This is a Validated Antibody Database (VAD) review about mouse Fosl1, based on 20 published articles (read how Labome selects the articles), using Fosl1 antibody in all methods. It is aimed to help Labome visitors find the most suited Fosl1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Fosl1 synonym: AW538199; Fra1; fra-1; fos-related antigen 1

Santa Cruz Biotechnology
mouse monoclonal (E-8)
  • western blot; zebrafish ; 1:100; loading ...; fig 4k
Santa Cruz Biotechnology Fosl1 antibody (SantaCruz, sc-166940X) was used in western blot on zebrafish samples at 1:100 (fig 4k). Genetics (2017) ncbi
mouse monoclonal (C-10)
  • immunohistochemistry; mouse; loading ...; fig 1b
Santa Cruz Biotechnology Fosl1 antibody (SantaCruz, SC-271243) was used in immunohistochemistry on mouse samples (fig 1b). Neuron (2017) ncbi
mouse monoclonal (C-12)
  • chromatin immunoprecipitation; human; loading ...; fig 4c
In order to determine that the transcriptional activities of liver X receptor alpha and beta are activated by raffinose, Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-28310) was used in chromatin immunoprecipitation on human samples (fig 4c). Sci Rep (2017) ncbi
mouse monoclonal (B-10)
  • western blot; human; fig 3a
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-48424) was used in western blot on human samples (fig 3a). Biosci Rep (2017) ncbi
mouse monoclonal (D-3)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 2g; 5c
  • immunohistochemistry; human; 1:200; fig 3i; 5b
  • western blot; human; 1:500; loading ...; fig S5d
In order to report FOSL1 as a common transcriptional signature across mutant KRAS cancers of distinct tissue origin, Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-376148) was used in immunohistochemistry on mouse samples at 1:500 (fig 2g; 5c), in immunohistochemistry on human samples at 1:200 (fig 3i; 5b) and in western blot on human samples at 1:500 (fig S5d). Nat Commun (2017) ncbi
mouse monoclonal (C-10)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4a
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz Biotechnology, sc-271243) was used in immunohistochemistry on mouse samples at 1:500 (fig 4a). Dis Model Mech (2017) ncbi
mouse monoclonal (C-12)
  • chromatin immunoprecipitation; human; loading ...; fig 1g
  • western blot; human; loading ...; fig 1j
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-28310) was used in chromatin immunoprecipitation on human samples (fig 1g) and in western blot on human samples (fig 1j). Cell Death Dis (2016) ncbi
mouse monoclonal (C-10)
  • western blot; human; 1:1000; fig 4
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-271243) was used in western blot on human samples at 1:1000 (fig 4). Mol Med Rep (2016) ncbi
mouse monoclonal (E-8)
  • western blot; human; loading ...; fig 9a
In order to demonstrate that both Ras and Rap1 are required for cyclic adenosine monophosphate signaling to extracellular signal-regulated kinase, Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-166940) was used in western blot on human samples (fig 9a). J Biol Chem (2016) ncbi
mouse monoclonal (C-12)
  • immunoprecipitation; human; fig 2d
  • western blot; human; fig 2d
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-28310) was used in immunoprecipitation on human samples (fig 2d) and in western blot on human samples (fig 2d). Oncotarget (2016) ncbi
mouse monoclonal (C-12)
  • western blot; human; 1:500; fig 5
In order to research induction of epithelial-to-mesenchymal transition by Polo-like kinase 1 and promotion of epithelial cell motility by activating CRAF/ERK signaling, Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-28310) was used in western blot on human samples at 1:500 (fig 5). elife (2016) ncbi
mouse monoclonal (6-2H-2F)
  • western blot; mouse; fig 5
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-447) was used in western blot on mouse samples (fig 5). Int J Mol Med (2016) ncbi
mouse monoclonal (C-12)
  • immunohistochemistry - paraffin section; human; 1:200; fig 2
  • western blot; human; fig 2
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-28310) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 2) and in western blot on human samples (fig 2). Oncotarget (2015) ncbi
mouse monoclonal (6-2H-2F)
  • EMSA; human; loading ...; fig 4b
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz Biotechnology, sc-447) was used in EMSA on human samples (fig 4b). Int J Mol Med (2015) ncbi
mouse monoclonal (6-2H-2F)
  • western blot; human; fig 2
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-447) was used in western blot on human samples (fig 2). Arch Med Sci (2015) ncbi
mouse monoclonal (E-8)
  • immunohistochemistry - paraffin section; rat; 1:5000
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz, sc-166940) was used in immunohistochemistry - paraffin section on rat samples at 1:5000. Neuroscience (2015) ncbi
mouse monoclonal (C-12)
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3c
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz Biotechnology, C12) was used in immunohistochemistry on mouse samples at 1:100 (fig 3c). Development (2014) ncbi
mouse monoclonal (C-10)
  • EMSA; human
Santa Cruz Biotechnology Fosl1 antibody (Santa Cruz Biotechnology, sc271243) was used in EMSA on human samples . Int Immunol (2014) ncbi
Cell Signaling Technology
rabbit monoclonal (D22B1)
  • western blot; human; 1:1000; loading ...; fig 2b;
In order to report FOSL1 as a common transcriptional signature across mutant KRAS cancers of distinct tissue origin, Cell Signaling Technology Fosl1 antibody (Cell Signaling, 5841) was used in western blot on human samples at 1:1000 (fig 2b;). Nat Commun (2017) ncbi
rabbit monoclonal (D22B1)
  • western blot; human; fig 3b
Cell Signaling Technology Fosl1 antibody (Cell Signaling, 5841) was used in western blot on human samples (fig 3b). Oncotarget (2016) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 2a
Cell Signaling Technology Fosl1 antibody (Cell Signaling, 3880) was used in western blot on human samples (fig 2a). Oncotarget (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; fig 5
In order to assess the interaction between Ezh2 and ERK1/2 with Fra-2/AP-1 and regulation of terminal epidermal differentiation, Cell Signaling Technology Fosl1 antibody (Cell Signaling, 3880) was used in western blot on mouse samples at 1:1000 (fig 5). Genes Dev (2015) ncbi
Articles Reviewed
  1. Pena I, Roussel Y, Daniel K, Mongeon K, Johnstone D, Weinschutz Mendes H, et al. Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency. Genetics. 2017;207:1501-1518 pubmed publisher
  2. Liu J, Conde K, Zhang P, Lilascharoen V, Xu Z, Lim B, et al. Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus. Neuron. 2017;96:897-909.e5 pubmed publisher
  3. Na T, Kim G, Oh H, Lee M, Han Y, Kim K, et al. The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor. Sci Rep. 2017;7:43823 pubmed publisher
  4. Zhang L, Liu H, Mu X, Cui J, Peng Z. Dysregulation of Fra1 expression by Wnt/β-catenin signalling promotes glioma aggressiveness through epithelial-mesenchymal transition. Biosci Rep. 2017;37: pubmed publisher
  5. Vallejo A, Perurena N, Guruceaga E, Mazur P, Martínez Canarias S, Zandueta C, et al. An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. Nat Commun. 2017;8:14294 pubmed publisher
  6. Ladrón de Guevara Miranda D, Millón C, Rosell Valle C, Pérez Fernández M, Missiroli M, Serrano A, et al. Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. Dis Model Mech. 2017;10:323-336 pubmed publisher
  7. Wu J, Sun Y, Zhang P, Qian M, Zhang H, Chen X, et al. The Fra-1-miR-134-SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells. Cell Death Dis. 2016;7:e2384 pubmed publisher
  8. Shang W, Zhao L, Dong X, Zhao Z, Li J, Zhang B, et al. Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways. Mol Med Rep. 2016;14:3620-6 pubmed publisher
  9. Li Y, Dillon T, Takahashi M, Earley K, Stork P. Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP. J Biol Chem. 2016;291:21584-21595 pubmed
  10. Hanson R, Brown R, Steele M, Grandgenett P, Grunkemeyer J, Hollingsworth M. Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis. Oncotarget. 2016;7:39996-40011 pubmed publisher
  11. Wu J, Ivanov A, Fisher P, Fu Z. Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling. elife. 2016;5: pubmed publisher
  12. Kim J, Kim E, Lee B, Min J, Song D, Lim J, et al. The effects of Lycii Radicis Cortex on RANKL-induced osteoclast differentiation and activation in RAW 264.7 cells. Int J Mol Med. 2016;37:649-58 pubmed publisher
  13. Iskit S, Schlicker A, Wessels L, Peeper D. Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival. Oncotarget. 2015;6:43146-61 pubmed publisher
  14. Liu B, Wu S, Han L, Zhang C. β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Int J Mol Med. 2015;36:1572-82 pubmed publisher
  15. Lan G, Yang L, Xie X, Peng L, Wang Y. MicroRNA-490-5p is a novel tumor suppressor targeting c-FOS in human bladder cancer. Arch Med Sci. 2015;11:561-9 pubmed publisher
  16. Qiao Y, Shiue C, Zhu J, Zhuang T, Jonsson P, Wright A, et al. AP-1-mediated chromatin looping regulates ZEB2 transcription: new insights into TNFα-induced epithelial-mesenchymal transition in triple-negative breast cancer. Oncotarget. 2015;6:7804-14 pubmed
  17. Liu W, Crews F. Adolescent intermittent ethanol exposure enhances ethanol activation of the nucleus accumbens while blunting the prefrontal cortex responses in adult rat. Neuroscience. 2015;293:92-108 pubmed publisher
  18. Wurm S, Zhang J, Guinea Viniegra J, García F, Muñoz J, Bakiri L, et al. Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes Dev. 2015;29:144-56 pubmed publisher
  19. Delgado Olguín P, Dang L, He D, Thomas S, Chi L, Sukonnik T, et al. Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. Development. 2014;141:4610-7 pubmed publisher
  20. Davidson C, Cameron L, Burshtyn D. The AP-1 transcription factor JunD activates the leukocyte immunoglobulin-like receptor 1 distal promoter. Int Immunol. 2014;26:21-33 pubmed publisher