This is a Validated Antibody Database (VAD) review about mouse Ctsd, based on 29 published articles (read how Labome selects the articles), using Ctsd antibody in all methods. It is aimed to help Labome visitors find the most suited Ctsd antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Ctsd synonym: CD; CatD

Knockout validation
Abcam
domestic rabbit monoclonal (EPR3057Y)
  • western blot knockout validation; human; loading ...; fig s3b
  • immunocytochemistry; human; fig 3b
Abcam Ctsd antibody (Abcam, ab75852) was used in western blot knockout validation on human samples (fig s3b) and in immunocytochemistry on human samples (fig 3b). Invest Ophthalmol Vis Sci (2021) ncbi
Individual Researcher
mouse monoclonal (sII-10)
  • western blot knockout validation; mouse; fig 3c
Individual Researcher Ctsd antibody (Individual Researcher, sctd-sh-25903133) was used in western blot knockout validation on mouse samples (fig 3c). J Biol Chem (2015) ncbi
Abcam
domestic rabbit monoclonal (EPR3057Y)
  • western blot knockout validation; human; loading ...; fig s3b
  • immunocytochemistry; human; fig 3b
Abcam Ctsd antibody (Abcam, ab75852) was used in western blot knockout validation on human samples (fig s3b) and in immunocytochemistry on human samples (fig 3b). Invest Ophthalmol Vis Sci (2021) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • western blot; human; loading ...; fig 5c
Abcam Ctsd antibody (Abcam, ab75852) was used in western blot on human samples (fig 5c). J Exp Clin Cancer Res (2019) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • immunocytochemistry; human; 1:50; loading ...; fig 2d
Abcam Ctsd antibody (Abcam, ab75852) was used in immunocytochemistry on human samples at 1:50 (fig 2d). Nat Commun (2019) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • western blot; mouse; loading ...; fig 3d
Abcam Ctsd antibody (Abcam, ab75852) was used in western blot on mouse samples (fig 3d). EMBO J (2018) ncbi
mouse monoclonal (CTD-19)
  • western blot; mouse; loading ...; fig 4a
In order to find that continued 26S proteasome dysfunction in mouse brain cortical neurons causes paranuclear accumulation of fragmented dysfunctional mitochondria, associated with earlier recruitment of Parkin and lysine 48-linked ubiquitination of mitochond, Abcam Ctsd antibody (Abcam, ab6313) was used in western blot on mouse samples (fig 4a). Cell Death Dis (2017) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; loading ...; fig 2b
In order to determine the role of SNAPIN in macrophages, Abcam Ctsd antibody (Abcam, ab6313) was used in western blot on human samples (fig 2b). Autophagy (2017) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; 1:2000; loading ...; fig 4e
Abcam Ctsd antibody (Abcam, ab6313) was used in western blot on human samples at 1:2000 (fig 4e). Oncogene (2017) ncbi
mouse monoclonal (CTD-19)
  • immunocytochemistry; human; 1:200; loading ...; fig 1f
  • western blot; human; 1:1000; loading ...; fig 1g
Abcam Ctsd antibody (Abcam, ab6313) was used in immunocytochemistry on human samples at 1:200 (fig 1f) and in western blot on human samples at 1:1000 (fig 1g). Br J Cancer (2016) ncbi
mouse monoclonal (CTD-19)
  • western blot; mouse; 1:1000; fig 5
In order to study the attenuation of Alzheimer's pathology in mice due to kallikrein-8 inhibition, Abcam Ctsd antibody (abcam, ab6313) was used in western blot on mouse samples at 1:1000 (fig 5). Alzheimers Dement (2016) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • immunohistochemistry - paraffin section; human; 1:750; fig 2
Abcam Ctsd antibody (Epitomics, 2487-1) was used in immunohistochemistry - paraffin section on human samples at 1:750 (fig 2). Oncol Lett (2016) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • immunohistochemistry; mouse; 1:300; loading ...; fig 6a
  • western blot; mouse; 1:1000; loading ...; fig 5a
In order to test if the beta-amyloid peptide disrupts microtubules, Abcam Ctsd antibody (Abcam, ab75852) was used in immunohistochemistry on mouse samples at 1:300 (fig 6a) and in western blot on mouse samples at 1:1000 (fig 5a). Acta Neuropathol (2016) ncbi
mouse monoclonal (CTD-19)
  • immunohistochemistry - paraffin section; human; 1:500; tbl 2
In order to characterize autophagic and lysosomal defects in human tauopathies from post-mortem brain from patients with familial Alzheimer disease, progressive supranuclear palsy, and coricobasal degeneration, Abcam Ctsd antibody (Abcam, Ab6313) was used in immunohistochemistry - paraffin section on human samples at 1:500 (tbl 2). Acta Neuropathol Commun (2016) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; 1:20,000; fig 3
In order to discuss how mutations in superoxide dismutase-1 affect the motor system, Abcam Ctsd antibody (Abcam, ab6313) was used in western blot on human samples at 1:20,000 (fig 3). Acta Neuropathol Commun (2016) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • immunocytochemistry; human; 1:100; fig s5
In order to analyze how Serpina3n overexpression halts muscular dystrophy in mice, Abcam Ctsd antibody (Abcam, ab75852) was used in immunocytochemistry on human samples at 1:100 (fig s5). Hum Mol Genet (2016) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; fig 5
In order to study the fusion between lysosomes and amphisomes/MVBs regulated by mahogunin via ubiquitination of TSG101, Abcam Ctsd antibody (Abcam, ab6313) was used in western blot on human samples (fig 5). Cell Death Dis (2015) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; loading ...; fig 6d
Abcam Ctsd antibody (Abcam, ab6313) was used in western blot on human samples (fig 6d). J Neurochem (2016) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; 1:1000; fig 1
Abcam Ctsd antibody (Abcam, ab6313) was used in western blot on human samples at 1:1000 (fig 1). Cell Death Dis (2015) ncbi
mouse monoclonal (CTD-19)
  • immunohistochemistry - paraffin section; human; 1:1000; fig 1g
  • immunocytochemistry; human; 1:200; fig 1
  • western blot; human; 1:500; fig 1
Abcam Ctsd antibody (Abcam, CTD-19) was used in immunohistochemistry - paraffin section on human samples at 1:1000 (fig 1g), in immunocytochemistry on human samples at 1:200 (fig 1) and in western blot on human samples at 1:500 (fig 1). Lung Cancer (2015) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • western blot; roundworm ; fig s5
Abcam Ctsd antibody (Abcam, ab75852) was used in western blot on roundworm samples (fig s5). Autophagy (2014) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • immunohistochemistry - frozen section; mouse; 1:500
Abcam Ctsd antibody (Abcam, ab75852) was used in immunohistochemistry - frozen section on mouse samples at 1:500. J Muscle Res Cell Motil (2013) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • western blot; mouse; 1:1000
Abcam Ctsd antibody (Abcam, ab75852) was used in western blot on mouse samples at 1:1000. Traffic (2012) ncbi
Santa Cruz Biotechnology
mouse monoclonal (D-7)
  • western blot; human; 1:500; loading ...; fig 4e
Santa Cruz Biotechnology Ctsd antibody (SantaCruz, sc-377299) was used in western blot on human samples at 1:500 (fig 4e). Antioxidants (Basel) (2021) ncbi
mouse monoclonal (D-7)
  • western blot; rat; fig 2
Santa Cruz Biotechnology Ctsd antibody (Santa Cruz, sc377299) was used in western blot on rat samples (fig 2). J Neurochem (2015) ncbi
mouse monoclonal (D-7)
  • immunocytochemistry; rat
Santa Cruz Biotechnology Ctsd antibody (Santa Cruz Biotechnology, sc-377299) was used in immunocytochemistry on rat samples . Life Sci (2015) ncbi
mouse monoclonal (F-12)
  • western blot; human; loading ...; fig 3
Santa Cruz Biotechnology Ctsd antibody (Santa Cruz Biotechnology, sc-374381) was used in western blot on human samples (fig 3). Breast Cancer Res Treat (2014) ncbi
R&D Systems
rat monoclonal (204712)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5d
  • western blot; mouse; 1:1000; loading ...; fig 5f
R&D Systems Ctsd antibody (RD Biosystems, MAB 1029) was used in immunohistochemistry on mouse samples at 1:500 (fig 5d) and in western blot on mouse samples at 1:1000 (fig 5f). Proc Natl Acad Sci U S A (2021) ncbi
domestic goat polyclonal
  • immunohistochemistry; mouse; 1:500; fig 6h
R&D Systems Ctsd antibody (R&D systems, AF1029) was used in immunohistochemistry on mouse samples at 1:500 (fig 6h). J Neuroinflammation (2021) ncbi
Individual Researcher
mouse monoclonal (sII-10)
  • western blot knockout validation; mouse; fig 3c
Individual Researcher Ctsd antibody (Individual Researcher, sctd-sh-25903133) was used in western blot knockout validation on mouse samples (fig 3c). J Biol Chem (2015) ncbi
BioVision
  • western blot; mouse
BioVision Ctsd antibody (BioVision, 3191R-100) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
Articles Reviewed
  1. Ashok A, Chaudhary S, Wise A, Rana N, McDonald D, Kritikos A, et al. Release of Iron-Loaded Ferritin in Sodium Iodate-Induced Model of Age Related Macular Degeneration: An In-Vitro and In-Vivo Study. Antioxidants (Basel). 2021;10: pubmed publisher
  2. Glajch K, Moors T, Chen Y, Bechade P, Nam A, Rajsombath M, et al. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  3. Escrevente C, Falcão A, Hall M, Lopes da Silva M, Antas P, Mesquita M, et al. Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction. Invest Ophthalmol Vis Sci. 2021;62:39 pubmed publisher
  4. Takahashi K, Nakamura S, Otsu W, Shimazawa M, Hara H. Progranulin deficiency in Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation. J Neuroinflammation. 2021;18:164 pubmed publisher
  5. He R, Wang M, Zhao C, Shen M, Yu Y, He L, et al. TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells. J Exp Clin Cancer Res. 2019;38:340 pubmed publisher
  6. Sapmaz A, Berlin I, Bos E, Wijdeven R, Janssen H, Konietzny R, et al. USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7. Nat Commun. 2019;10:1454 pubmed publisher
  7. Hartlova A, Herbst S, Peltier J, Rodgers A, Bilkei Gorzo O, Fearns A, et al. LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages. EMBO J. 2018;37: pubmed publisher
  8. Ugun Klusek A, Tatham M, Elkharaz J, Constantin Teodosiu D, Lawler K, Mohamed H, et al. Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway. Cell Death Dis. 2017;8:e2531 pubmed publisher
  9. Shi B, Huang Q, Birkett R, Doyle R, Dorfleutner A, Stehlik C, et al. SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. Autophagy. 2017;13:285-301 pubmed publisher
  10. Harrod A, Fulton J, Nguyen V, Periyasamy M, Ramos Garcia L, Lai C, et al. Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. Oncogene. 2017;36:2286-2296 pubmed publisher
  11. Karagounis I, Kalamida D, Mitrakas A, Pouliliou S, Liousia M, Giatromanolaki A, et al. Repression of the autophagic response sensitises lung cancer cells to radiation and chemotherapy. Br J Cancer. 2016;115:312-21 pubmed publisher
  12. Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed publisher
  13. Zhang J, Jin Y, Xu S, Zheng J, Zhang Q, Wang Y, et al. AGR2 is associated with gastric cancer progression and poor survival. Oncol Lett. 2016;11:2075-2083 pubmed
  14. Sadleir K, Kandalepas P, Buggia Prevot V, Nicholson D, Thinakaran G, Vassar R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease. Acta Neuropathol. 2016;132:235-56 pubmed publisher
  15. Piras A, Collin L, Grüninger F, Graff C, Rönnbäck A. Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathol Commun. 2016;4:22 pubmed publisher
  16. Tokuda E, Brännström T, Andersen P, Marklund S. Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase. Acta Neuropathol Commun. 2016;4:6 pubmed publisher
  17. Tjondrokoesoemo A, Schips T, Kanisicak O, Sargent M, Molkentin J. Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Hum Mol Genet. 2016;25:1192-202 pubmed publisher
  18. Majumder P, Chakrabarti O. Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101. Cell Death Dis. 2015;6:e1970 pubmed publisher
  19. Ivankovic D, Chau K, Schapira A, Gegg M. Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy. J Neurochem. 2016;136:388-402 pubmed publisher
  20. Bae E, Yang N, Lee C, Kim S, Lee H, Lee S. Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates. Cell Death Dis. 2015;6:e1901 pubmed publisher
  21. Giatromanolaki A, Kalamida D, Sivridis E, Karagounis I, Gatter K, Harris A, et al. Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer. Lung Cancer. 2015;90:98-105 pubmed publisher
  22. Kissing S, Hermsen C, Repnik U, Nesset C, von Bargen K, Griffiths G, et al. Vacuolar ATPase in phagosome-lysosome fusion. J Biol Chem. 2015;290:14166-80 pubmed publisher
  23. Tome M, Schaefer C, Jacobs L, Zhang Y, Herndon J, Matty F, et al. Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels. J Neurochem. 2015;134:200-10 pubmed publisher
  24. Liu H, Xie Q, Xin B, Liu J, Liu Y, Li Y, et al. Inhibition of autophagy recovers cardiac dysfunction and atrophy in response to tail-suspension. Life Sci. 2015;121:1-9 pubmed publisher
  25. Yamasaki T, Suzuki A, Hasebe R, Horiuchi M. Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cells. PLoS ONE. 2014;9:e106516 pubmed publisher
  26. Guo B, Huang J, Wu W, Feng D, Wang X, Chen Y, et al. The nascent polypeptide-associated complex is essential for autophagic flux. Autophagy. 2014;10:1738-48 pubmed publisher
  27. Varley K, Gertz J, Roberts B, Davis N, Bowling K, Kirby M, et al. Recurrent read-through fusion transcripts in breast cancer. Breast Cancer Res Treat. 2014;146:287-97 pubmed publisher
  28. Sharpe K, Premsukh M, Townsend D. Alterations of dystrophin-associated glycoproteins in the heart lacking dystrophin or dystrophin and utrophin. J Muscle Res Cell Motil. 2013;34:395-405 pubmed publisher
  29. Durieux A, Vassilopoulos S, Laine J, Fraysse B, Brinas L, Prudhon B, et al. A centronuclear myopathy--dynamin 2 mutation impairs autophagy in mice. Traffic. 2012;13:869-79 pubmed publisher