This is a Validated Antibody Database (VAD) review about mouse Cbl b, based on 13 published articles (read how Labome selects the articles), using Cbl b antibody in all methods. It is aimed to help Labome visitors find the most suited Cbl b antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Cbl b synonym: AI429560; AI851073; Cbl-b

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (B-5)
  • western blot knockout validation; mouse; fig 6
Santa Cruz Biotechnology Cbl b antibody (santa Cruz, sc-376409) was used in western blot knockout validation on mouse samples (fig 6). Mol Syst Biol (2016) ncbi
Abcam
mouse monoclonal (246C5a)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 3f
Abcam Cbl b antibody (Abcam, 54362) was used in western blot knockout validation on mouse samples at 1:1000 (fig 3f). J Immunother Cancer (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D3C12)
  • western blot knockout validation; mouse; fig 1
Cell Signaling Technology Cbl b antibody (Cell Signaling, D3C12) was used in western blot knockout validation on mouse samples (fig 1). Oncotarget (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (G-1)
  • western blot; human; 1:200; loading ...; fig s9b
Santa Cruz Biotechnology Cbl b antibody (Santa Cruz, sc-8006) was used in western blot on human samples at 1:200 (fig s9b). Nat Commun (2021) ncbi
mouse monoclonal (G-1)
  • western blot; mouse; loading ...; fig 6c
Santa Cruz Biotechnology Cbl b antibody (Santa, SC-8006) was used in western blot on mouse samples (fig 6c). Sci Signal (2018) ncbi
mouse monoclonal (B-5)
  • western blot knockout validation; mouse; fig 6
Santa Cruz Biotechnology Cbl b antibody (santa Cruz, sc-376409) was used in western blot knockout validation on mouse samples (fig 6). Mol Syst Biol (2016) ncbi
mouse monoclonal (G-1)
  • immunoprecipitation; mouse; loading ...; fig 2a
  • western blot; mouse; loading ...; fig 6c
Santa Cruz Biotechnology Cbl b antibody (SantaCruz, G-1) was used in immunoprecipitation on mouse samples (fig 2a) and in western blot on mouse samples (fig 6c). Nat Med (2016) ncbi
mouse monoclonal (G-1)
  • western blot; human; loading ...; fig 6b
In order to establish an integrated multilayered proteomics approach to study receptor signaling, Santa Cruz Biotechnology Cbl b antibody (SantaCruz, sc-8006) was used in western blot on human samples (fig 6b). Nat Struct Mol Biol (2016) ncbi
mouse monoclonal (G-1)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, Santa Cruz Biotechnology Cbl b antibody (SCBT, G-1) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
mouse monoclonal (G-1)
  • western blot; human; fig 1e
In order to characterize enhancement of tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b by H19 non coding RNA-derived miR-675, Santa Cruz Biotechnology Cbl b antibody (Santa Cruz, sc-8006) was used in western blot on human samples (fig 1e). Oncotarget (2015) ncbi
mouse monoclonal (G-1)
  • flow cytometry; human
In order to study the molecular signaling responsible for retinoic acid-induced differentiation, Santa Cruz Biotechnology Cbl b antibody (Santa Cruz Biotechnology, sc-8006) was used in flow cytometry on human samples . PLoS ONE (2015) ncbi
mouse monoclonal (B-5)
  • immunohistochemistry - paraffin section; human; 1:250; fig 2
Santa Cruz Biotechnology Cbl b antibody (santa Cruz, sc-376409) was used in immunohistochemistry - paraffin section on human samples at 1:250 (fig 2). Oncotarget (2015) ncbi
Abcam
mouse monoclonal (246C5a)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 3f
Abcam Cbl b antibody (Abcam, 54362) was used in western blot knockout validation on mouse samples at 1:1000 (fig 3f). J Immunother Cancer (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D3C12)
  • western blot; human; fig 8c
Cell Signaling Technology Cbl b antibody (Cell Signaling, 9498S) was used in western blot on human samples (fig 8c). Cancer Cell (2017) ncbi
domestic rabbit monoclonal (D3C12)
  • western blot knockout validation; mouse; fig 1
Cell Signaling Technology Cbl b antibody (Cell Signaling, D3C12) was used in western blot knockout validation on mouse samples (fig 1). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D3C12)
  • western blot; human; loading ...; fig 7
Cell Signaling Technology Cbl b antibody (Cell Signaling, 9498) was used in western blot on human samples (fig 7). J Biol Chem (2016) ncbi
domestic rabbit monoclonal (D3C12)
  • western blot; human
In order to study the molecular signaling responsible for retinoic acid-induced differentiation, Cell Signaling Technology Cbl b antibody (Cell Signaling, 9498) was used in western blot on human samples . PLoS ONE (2015) ncbi
Articles Reviewed
  1. Yamagishi M, Kubokawa M, Kuze Y, Suzuki A, Yokomizo A, Kobayashi S, et al. Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma. Nat Commun. 2021;12:4821 pubmed publisher
  2. Schanz O, Cornez I, Yajnanarayana S, David F, Peer S, Gruber T, et al. Tumor rejection in Cblb -/- mice depends on IL-9 and Th9 cells. J Immunother Cancer. 2021;9: pubmed publisher
  3. Roy N, MacKay J, Robertson T, Hammer D, Burkhardt J. Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1. Sci Signal. 2018;11: pubmed publisher
  4. Robles Valero J, Lorenzo Martín L, Menacho Márquez M, Fernández Pisonero I, Abad A, Camos M, et al. A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2017;32:608-623.e9 pubmed publisher
  5. Voisinne G, García Blesa A, Chaoui K, Fiore F, Bergot E, Girard L, et al. Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation. Mol Syst Biol. 2016;12:876 pubmed publisher
  6. Xiao Y, Tang J, Guo H, Zhao Y, Tang R, Ouyang S, et al. Targeting CBLB as a potential therapeutic approach for disseminated candidiasis. Nat Med. 2016;22:906-14 pubmed publisher
  7. Goetz B, An W, Mohapatra B, Zutshi N, Iseka F, Storck M, et al. A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells. Oncotarget. 2016;7:51107-51123 pubmed publisher
  8. Francavilla C, Papetti M, Rigbolt K, Pedersen A, Sigurdsson J, Cazzamali G, et al. Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking. Nat Struct Mol Biol. 2016;23:608-18 pubmed publisher
  9. Rorsman C, Tsioumpekou M, Heldin C, Lennartsson J. The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling. J Biol Chem. 2016;291:11608-18 pubmed publisher
  10. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  11. Vennin C, Spruyt N, Dahmani F, Julien S, Bertucci F, Finetti P, et al. H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b. Oncotarget. 2015;6:29209-23 pubmed publisher
  12. Bunaciu R, Jensen H, Macdonald R, Latocha D, Varner J, Yen A. 6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells. PLoS ONE. 2015;10:e0135668 pubmed publisher
  13. Zhang L, Teng Y, Fan Y, Wang Y, Li W, Shi J, et al. The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis. Oncotarget. 2015;6:22918-33 pubmed