This is a Validated Antibody Database (VAD) review about mouse Epas1, based on 73 published articles (read how Labome selects the articles), using Epas1 antibody in all methods. It is aimed to help Labome visitors find the most suited Epas1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Epas1 synonym: HIF-2alpha; HIF2A; HLF; HRF; MOP2; bHLHe73

Knockout validation
Novus Biologicals
domestic rabbit polyclonal (1B10)
  • western blot knockout validation; mouse; fig 3
  • western blot; human; fig 3
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot knockout validation on mouse samples (fig 3) and in western blot on human samples (fig 3). Sci Rep (2016) ncbi
Abcam
domestic rabbit polyclonal
  • western blot knockout validation; mouse; fig 3
In order to investigate if hypoxia regulates TSP1 in the lung to contribute to pulmonary arterial hypertension, Abcam Epas1 antibody (Abcam, ab199) was used in western blot knockout validation on mouse samples (fig 3). Cardiovasc Res (2016) ncbi
Novus Biologicals
domestic rabbit polyclonal (1B10)
  • chromatin immunoprecipitation; human; loading ...; fig 1d, s2
  • western blot; human; 1:1000; loading ...; fig 1a
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in chromatin immunoprecipitation on human samples (fig 1d, s2) and in western blot on human samples at 1:1000 (fig 1a). Sci Adv (2021) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; mouse; fig 3c
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot on mouse samples (fig 3c). elife (2021) ncbi
domestic rabbit polyclonal (1B10)
  • immunohistochemistry; mouse; loading ...; fig 1d
  • western blot; mouse; loading ...; fig 1b
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in immunohistochemistry on mouse samples (fig 1d) and in western blot on mouse samples (fig 1b). Exp Mol Med (2021) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; human; 1:1000; loading ...; fig 2f, 2g
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in western blot on human samples at 1:1000 (fig 2f, 2g). Commun Biol (2021) ncbi
mouse monoclonal (ep190b)
  • western blot; mouse; loading ...; fig s13g
Novus Biologicals Epas1 antibody (Bio Connect, NB100-132) was used in western blot on mouse samples (fig s13g). Science (2019) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; mouse; loading ...; fig 1a, 5b
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot on mouse samples (fig 1a, 5b). Sci Adv (2019) ncbi
domestic rabbit polyclonal (1B10)
  • immunohistochemistry; mouse; 1:200; loading ...; fig 4c
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in immunohistochemistry on mouse samples at 1:200 (fig 4c). Nat Commun (2019) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; mouse; loading ...; fig s4c
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in western blot on mouse samples (fig s4c). Antioxid Redox Signal (2019) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; mouse; 1:100; loading ...; fig 1j
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in western blot on mouse samples at 1:100 (fig 1j). Haematologica (2019) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; mouse; loading ...; fig 6c
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in western blot on mouse samples (fig 6c). J Clin Invest (2019) ncbi
mouse monoclonal (ep190b)
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 6a
  • immunocytochemistry; mouse; loading ...; fig 6h
Novus Biologicals Epas1 antibody (Novus, NB100-132) was used in immunohistochemistry - paraffin section on mouse samples (fig 6a) and in immunocytochemistry on mouse samples (fig 6h). J Clin Invest (2019) ncbi
domestic rabbit polyclonal (1B10)
  • immunohistochemistry - paraffin section; mouse; fig 2g
Novus Biologicals Epas1 antibody (Novus, 100-122) was used in immunohistochemistry - paraffin section on mouse samples (fig 2g). J Clin Invest (2019) ncbi
domestic rabbit polyclonal (1B10)
  • immunohistochemistry - frozen section; mouse; loading ...; fig 3b
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in immunohistochemistry - frozen section on mouse samples (fig 3b). Dis Model Mech (2018) ncbi
domestic rabbit polyclonal (1B10)
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1d
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in immunohistochemistry - paraffin section on mouse samples (fig 1d). PLoS ONE (2017) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; mouse; loading ...; fig 5c
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot on mouse samples (fig 5c). J Mol Cell Cardiol (2017) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; human; 1:500; tbl s1
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot on human samples at 1:500 (tbl s1). Stem Cell Reports (2017) ncbi
domestic rabbit polyclonal (1B10)
  • immunocytochemistry; mouse; 1:200; loading ...; fig 6c
  • western blot; mouse; loading ...; fig 6a
In order to establish that epithelial cell adhesion molecule and extracellular domain of EpCAM enhance the efficiency of OSKM reprogramming, Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in immunocytochemistry on mouse samples at 1:200 (fig 6c) and in western blot on mouse samples (fig 6a). Sci Rep (2017) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; mouse; loading ...; fig 5b
In order to report the role of hypoxia inducible factors in myeloid trafficking during inflammation in a mouse model of human uveitis, Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in western blot on mouse samples (fig 5b). Sci Rep (2017) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; human; loading ...; fig s2
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot on human samples (fig s2). Oncotarget (2017) ncbi
mouse monoclonal (ep190b)
  • chromatin immunoprecipitation; human; 1:1000; loading ...; fig 5c
  • western blot; human; 1:3000; loading ...; fig 2a
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100?\132) was used in chromatin immunoprecipitation on human samples at 1:1000 (fig 5c) and in western blot on human samples at 1:3000 (fig 2a). Cancer Sci (2017) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; human; fig 1e
In order to find compounds that are synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma, Novus Biologicals Epas1 antibody (Novus Biological, NB100-122) was used in western blot on human samples (fig 1e). Oncogene (2017) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; mouse; 1:1000; loading ...; fig 4f
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in western blot on mouse samples at 1:1000 (fig 4f). Nature (2016) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; human; loading ...; fig 1c
In order to elucidate the role of HIF in pseudohypoxia, Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in western blot on human samples (fig 1c). Sci Rep (2016) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; human; 1:1000; loading ...; fig 3a
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot on human samples at 1:1000 (fig 3a). Cell Death Dis (2016) ncbi
mouse monoclonal (ep190b)
  • immunocytochemistry; mouse; 1:100; fig s5
Novus Biologicals Epas1 antibody (Novus Biologicals, ep190b) was used in immunocytochemistry on mouse samples at 1:100 (fig s5). Sci Rep (2016) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; human; loading ...; fig 1a
  • western blot; African green monkey; loading ...; fig 3
In order to propose that HIF-2-alpha is a negative regulator of estrogen receptor expression in breast cancer, Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot on human samples (fig 1a) and in western blot on African green monkey samples (fig 3). FEBS Lett (2016) ncbi
domestic rabbit polyclonal (1B10)
  • immunohistochemistry; human; fig 1B
  • western blot; human; 1:500; fig 1B
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in immunohistochemistry on human samples (fig 1B) and in western blot on human samples at 1:500 (fig 1B). Front Pharmacol (2016) ncbi
domestic rabbit polyclonal (1B10)
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1a
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 1a). Nat Commun (2016) ncbi
mouse monoclonal (ep190b)
  • western blot; human; loading ...; fig s7
Novus Biologicals Epas1 antibody (Novus biologicals, NB100-132) was used in western blot on human samples (fig s7). Oncotarget (2016) ncbi
domestic rabbit polyclonal (1B10)
  • chromatin immunoprecipitation; human; 1:150; loading ...; fig 3b
In order to ask if hypoxia-inducible factors modulate transcription of markers of breast cancer stem cells, Novus Biologicals Epas1 antibody (Novus Biologicals, 100-122) was used in chromatin immunoprecipitation on human samples at 1:150 (fig 3b). Mol Cancer (2016) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; human; fig 3
In order to determine the regulation of von Hippel Lindau proteostasis and function by phosphorylation-dependent cleavage, Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot on human samples (fig 3). Oncogene (2016) ncbi
mouse monoclonal (ep190b)
  • immunohistochemistry; mouse; 1:150; fig 5
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-132) was used in immunohistochemistry on mouse samples at 1:150 (fig 5). PLoS ONE (2016) ncbi
domestic rabbit polyclonal (1B10)
  • western blot knockout validation; mouse; fig 3
  • western blot; human; fig 3
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot knockout validation on mouse samples (fig 3) and in western blot on human samples (fig 3). Sci Rep (2016) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; human; fig 1c
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot on human samples (fig 1c). J Biol Chem (2016) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; mouse; 1:1000; fig 4f
In order to analyze the suppression of soft tissue sarcoma growth due to epigenetic re-expression of HIF-2 alpha, Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot on mouse samples at 1:1000 (fig 4f). Nat Commun (2016) ncbi
domestic rabbit polyclonal (1B10)
  • chromatin immunoprecipitation; human; fig 10
  • immunoprecipitation; human; fig 1
  • western blot; human; fig 1
In order to determine how prolonged hypoxia conditions are negative regulators of hypoxia-inducible factors by PRDX2 and PRDX4, Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in chromatin immunoprecipitation on human samples (fig 10), in immunoprecipitation on human samples (fig 1) and in western blot on human samples (fig 1). Oncotarget (2016) ncbi
domestic rabbit polyclonal (1B10)
  • chromatin immunoprecipitation; human; fig 4d
  • western blot; human; fig 2a
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in chromatin immunoprecipitation on human samples (fig 4d) and in western blot on human samples (fig 2a). Cancer Res (2016) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; mouse; 1:1000; fig s2
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in western blot on mouse samples at 1:1000 (fig s2). Nat Commun (2016) ncbi
domestic rabbit polyclonal (1B10)
  • western blot; human; 1:500; fig 7
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-12) was used in western blot on human samples at 1:500 (fig 7). J Cell Sci (2016) ncbi
mouse monoclonal (ep190b)
  • immunohistochemistry; human; 1:200
In order to report the contribution of DYRK1A and DYRK1B in cancer stem cells, Novus Biologicals Epas1 antibody (Novus Biological, NB100-132) was used in immunohistochemistry on human samples at 1:200. Nature (2016) ncbi
domestic rabbit polyclonal (1B10)
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used . Radiat Oncol (2015) ncbi
domestic rabbit polyclonal (1B10)
  • immunocytochemistry; human; 1:100; fig 4
  • western blot; human; 1:500; fig 3
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used in immunocytochemistry on human samples at 1:100 (fig 4) and in western blot on human samples at 1:500 (fig 3). Oncol Rep (2016) ncbi
domestic rabbit polyclonal (1B10)
  • immunoprecipitation; human; 1:2000; loading ...; fig 2a
In order to examine the association between central nervous system hemangioblastomas and HIF2A mutations, Novus Biologicals Epas1 antibody (Novus, NB100-122) was used in immunoprecipitation on human samples at 1:2000 (fig 2a). J Neurooncol (2016) ncbi
domestic rabbit polyclonal (1B10)
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used . PLoS ONE (2015) ncbi
domestic rabbit polyclonal (1B10)
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used . Mol Cancer (2015) ncbi
mouse monoclonal (ep190b)
  • immunohistochemistry - frozen section; mouse; 1:150
  • immunohistochemistry; mouse
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-132) was used in immunohistochemistry - frozen section on mouse samples at 1:150 and in immunohistochemistry on mouse samples . Sci Rep (2015) ncbi
mouse monoclonal (ep190b)
  • immunohistochemistry - paraffin section; human
  • western blot; human
  • immunohistochemistry - paraffin section; mouse
  • immunohistochemistry; mouse; loading ...; fig 4b
  • western blot; mouse; loading ...; fig 2a
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-132) was used in immunohistochemistry - paraffin section on human samples , in western blot on human samples , in immunohistochemistry - paraffin section on mouse samples , in immunohistochemistry on mouse samples (fig 4b) and in western blot on mouse samples (fig 2a). PLoS ONE (2015) ncbi
domestic rabbit polyclonal (1B10)
In order to analyze an innate defense against uropathogenic Escherichia coli infection and the role of hypoxia inducible factor-1alpha (HIF-1alpha), Novus Biologicals Epas1 antibody (Novus Biological, NB100-122) was used . PLoS Pathog (2015) ncbi
domestic rabbit polyclonal (1B10)
Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-122) was used . Mol Cancer (2015) ncbi
domestic rabbit polyclonal (1B10)
Novus Biologicals Epas1 antibody (Novus Biological, NB100-122) was used . PLoS ONE (2015) ncbi
domestic rabbit polyclonal (1B10)
Novus Biologicals Epas1 antibody (Novus Biologicals, NB-100-122) was used . J Cell Mol Med (2015) ncbi
domestic rabbit polyclonal (1B10)
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used . Oncogene (2015) ncbi
domestic rabbit polyclonal (1B10)
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used . Cancer Res (2015) ncbi
mouse monoclonal (ep190b)
  • chromatin immunoprecipitation; mouse; 1,000 ug/ml; fig 2
  • immunoprecipitation; mouse; fig 2
  • western blot; mouse; 1:1000; fig 2
  • chromatin immunoprecipitation; human; fig s1
  • immunoprecipitation; human; fig 1
  • western blot; human; fig 1
In order to study stress erythropoiesis regulated by an acetate switch, Novus Biologicals Epas1 antibody (Novus Biologicals, NB100-132) was used in chromatin immunoprecipitation on mouse samples at 1,000 ug/ml (fig 2), in immunoprecipitation on mouse samples (fig 2), in western blot on mouse samples at 1:1000 (fig 2), in chromatin immunoprecipitation on human samples (fig s1), in immunoprecipitation on human samples (fig 1) and in western blot on human samples (fig 1). Nat Med (2014) ncbi
domestic rabbit polyclonal (1B10)
Novus Biologicals Epas1 antibody (Novus, NB100-122) was used . Oncogene (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (190b)
  • proximity ligation assay; human; loading ...; fig 4c
Santa Cruz Biotechnology Epas1 antibody (Santa Cruz, sc-13596) was used in proximity ligation assay on human samples (fig 4c). Oncogene (2021) ncbi
mouse monoclonal (190b)
  • immunohistochemistry; mouse; loading ...; fig s1a
Santa Cruz Biotechnology Epas1 antibody (Santa Cruz, sc13596) was used in immunohistochemistry on mouse samples (fig s1a). Exp Mol Med (2021) ncbi
mouse monoclonal (190b)
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5e
Santa Cruz Biotechnology Epas1 antibody (Santa, sc-13596) was used in immunohistochemistry on mouse samples at 1:100 (fig 5e). Invest Ophthalmol Vis Sci (2019) ncbi
mouse monoclonal (190b)
  • western blot; human; fig 2
In order to study pVHL-mediated degradation of B-Myb and hypoxia-inducible factor alpha by parallele regulation of von Hippel-Lindau disease, Santa Cruz Biotechnology Epas1 antibody (Santa Cruz Biotechnology, sc-13596) was used in western blot on human samples (fig 2). Mol Cell Biol (2016) ncbi
mouse monoclonal (190b)
  • western blot; human; 1:250; fig 3
In order to report the contribution of DYRK1A and DYRK1B in cancer stem cells, Santa Cruz Biotechnology Epas1 antibody (Santa Cruz Biotechnology, sc-13596) was used in western blot on human samples at 1:250 (fig 3). Nature (2016) ncbi
mouse monoclonal (190b)
  • western blot; human; 1:500; fig 1
Santa Cruz Biotechnology Epas1 antibody (Santa Cruz, sc-13596) was used in western blot on human samples at 1:500 (fig 1). Mol Med Rep (2015) ncbi
mouse monoclonal (190b)
  • western blot; bovine; loading ...; fig 2b
Santa Cruz Biotechnology Epas1 antibody (Santa Cruz, SC-13596) was used in western blot on bovine samples (fig 2b). Oncogene (2014) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s8
Abcam Epas1 antibody (Abcam, ab199) was used in western blot on human samples (fig s8). Nat Commun (2022) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4e
Abcam Epas1 antibody (Abcam, ab199) was used in immunohistochemistry - paraffin section on mouse samples (fig 4e). Science (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; loading ...; fig 5e
Abcam Epas1 antibody (Abcam, ab199) was used in western blot on mouse samples at 1:500 (fig 5e). J Biol Chem (2018) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4a
Abcam Epas1 antibody (Abcam, ab199) was used in western blot on mouse samples (fig 4a). Mol Cell Biol (2017) ncbi
domestic rabbit polyclonal
  • chromatin immunoprecipitation; human; fig 4d
  • western blot; human; loading ...; fig 4f
In order to measure class II histone deacetylase expression in clear cell renal cell carcinoma, Abcam Epas1 antibody (Abcam, ab199) was used in chromatin immunoprecipitation on human samples (fig 4d) and in western blot on human samples (fig 4f). BMC Cancer (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig 4e
Abcam Epas1 antibody (Abcam, ab199) was used in western blot on human samples at 1:500 (fig 4e). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; mouse; fig 3
In order to investigate if hypoxia regulates TSP1 in the lung to contribute to pulmonary arterial hypertension, Abcam Epas1 antibody (Abcam, ab199) was used in western blot knockout validation on mouse samples (fig 3). Cardiovasc Res (2016) ncbi
mouse monoclonal (ep190b)
  • western blot; human; fig 3
Abcam Epas1 antibody (Abcam, ab8365) was used in western blot on human samples (fig 3). Sci Rep (2015) ncbi
mouse monoclonal (ep190b)
  • immunohistochemistry - paraffin section; human; 1:100
Abcam Epas1 antibody (Abcam, ab8365) was used in immunohistochemistry - paraffin section on human samples at 1:100. Cell Death Dis (2014) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 6b
In order to find the specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response, Invitrogen Epas1 antibody (ThermoScientific, PA116510) was used in western blot on human samples at 1:1000 (fig 6b). Oncotarget (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; fig s2a
In order to analyze the suppression of soft tissue sarcoma growth due to epigenetic re-expression of HIF-2 alpha, Invitrogen Epas1 antibody (ThermoPierce, PA1-16510) was used in immunohistochemistry on mouse samples (fig s2a). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 4
In order to investigate factors that control PHD1 activity, Invitrogen Epas1 antibody (Thermo Scientific, PA1-16510) was used in western blot on human samples at 1:1000 (fig 4). J Cell Sci (2016) ncbi
domestic rabbit polyclonal
In order to report that expression of HIF2alpha is regulated by the deubiquitylase Cezanne in an E2F1-dependent manner, Invitrogen Epas1 antibody (Thermo Scientific, PA1-16510) was used . J Cell Sci (2015) ncbi
domestic rabbit polyclonal
In order to study the effect of allopurinol treatment during hypoxia, Invitrogen Epas1 antibody (Thermo Fisher Scientific, PA1-16510) was used . PLoS ONE (2015) ncbi
Abnova
domestic rabbit polyclonal
  • western blot; human; fig 1
Abnova Epas1 antibody (Abnova, PAB12124) was used in western blot on human samples (fig 1). Int J Cancer (2016) ncbi
Articles Reviewed
  1. Zhang M, Cui J, Lee D, Yuen V, Chiu D, Goh C, et al. Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer. Nat Commun. 2022;13:954 pubmed publisher
  2. Wang Y, Lyu Y, Tu K, Xu Q, Yang Y, Salman S, et al. Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization. Sci Adv. 2021;7: pubmed publisher
  3. Shen M, Zhang R, Jia W, Zhu Z, Zhao X, Zhao L, et al. Nuclear scaffold protein p54nrb/NONO facilitates the hypoxia-enhanced progression of hepatocellular carcinoma. Oncogene. 2021;40:4167-4183 pubmed publisher
  4. Geng G, Liu J, Xu C, Pei Y, Chen L, Mu C, et al. Receptor-mediated mitophagy regulates EPO production and protects against renal anemia. elife. 2021;10: pubmed publisher
  5. Lee S, Park K, Lee G, Kim S, Song W, Kwon S, et al. Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Exp Mol Med. 2021;53:591-604 pubmed publisher
  6. Dufies M, Verbiest A, Cooley L, Ndiaye P, He X, Nottet N, et al. Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma. Commun Biol. 2021;4:166 pubmed publisher
  7. Chi Y, Remšík J, Kiseliovas V, Derderian C, Sener U, Alghader M, et al. Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science. 2020;369:276-282 pubmed publisher
  8. Moya I, Castaldo S, Van den Mooter L, Soheily S, Sansores Garcia L, Jacobs J, et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science. 2019;366:1029-1034 pubmed publisher
  9. Lee Y, Riopel M, Cabrales P, Bandyopadhyay G. Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. Sci Adv. 2019;5:eaaw4176 pubmed publisher
  10. Chang S, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. Nat Commun. 2019;10:1442 pubmed publisher
  11. Halvarsson C, Rörby E, Eliasson P, Lang S, Soneji S, Jönsson J. Putative role of NF-kB but not HIF-1α in hypoxia-dependent regulation of oxidative stress in hematopoietic stem and progenitor cells. Antioxid Redox Signal. 2019;: pubmed publisher
  12. Santana Codina N, Gableske S, Quiles Del Rey M, Małachowska B, Jedrychowski M, Biancur D, et al. NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Haematologica. 2019;: pubmed publisher
  13. Jassim A, Inman D. Evidence of Hypoxic Glial Cells in a Model of Ocular Hypertension. Invest Ophthalmol Vis Sci. 2019;60:1-15 pubmed publisher
  14. Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. 2019;129:631-646 pubmed publisher
  15. Schwartz A, Das N, Ramakrishnan S, Jain C, Jurkovic M, Wu J, et al. Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload. J Clin Invest. 2019;129:336-348 pubmed publisher
  16. Kim Y, Lee M, Gu H, Kim J, Jeong S, Yeo S, et al. HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice. Dis Model Mech. 2018;11: pubmed publisher
  17. Bäcker V, Cheung F, Siveke J, Fandrey J, Winning S. Knockdown of myeloid cell hypoxia-inducible factor-1? ameliorates the acute pathology in DSS-induced colitis. PLoS ONE. 2017;12:e0190074 pubmed publisher
  18. Sala M, Chen C, Zhang Q, Do Umehara H, Wu W, Misharin A, et al. JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension. J Biol Chem. 2018;293:271-284 pubmed publisher
  19. He X, Zeng H, Chen S, Roman R, Aschner J, Didion S, et al. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. J Mol Cell Cardiol. 2017;112:104-113 pubmed publisher
  20. Yasui T, Uezono N, Nakashima H, Noguchi H, Matsuda T, Noda Andoh T, et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports. 2017;8:1743-1756 pubmed publisher
  21. Kuan I, Liang K, Wang Y, Kuo T, Meir Y, Wu S, et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Sci Rep. 2017;7:41852 pubmed publisher
  22. Gardner P, Liyanage S, Cristante E, Sampson R, Dick A, Ali R, et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye. Sci Rep. 2017;7:40830 pubmed publisher
  23. Kozlova N, Wottawa M, Katschinski D, Kristiansen G, Kietzmann T. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget. 2017;8:9885-9898 pubmed publisher
  24. Rychtarčíková Z, Lettlova S, Tomkova V, Korenkova V, Langerova L, Simonova E, et al. Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. Oncotarget. 2017;8:6376-6398 pubmed publisher
  25. Shiraishi A, Tachi K, Essid N, Tsuboi I, Nagano M, Kato T, et al. Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cells. Cancer Sci. 2017;108:362-372 pubmed publisher
  26. Thompson J, Nguyen Q, Singh M, Pavesic M, Nesterenko I, Nelson L, et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene. 2017;36:1080-1089 pubmed publisher
  27. Myllymäki M, Määttä J, Dimova E, Izzi V, Väisänen T, Myllyharju J, et al. Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice. Mol Cell Biol. 2017;37: pubmed publisher
  28. Chen W, Hill H, Christie A, Kim M, Holloman E, Pavía Jiménez A, et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature. 2016;539:112-117 pubmed publisher
  29. Ramakrishnan S, Ku S, Ciamporcero E, Miles K, Attwood K, Chintala S, et al. HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma. BMC Cancer. 2016;16:617 pubmed publisher
  30. Lee M, Huang H, Chang T, Huang H, Hsieh S, Chen Y, et al. Genome-wide analysis of HIF-2? chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions. Sci Rep. 2016;6:29311 pubmed publisher
  31. Mandl M, Lieberum M, Depping R. A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT. Cell Death Dis. 2016;7:e2284 pubmed publisher
  32. Schokrpur S, Hu J, Moughon D, Liu P, Lin L, Hermann K, et al. CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. Sci Rep. 2016;6:29032 pubmed publisher
  33. Higashimura Y, Kitakaze T, Harada N, Inui H, Nakano Y, Yamaji R. pVHL-mediated degradation of HIF-2? regulates estrogen receptor ? expression in normoxic breast cancer cells. FEBS Lett. 2016;590:2690-9 pubmed publisher
  34. Maugeri G, D Amico A, Reitano R, Magro G, Cavallaro S, Salomone S, et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol. 2016;7:139 pubmed publisher
  35. Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun. 2016;7:ncomms11845 pubmed publisher
  36. Kwak J, Lee N, Lee H, Hong I, Nam J. HIF2?/EFEMP1 cascade mediates hypoxic effects on breast cancer stem cell hierarchy. Oncotarget. 2016;7:43518-43533 pubmed publisher
  37. Bourseau Guilmain E, Menard J, Lindqvist E, Indira Chandran V, Christianson H, Cerezo Magaña M, et al. Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells. Nat Commun. 2016;7:11371 pubmed publisher
  38. Okumura F, Uematsu K, Byrne S, Hirano M, Joo Okumura A, Nishikimi A, et al. Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor ?. Mol Cell Biol. 2016;36:1803-17 pubmed publisher
  39. Brooks D, Schwab L, Krutilina R, Parke D, Sethuraman A, Hoogewijs D, et al. ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models. Mol Cancer. 2016;15:26 pubmed publisher
  40. German P, Bai S, Liu X, Sun M, Zhou L, Kalra S, et al. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene. 2016;35:4973-80 pubmed publisher
  41. Ruf M, Moch H, Schraml P. PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma. Int J Cancer. 2016;139:396-403 pubmed publisher
  42. Espana Agusti J, Zou X, Wong K, Fu B, Yang F, Tuveson D, et al. Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells. PLoS ONE. 2016;11:e0148055 pubmed publisher
  43. Mori H, Yao Y, Learman B, Kurozumi K, Ishida J, Ramakrishnan S, et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep. 2016;6:21520 pubmed publisher
  44. Heir P, Srikumar T, Bikopoulos G, Bunda S, Poon B, Lee J, et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J Biol Chem. 2016;291:7357-72 pubmed publisher
  45. Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed publisher
  46. Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza G. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. 2016;7:6379-97 pubmed publisher
  47. Regan Anderson T, Ma S, Raj G, Cidlowski J, Helle T, Knutson T, et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016;76:1653-63 pubmed publisher
  48. Kim Y, Nam H, Lee J, Park D, Kim C, Yu Y, et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun. 2016;7:10347 pubmed publisher
  49. Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. J Cell Sci. 2016;129:817-30 pubmed publisher
  50. Lee S, Frattini V, Bansal M, Castano A, Sherman D, Hutchinson K, et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016;529:172-7 pubmed publisher
  51. Ortmann B, Bensaddek D, Carvalhal S, Moser S, Mudie S, Griffis E, et al. CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. J Cell Sci. 2016;129:191-205 pubmed publisher
  52. Mandl M, Lieberum M, Dunst J, Depping R. The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Radiat Oncol. 2015;10:229 pubmed publisher
  53. Aquino Gálvez A, González Ávila G, Delgado Tello J, Castillejos López M, Mendoza Milla C, Zúñiga J, et al. Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncol Rep. 2016;35:577-83 pubmed publisher
  54. Taïeb D, Barlier A, Yang C, Pertuit M, Tchoghandjian A, Rochette C, et al. Somatic gain-of-function HIF2A mutations in sporadic central nervous system hemangioblastomas. J Neurooncol. 2016;126:473-81 pubmed publisher
  55. Labrousse Arias D, Castillo González R, Rogers N, Torres Capelli M, Barreira B, Aragonés J, et al. HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction. Cardiovasc Res. 2016;109:115-30 pubmed publisher
  56. Saini Y, Proper S, Dornbos P, Greenwood K, Kopec A, Lynn S, et al. Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice. PLoS ONE. 2015;10:e0139270 pubmed publisher
  57. Högel H, Miikkulainen P, Bino L, Jaakkola P. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol Cancer. 2015;14:143 pubmed publisher
  58. Moniz S, Bandarra D, Biddlestone J, Campbell K, Komander D, Bremm A, et al. Cezanne regulates E2F1-dependent HIF2α expression. J Cell Sci. 2015;128:3082-93 pubmed publisher
  59. Cimmino F, Pezone L, Avitabile M, Acierno G, Andolfo I, Capasso M, et al. Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells. Sci Rep. 2015;5:11158 pubmed publisher
  60. Espana Agusti J, Tuveson D, Adams D, Matakidou A. A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep. 2015;5:11061 pubmed publisher
  61. Her Y, Nelson Holte M, MAHER L. Oxygen concentration controls epigenetic effects in models of familial paraganglioma. PLoS ONE. 2015;10:e0127471 pubmed publisher
  62. Lin A, Beasley F, Olson J, Keller N, Shalwitz R, Hannan T, et al. Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015;11:e1004818 pubmed publisher
  63. Koizume S, Ito S, Nakamura Y, Yoshihara M, Furuya M, Yamada R, et al. Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer. Mol Cancer. 2015;14:77 pubmed publisher
  64. Sun Y, George J, Rocha S. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS ONE. 2015;10:e0123649 pubmed publisher
  65. McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew D, et al. Pharmacological inhibition of FTO. PLoS ONE. 2015;10:e0121829 pubmed publisher
  66. Zeng H, Vaka V, He X, Booz G, Chen J. High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. J Cell Mol Med. 2015;19:1847-56 pubmed publisher
  67. Yu C, Yang S, Fang X, Jiang J, Sun C, Huang T. Hypoxia disrupts the expression levels of circadian rhythm genes in hepatocellular carcinoma. Mol Med Rep. 2015;11:4002-8 pubmed publisher
  68. Singleton D, Rouhi P, Zois C, Haider S, Li J, Kessler B, et al. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene. 2015;34:4713-22 pubmed publisher
  69. Koh M, Nguyen V, Lemos R, Darnay B, Kiriakova G, Abdelmelek M, et al. Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma. Cancer Res. 2015;75:316-29 pubmed publisher
  70. Chavali P, Saini R, Zhai Q, Vizlin Hodzic D, Venkatabalasubramanian S, Hayashi A, et al. TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival. Cell Death Dis. 2014;5:e1502 pubmed publisher
  71. Xu M, Nagati J, Xie J, Li J, Walters H, Moon Y, et al. An acetate switch regulates stress erythropoiesis. Nat Med. 2014;20:1018-26 pubmed publisher
  72. Liu X, Yao J, Tripathi D, Ding Z, Xu Y, Sun M, et al. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene. 2015;34:2450-60 pubmed publisher
  73. Medjkane S, Perichon M, Marsolier J, Dairou J, Weitzman J. Theileria induces oxidative stress and HIF1? activation that are essential for host leukocyte transformation. Oncogene. 2014;33:1809-17 pubmed publisher