  11. Chien C, Yu H, Chen S, Chiang B. Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells. Sci Rep. 2017;7:46348 pubmed publisher
  12. Ansa Addo E, Zhang Y, Yang Y, Hussey G, Howley B, Salem M, et al. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. J Clin Invest. 2017;127:1321-1337 pubmed publisher
  13. Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, et al. CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis. Nat Commun. 2017;8:14715 pubmed publisher
  14. Weingartner E, Courneya J, Keegan A, Golding A. A novel method for assaying human regulatory T cell direct suppression of B cell effector function. J Immunol Methods. 2017;441:1-7 pubmed publisher
  15. Peters C, Häsler R, Wesch D, Kabelitz D. Human Vδ2 T cells are a major source of interleukin-9. Proc Natl Acad Sci U S A. 2016;113:12520-12525 pubmed
  16. Gerriets V, Kishton R, Johnson M, Cohen S, Siska P, Nichols A, et al. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nat Immunol. 2016;17:1459-1466 pubmed publisher
  17. He R, Hou S, Liu C, Zhang A, Bai Q, Han M, et al. Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection. Nature. 2016;537:412-428 pubmed publisher
  18. Brinkman C, Iwami D, Hritzo M, Xiong Y, Ahmad S, Simon T, et al. Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration. Nat Commun. 2016;7:12021 pubmed publisher
  19. Saha A, O Connor R, Thangavelu G, Lovitch S, Dandamudi D, Wilson C, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016;126:2642-60 pubmed publisher
  20. Seidel P, Remus M, Delacher M, Grigaravicius P, Reuss D, Frappart L, et al. Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis. Oncotarget. 2016;7:23006-18 pubmed publisher
  21. Rueda C, Presicce P, Jackson C, Miller L, Kallapur S, Jobe A, et al. Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque. J Immunol. 2016;196:3706-15 pubmed publisher
  22. Tosiek M, Fiette L, El Daker S, Eberl G, Freitas A. IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease. Nat Commun. 2016;7:10888 pubmed publisher
  23. Kabat A, Harrison O, Riffelmacher T, Moghaddam A, Pearson C, Laing A, et al. The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. elife. 2016;5:e12444 pubmed publisher
  24. Kim J, Phan T, Nguyen V, Dinh Vu H, Zheng J, Yun M, et al. Salmonella typhimurium Suppresses Tumor Growth via the Pro-Inflammatory Cytokine Interleukin-1β. Theranostics. 2015;5:1328-42 pubmed publisher
  25. Zhang L, Reckling S, Dean G. Phenotypic and functional analysis of CD1a+ dendritic cells from cats chronically infected with feline immunodeficiency virus. Comp Immunol Microbiol Infect Dis. 2015;42:53-9 pubmed publisher
  26. Leeansyah E, Svärd J, Dias J, Buggert M, Nyström J, Quigley M, et al. Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection. PLoS Pathog. 2015;11:e1005072 pubmed publisher
  27. Redpath S, Van Der Werf N, MacDonald A, Maizels R, Taylor M. Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase. Infect Immun. 2015;83:3881-9 pubmed publisher
  28. Rissiek A, Baumann I, Cuapio A, Mautner A, Kolster M, Arck P, et al. The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation. J Autoimmun. 2015;58:12-20 pubmed publisher
  29. Singh K, Hjort M, Thorvaldson L, Sandler S. Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice. Sci Rep. 2015;5:7767 pubmed publisher
  30. Käser T, Mair K, Hammer S, Gerner W, Saalmüller A. Natural and inducible Tregs in swine: Helios expression and functional properties. Dev Comp Immunol. 2015;49:323-31 pubmed publisher
  31. Baptista A, Roozendaal R, Reijmers R, Koning J, Unger W, Greuter M, et al. Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation. elife. 2014;3: pubmed publisher
  32. Kreiser S, Eckhardt J, Kuhnt C, Stein M, Krzyzak L, Seitz C, et al. Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo. Immunobiology. 2015;220:270-9 pubmed publisher
  33. Berod L, Stüve P, Varela F, Behrends J, Swallow M, Kruse F, et al. Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity. PLoS ONE. 2014;9:e102804 pubmed publisher
  34. Bedke T, Iannitti R, De Luca A, Giovannini G, Fallarino F, Berges C, et al. Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and mice. Immunol Cell Biol. 2014;92:659-70 pubmed publisher
  35. Ito S, Bollard C, Carlsten M, Melenhorst J, Biancotto A, Wang E, et al. Ultra-low dose interleukin-2 promotes immune-modulating function of regulatory T cells and natural killer cells in healthy volunteers. Mol Ther. 2014;22:1388-1395 pubmed publisher
  36. Kim E, Gasper D, Lee S, Plisch E, Svaren J, Suresh M. Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice. J Immunol. 2014;192:985-95 pubmed publisher