This is a Validated Antibody Database (VAD) review about mouse Casp4, based on 27 published articles (read how Labome selects the articles), using Casp4 antibody in all methods. It is aimed to help Labome visitors find the most suited Casp4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Casp4 synonym: CASP-11; CASP-4; Casp11; Caspl; ich-3

Knockout validation
Novus Biologicals
rat monoclonal (17D9)
  • western blot knockout validation; mouse; fig 6a
Novus Biologicals Casp4 antibody (Novus Biologicals, NB-120-10454) was used in western blot knockout validation on mouse samples (fig 6a). J Clin Invest (2017) ncbi
Santa Cruz Biotechnology
rat monoclonal (17D9)
  • western blot knockout validation; human; fig 5
Santa Cruz Biotechnology Casp4 antibody (Santa Cruz, 17D9) was used in western blot knockout validation on human samples (fig 5). Nature (2014) ncbi
MBL International
mouse monoclonal (4B9)
  • western blot knockout validation; human; fig 1
MBL International Casp4 antibody (MBL, 4B9) was used in western blot knockout validation on human samples (fig 1). Nature (2014) ncbi
MilliporeSigma
rat monoclonal (17D9)
  • western blot knockout validation; mouse; loading ...; fig 3a
MilliporeSigma Casp4 antibody (Sigma, C1354) was used in western blot knockout validation on mouse samples (fig 3a). Oncogene (2019) ncbi
MilliporeSigma
rat monoclonal (17D9)
  • western blot knockout validation; human; loading ...; fig 6b
MilliporeSigma Casp4 antibody (Sigma, 17D9) was used in western blot knockout validation on human samples (fig 6b). Nat Commun (2018) ncbi
MilliporeSigma
rat monoclonal (17D9)
  • western blot knockout validation; mouse; 1:500; loading ...; fig 1k
MilliporeSigma Casp4 antibody (Sigma-Aldrich, 17D9) was used in western blot knockout validation on mouse samples at 1:500 (fig 1k). J Exp Med (2016) ncbi
Abcam
domestic rabbit monoclonal (EPR18628)
  • western blot; mouse; 1:1000; loading ...; fig 5a, 5c
Abcam Casp4 antibody (Abcam, ab180673) was used in western blot on mouse samples at 1:1000 (fig 5a, 5c). Mucosal Immunol (2022) ncbi
domestic rabbit monoclonal (EPR18628)
  • western blot; mouse; loading ...; fig 2b
Abcam Casp4 antibody (Abcam, ab180673) was used in western blot on mouse samples (fig 2b). Front Cell Dev Biol (2021) ncbi
domestic rabbit monoclonal (EPR18628)
  • western blot; mouse; loading ...; fig 7c
Abcam Casp4 antibody (Abcam, 180673) was used in western blot on mouse samples (fig 7c). JCI Insight (2020) ncbi
domestic rabbit monoclonal (EPR18628)
  • western blot; mouse; loading ...; fig 3c
Abcam Casp4 antibody (Abcam, EPR18628) was used in western blot on mouse samples (fig 3c). J Mol Biol (2018) ncbi
Novus Biologicals
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig 3a
Novus Biologicals Casp4 antibody (Novus Biologicals, NB120-10454) was used in western blot on mouse samples (fig 3a). Cell (2021) ncbi
rat monoclonal (17D9)
  • western blot; mouse; fig s7a
Novus Biologicals Casp4 antibody (Novus Biologicals, NB120-10454) was used in western blot on mouse samples (fig s7a). J Clin Invest (2018) ncbi
rat monoclonal (17D9)
  • western blot knockout validation; mouse; fig 6a
Novus Biologicals Casp4 antibody (Novus Biologicals, NB-120-10454) was used in western blot knockout validation on mouse samples (fig 6a). J Clin Invest (2017) ncbi
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig 4a
Novus Biologicals Casp4 antibody (Novus Biologicals, 17D9) was used in western blot on mouse samples (fig 4a). Immunology (2017) ncbi
rat monoclonal (17D9)
  • western blot; mouse; 1:1000; loading ...; fig 2d
Novus Biologicals Casp4 antibody (Novus Biologicals, 17D9) was used in western blot on mouse samples at 1:1000 (fig 2d). Nat Immunol (2016) ncbi
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig s7d
Novus Biologicals Casp4 antibody (Novus Biologicals, 17D9) was used in western blot on mouse samples (fig s7d). Nature (2015) ncbi
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig s6b
Novus Biologicals Casp4 antibody (Novus Biologicals, NB120-10454) was used in western blot on mouse samples (fig s6b). Nature (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (A-2)
  • western blot; mouse; 1:1000; loading ...; fig 3b
Santa Cruz Biotechnology Casp4 antibody (Santa Cruz, sc-374615) was used in western blot on mouse samples at 1:1000 (fig 3b). Nat Commun (2019) ncbi
mouse monoclonal (A-2)
  • western blot; mouse; loading ...; fig 3c, 3f, 3g
Santa Cruz Biotechnology Casp4 antibody (Santa Cruz, sc-374615) was used in western blot on mouse samples (fig 3c, 3f, 3g). Front Immunol (2018) ncbi
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig 4c
Santa Cruz Biotechnology Casp4 antibody (Santa Cruz, sc-56038) was used in western blot on mouse samples (fig 4c). Cell Rep (2017) ncbi
mouse monoclonal (A-2)
  • western blot; mouse; loading ...; fig 3b
In order to test if inhibition of the NLRP3 inflammasome prevents inflammatory hyperalgesia induced by lipopolysaccharide, Santa Cruz Biotechnology Casp4 antibody (Santa Cruz, sc-374615) was used in western blot on mouse samples (fig 3b). Inflammation (2017) ncbi
rat monoclonal (17D9)
  • western blot knockout validation; human; fig 5
Santa Cruz Biotechnology Casp4 antibody (Santa Cruz, 17D9) was used in western blot knockout validation on human samples (fig 5). Nature (2014) ncbi
Invitrogen
rat monoclonal (17D9)
  • western blot; mouse
Invitrogen Casp4 antibody (eBioscience, 17D9) was used in western blot on mouse samples . J Immunol (2014) ncbi
Cell Signaling Technology
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig 1d
Cell Signaling Technology Casp4 antibody (Cell Signaling, 14340) was used in western blot on mouse samples (fig 1d). Sci Adv (2019) ncbi
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig 3b
Cell Signaling Technology Casp4 antibody (Cell Signaling Technology, 14340) was used in western blot on mouse samples (fig 3b). Front Immunol (2018) ncbi
MBL International
mouse monoclonal (4B9)
  • western blot; human; loading ...; fig 1c
MBL International Casp4 antibody (MBL, M029-3) was used in western blot on human samples (fig 1c). Front Cell Dev Biol (2021) ncbi
mouse monoclonal (4B9)
  • western blot; human; 1:1000
In order to assess the effect of carnosic acid on apoptosis induced by Abeta42 or Abeta43 in human neuroblastoma cells, MBL International Casp4 antibody (Medical & Biological Laboratories, #M029-3) was used in western blot on human samples at 1:1000. Neurosci Res (2015) ncbi
mouse monoclonal (4B9)
  • western blot knockout validation; human; fig 1
MBL International Casp4 antibody (MBL, 4B9) was used in western blot knockout validation on human samples (fig 1). Nature (2014) ncbi
mouse monoclonal (4B9)
  • western blot; mouse; 1:1000; fig 5
MBL International Casp4 antibody (MBL, M029-3) was used in western blot on mouse samples at 1:1000 (fig 5). Cell Death Dis (2014) ncbi
MilliporeSigma
rat monoclonal (17D9)
  • western blot knockout validation; mouse; loading ...; fig 3a
MilliporeSigma Casp4 antibody (Sigma, C1354) was used in western blot knockout validation on mouse samples (fig 3a). Oncogene (2019) ncbi
rat monoclonal (17D9)
  • western blot knockout validation; human; loading ...; fig 6b
MilliporeSigma Casp4 antibody (Sigma, 17D9) was used in western blot knockout validation on human samples (fig 6b). Nat Commun (2018) ncbi
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig 3c
MilliporeSigma Casp4 antibody (Sigma, 17D9) was used in western blot on mouse samples (fig 3c). J Mol Biol (2018) ncbi
rat monoclonal (17D9)
  • western blot; mouse; 1:1000; loading ...; fig 1g
MilliporeSigma Casp4 antibody (Sigma, 17D9) was used in western blot on mouse samples at 1:1000 (fig 1g). Nat Commun (2016) ncbi
rat monoclonal (17D9)
  • western blot knockout validation; mouse; 1:500; loading ...; fig 1k
MilliporeSigma Casp4 antibody (Sigma-Aldrich, 17D9) was used in western blot knockout validation on mouse samples at 1:500 (fig 1k). J Exp Med (2016) ncbi
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig s1a
In order to study the roles caspase-11 and caspase-12 in obesity and insulin resistance, MilliporeSigma Casp4 antibody (Sigma, C1354) was used in western blot on mouse samples (fig s1a). J Immunol (2016) ncbi
Articles Reviewed
  1. Melhem H, Kaya B, Kaymak T, Wuggenig P, Flint E, Roux J, et al. Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity. Mucosal Immunol. 2022;15:443-458 pubmed publisher
  2. Soffientini U, Beaton N, Baweja S, Weiss E, Bihari C, Habtesion A, et al. The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury. Front Cell Dev Biol. 2021;9:668459 pubmed publisher
  3. Chen Q, Liu X, Wang D, Zheng J, Chen L, Xie Q, et al. Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis. Front Cell Dev Biol. 2021;9:663037 pubmed publisher
  4. Karki R, Sharma B, Tuladhar S, Williams E, Zalduondo L, Samir P, et al. Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. Cell. 2021;184:149-168.e17 pubmed publisher
  5. Tian Y, Qu S, Alam H, Williams A, Wu Z, Deng Q, et al. Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis. JCI Insight. 2020;5: pubmed publisher
  6. Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher
  7. Chen R, Zeng L, Zhu S, Liu J, Zeh H, Kroemer G, et al. cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis. Sci Adv. 2019;5:eaav5562 pubmed publisher
  8. Flood B, Manils J, Nulty C, Flis E, Kenealy S, Barber G, et al. Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis. Oncogene. 2019;38:2658-2674 pubmed publisher
  9. Mouhadeb O, Ben Shlomo S, Cohen K, Farkash I, Gruber S, Maharshak N, et al. Impaired COMMD10-Mediated Regulation of Ly6Chi Monocyte-Driven Inflammation Disrupts Gut Barrier Function. Front Immunol. 2018;9:2623 pubmed publisher
  10. Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher
  11. Qu W, Wang Y, Wu Y, Liu Y, Chen K, Liu X, et al. Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis. Front Immunol. 2018;9:1121 pubmed publisher
  12. Chu L, Indramohan M, Ratsimandresy R, Gangopadhyay A, Morris E, Monack D, et al. The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun. 2018;9:996 pubmed publisher
  13. Sagulenko V, Vitak N, Vajjhala P, Vince J, Stacey K. Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8. J Mol Biol. 2018;430:238-247 pubmed publisher
  14. Cheng K, Xiong S, Ye Z, Hong Z, Di A, Tsang K, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127:4124-4135 pubmed publisher
  15. Tsugita M, Morimoto N, Tashiro M, Kinoshita K, Nakayama M. SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation. Cell Rep. 2017;18:1298-1311 pubmed publisher
  16. Dolunay A, Senol S, Temiz Resitoglu M, Guden D, Sari A, Sahan Firat S, et al. Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-?B, Caspase-1/11, ASC, NOX, and NOS Isoforms. Inflammation. 2017;40:366-386 pubmed publisher
  17. Klaska I, Muckersie E, Martin Granados C, Christofi M, Forrester J. Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms. Immunology. 2017;150:364-377 pubmed publisher
  18. Thurston T, Matthews S, Jennings E, Alix E, Shao F, Shenoy A, et al. Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death. Nat Commun. 2016;7:13292 pubmed publisher
  19. Napier B, Brubaker S, Sweeney T, Monette P, Rothmeier G, Gertsvolf N, et al. Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity. J Exp Med. 2016;213:2365-2382 pubmed
  20. Mortimer L, Moreau F, MacDonald J, Chadee K. NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations. Nat Immunol. 2016;17:1176-86 pubmed publisher
  21. Skeldon A, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, et al. Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance. J Immunol. 2016;196:437-47 pubmed publisher
  22. Kayagaki N, Stowe I, Lee B, O Rourke K, Anderson K, Warming S, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015;526:666-71 pubmed publisher
  23. Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526:660-5 pubmed publisher
  24. Meng P, Yoshida H, Tanji K, Matsumiya T, Xing F, Hayakari R, et al. Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells. Neurosci Res. 2015;94:1-9 pubmed publisher
  25. Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, et al. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014;514:187-92 pubmed publisher
  26. Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, et al. Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor. Cell Death Dis. 2014;5:e1332 pubmed publisher
  27. Kajiwara Y, Schiff T, Voloudakis G, Gama Sosa M, Elder G, Bozdagi O, et al. A critical role for human caspase-4 in endotoxin sensitivity. J Immunol. 2014;193:335-43 pubmed publisher