This is a Validated Antibody Database (VAD) review about mouse Erbb4, based on 28 published articles (read how Labome selects the articles), using Erbb4 antibody in all methods. It is aimed to help Labome visitors find the most suited Erbb4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Erbb4 synonym: Her4; c-erbB-4

Abcam
mouse monoclonal (HFR-1)
  • immunohistochemistry - paraffin section; human; 1:150; loading ...; fig 2
Abcam Erbb4 antibody (Abcam, ab19391) was used in immunohistochemistry - paraffin section on human samples at 1:150 (fig 2). BMC Cancer (2020) ncbi
  • western blot; rat; 1:500; fig 5a
Abcam Erbb4 antibody (Abcam, ab61059) was used in western blot on rat samples at 1:500 (fig 5a). Biomed Res Int (2019) ncbi
domestic rabbit monoclonal (E200)
  • western blot; human; 1:1000; loading ...; fig 5i
Abcam Erbb4 antibody (Abcam, E200) was used in western blot on human samples at 1:1000 (fig 5i). Cell Mol Life Sci (2019) ncbi
domestic rabbit monoclonal (E200)
  • flow cytometry; human; 1:40; loading ...; fig 5a
In order to observe a novel role for ErbB4 in macrophage apoptosis, Abcam Erbb4 antibody (Abcam, ab32375) was used in flow cytometry on human samples at 1:40 (fig 5a). Cell Death Dis (2017) ncbi
domestic rabbit monoclonal (EPR2273(2))
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5a
Abcam Erbb4 antibody (Abcam, ab109273) was used in immunohistochemistry on mouse samples at 1:100 (fig 5a). J Clin Invest (2016) ncbi
domestic rabbit monoclonal (EPR2273(2))
  • western blot; mouse; fig 1
Abcam Erbb4 antibody (Abcam, ab109273) was used in western blot on mouse samples (fig 1). Cell Death Dis (2015) ncbi
mouse monoclonal (HFR-1)
  • western blot; mouse; fig 1
Abcam Erbb4 antibody (Abcam, ab19391) was used in western blot on mouse samples (fig 1). Cell Death Dis (2015) ncbi
  • immunohistochemistry - free floating section; mouse; 1:200
In order to assess the effects of peripherally administered Nrg1beta1 in a toxin-based mouse model of Parkinson's disease, Abcam Erbb4 antibody (Abcam, ab61059) was used in immunohistochemistry - free floating section on mouse samples at 1:200. J Neurochem (2015) ncbi
mouse monoclonal (HFR-1)
  • immunohistochemistry - paraffin section; human
Abcam Erbb4 antibody (Abcam, ab19391) was used in immunohistochemistry - paraffin section on human samples . Cancer Prev Res (Phila) (2014) ncbi
Invitrogen
mouse monoclonal (HFR1)
  • immunohistochemistry - paraffin section; human; 1:100; fig 3b
Invitrogen Erbb4 antibody (Thermo Fisher, MA1-861) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 3b). Sci Rep (2021) ncbi
mouse monoclonal (H4.77.16 (Ab77))
  • immunocytochemistry; mouse; 1:300; loading ...; fig 2a
Invitrogen Erbb4 antibody (Thermo, MA5?\12888) was used in immunocytochemistry on mouse samples at 1:300 (fig 2a). EMBO J (2018) ncbi
mouse monoclonal (HFR1)
  • western blot; mouse; loading ...; fig 3f
In order to investigate the reemergence of hippocampal long-term potential in a mouse model of Alzheimer's disease, Invitrogen Erbb4 antibody (Thermo Scientific, MAI-861) was used in western blot on mouse samples (fig 3f). Sci Rep (2016) ncbi
mouse monoclonal (H4.77.16 (Ab77))
  • immunohistochemistry; mouse; 1:300; fig 6
In order to study neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons by Neuregulin 1, Invitrogen Erbb4 antibody (Thermo Fisher Scientific, MS-270-P0) was used in immunohistochemistry on mouse samples at 1:300 (fig 6). Acta Neuropathol Commun (2016) ncbi
mouse monoclonal (H4.72.8 (Ab72))
  • immunohistochemistry - frozen section; mouse; fig 7
In order to study the time course of behavioral deficits and neuropathology in PDGF-beta human wild type alpha-synuclein transgenic mice, Invitrogen Erbb4 antibody (LabVision, mAb-77) was used in immunohistochemistry - frozen section on mouse samples (fig 7). BMC Neurosci (2013) ncbi
mouse monoclonal (HFR1)
  • immunohistochemistry; human
In order to discuss revising the classification systems for breast cancer, Invitrogen Erbb4 antibody (Neomarkers, HFR1) was used in immunohistochemistry on human samples . Int J Cancer (2005) ncbi
Novus Biologicals
mouse monoclonal (H4.77.16 (Ab77))
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 4a
Novus Biologicals Erbb4 antibody (Novus Biologicals, H4.77.16) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig 4a). Transl Psychiatry (2017) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (21A9)
  • western blot; mouse; 1:500; loading ...; fig s26e
Cell Signaling Technology Erbb4 antibody (Cell Signaling, 4757) was used in western blot on mouse samples at 1:500 (fig s26e). J Clin Invest (2022) ncbi
domestic rabbit monoclonal (111B2)
  • western blot; mouse; 1:1000; loading ...; fig 4a
Cell Signaling Technology Erbb4 antibody (Cell Signaling Technology, 4795) was used in western blot on mouse samples at 1:1000 (fig 4a). Transl Psychiatry (2021) ncbi
domestic rabbit monoclonal (111B2)
  • western blot; human; 1:1000; loading ...; fig s4b
Cell Signaling Technology Erbb4 antibody (Cell Signaling, 4795) was used in western blot on human samples at 1:1000 (fig s4b). Cancers (Basel) (2020) ncbi
domestic rabbit monoclonal (21A9)
  • western blot; human; 1:500; loading ...; fig 5i
Cell Signaling Technology Erbb4 antibody (Cell Signaling Technology, 21A9) was used in western blot on human samples at 1:500 (fig 5i). Cell Mol Life Sci (2019) ncbi
domestic rabbit monoclonal (111B2)
  • western blot; human; loading ...; fig 5e
Cell Signaling Technology Erbb4 antibody (Cell Signaling, 4795) was used in western blot on human samples (fig 5e). Cell Res (2018) ncbi
domestic rabbit monoclonal (21A9)
  • western blot; human; loading ...; fig 5e
Cell Signaling Technology Erbb4 antibody (Cell Signaling, 4757) was used in western blot on human samples (fig 5e). Cell Res (2018) ncbi
domestic rabbit monoclonal (21A9)
  • western blot; human; 1:1000; loading ...; fig 3e
Cell Signaling Technology Erbb4 antibody (Cell Signaling, 21A9) was used in western blot on human samples at 1:1000 (fig 3e). Transl Psychiatry (2017) ncbi
domestic rabbit monoclonal (111B2)
  • western blot; human; 1:1000; loading ...; fig 3
In order to assess the contribution of amphiregulin, epidermal growth factor, heparin-binding epidermal growth factor, and transforming growth factor alpha in the responsiveness of gastric cancer cell lines to cetuximab and trastuzumab, Cell Signaling Technology Erbb4 antibody (Cell Signaling, 4795) was used in western blot on human samples at 1:1000 (fig 3). J Cancer Res Clin Oncol (2017) ncbi
domestic rabbit monoclonal (21A9)
  • western blot; human; 1:1000; loading ...; fig 3
In order to assess the contribution of amphiregulin, epidermal growth factor, heparin-binding epidermal growth factor, and transforming growth factor alpha in the responsiveness of gastric cancer cell lines to cetuximab and trastuzumab, Cell Signaling Technology Erbb4 antibody (Cell Signaling, 4757) was used in western blot on human samples at 1:1000 (fig 3). J Cancer Res Clin Oncol (2017) ncbi
domestic rabbit monoclonal (21A9)
  • western blot; mouse; fig 1
Cell Signaling Technology Erbb4 antibody (Cell signaling, 4757) was used in western blot on mouse samples (fig 1). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (111B2)
  • western blot; mouse; fig 1
Cell Signaling Technology Erbb4 antibody (Cell signaling, 4795) was used in western blot on mouse samples (fig 1). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (111B2)
  • western blot; human; 1:850
Cell Signaling Technology Erbb4 antibody (Cell Signaling, 4795) was used in western blot on human samples at 1:850. J Biol Chem (2015) ncbi
domestic rabbit monoclonal (111B2)
  • western blot; human; 1:200; fig 1
In order to study anti-tumor activity of breast cancer models resistant to anti-HER2 drugs due to a dual fatty acid synthase and HER2 signaling blockade, Cell Signaling Technology Erbb4 antibody (Cell signaling, 4795) was used in western blot on human samples at 1:200 (fig 1). PLoS ONE (2015) ncbi
domestic rabbit monoclonal (21A9)
  • western blot; human; 1:200; fig 1
In order to study anti-tumor activity of breast cancer models resistant to anti-HER2 drugs due to a dual fatty acid synthase and HER2 signaling blockade, Cell Signaling Technology Erbb4 antibody (Cell signaling, 4757) was used in western blot on human samples at 1:200 (fig 1). PLoS ONE (2015) ncbi
domestic rabbit monoclonal (21A9)
  • western blot; human
In order to characterize nine mutations in the receptor tyrosine kinase ERBB4 identified in lung adenocarcinoma, Cell Signaling Technology Erbb4 antibody (Cell Signaling Technology, 4757) was used in western blot on human samples . Oncogene (2016) ncbi
domestic rabbit monoclonal (111B2)
  • western blot; human; fig 3
In order to use a cell culture model for aromatase inhibitor-resistant breast cancer to show how fulvestrant treatment and cross-resistance between exemestane and letrozole shows sensitivity, Cell Signaling Technology Erbb4 antibody (Cell Signaling Technology, 4795) was used in western blot on human samples (fig 3). Int J Oncol (2015) ncbi
domestic rabbit monoclonal (21A9)
  • western blot; human; fig 5
Cell Signaling Technology Erbb4 antibody (Cell signaling, 4757) was used in western blot on human samples (fig 5). J Biol Chem (2014) ncbi
domestic rabbit monoclonal (111B2)
  • western blot; human; fig 2
In order to study targeting sEcad for treatment of breast cancer, Cell Signaling Technology Erbb4 antibody (Cell Signaling, 4795) was used in western blot on human samples (fig 2). Mol Carcinog (2014) ncbi
domestic rabbit monoclonal (21A9)
  • western blot; human; fig 2
In order to study targeting sEcad for treatment of breast cancer, Cell Signaling Technology Erbb4 antibody (Cell Signaling, 4757) was used in western blot on human samples (fig 2). Mol Carcinog (2014) ncbi
domestic rabbit monoclonal (111B2)
  • western blot; mouse; 1:1000
Cell Signaling Technology Erbb4 antibody (Cell Signaling, 111B2) was used in western blot on mouse samples at 1:1000. Dev Biol (2013) ncbi
Articles Reviewed
  1. Humeres C, Shinde A, Hanna A, Alex L, Hern xe1 ndez S, Li R, et al. Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure. J Clin Invest. 2022;132: pubmed publisher
  2. Luo B, Liu Z, Lin D, Chen W, Ren D, Yu Z, et al. ErbB4 promotes inhibitory synapse formation by cell adhesion, independent of its kinase activity. Transl Psychiatry. 2021;11:361 pubmed publisher
  3. Foth R, Shomroni O, Sigler M, Hörer J, Cleuziou J, Paul T, et al. Screening for potential targets to reduce stenosis in bioprosthetic heart valves. Sci Rep. 2021;11:2464 pubmed publisher
  4. Padthaisong S, Thanee M, Namwat N, Phetcharaburanin J, Klanrit P, Khuntikeo N, et al. A panel of protein kinase high expression is associated with postoperative recurrence in cholangiocarcinoma. BMC Cancer. 2020;20:154 pubmed publisher
  5. Rao L, Giannico D, Leone P, Solimando A, Maiorano E, Caporusso C, et al. HB-EGF-EGFR Signaling in Bone Marrow Endothelial Cells Mediates Angiogenesis Associated with Multiple Myeloma. Cancers (Basel). 2020;12: pubmed publisher
  6. Yin Y, Zhang Q, Zhao Q, Ding G, Wei C, Chang L, et al. Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition. Biomed Res Int. 2019;2019:6595437 pubmed publisher
  7. Wintgens J, Wichert S, Popovic L, Rossner M, Wehr M. Monitoring activities of receptor tyrosine kinases using a universal adapter in genetically encoded split TEV assays. Cell Mol Life Sci. 2019;76:1185-1199 pubmed publisher
  8. Muller T, Braud S, Jüttner R, Voigt B, Paulick K, Sheean M, et al. Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons. EMBO J. 2018;37: pubmed publisher
  9. Xue Z, Vis D, Bruna A, Sustic T, van Wageningen S, Batra A, et al. MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models. Cell Res. 2018;28:719-729 pubmed publisher
  10. Kawata M, Morikawa S, Shiosaka S, Tamura H. Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation. Transl Psychiatry. 2017;7:e1052 pubmed publisher
  11. Schumacher M, Hedl M, Abraham C, Bernard J, Lozano P, Hsieh J, et al. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017;8:e2622 pubmed publisher
  12. Kneissl J, Hartmann A, Pfarr N, Erlmeier F, Lorber T, Keller S, et al. Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines. J Cancer Res Clin Oncol. 2017;143:573-600 pubmed publisher
  13. Shekhar A, Lin X, Liu F, Zhang J, Mo H, Bastarache L, et al. Transcription factor ETV1 is essential for rapid conduction in the heart. J Clin Invest. 2016;126:4444-4459 pubmed publisher
  14. Huh S, Baek S, Lee K, Whitcomb D, Jo J, Choi S, et al. The reemergence of long-term potentiation in aged Alzheimer's disease mouse model. Sci Rep. 2016;6:29152 pubmed publisher
  15. Lasiene J, Komine O, Fujimori Tonou N, Powers B, Endo F, Watanabe S, et al. Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. Acta Neuropathol Commun. 2016;4:15 pubmed publisher
  16. Wandinger S, Lahortiga I, Jacobs K, Klammer M, Jordan N, Elschenbroich S, et al. Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling. PLoS ONE. 2016;11:e0146100 pubmed publisher
  17. Higa Nakamine S, Maeda N, Toku S, Yamamoto H. Involvement of Protein Kinase D1 in Signal Transduction from the Protein Kinase C Pathway to the Tyrosine Kinase Pathway in Response to Gonadotropin-releasing Hormone. J Biol Chem. 2015;290:25974-85 pubmed publisher
  18. Blancafort A, Giró Perafita A, Oliveras G, Palomeras S, Turrado C, Campuzano Ã, et al. Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs. PLoS ONE. 2015;10:e0131241 pubmed publisher
  19. Kurppa K, Denessiouk K, Johnson M, Elenius K. Activating ERBB4 mutations in non-small cell lung cancer. Oncogene. 2016;35:1283-91 pubmed publisher
  20. Liang X, Ding Y, Zhang Y, Chai Y, He J, Chiu S, et al. Activation of NRG1-ERBB4 signaling potentiates mesenchymal stem cell-mediated myocardial repairs following myocardial infarction. Cell Death Dis. 2015;6:e1765 pubmed publisher
  21. Hole S, Pedersen A, Hansen S, Lundqvist J, Yde C, Lykkesfeldt A. New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane. Int J Oncol. 2015;46:1481-90 pubmed publisher
  22. Depboylu C, Rösler T, de Andrade A, Oertel W, Höglinger G. Systemically administered neuregulin-1β1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson's disease. J Neurochem. 2015;133:590-7 pubmed publisher
  23. Paatero I, Seagroves T, Vaparanta K, Han W, Jones F, Johnson R, et al. Hypoxia-inducible factor-1? induces ErbB4 signaling in the differentiating mammary gland. J Biol Chem. 2014;289:22459-69 pubmed publisher
  24. Gruessner C, Gruessner A, Glaser K, Abushahin N, Zhou Y, Laughren C, et al. Flutamide and biomarkers in women at high risk for ovarian cancer: preclinical and clinical evidence. Cancer Prev Res (Phila). 2014;7:896-905 pubmed publisher
  25. Brouxhon S, Kyrkanides S, Teng X, O Banion M, Clarke R, Byers S, et al. Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers. Mol Carcinog. 2014;53:893-906 pubmed publisher
  26. Amschl D, Neddens J, Havas D, Flunkert S, Rabl R, Römer H, et al. Time course and progression of wild type ?-synuclein accumulation in a transgenic mouse model. BMC Neurosci. 2013;14:6 pubmed publisher
  27. Harmelink C, Peng Y, Debenedittis P, Chen H, Shou W, Jiao K. Myocardial Mycn is essential for mouse ventricular wall morphogenesis. Dev Biol. 2013;373:53-63 pubmed publisher
  28. Abd El Rehim D, Ball G, Pinder S, Rakha E, Paish C, Robertson J, et al. High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses. Int J Cancer. 2005;116:340-50 pubmed