This is a Validated Antibody Database (VAD) review about mouse Chek2, based on 34 published articles (read how Labome selects the articles), using Chek2 antibody in all methods. It is aimed to help Labome visitors find the most suited Chek2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Chek2 synonym: CHK2; Cds1; HUCDS1; Rad53

Santa Cruz Biotechnology
mouse monoclonal (A-12)
  • western blot; human; 1:100; loading ...; fig s9a
Santa Cruz Biotechnology Chek2 antibody (Santa Cruz, sc-5278) was used in western blot on human samples at 1:100 (fig s9a). Cancer Res (2021) ncbi
mouse monoclonal (A-12)
  • flow cytometry; human; loading ...; fig 6b
Santa Cruz Biotechnology Chek2 antibody (Santa Cruz Biotechnology, A-12) was used in flow cytometry on human samples (fig 6b). Cell Mol Gastroenterol Hepatol (2021) ncbi
mouse monoclonal (A-11)
  • western blot; human; 1:500; loading ...; fig s4c
Santa Cruz Biotechnology Chek2 antibody (Santa, sc-17747) was used in western blot on human samples at 1:500 (fig s4c). Sci Adv (2019) ncbi
mouse monoclonal (A-11)
  • western blot; human; 1:1000; loading ...; fig s4c
In order to analyze the effect of CX-5461 as a G-quadruplex DNA stabilizer, Santa Cruz Biotechnology Chek2 antibody (Santa CruZ, SC-17747) was used in western blot on human samples at 1:1000 (fig s4c). Nat Commun (2017) ncbi
mouse monoclonal (A-11)
  • immunoprecipitation; human; 1:500; loading ...; fig 1b
  • western blot; human; 1:500; loading ...; fig 2a,2b
  • western blot; mouse; 1:500; loading ...; fig 6e
Santa Cruz Biotechnology Chek2 antibody (Santa Cruz Biotechnology, sc-17747) was used in immunoprecipitation on human samples at 1:500 (fig 1b), in western blot on human samples at 1:500 (fig 2a,2b) and in western blot on mouse samples at 1:500 (fig 6e). Nat Commun (2017) ncbi
mouse monoclonal (A-12)
  • western blot; mouse; loading ...; fig 5b
In order to engineer and characterize a second-generation, high-affinity AXL decoy receptor, Santa Cruz Biotechnology Chek2 antibody (Santa Cruz, sc-5278) was used in western blot on mouse samples (fig 5b). J Clin Invest (2017) ncbi
mouse monoclonal (A-11)
  • western blot; human; loading ...; fig 1a
In order to study quinacrine-induced apoptosis, Santa Cruz Biotechnology Chek2 antibody (Santa Cruz, sc17747) was used in western blot on human samples (fig 1a). Biochem Pharmacol (2016) ncbi
mouse monoclonal (A-11)
  • western blot; human; fig 2d
Santa Cruz Biotechnology Chek2 antibody (Santa Cruz Biotechnology, sc-17747) was used in western blot on human samples (fig 2d). Nucleic Acids Res (2016) ncbi
mouse monoclonal (A-12)
  • western blot; human
Santa Cruz Biotechnology Chek2 antibody (Santa Cruz Biotechnology, sc-5278) was used in western blot on human samples . Cancer Res (2014) ncbi
mouse monoclonal (DCS-273)
  • western blot; human
Santa Cruz Biotechnology Chek2 antibody (Santa Cruz, sc-56297) was used in western blot on human samples . Nucleic Acids Res (2012) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; rat; fig 2b
  • western blot; human; 1:500; loading ...; fig 2b
Abcam Chek2 antibody (Abcam, ab59408) was used in western blot on rat samples (fig 2b) and in western blot on human samples at 1:500 (fig 2b). J Exp Clin Cancer Res (2019) ncbi
  • western blot; human; 1:1000; loading ...; fig 2b
  • western blot; rat; fig 2b
Abcam Chek2 antibody (Abcam, ab47433) was used in western blot on human samples at 1:1000 (fig 2b) and in western blot on rat samples (fig 2b). J Exp Clin Cancer Res (2019) ncbi
  • western blot; mouse
Abcam Chek2 antibody (Abcam, ab47433) was used in western blot on mouse samples . J Biol Chem (2012) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig s10a, s10b
Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662) was used in western blot on human samples at 1:1000 (fig s10a, s10b). Nat Commun (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 3c
Cell Signaling Technology Chek2 antibody (CST, 2662S) was used in western blot on human samples (fig 3c). Antioxidants (Basel) (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 1a, 1b
Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662) was used in western blot on human samples at 1:1000 (fig 1a, 1b). Sci Rep (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4c
Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662) was used in western blot on mouse samples (fig 4c). Biol Open (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2b
Cell Signaling Technology Chek2 antibody (Cell Signalling Technologies, 2662S) was used in western blot on human samples (fig 2b). elife (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 4c
Cell Signaling Technology Chek2 antibody (Cell Signaling Technology, 2662) was used in western blot on mouse samples at 1:1000 (fig 4c). Cancer Discov (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 5c
In order to assess the effect of the ROS burst on DNA integrity, cell death and differentiation potential of monocytes, Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662) was used in western blot on human samples (fig 5c). PLoS ONE (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3
Cell Signaling Technology Chek2 antibody (Cell Signaling Technology, 2662) was used in western blot on human samples at 1:1000 (fig 3). PLoS ONE (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 1d
Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662) was used in western blot on human samples (fig 1d). Sci Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 2a
In order to examine ultraviolet radiation-induced ATR and ATM recruitment during G1 and S phases, Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662) was used in western blot on human samples (fig 2a). PLoS ONE (2016) ncbi
domestic rabbit polyclonal
  • western blot; human
Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662) was used in western blot on human samples . PLoS Genet (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 2
Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662S) was used in western blot on human samples at 1:1000 (fig 2). Viruses (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:3000; fig 8
In order to study kinase DYRK1A selective inhibition by targeting its folding process, Cell Signaling Technology Chek2 antibody (Cell Signaling Technology, 2662S) was used in western blot on human samples at 1:3000 (fig 8). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 1a
Cell Signaling Technology Chek2 antibody (cell signalling, 2662) was used in western blot on human samples (fig 1a). J Biol Chem (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig s6
Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662) was used in western blot on human samples at 1:1000 (fig s6). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig s5
Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662) was used in western blot on human samples (fig s5). Nucleic Acids Res (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 1
Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662) was used in western blot on human samples at 1:1000 (fig 1). Nucleic Acids Res (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 1
Cell Signaling Technology Chek2 antibody (Cell Signaling, 2662) was used in western blot on human samples (fig 1). Oncogene (2016) ncbi
BD Biosciences
mouse monoclonal (19/Chk2)
  • western blot; mouse; loading ...; fig 1f
BD Biosciences Chek2 antibody (BD Biosciences, 611570) was used in western blot on mouse samples (fig 1f). Nature (2018) ncbi
mouse monoclonal (19/Chk2)
  • western blot; mouse; 1:2000; fig 1
BD Biosciences Chek2 antibody (BD Biosciences, 611570) was used in western blot on mouse samples at 1:2000 (fig 1). Nat Commun (2016) ncbi
mouse monoclonal (19/Chk2)
  • immunocytochemistry; mouse; fig s4
  • western blot; mouse; 1:1000; fig 3
In order to report the role of MAD2L2 in DNA repair at mammalian telomeres, BD Biosciences Chek2 antibody (BD, 611570) was used in immunocytochemistry on mouse samples (fig s4) and in western blot on mouse samples at 1:1000 (fig 3). Nature (2015) ncbi
mouse monoclonal (19/Chk2)
  • western blot; human; fig 3
BD Biosciences Chek2 antibody (BD Biosciences, 611570) was used in western blot on human samples (fig 3). Oncotarget (2015) ncbi
Articles Reviewed
  1. Laine A, Nagelli S, Farrington C, Butt U, Cvrljevic A, Vainonen J, et al. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Cancer Res. 2021;81:4319-4331 pubmed publisher
  2. Nam J, Kim A, Choi S, Kim J, Choi K, Cho S, et al. An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage. Nat Commun. 2021;12:3279 pubmed publisher
  3. Dahou H, Minati M, Jacquemin P, Assi M. Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells. Antioxidants (Basel). 2021;10: pubmed publisher
  4. Ho K, Luo H, Zhu W, Tang Y. Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress. Sci Rep. 2021;11:7502 pubmed publisher
  5. Qiao F, Law H, Krieger K, Clement E, Xiao Y, Buckley S, et al. Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs. Biol Open. 2021;10: pubmed publisher
  6. Sun R, Hedl M, Abraham C. TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants. Cell Mol Gastroenterol Hepatol. 2021;11:249-272 pubmed publisher
  7. Lochab S, Singh Y, Sengupta S, Nandicoori V. Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome. elife. 2020;9: pubmed publisher
  8. Sonego M, Pellarin I, Costa A, Vinciguerra G, Coan M, Kraut A, et al. USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability. Sci Adv. 2019;5:eaav3235 pubmed publisher
  9. Liu X, Zhao P, Wang X, Wang L, Zhu Y, Song Y, et al. Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells. J Exp Clin Cancer Res. 2019;38:184 pubmed publisher
  10. Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, et al. 53BP1-RIF1-shieldin counteracts DSB resection through CST- and PolĪ±-dependent fill-in. Nature. 2018;560:112-116 pubmed publisher
  11. Haricharan S, Punturi N, Singh P, Holloway K, Anurag M, Schmelz J, et al. Loss of MutL Disrupts CHK2-Dependent Cell-Cycle Control through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer. Cancer Discov. 2017;7:1168-1183 pubmed publisher
  12. Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O Neil N, et al. CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours. Nat Commun. 2017;8:14432 pubmed publisher
  13. Ponath V, Kaina B. Death of Monocytes through Oxidative Burst of Macrophages and Neutrophils: Killing in Trans. PLoS ONE. 2017;12:e0170347 pubmed publisher
  14. Aksoy P, Meneses P. The Role of DCT in HPV16 Infection of HaCaTs. PLoS ONE. 2017;12:e0170158 pubmed publisher
  15. Xu X, Fan Z, Liang C, Li L, Wang L, Liang Y, et al. A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity. Nat Commun. 2017;8:14059 pubmed publisher
  16. Kariolis M, Miao Y, Diep A, Nash S, Olcina M, Jiang D, et al. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017;127:183-198 pubmed publisher
  17. Nagano T, Nakano M, Nakashima A, Onishi K, Yamao S, Enari M, et al. Identification of cellular senescence-specific genes by comparative transcriptomics. Sci Rep. 2016;6:31758 pubmed publisher
  18. Ray A, Blevins C, Wani G, Wani A. ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle. PLoS ONE. 2016;11:e0159344 pubmed publisher
  19. Morales J, Richard P, Patidar P, Motea E, Dang T, Manley J, et al. XRN2 Links Transcription Termination to DNA Damage and Replication Stress. PLoS Genet. 2016;12:e1006107 pubmed publisher
  20. Bristol M, Wang X, Smith N, Son M, Evans M, Morgan I. DNA Damage Reduces the Quality, but Not the Quantity of Human Papillomavirus 16 E1 and E2 DNA Replication. Viruses. 2016;8: pubmed publisher
  21. Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, et al. Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016;7:11391 pubmed publisher
  22. Rai R, Chen Y, Lei M, Chang S. TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions. Nat Commun. 2016;7:10881 pubmed publisher
  23. Kemp M, Sancar A. ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress. J Biol Chem. 2016;291:9330-42 pubmed publisher
  24. Preet R, Siddharth S, Satapathy S, Das S, Nayak A, Das D, et al. Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade. Biochem Pharmacol. 2016;105:23-33 pubmed publisher
  25. Franz A, Pirson P, Pilger D, Halder S, Achuthankutty D, Kashkar H, et al. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 2016;7:10612 pubmed publisher
  26. Baude A, Aaes T, Zhai B, Al Nakouzi N, Oo H, Daugaard M, et al. Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination. Nucleic Acids Res. 2016;44:2214-26 pubmed publisher
  27. Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res. 2016;44:1161-78 pubmed publisher
  28. Ortega Atienza S, Wong V, Deloughery Z, Luczak M, Zhitkovich A. ATM and KAT5 safeguard replicating chromatin against formaldehyde damage. Nucleic Acids Res. 2016;44:198-209 pubmed publisher
  29. Park S, Shim J, Park H, Eum D, Park M, Mi Yi J, et al. MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28B. Oncogene. 2016;35:1292-301 pubmed publisher
  30. Boersma V, Moatti N, Segura Bayona S, Peuscher M, van der Torre J, Wevers B, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 2015;521:537-540 pubmed publisher
  31. Smith Roe S, Nakamura J, Holley D, Chastain P, Rosson G, Simpson D, et al. SWI/SNF complexes are required for full activation of the DNA-damage response. Oncotarget. 2015;6:732-45 pubmed
  32. Pattabiraman C, Hong S, Gunasekharan V, Pranatharthi A, Bajaj J, Srivastava S, et al. CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits. Cancer Res. 2014;74:6682-92 pubmed publisher
  33. Mund A, Schubert T, Staege H, Kinkley S, Reumann K, Kriegs M, et al. SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response. Nucleic Acids Res. 2012;40:11363-79 pubmed publisher
  34. Singh K, Shukla P, Quan A, Desjardins J, Lovren F, Pan Y, et al. BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure. J Biol Chem. 2012;287:6604-14 pubmed publisher