This is a Validated Antibody Database (VAD) review about mouse Ctsl, based on 5 published articles (read how Labome selects the articles), using Ctsl antibody in all methods. It is aimed to help Labome visitors find the most suited Ctsl antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Ctsl synonym: 1190035F06Rik; CatL; Ctsl1; MEP; nkt; cathepsin L1; Cat L; major excreted protein; p39 cysteine proteinase

Knockout validation
R&D Systems
goat polyclonal
  • western blot knockout validation; mouse; fig 3c
R&D Systems Ctsl antibody (R&D Systems, AF1515) was used in western blot knockout validation on mouse samples (fig 3c). J Biol Chem (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (H-1)
  • western blot; human; loading ...; fig 5a
Santa Cruz Biotechnology Ctsl antibody (Santa Cruz Biotechnology, sc-376803) was used in western blot on human samples (fig 5a). Autophagy (2018) ncbi
R&D Systems
goat polyclonal
  • western blot; mouse; 1 ug/ml; loading ...; fig 2j, 3e
R&D Systems Ctsl antibody (R&D Systems, AF1515) was used in western blot on mouse samples at 1 ug/ml (fig 2j, 3e). Mol Neurodegener (2018) ncbi
goat polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 7d
R&D Systems Ctsl antibody (R&D, AF1515) was used in western blot on mouse samples at 1:1000 (fig 7d). Oncotarget (2015) ncbi
goat polyclonal
  • immunohistochemistry; mouse; loading ...; fig 2a
  • western blot; mouse; loading ...; fig 1b
R&D Systems Ctsl antibody (R&D Systems, AF1515) was used in immunohistochemistry on mouse samples (fig 2a) and in western blot on mouse samples (fig 1b). PLoS ONE (2015) ncbi
goat polyclonal
  • western blot knockout validation; mouse; fig 3c
R&D Systems Ctsl antibody (R&D Systems, AF1515) was used in western blot knockout validation on mouse samples (fig 3c). J Biol Chem (2015) ncbi
Articles Reviewed
  1. Götzl J, Colombo A, Fellerer K, Reifschneider A, Werner G, Tahirovic S, et al. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Mol Neurodegener. 2018;13:48 pubmed publisher
  2. Wang W, Xia Z, Farre J, Subramani S. TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis. Autophagy. 2018;14:1574-1585 pubmed publisher
  3. Edgington Mitchell L, Rautela J, Duivenvoorden H, Jayatilleke K, van der Linden W, Verdoes M, et al. Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer. Oncotarget. 2015;6:27008-22 pubmed publisher
  4. Brindle N, Joyce J, Rostker F, Lawlor E, Swigart Brown L, Evan G, et al. Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer. PLoS ONE. 2015;10:e0120348 pubmed publisher
  5. Kissing S, Hermsen C, Repnik U, Nesset C, von Bargen K, Griffiths G, et al. Vacuolar ATPase in phagosome-lysosome fusion. J Biol Chem. 2015;290:14166-80 pubmed publisher