This is a Validated Antibody Database (VAD) review about mouse Btrc, based on 35 published articles (read how Labome selects the articles), using Btrc antibody in all methods. It is aimed to help Labome visitors find the most suited Btrc antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Btrc synonym: Beta-Trcp1; E3RS-IkappaB; E3RSIkappaB; FWD1; Fbw1a; HOS; SCF b-TRCP; Slimb; b-TrCP; beta-TrCP

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D13F10)
  • western blot knockout validation; mouse; loading ...; fig 8e
  • western blot; human; loading ...; fig 1d
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394) was used in western blot knockout validation on mouse samples (fig 8e) and in western blot on human samples (fig 1d). Sci Signal (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (F-10)
  • western blot; human; loading ...; fig 4c
Santa Cruz Biotechnology Btrc antibody (Santa Cruz, sc-166492) was used in western blot on human samples (fig 4c). Stem Cell Reports (2020) ncbi
mouse monoclonal (F-10)
  • western blot; human; 1:500; loading ...; fig 3i
Santa Cruz Biotechnology Btrc antibody (Santa, sc-166492) was used in western blot on human samples at 1:500 (fig 3i). Nat Cell Biol (2019) ncbi
mouse monoclonal (C-6)
  • western blot; human; loading ...; fig 4g
Santa Cruz Biotechnology Btrc antibody (Santa, sc-390629) was used in western blot on human samples (fig 4g). J Pathol (2019) ncbi
mouse monoclonal (F-10)
  • western blot; human
Santa Cruz Biotechnology Btrc antibody (Santa Cruz Biotechnology, sc-166492) was used in western blot on human samples . Cell Signal (2015) ncbi
mouse monoclonal (C-6)
  • western blot; human; fig 4
Santa Cruz Biotechnology Btrc antibody (Santa Cruz, sc-390629) was used in western blot on human samples (fig 4). Exp Mol Med (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D13F10)
  • western blot; human; 1:1000; loading ...; fig 4i
  • western blot; mouse; 1:1000; fig s7e
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394S) was used in western blot on human samples at 1:1000 (fig 4i) and in western blot on mouse samples at 1:1000 (fig s7e). J Immunother Cancer (2022) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; 1:1000; loading ...; fig 6g
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394) was used in western blot on human samples at 1:1000 (fig 6g). Front Immunol (2022) ncbi
domestic rabbit monoclonal (D12C8)
  • western blot; human; fig 4g
Cell Signaling Technology Btrc antibody (Cell Signaling Technology, 11984) was used in western blot on human samples (fig 4g). Theranostics (2021) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; loading ...; fig 3b
Cell Signaling Technology Btrc antibody (CST, 4394S) was used in western blot on human samples (fig 3b). Cell (2020) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; loading ...; fig 2d
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394) was used in western blot on human samples (fig 2d). Cell Death Dis (2019) ncbi
domestic rabbit monoclonal (D12C8)
  • western blot; mouse; loading ...; fig 4c
Cell Signaling Technology Btrc antibody (Cell Signaling, D12C8) was used in western blot on mouse samples (fig 4c). Science (2019) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; 1:1000; loading ...; fig s4m
Cell Signaling Technology Btrc antibody (Cell Signaling Technologies, D13F10) was used in western blot on human samples at 1:1000 (fig s4m). Nat Commun (2019) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; loading ...; fig 5e
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394) was used in western blot on human samples (fig 5e). Cell Death Differ (2019) ncbi
domestic rabbit monoclonal (D13F10)
  • immunoprecipitation; human; loading ...; fig 3c
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394) was used in immunoprecipitation on human samples (fig 3c). Oncogene (2018) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; loading ...; fig 4d
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394) was used in western blot on human samples (fig 4d). Oncogene (2017) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; loading ...; fig 5c
In order to investigate the role of CRB3 downregulation in maintaining breast cancer stem cells, Cell Signaling Technology Btrc antibody (Cell Signaling, 4394) was used in western blot on human samples (fig 5c). Oncogenesis (2017) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; loading ...; fig 3d
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394S) was used in western blot on human samples (fig 3d). Nature (2017) ncbi
domestic rabbit monoclonal (D13F10)
  • immunoprecipitation; human; loading ...; fig 1a
  • immunohistochemistry; human; 1:500; loading ...; fig 6b
  • western blot; human; 1:1000; loading ...; fig 6b
Cell Signaling Technology Btrc antibody (cell signalling, 4394) was used in immunoprecipitation on human samples (fig 1a), in immunohistochemistry on human samples at 1:500 (fig 6b) and in western blot on human samples at 1:1000 (fig 6b). Nat Commun (2017) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot knockout validation; mouse; loading ...; fig 8e
  • western blot; human; loading ...; fig 1d
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394) was used in western blot knockout validation on mouse samples (fig 8e) and in western blot on human samples (fig 1d). Sci Signal (2017) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; loading ...; fig 2e
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394) was used in western blot on human samples (fig 2e). Oncotarget (2017) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; loading ...; fig 4f
Cell Signaling Technology Btrc antibody (cell signalling, 4394) was used in western blot on human samples (fig 4f). J Clin Invest (2016) ncbi
domestic rabbit monoclonal (D12C8)
  • western blot; human; 1:1000; loading ...; fig 2e
In order to identify and characterize an inhibitor of the COP9 signalosome, Cell Signaling Technology Btrc antibody (Cell Signaling, 11984) was used in western blot on human samples at 1:1000 (fig 2e). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; loading ...; fig 1e
In order to determine the rotavirus NSP1-host protein interaction network, Cell Signaling Technology Btrc antibody (Cell Signaling Technology, D13F10) was used in western blot on human samples (fig 1e). PLoS Pathog (2016) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; 1:1000; loading ...; fig s6b
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394) was used in western blot on human samples at 1:1000 (fig s6b). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; loading ...; fig 7b
In order to describe an alternative E3-E3 tagging cascade, Cell Signaling Technology Btrc antibody (Cell Signaling, D13F10) was used in western blot on human samples (fig 7b). Cell (2016) ncbi
domestic rabbit monoclonal (D13F10)
  • immunoprecipitation; mouse; loading ...; fig 3f
  • western blot; mouse; loading ...; fig 3g
Cell Signaling Technology Btrc antibody (Cell Signaling, 4394) was used in immunoprecipitation on mouse samples (fig 3f) and in western blot on mouse samples (fig 3g). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D13F10)
  • immunoprecipitation; human
  • western blot; human
Cell Signaling Technology Btrc antibody (CST, 4394) was used in immunoprecipitation on human samples and in western blot on human samples . Cell Signal (2015) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; fig 1
Cell Signaling Technology Btrc antibody (Cell signaling, 4394) was used in western blot on human samples (fig 1). Exp Mol Med (2015) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; 1:1000; fig s5
Cell Signaling Technology Btrc antibody (Cell signaling, 4394) was used in western blot on human samples at 1:1000 (fig s5). Nat Commun (2015) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; 1:500; fig 2
In order to report how Cep68 regulates centriole disengagement, Cell Signaling Technology Btrc antibody (Cell Signaling, D13F10) was used in western blot on human samples at 1:500 (fig 2). Nat Cell Biol (2015) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human
In order to use the parallel adapter capture proteomics approach to identify substrates of betaTrCP2/FBXW11, Cell Signaling Technology Btrc antibody (Cell Signaling Technology, D13F10) was used in western blot on human samples . Mol Cell Biol (2015) ncbi
domestic rabbit monoclonal (D13F10)
  • immunocytochemistry; human
  • western blot; human
Cell Signaling Technology Btrc antibody (Cell Signaling Technology, 4394) was used in immunocytochemistry on human samples and in western blot on human samples . FEBS Lett (2014) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; loading ...; fig 2b
Cell Signaling Technology Btrc antibody (Cell signaling, 4394) was used in western blot on human samples (fig 2b). Nucleic Acids Res (2014) ncbi
domestic rabbit monoclonal (D13F10)
In order to analyze NF-kappaB activity and its negative regulation by brain-specific TRIpartite Motif protein 9, Cell Signaling Technology Btrc antibody (Cell Signaling, D13F10) was used . Nat Commun (2014) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human
Cell Signaling Technology Btrc antibody (Cell Signaling technology, 4394S) was used in western blot on human samples . Biochem Biophys Res Commun (2014) ncbi
domestic rabbit monoclonal (D13F10)
  • western blot; human; fig 5
Cell Signaling Technology Btrc antibody (Cell Signaling Technology, D13F10) was used in western blot on human samples (fig 5). Cell (2014) ncbi
domestic rabbit monoclonal (D13F10)
  • immunoprecipitation; human; fig 1
  • western blot; human; fig 1
Cell Signaling Technology Btrc antibody (Cell Signaling Technology, 4394) was used in immunoprecipitation on human samples (fig 1) and in western blot on human samples (fig 1). J Biol Chem (2014) ncbi
Articles Reviewed
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  3. Bi Y, Chen X, Wei B, Wang L, Gong L, Li H, et al. DEPTOR stabilizes ErbB2 to promote the proliferation and survival of ErbB2-positive breast cancer cells. Theranostics. 2021;11:6355-6369 pubmed publisher
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  5. Liao W, Hsu C, Chan T, Yen C, Chen W, Pan H, et al. Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma. Stem Cell Reports. 2020;14:462-477 pubmed publisher
  6. Liu G, Zhang Q, Xia L, Shi M, Cai J, Zhang H, et al. RNA-binding protein CELF6 is cell cycle regulated and controls cancer cell proliferation by stabilizing p21. Cell Death Dis. 2019;10:688 pubmed publisher
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  10. Paul D, Islam S, Manne R, Dinesh U, Malonia S, Maity B, et al. F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β-catenin function. J Pathol. 2019;248:266-279 pubmed publisher
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  15. Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, et al. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer. Nature. 2017;542:484-488 pubmed publisher
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  17. Shimizu K, Fukushima H, Ogura K, Lien E, Nihira N, Zhang J, et al. The SCF?-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Sci Signal. 2017;10: pubmed publisher
  18. Nagashima K, Fukushima H, Shimizu K, Yamada A, Hidaka M, Hasumi H, et al. Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression. Oncotarget. 2017;8:9947-9960 pubmed publisher
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  21. Ding S, Mooney N, Li B, Kelly M, Feng N, Loktev A, et al. Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex. PLoS Pathog. 2016;12:e1005929 pubmed publisher
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  25. Tang X, Chen X, Xu Y, Qiao Y, Zhang X, Wang Y, et al. CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells. Cell Signal. 2015;27:1694-702 pubmed publisher
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  28. Pagan J, Marzio A, Jones M, Saraf A, Jallepalli P, Florens L, et al. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nat Cell Biol. 2015;17:31-43 pubmed publisher
  29. Kim T, Siesser P, Rossman K, Goldfarb D, Mackinnon K, Yan F, et al. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Mol Cell Biol. 2015;35:167-81 pubmed publisher
  30. Xu S, Tong M, Huang J, Zhang Y, Qiao Y, Weng W, et al. TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells. FEBS Lett. 2014;588:4334-41 pubmed publisher
  31. Chen Z, Liu B, Tang N, Xu Y, Ye X, Li Z, et al. FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response. Nucleic Acids Res. 2014;42:11560-9 pubmed publisher
  32. Shi M, Cho H, Inn K, Yang A, Zhao Z, Liang Q, et al. Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. Nat Commun. 2014;5:4820 pubmed publisher
  33. Ma L, Pan Q, Sun F, Yu Y, Wang J. Cluster of differentiation 166 (CD166) regulates cluster of differentiation (CD44) via NF-?B in liver cancer cell line Bel-7402. Biochem Biophys Res Commun. 2014;451:334-8 pubmed publisher
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  35. Zhu G, Fan Z, Ding M, Mu L, Liang J, Ding Y, et al. DNA damage induces the accumulation of Tiam1 by blocking ?-TrCP-dependent degradation. J Biol Chem. 2014;289:15482-94 pubmed publisher