This is a Validated Antibody Database (VAD) review about mouse Casp2, based on 11 published articles (read how Labome selects the articles), using Casp2 antibody in all methods. It is aimed to help Labome visitors find the most suited Casp2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Casp2 synonym: CASP-2; ICH-1; NEDD-2; Nedd2; caspase-2; neural precursor cell expressed developmentally down-regulated protein 2; protease ICH-1

Abcam
rabbit monoclonal (EPR16796)
  • western blot; mouse; loading ...; fig 6b
Abcam Casp2 antibody (Abcam, ab179520) was used in western blot on mouse samples (fig 6b). Autophagy (2017) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse
Abcam Casp2 antibody (Abcam, ab2251) was used in immunohistochemistry - paraffin section on mouse samples . Hum Reprod (2014) ncbi
rabbit polyclonal
  • western blot; mouse
Abcam Casp2 antibody (Abcam, ab18737) was used in western blot on mouse samples . Cell Death Differ (2014) ncbi
rabbit polyclonal
  • immunohistochemistry; mouse; 1:200
Abcam Casp2 antibody (Abcam, ab2251) was used in immunohistochemistry on mouse samples at 1:200. Toxicol Appl Pharmacol (2013) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:50
  • western blot; human
Abcam Casp2 antibody (Abcam, ab 18737) was used in immunocytochemistry on human samples at 1:50 and in western blot on human samples . Cancer Cell Int (2013) ncbi
EMD Millipore
rat monoclonal (11B4)
  • western blot; human; loading ...; fig 2a
EMD Millipore Casp2 antibody (EMD Millipore, 11B4) was used in western blot on human samples (fig 2a). J Cell Biol (2017) ncbi
rat monoclonal (11B4)
  • western blot; mouse
EMD Millipore Casp2 antibody (Millipore, MAB3507) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
rat monoclonal (10C6)
  • western blot; mouse
EMD Millipore Casp2 antibody (Chemicon / EMD Millipore, MAB3501) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
rat monoclonal (11B4)
  • western blot; human
EMD Millipore Casp2 antibody (Millipore, MAB3507) was used in western blot on human samples . Cell Cycle (2014) ncbi
rat monoclonal (11B4)
  • western blot; mouse
In order to examine the possible role of caspase-2 as a tumor suppressor in the mouse mammary carcinogenesis model, EMD Millipore Casp2 antibody (EMD Millipore, 11B4) was used in western blot on mouse samples . Cell Death Differ (2013) ncbi
rat monoclonal (11B4)
  • western blot; human; fig 7
EMD Millipore Casp2 antibody (Millipore, MAB3507) was used in western blot on human samples (fig 7). Cell Death Dis (2012) ncbi
Articles Reviewed
  1. Ando K, PARSONS M, Shah R, Charendoff C, Paris S, Liu P, et al. NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol. 2017;216:1795-1810 pubmed publisher
  2. Liu J, Wang H, Gu J, Deng T, Yuan Z, Hu B, et al. BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein. Autophagy. 2017;13:739-753 pubmed publisher
  3. Sobinoff A, Sutherland J, Beckett E, Stanger S, Johnson R, Jarnicki A, et al. Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility. Hum Reprod. 2014;29:2719-35 pubmed publisher
  4. Sharma R, Callaway D, Vanegas D, Bendele M, Lopez Cruzan M, Horn D, et al. Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts. PLoS ONE. 2014;9:e93696 pubmed publisher
  5. Mahajan I, Chen M, Muro I, Robertson J, Wright C, Bratton S. BH3-only protein BIM mediates heat shock-induced apoptosis. PLoS ONE. 2014;9:e84388 pubmed publisher
  6. Sandow J, Dorstyn L, O Reilly L, Tailler M, Kumar S, Strasser A, et al. ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis. Cell Death Differ. 2014;21:475-80 pubmed publisher
  7. Del Nagro C, Choi J, Xiao Y, Rangell L, Mohan S, Pandita A, et al. Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death. Cell Cycle. 2014;13:303-14 pubmed publisher
  8. Sobinoff A, Beckett E, Jarnicki A, Sutherland J, McCluskey A, Hansbro P, et al. Scrambled and fried: cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress. Toxicol Appl Pharmacol. 2013;271:156-67 pubmed publisher
  9. Jelinek M, Balusikova K, Kopperová D, Němcová Fürstová V, Srámek J, Fidlerova J, et al. Caspase-2 is involved in cell death induction by taxanes in breast cancer cells. Cancer Cell Int. 2013;13:42 pubmed publisher
  10. Parsons M, McCormick L, Janke L, Howard A, Bouchier Hayes L, Green D. Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ. 2013;20:1174-82 pubmed publisher
  11. Orzáez M, Guevara T, Sancho M, Perez Paya E. Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment. Cell Death Dis. 2012;3:e415 pubmed publisher