This is a Validated Antibody Database (VAD) review about mouse Fus, based on 5 published articles (read how Labome selects the articles), using Fus antibody in all methods. It is aimed to help Labome visitors find the most suited Fus antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Fus synonym: D430004D17Rik; D930039C12Rik; Fus1; Tls; RNA-binding protein FUS; fusion, derived from t(12;16) malignant liposarcoma; hnRNP P2; pigpen protein; protein pigpen; translocated in liposarcoma

Knockout validation
Abcam
rabbit polyclonal
  • immunocytochemistry knockout validation; mouse; fig 1
In order to study the role of loss of spliceosome integrity in the development of amyotrophic lateral sclerosis and spinal muscular atrophy, Abcam Fus antibody (Abcam, 70381) was used in immunocytochemistry knockout validation on mouse samples (fig 1). EMBO Mol Med (2013) ncbi
Abcam
rabbit polyclonal
  • immunocytochemistry; common platanna; loading ...; fig 3c
Abcam Fus antibody (Abcam, ab70381) was used in immunocytochemistry on common platanna samples (fig 3c). Neuron (2018) ncbi
rabbit polyclonal
  • western blot; human; fig 5
Abcam Fus antibody (Abcam, ab23439) was used in western blot on human samples (fig 5). Nucleic Acids Res (2015) ncbi
rabbit polyclonal
  • western blot; human; fig 1
Abcam Fus antibody (Abcam, ab23439) was used in western blot on human samples (fig 1). Nat Neurosci (2013) ncbi
rabbit polyclonal
  • immunocytochemistry knockout validation; mouse; fig 1
In order to study the role of loss of spliceosome integrity in the development of amyotrophic lateral sclerosis and spinal muscular atrophy, Abcam Fus antibody (Abcam, 70381) was used in immunocytochemistry knockout validation on mouse samples (fig 1). EMBO Mol Med (2013) ncbi
Invitrogen
rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig 3a
  • western blot; mouse; 1:1000; loading ...; fig 1b
In order to test if neuronal loss is caused by toxic gain-of-function cytoplasmic aggregates or loss of nuclear RNA-binding protein function in patients with sporadic and familial amyotrophic lateral sclerosis, Invitrogen Fus antibody (Thermo Fischer Scientific, PA5-23696) was used in immunohistochemistry on mouse samples (fig 3a) and in western blot on mouse samples at 1:1000 (fig 1b). Brain (2016) ncbi
Articles Reviewed
  1. Cagnetta R, Frese C, Shigeoka T, Krijgsveld J, Holt C. Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome. Neuron. 2018;99:29-46.e4 pubmed publisher
  2. Shiihashi G, Ito D, Yagi T, Nihei Y, Ebine T, Suzuki N. Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice. Brain. 2016;139:2380-94 pubmed publisher
  3. Shen W, Liang X, Sun H, Crooke S. 2'-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF. Nucleic Acids Res. 2015;43:4569-78 pubmed publisher
  4. Chesi A, Staahl B, Jovicic A, Couthouis J, Fasolino M, Raphael A, et al. Exome sequencing to identify de novo mutations in sporadic ALS trios. Nat Neurosci. 2013;16:851-5 pubmed publisher
  5. Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, et al. Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. EMBO Mol Med. 2013;5:221-34 pubmed publisher