This is a Validated Antibody Database (VAD) review about mouse Fyn, based on 38 published articles (read how Labome selects the articles), using Fyn antibody in all methods. It is aimed to help Labome visitors find the most suited Fyn antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Fyn synonym: AI448320; AW552119

Knockout validation
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1g
  • western blot; rat; loading ...; fig 1e
In order to probe the interaction between STEP and PSD-95, Cell Signaling Technology Fyn antibody (Cell Signaling, 4023) was used in western blot knockout validation on mouse samples (fig 1g) and in western blot on rat samples (fig 1e). Proc Natl Acad Sci U S A (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (15)
  • western blot; mouse; 1:1000; loading ...; fig 4b
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-434) was used in western blot on mouse samples at 1:1000 (fig 4b). Cell Rep Med (2022) ncbi
mouse monoclonal (15)
  • western blot; mouse; 1:200; loading ...; fig 4g
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-434) was used in western blot on mouse samples at 1:200 (fig 4g). Front Pharmacol (2020) ncbi
mouse monoclonal (E-3)
  • western blot; human; loading ...; fig 3c
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, SC-365913) was used in western blot on human samples (fig 3c). Redox Biol (2017) ncbi
mouse monoclonal
  • western blot; human; 1:1000; loading ...; fig s9b
In order to examine whether p140Cap protein levels in ERBB2-amplified breast cancer patients correlate with survival, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, B-12) was used in western blot on human samples at 1:1000 (fig s9b). Nat Commun (2017) ncbi
mouse monoclonal (B-12)
  • western blot; human; 1:1000; loading ...; fig s9b
In order to examine whether p140Cap protein levels in ERBB2-amplified breast cancer patients correlate with survival, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, B-12) was used in western blot on human samples at 1:1000 (fig s9b). Nat Commun (2017) ncbi
mouse monoclonal (E-12)
  • western blot; human; fig s17b
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-271294) was used in western blot on human samples (fig s17b). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (B-12)
  • western blot; rat; loading ...
In order to examine the impact of ischemia/reperfusion injury on sodium potassium ATPase enzymatic and signaling functions, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, Sc-8056) was used in western blot on rat samples . Physiol Rep (2016) ncbi
mouse monoclonal (E-3)
  • western blot; human; loading ...; fig 4c
In order to characterize the molecular changes involved in human aortic smooth muscle cell proliferation, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, SC-365913) was used in western blot on human samples (fig 4c). Sci Rep (2016) ncbi
mouse monoclonal (B-12)
  • western blot; human; fig 2
In order to determine an enrichment in insulin-like growth factor I receptor, c-Src, G-protein-coupled receptor kinases, and focal adhesion kinase in porstate cancer cell exosomes, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc8056) was used in western blot on human samples (fig 2). J Cell Biochem (2017) ncbi
mouse monoclonal (B-12)
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
  • immunoprecipitation; human; 1:50; fig 4
  • immunocytochemistry; human; 1:100; fig 4
  • western blot; human; 1:200; fig 1
In order to study improvement of the pathology of hypertrophic scar by simultaneous deactivation of FAK and Src, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in immunohistochemistry - paraffin section on human samples at 1:50 (fig 1), in immunoprecipitation on human samples at 1:50 (fig 4), in immunocytochemistry on human samples at 1:100 (fig 4) and in western blot on human samples at 1:200 (fig 1). Sci Rep (2016) ncbi
mouse monoclonal (B-12)
  • western blot; human; 1:200; fig 1
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056;) was used in western blot on human samples at 1:200 (fig 1). Int J Mol Med (2016) ncbi
mouse monoclonal (B-12)
  • western blot; rat; loading ...; fig 8a
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc8056) was used in western blot on rat samples (fig 8a). J Cell Mol Med (2016) ncbi
mouse monoclonal (15)
  • western blot; rat
In order to study how BDNF activation and phosphorylation of Fyn regulate oligodendrocyte myelination, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotech, sc-434) was used in western blot on rat samples . Glia (2016) ncbi
mouse monoclonal (B-12)
  • immunocytochemistry; mouse
In order to investigate the molecular mechanisms involved in TASK1 internalization in PC12 cells, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in immunocytochemistry on mouse samples . Am J Physiol Cell Physiol (2015) ncbi
mouse monoclonal (B-12)
  • western blot; human
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056) was used in western blot on human samples . Mol Cell Endocrinol (2015) ncbi
mouse monoclonal (B-12)
  • western blot; human; 1:1000; fig 5
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056 B-12) was used in western blot on human samples at 1:1000 (fig 5). PLoS ONE (2015) ncbi
mouse monoclonal (B-12)
  • immunohistochemistry - paraffin section; human; 1:50
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc8056) was used in immunohistochemistry - paraffin section on human samples at 1:50. Exp Dermatol (2015) ncbi
mouse monoclonal (B-12)
  • immunocytochemistry; human; 1:50
  • western blot; human; 1:200
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, Sc-8056) was used in immunocytochemistry on human samples at 1:50 and in western blot on human samples at 1:200. Cell Signal (2015) ncbi
mouse monoclonal (B-12)
  • western blot; mouse; fig 8
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in western blot on mouse samples (fig 8). J Neurosci (2015) ncbi
mouse monoclonal (FYN-59)
  • western blot; human; loading ...; fig 2c
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, SC-73388) was used in western blot on human samples (fig 2c). Mol Carcinog (2015) ncbi
mouse monoclonal (B-12)
  • western blot; pigs
In order to study the effect of ouabain on Src kinase and Na(+)/K(+)-ATPase, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in western blot on pigs samples . Biochem Biophys Res Commun (2014) ncbi
mouse monoclonal (B-12)
  • immunohistochemistry - paraffin section; human; 1:150
  • immunoprecipitation; human
  • western blot; human; 1:1000
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056) was used in immunohistochemistry - paraffin section on human samples at 1:150, in immunoprecipitation on human samples and in western blot on human samples at 1:1000. Int J Cancer (2014) ncbi
mouse monoclonal (B-12)
  • western blot; human
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in western blot on human samples . Eur J Cancer (2014) ncbi
mouse monoclonal (B-12)
  • western blot; mouse
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056) was used in western blot on mouse samples . J Hepatol (2014) ncbi
mouse monoclonal (15)
  • immunoprecipitation; human
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-434) was used in immunoprecipitation on human samples . J Biol Chem (2013) ncbi
Abcam
domestic rabbit monoclonal (EPR5500)
  • western blot; mouse; 1:3000; loading ...; fig 3e
Abcam Fyn antibody (Abcam, ab125016) was used in western blot on mouse samples at 1:3000 (fig 3e). Front Aging Neurosci (2019) ncbi
domestic rabbit monoclonal (EPR5500)
  • western blot; rat
In order to determine the role of miR-125a-3p and Fyn in granulosa cells, Abcam Fyn antibody (Abcam, ab125016) was used in western blot on rat samples . FASEB J (2015) ncbi
mouse monoclonal (FYN-01)
  • western blot; human; 1:1000; tbl 4
Abcam Fyn antibody (Abcam, AB1881) was used in western blot on human samples at 1:1000 (tbl 4). Methods Mol Biol (2014) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4b
Cell Signaling Technology Fyn antibody (Cell Signaling, 4023) was used in western blot on mouse samples (fig 4b). Cell Rep Med (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 2a
Cell Signaling Technology Fyn antibody (Cell Signaling, 4023) was used in western blot on mouse samples (fig 2a). iScience (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig s4b
Cell Signaling Technology Fyn antibody (Cell Signaling, 4023) was used in western blot on mouse samples at 1:1000 (fig s4b). Acta Neuropathol Commun (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 7f
Cell Signaling Technology Fyn antibody (Cell Signaling, 4023T) was used in western blot on human samples (fig 7f). Science (2019) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; 1:500; loading ...; fig 4a
Cell Signaling Technology Fyn antibody (CST, 4023) was used in immunocytochemistry on mouse samples at 1:500 (fig 4a). elife (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 2g
Cell Signaling Technology Fyn antibody (Cell Signaling Technology, 4023S) was used in western blot on mouse samples at 1:1000 (fig 2g). J Neurosci (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 6c
Cell Signaling Technology Fyn antibody (Cell Signaling, 4023) was used in western blot on mouse samples at 1:1000 (fig 6c). Nat Commun (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 6a
  • western blot; pigs ; loading ...; fig 5j
In order to study amyloid precursor protein Tyr phosphorylation in mouse model of Alzheimer's disease, Cell Signaling Technology Fyn antibody (Cell Signaling, 4023) was used in western blot on human samples (fig 6a) and in western blot on pigs samples (fig 5j). Front Mol Neurosci (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:200; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology Fyn antibody (Cell Signaling, 4023P) was used in western blot on human samples at 1:200 (fig st1). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1g
  • western blot; rat; loading ...; fig 1e
In order to probe the interaction between STEP and PSD-95, Cell Signaling Technology Fyn antibody (Cell Signaling, 4023) was used in western blot knockout validation on mouse samples (fig 1g) and in western blot on rat samples (fig 1e). Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 1
Cell Signaling Technology Fyn antibody (Cell signaling, 4023) was used in western blot on human samples (fig 1). FASEB J (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:3000; fig 8
In order to study kinase DYRK1A selective inhibition by targeting its folding process, Cell Signaling Technology Fyn antibody (Cell Signaling Technology, 4023BC) was used in western blot on human samples at 1:3000 (fig 8). Nat Commun (2016) ncbi
Articles Reviewed
  1. Shiwaku H, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, et al. Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice. Cell Rep Med. 2022;3:100597 pubmed publisher
  2. Amaral A, Perez Nievas B, Siao Tick Chong M, González Martínez A, Argente Escrig H, Rubio Guerra S, et al. Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation. iScience. 2021;24:102058 pubmed publisher
  3. Tang S, Fesharaki Zadeh A, Takahashi H, Nies S, Smith L, Luo A, et al. Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy. Acta Neuropathol Commun. 2020;8:96 pubmed publisher
  4. Tan Y, Xu Y, Cheng C, Zheng C, Zeng W, Wang J, et al. LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP. Front Pharmacol. 2020;11:183 pubmed publisher
  5. Yao X, Xian X, Fang M, Fan S, Li W. Loss of miR-369 Promotes Tau Phosphorylation by Targeting the Fyn and Serine/Threonine-Protein Kinase 2 Signaling Pathways in Alzheimer's Disease Mice. Front Aging Neurosci. 2019;11:365 pubmed publisher
  6. Timms R, Zhang Z, Rhee D, Harper J, Koren I, Elledge S. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science. 2019;365: pubmed publisher
  7. Padmanabhan P, Martínez Mármol R, Xia D, Götz J, Meunier F. Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. elife. 2019;8: pubmed publisher
  8. Salazar S, Cox T, Lee S, Brody A, Chyung A, Haas L, et al. Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss. J Neurosci. 2019;39:758-772 pubmed publisher
  9. Kim H, Mun Y, Lee K, Park Y, Park J, Park J, et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018;9:3630 pubmed publisher
  10. Poulsen E, Iannuzzi F, Rasmussen H, Maier T, Enghild J, Jørgensen A, et al. An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients. Front Mol Neurosci. 2017;10:59 pubmed publisher
  11. Chattopadhyay R, Raghavan S, Rao G. Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function. Redox Biol. 2017;12:438-455 pubmed publisher
  12. Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, et al. The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries. Nat Commun. 2017;8:14797 pubmed publisher
  13. Sanchez Martin M, Ambesi Impiombato A, Qin Y, Herranz D, Bansal M, Girardi T, et al. Synergistic antileukemic therapies in NOTCH1-induced T-ALL. Proc Natl Acad Sci U S A. 2017;114:2006-2011 pubmed publisher
  14. Belliard A, Gulati G, Duan Q, Alves R, Brewer S, Madan N, et al. Ischemia/reperfusion-induced alterations of enzymatic and signaling functions of the rat cardiac Na+/K+-ATPase: protection by ouabain preconditioning. Physiol Rep. 2016;4: pubmed
  15. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  16. Won S, Incontro S, Nicoll R, Roche K. PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61. Proc Natl Acad Sci U S A. 2016;113:E4736-44 pubmed publisher
  17. Janjanam J, Rao G. Novel role of cortactin in G protein-coupled receptor agonist-induced nuclear export and degradation of p21Cip1. Sci Rep. 2016;6:28687 pubmed publisher
  18. Subramaniam S, Ozdener M, Abdoul Azize S, Saito K, Malik B, Maquart G, et al. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J. 2016;30:3489-3500 pubmed
  19. DeRita R, Zerlanko B, Singh A, Lu H, Iozzo R, Benovic J, et al. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes. J Cell Biochem. 2017;118:66-73 pubmed publisher
  20. Su L, Li X, Wu X, Hui B, Han S, Gao J, et al. Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar. Sci Rep. 2016;6:26023 pubmed publisher
  21. Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, et al. Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016;7:11391 pubmed publisher
  22. Wu X, Yang L, Zheng Z, Li Z, Shi J, Li Y, et al. Src promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway. Int J Mol Med. 2016;37:639-48 pubmed publisher
  23. Peng K, Tian X, Qian Y, Skibba M, Zou C, Liu Z, et al. Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II. J Cell Mol Med. 2016;20:482-94 pubmed publisher
  24. Peckham H, Giuffrida L, Wood R, Gonsalvez D, Ferner A, Kilpatrick T, et al. Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination. Glia. 2016;64:255-69 pubmed publisher
  25. Matsuoka H, Inoue M. Src mediates endocytosis of TWIK-related acid-sensitive K+ 1 channels in PC12 cells in response to nerve growth factor. Am J Physiol Cell Physiol. 2015;309:C251-63 pubmed publisher
  26. Grossman H, Chuderland D, Ninio Many L, Hasky N, Kaplan Kraicer R, Shalgi R. A novel regulatory pathway in granulosa cells, the LH/human chorionic gonadotropin-microRNA-125a-3p-Fyn pathway, is required for ovulation. FASEB J. 2015;29:3206-16 pubmed publisher
  27. Chien P, Lin C, Hsiao L, Yang C. c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. Mol Cell Endocrinol. 2015;409:59-72 pubmed publisher
  28. Carnesecchi J, Malbouyres M, de Mets R, Balland M, Beauchef G, Vié K, et al. Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30. PLoS ONE. 2015;10:e0120672 pubmed publisher
  29. Choi C, Kim Y, Sohn J, Lee H, Kim W. Focal adhesion kinase and Src expression in premalignant and malignant skin lesions. Exp Dermatol. 2015;24:361-4 pubmed publisher
  30. Tamilzhalagan S, Muthuswami M, Periasamy J, Lee M, Rha S, Tan P, et al. Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. Cell Signal. 2015;27:1075-86 pubmed publisher
  31. Sheng L, Leshchyns ka I, Sytnyk V. Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels. J Neurosci. 2015;35:1739-52 pubmed publisher
  32. Cox S. Intracellular signaling of CTLs. Methods Mol Biol. 2014;1186:49-63 pubmed publisher
  33. Fenton S, Hutchens K, Denning M. Targeting Fyn in Ras-transformed cells induces F-actin to promote adherens junction-mediated cell-cell adhesion. Mol Carcinog. 2015;54:1181-93 pubmed publisher
  34. Gable M, Abdallah S, Najjar S, Liu L, Askari A. Digitalis-induced cell signaling by the sodium pump: on the relation of Src to Na(+)/K(+)-ATPase. Biochem Biophys Res Commun. 2014;446:1151-4 pubmed publisher
  35. Bouchekioua Bouzaghou K, Poulard C, Rambaud J, Lavergne E, Hussein N, Billaud M, et al. LKB1 when associated with methylatedER? is a marker of bad prognosis in breast cancer. Int J Cancer. 2014;135:1307-18 pubmed publisher
  36. Cao M, Hou D, Liang H, Gong F, Wang Y, Yan X, et al. miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signalling inhibitor 1. Eur J Cancer. 2014;50:1013-24 pubmed publisher
  37. Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, et al. PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-?B. J Hepatol. 2014;60:306-12 pubmed publisher
  38. Corvetta D, Chayka O, Gherardi S, D Acunto C, Cantilena S, Valli E, et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem. 2013;288:8332-41 pubmed publisher