This is a Validated Antibody Database (VAD) review about mouse Bcl6, based on 77 published articles (read how Labome selects the articles), using Bcl6 antibody in all methods. It is aimed to help Labome visitors find the most suited Bcl6 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Bcl6 synonym: Bcl5

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (D-8)
  • western blot knockout validation; mouse; loading ...; fig 3i
  • western blot; human; loading ...; fig 1b, 1c
Santa Cruz Biotechnology Bcl6 antibody (Santa Cruz, sc-7388) was used in western blot knockout validation on mouse samples (fig 3i) and in western blot on human samples (fig 1b, 1c). J Biol Chem (2019) ncbi
BioLegend
rat monoclonal (7D1)
  • flow cytometry; mouse; loading ...; fig s4b
BioLegend Bcl6 antibody (Biolegend, 7D1) was used in flow cytometry on mouse samples (fig s4b). Proc Natl Acad Sci U S A (2021) ncbi
mouse monoclonal (IG191E/A8)
  • flow cytometry; mouse; loading ...; fig 3c
BioLegend Bcl6 antibody (Biolegend, 648305) was used in flow cytometry on mouse samples (fig 3c). Nat Commun (2021) ncbi
rat monoclonal (7D1)
  • flow cytometry; human; loading ...
BioLegend Bcl6 antibody (BioLegend, 358504) was used in flow cytometry on human samples . Cell (2021) ncbi
rat monoclonal (7D1)
  • flow cytometry; mouse; 1:400; loading ...; fig 4d
BioLegend Bcl6 antibody (Biolegend, 7D1) was used in flow cytometry on mouse samples at 1:400 (fig 4d). Nat Commun (2018) ncbi
mouse monoclonal (IG191E/A8)
  • flow cytometry; mouse; 1:50; loading ...; fig s10a
In order to evaluate the use of a recombinant Newcastle disease virus expressing ICOS ligand to treat cancer, BioLegend Bcl6 antibody (Biolegend, 648308) was used in flow cytometry on mouse samples at 1:50 (fig s10a). Nat Commun (2017) ncbi
mouse monoclonal (IG191E/A8)
  • western blot; mouse; fig 7
BioLegend Bcl6 antibody (BioLegend, 648301) was used in western blot on mouse samples (fig 7). Cell Death Dis (2015) ncbi
mouse monoclonal (IG191E/A8)
  • flow cytometry; human; fig 4
BioLegend Bcl6 antibody (Biolegend, IG191E/A8) was used in flow cytometry on human samples (fig 4). Toxicol Sci (2015) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4d
Invitrogen Bcl6 antibody (Thermo Scientific, PA5-27390) was used in western blot on human samples (fig 4d). Cell Death Dis (2021) ncbi
mouse monoclonal (GI191E)
  • western blot; human; 1:500; loading ...
Invitrogen Bcl6 antibody (eBioscience, GI191E) was used in western blot on human samples at 1:500. Angiogenesis (2020) ncbi
rat monoclonal (BCL-DWN)
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s1a
In order to explore the function of autophagy in B cells, Invitrogen Bcl6 antibody (eBiosciences, BCLDWN) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig s1a). Science (2017) ncbi
mouse monoclonal (BL6.02 (PG-B6p))
  • immunocytochemistry; human; loading ...; fig s2a
In order to describe the crosstalk of alphavbeta6-integrin and androgen receptor in prostate cancer., Invitrogen Bcl6 antibody (Life Technologies, P1F6) was used in immunocytochemistry on human samples (fig s2a). Cancer Res (2016) ncbi
rat monoclonal (BCL-DWN)
  • flow cytometry; mouse; loading ...; fig 8b
In order to identify a B cell-intrinsic mechanism by which IFN signaling promotes lupus pathogenesis, Invitrogen Bcl6 antibody (eBiosciences, BCL-DWN) was used in flow cytometry on mouse samples (fig 8b). J Exp Med (2016) ncbi
rat monoclonal (BCL-DWN)
  • flow cytometry; mouse
Invitrogen Bcl6 antibody (eBioscience, BCL-DWN) was used in flow cytometry on mouse samples . J Virol (2014) ncbi
mouse monoclonal (GI191E)
  • flow cytometry; mouse
Invitrogen Bcl6 antibody (eBioscience, GI191E) was used in flow cytometry on mouse samples . J Immunol (2011) ncbi
mouse monoclonal (BL6.02 (PG-B6p))
  • immunohistochemistry - paraffin section; human; 1:20; fig 1
  • immunohistochemistry; human; 1:20
In order to investigate the correlation between miR-223 expression and gastric MALT lymphoma, Invitrogen Bcl6 antibody (Neomarker, clone P1F6+PGB6P) was used in immunohistochemistry - paraffin section on human samples at 1:20 (fig 1) and in immunohistochemistry on human samples at 1:20. Mod Pathol (2010) ncbi
Santa Cruz Biotechnology
mouse monoclonal (D-8)
  • immunocytochemistry; human; 1:100; loading ...; fig 4e
Santa Cruz Biotechnology Bcl6 antibody (Santa Cruz, sc-7388) was used in immunocytochemistry on human samples at 1:100 (fig 4e). Angiogenesis (2020) ncbi
mouse monoclonal (D-8)
  • western blot; mouse; 1:200; loading ...; fig 1e
Santa Cruz Biotechnology Bcl6 antibody (Santa, sc7388) was used in western blot on mouse samples at 1:200 (fig 1e). elife (2019) ncbi
mouse monoclonal (D-8)
  • western blot knockout validation; mouse; loading ...; fig 3i
  • western blot; human; loading ...; fig 1b, 1c
Santa Cruz Biotechnology Bcl6 antibody (Santa Cruz, sc-7388) was used in western blot knockout validation on mouse samples (fig 3i) and in western blot on human samples (fig 1b, 1c). J Biol Chem (2019) ncbi
mouse monoclonal (D-8)
  • chromatin immunoprecipitation; human; fig 1
  • western blot; human; fig 1
Santa Cruz Biotechnology Bcl6 antibody (Santa Cruz, SC-7388) was used in chromatin immunoprecipitation on human samples (fig 1) and in western blot on human samples (fig 1). Oncotarget (2016) ncbi
Abcam
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4g
In order to study histone deacetylase 9 in diffuse large B-cell lymphoma, Abcam Bcl6 antibody (Abcam, ab19011) was used in immunohistochemistry - paraffin section on mouse samples (fig 4g). Dis Model Mech (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 2b
Abcam Bcl6 antibody (Abcam, ab19011) was used in western blot on mouse samples (fig 2b). Open Biol (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D65C10)
  • western blot; human; loading ...; fig 6d
Cell Signaling Technology Bcl6 antibody (CST, 5650) was used in western blot on human samples (fig 6d). Sci Adv (2020) ncbi
domestic rabbit monoclonal (D65C10)
  • ChIP-Seq; human; 1-2 ug / 500 ul chr; loading ...; fig 4c
  • chromatin immunoprecipitation; human; loading ...; fig 4c
Cell Signaling Technology Bcl6 antibody (Cell Signaling, 5650) was used in ChIP-Seq on human samples at 1-2 ug / 500 ul chr (fig 4c) and in chromatin immunoprecipitation on human samples (fig 4c). Cell Rep (2019) ncbi
domestic rabbit monoclonal (D65C10)
  • immunoprecipitation; human; loading ...; fig 6b
Cell Signaling Technology Bcl6 antibody (Cell Signaling, D65C10) was used in immunoprecipitation on human samples (fig 6b). Nat Commun (2018) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 5g
In order to show that Kruppel-like transcription factor 6-B cell leukemia/lymphoma 6 regulates macrophage inflammatory gene expression and function, Cell Signaling Technology Bcl6 antibody (Cell Signaling, 4242S) was used in western blot on mouse samples at 1:1000 (fig 5g). J Biol Chem (2016) ncbi
domestic rabbit monoclonal (D65C10)
  • chromatin immunoprecipitation; mouse; loading ...; fig 5d
  • western blot; mouse; loading ...; fig 2g
Cell Signaling Technology Bcl6 antibody (Cell signaling, D65C10) was used in chromatin immunoprecipitation on mouse samples (fig 5d) and in western blot on mouse samples (fig 2g). Open Biol (2016) ncbi
domestic rabbit monoclonal (D65C10)
  • western blot; human; 1:1000; fig 4
Cell Signaling Technology Bcl6 antibody (Cell Signaling Technology, D65C10) was used in western blot on human samples at 1:1000 (fig 4). Int J Mol Med (2016) ncbi
Agilent Technologies
monoclonal (PG-B6p)
  • immunohistochemistry - paraffin section; human; loading ...; fig 2
Agilent Technologies Bcl6 antibody (Agilent, M721101) was used in immunohistochemistry - paraffin section on human samples (fig 2). J Clin Invest (2019) ncbi
BD Biosciences
mouse monoclonal (K112-91)
  • flow cytometry; human; loading ...; fig 2b
  • western blot; human; fig 1g
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on human samples (fig 2b) and in western blot on human samples (fig 1g). Sci Adv (2021) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; 1:40
BD Biosciences Bcl6 antibody (BD Biosciences, 561522) was used in flow cytometry on mouse samples at 1:40. elife (2021) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; 1:100; loading ...
BD Biosciences Bcl6 antibody (BD, 561522) was used in flow cytometry on mouse samples at 1:100. Nature (2021) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; loading ...
  • flow cytometry; mouse; fig 1
BD Biosciences Bcl6 antibody (BD, KI 12-91) was used in flow cytometry on human samples and in flow cytometry on mouse samples (fig 1). Aging Cell (2021) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; 1:100; loading ...; fig 8i
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on mouse samples at 1:100 (fig 8i). elife (2020) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 1g
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on mouse samples (fig 1g). Blood Adv (2020) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 3f
BD Biosciences Bcl6 antibody (BD Biosciences, 561522) was used in flow cytometry on mouse samples (fig 3f). Cell Rep (2019) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 2f
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on mouse samples (fig 2f). Science (2019) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; 1:50; loading ...; fig 3c, 3f, s6c
BD Biosciences Bcl6 antibody (BD Horizon, K112-91) was used in flow cytometry on mouse samples at 1:50 (fig 3c, 3f, s6c). Science (2019) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; loading ...; fig 4d
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on human samples (fig 4d). J Exp Med (2019) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 1c
BD Biosciences Bcl6 antibody (BD, K112-91) was used in flow cytometry on mouse samples (fig 1c). J Exp Med (2019) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 7c
BD Biosciences Bcl6 antibody (BD, K112-91) was used in flow cytometry on mouse samples (fig 7c). Front Immunol (2019) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 1d
BD Biosciences Bcl6 antibody (BD, K112-91) was used in flow cytometry on mouse samples (fig 1d). Nat Commun (2018) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; loading ...; fig 2b
BD Biosciences Bcl6 antibody (BD Biosciences, 561525) was used in flow cytometry on human samples (fig 2b). Cell Rep (2018) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig s2c
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on mouse samples (fig s2c). Infect Immun (2018) ncbi
mouse monoclonal (K112-91)
  • immunohistochemistry - frozen section; human; fig 1a
  • flow cytometry; human; loading ...; fig 3d
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in immunohistochemistry - frozen section on human samples (fig 1a) and in flow cytometry on human samples (fig 3d). J Exp Med (2018) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; fig 2f
BD Biosciences Bcl6 antibody (BD Pharmingen, K112-91) was used in flow cytometry on mouse samples (fig 2f). J Virol (2018) ncbi
mouse monoclonal (K112-91)
  • immunohistochemistry; mouse; loading ...; fig 2h
BD Biosciences Bcl6 antibody (BD Bioscience, K112-91) was used in immunohistochemistry on mouse samples (fig 2h). J Exp Med (2018) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 2d
BD Biosciences Bcl6 antibody (BD bioscience, K112-91) was used in flow cytometry on mouse samples (fig 2d). Nat Commun (2018) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; 1:100; loading ...; fig s2a
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on mouse samples at 1:100 (fig s2a). Nat Commun (2018) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; loading ...; fig 8a
BD Biosciences Bcl6 antibody (BD, 563581) was used in flow cytometry on human samples (fig 8a). J Virol (2018) ncbi
mouse monoclonal (K112-91)
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2a
BD Biosciences Bcl6 antibody (BD, K112-91) was used in immunohistochemistry - frozen section on mouse samples (fig 2a). J Exp Med (2018) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; 1:50; loading ...; fig 1a, 1e
  • western blot; mouse; ; loading ...; fig 4f
BD Biosciences Bcl6 antibody (BD, K112-91) was used in flow cytometry on mouse samples at 1:50 (fig 1a, 1e) and in western blot on mouse samples at (fig 4f). Nat Commun (2017) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human
In order to investigate the role of dopamine in B cell maturation in germinal centres, BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on human samples . Nature (2017) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; rhesus macaque; loading ...; fig 4b
In order to study CXCR5+ CD8 T cells in SIV-infected animals, BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on rhesus macaque samples (fig 4b). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 2b
In order to demonstrate that Ephrin-B1 is a specific marker of mature germinal center B cells, BD Biosciences Bcl6 antibody (BD, 561525) was used in flow cytometry on mouse samples (fig 2b). J Exp Med (2017) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; loading ...; fig s2a
BD Biosciences Bcl6 antibody (BD, K112-91) was used in flow cytometry on human samples (fig s2a). JCI Insight (2017) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; tbl 3
In order to document and describe lymphocyte predominant cells from lymph nodes involved in nodular lymphocyte predominant Hodgkin lymphoma, BD Biosciences Bcl6 antibody (BD Pharmingen, K112-91) was used in flow cytometry on human samples (tbl 3). Am J Pathol (2017) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 1f
In order to report that differentiation and self-renewal arise as opposing outcomes of sibling CD4 positive T cells during challenge with influenza, BD Biosciences Bcl6 antibody (BD, K112-91) was used in flow cytometry on mouse samples (fig 1f). J Exp Med (2017) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; 2:100; loading ...; fig 4b
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on mouse samples at 2:100 (fig 4b). Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; loading ...; fig s7
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on human samples (fig s7). Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 1h
In order to investigate the contribution of TGF-beta to the eomesodermin-driven CD4 T cell program during viral infection, BD Biosciences Bcl6 antibody (BD, K112-91) was used in flow cytometry on mouse samples (fig 1h). J Clin Invest (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...
In order to demonstrate that DNMT3a directs early CD8 positive T-cell effector and memory fate decisions, BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on mouse samples . Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; 1:50; loading ...; tbl s2
In order to identify and characterize follicular cytotoxic T cells, BD Biosciences Bcl6 antibody (BD, K112-91) was used in flow cytometry on mouse samples at 1:50 (tbl s2). Nat Immunol (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 2a
BD Biosciences Bcl6 antibody (BD, K112-91) was used in flow cytometry on mouse samples (fig 2a). J Exp Med (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; fig 1a
In order to assess the contribution of cytomorphology and flow cytometry to histopathological studies of brain biopsies, BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on human samples (fig 1a). Cytometry B Clin Cytom (2018) ncbi
mouse monoclonal (K112-91)
  • immunohistochemistry - frozen section; human; loading ...; fig 2a
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in immunohistochemistry - frozen section on human samples (fig 2a). Nat Immunol (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; loading ...; fig 3e
In order to discover that T follicular helper cells preferentially express the transcriptional coactivator Bob1, BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on mouse samples (fig 3e). Eur J Immunol (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; fig 9e
In order to identify a B cell-intrinsic mechanism by which IFN signaling promotes lupus pathogenesis, BD Biosciences Bcl6 antibody (BD, K112-91) was used in flow cytometry on human samples (fig 9e). J Exp Med (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; 1:50; fig s12
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on mouse samples at 1:50 (fig s12). Nat Commun (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; loading ...; fig 6a
BD Biosciences Bcl6 antibody (BD Pharmingen, K112-91) was used in flow cytometry on human samples (fig 6a). PLoS ONE (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; 1:50; fig 4, 7
In order to assess how IL-7 signaling represses TFH and Bcl-6, BD Biosciences Bcl6 antibody (BD Biosciences, K112.91) was used in flow cytometry on mouse samples at 1:50 (fig 4, 7). Nat Commun (2016) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; fig 3
BD Biosciences Bcl6 antibody (BD, 562198) was used in flow cytometry on human samples (fig 3). Nat Commun (2015) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; fig 4
In order to study apolipoprotein-1 during normocholesterolemic conditions, BD Biosciences Bcl6 antibody (BD Pharmingen, K112-91) was used in flow cytometry on mouse samples (fig 4). J Immunol (2015) ncbi
mouse monoclonal (K112-91)
  • immunohistochemistry - paraffin section; mouse
  • immunohistochemistry - paraffin section; Salmonella enterica
In order to study Cxcl12-expressing reticular cells in the germinal centers, BD Biosciences Bcl6 antibody (BD Pharmingen, K112-91) was used in immunohistochemistry - paraffin section on mouse samples and in immunohistochemistry - paraffin section on Salmonella enterica samples . J Immunol (2015) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; fig 1
  • immunocytochemistry; human; fig 2
  • flow cytometry; mouse; fig 5
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on human samples (fig 1), in immunocytochemistry on human samples (fig 2) and in flow cytometry on mouse samples (fig 5). Oncotarget (2015) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; fig 9a
In order to assess a CD 4 T-cell population during tuberculosis that has memory-like properties maintained by Bcl6 and ICOS-dependent pathways, BD Biosciences Bcl6 antibody (BD Bioscience, K112-91) was used in flow cytometry on mouse samples (fig 9a). J Exp Med (2015) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse
In order to investigate the differentiation and function of murine gamma-herpesvirus 68 (MHV-68)-specific CD4(+) T cells using gp150-specific TCR-transgenic mice, BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on mouse samples . J Immunol (2015) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; fig s5
In order to show that the PTEN-mTORC2 axis maintains T regulatory cell stability and coordinates their control of effector responses, BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on mouse samples (fig s5). Nat Immunol (2015) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human; fig 5
BD Biosciences Bcl6 antibody (BD Pharmingen, K112-91) was used in flow cytometry on human samples (fig 5). Toxicol Sci (2015) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; rhesus macaque
BD Biosciences Bcl6 antibody (BD Biosciences, K112-91) was used in flow cytometry on rhesus macaque samples . J Immunol (2014) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; human
BD Biosciences Bcl6 antibody (BD, K112-91) was used in flow cytometry on human samples . Eur J Immunol (2014) ncbi
mouse monoclonal (K112-91)
  • flow cytometry; mouse; 1:50; loading ...; fig 2b
In order to study the role of FoxP3 positive regulatory T cells in controlling T follicular helper and germinal center B-cell responses to influenza, BD Biosciences Bcl6 antibody (BD Biosciences, K112.91) was used in flow cytometry on mouse samples at 1:50 (fig 2b). Nat Commun (2014) ncbi
mouse monoclonal (K112-91)
  • western blot; mouse; fig 2
In order to examine how IL-2-signaling regulates the Bcl-6-Blimp-1 axis in Th1 cells, BD Biosciences Bcl6 antibody (BD Pharmingen, 561520) was used in western blot on mouse samples (fig 2). Nat Immunol (2012) ncbi
Articles Reviewed
  1. Horiuchi S, Wu H, Liu W, Schmitt N, Provot J, Liu Y, et al. Tox2 is required for the maintenance of GC TFH cells and the generation of memory TFH cells. Sci Adv. 2021;7:eabj1249 pubmed publisher
  2. Yuan Y, Cao W, Zhou H, Qian H, Wang H. H2A.Z acetylation by lincZNF337-AS1 via KAT5 implicated in the transcriptional misregulation in cancer signaling pathway in hepatocellular carcinoma. Cell Death Dis. 2021;12:609 pubmed publisher
  3. Lin X, Twelkmeyer T, Zhu D, Zhang L, Zhao Y, Zhang C, et al. Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  4. Sun Z, Yao Y, You M, Liu J, Guo W, Qi Z, et al. The kinase PDK1 is critical for promoting T follicular helper cell differentiation. elife. 2021;10: pubmed publisher
  5. Merkenschlager J, Finkin S, Ramos V, Kraft J, Cipolla M, Nowosad C, et al. Dynamic regulation of TFH selection during the germinal centre reaction. Nature. 2021;591:458-463 pubmed publisher
  6. Yang Y, Li X, Ma Z, Wang C, Yang Q, Byrne Steele M, et al. CTLA-4 expression by B-1a B cells is essential for immune tolerance. Nat Commun. 2021;12:525 pubmed publisher
  7. Webb L, Fra Bido S, Innocentin S, Matheson L, Attaf N, Bignon A, et al. Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ. Aging Cell. 2021;20:e13295 pubmed publisher
  8. Rodda L, Netland J, Shehata L, Pruner K, Morawski P, Thouvenel C, et al. Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Cell. 2021;184:169-183.e17 pubmed publisher
  9. Tacconi C, He Y, Ducoli L, Detmar M. Epigenetic regulation of the lineage specificity of primary human dermal lymphatic and blood vascular endothelial cells. Angiogenesis. 2020;: pubmed publisher
  10. Stebegg M, Bignon A, Hill D, Silva Cayetano A, Krueger C, Vanderleyden I, et al. Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination. elife. 2020;9: pubmed publisher
  11. Witalis M, Chang J, Zhong M, Bouklouch Y, Panneton V, Li J, et al. Progression of AITL-like tumors in mice is driven by Tfh signature proteins and T-B cross talk. Blood Adv. 2020;4:868-879 pubmed publisher
  12. Aldonza M, Ku J, Hong J, Kim D, Yu S, Lee M, et al. Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Sci Adv. 2020;6:eaav7416 pubmed publisher
  13. Senigl F, Maman Y, Dinesh R, Alinikula J, Seth R, Pecnova L, et al. Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation. Cell Rep. 2019;29:3902-3915.e8 pubmed publisher
  14. Wang L, Shen E, Luo L, Rabe H, Wang Q, Yin J, et al. Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep. 2019;29:1848-1861.e6 pubmed publisher
  15. Leone R, Zhao L, Englert J, Sun I, Oh M, Sun I, et al. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science. 2019;366:1013-1021 pubmed publisher
  16. Ansaldo E, Slayden L, Ching K, Koch M, Wolf N, Plichta D, et al. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science. 2019;364:1179-1184 pubmed publisher
  17. Canete P, Sweet R, Gonzalez Figueroa P, Papa I, Ohkura N, Bolton H, et al. Regulatory roles of IL-10-producing human follicular T cells. J Exp Med. 2019;: pubmed publisher
  18. Kotov J, Kotov D, Linehan J, Bardwell V, Gearhart M, Jenkins M. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216:1450-1464 pubmed publisher
  19. Mizuno R, Sugiura D, Shimizu K, Maruhashi T, Watada M, Okazaki I, et al. PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation. Front Immunol. 2019;10:630 pubmed publisher
  20. Sommars M, Ramachandran K, Senagolage M, Futtner C, Germain D, Allred A, et al. Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis. elife. 2019;8: pubmed publisher
  21. Li F, Zeng Z, Xing S, Gullicksrud J, Shan Q, Choi J, et al. Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun. 2018;9:5452 pubmed publisher
  22. Bouafia A, Lofek S, Bruneau J, Chentout L, Lamrini H, Trinquand A, et al. Loss of ARHGEF1 causes a human primary antibody deficiency. J Clin Invest. 2019;129:1047-1060 pubmed publisher
  23. Kim C, Hu B, Jadhav R, Jin J, Zhang H, Cavanagh M, et al. Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Cell Rep. 2018;25:2148-2162.e5 pubmed publisher
  24. Kim M, Song J, Koh D, Kim J, Hatano M, Jeon B, et al. Reciprocal negative regulation between the tumor suppressor protein p53 and B cell CLL/lymphoma 6 (BCL6) via control of caspase-1 expression. J Biol Chem. 2019;294:299-313 pubmed publisher
  25. Zhang C, Wang C, Jiang M, Gu C, Xiao J, Chen X, et al. Act1 is a negative regulator in T and B cells via direct inhibition of STAT3. Nat Commun. 2018;9:2745 pubmed publisher
  26. Noguchi N, Nakamura R, Hatano S, Yamada H, Sun X, Ohara N, et al. Interleukin-21 Induces Short-Lived Effector CD8+ T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice. Infect Immun. 2018;86: pubmed publisher
  27. Sayin I, Radtke A, Vella L, Jin W, Wherry E, Buggert M, et al. Spatial distribution and function of T follicular regulatory cells in human lymph nodes. J Exp Med. 2018;215:1531-1542 pubmed publisher
  28. Yang K, Liang Y, Sun Z, Xue D, Xu H, Zhu M, et al. T Cell-Derived Lymphotoxin Is Essential for the Anti-Herpes Simplex Virus 1 Humoral Immune Response. J Virol. 2018;92: pubmed publisher
  29. Zhang Y, Tech L, George L, Acs A, Durrett R, Hess H, et al. Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells. J Exp Med. 2018;215:1227-1243 pubmed publisher
  30. Gaddis D, Padgett L, Wu R, McSkimming C, Romines V, Taylor A, et al. Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis. Nat Commun. 2018;9:1095 pubmed publisher
  31. Yeh C, Nojima T, Kuraoka M, Kelsoe G. Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density. Nat Commun. 2018;9:928 pubmed publisher
  32. Jegaskanda S, Mason R, Andrews S, Wheatley A, Zhang R, Reynoso G, et al. Intranasal Live Influenza Vaccine Priming Elicits Localized B Cell Responses in Mediastinal Lymph Nodes. J Virol. 2018;92: pubmed publisher
  33. Kara E, Bastow C, McKenzie D, Gregor C, Fenix K, Babb R, et al. Atypical chemokine receptor 4 shapes activated B cell fate. J Exp Med. 2018;215:801-813 pubmed publisher
  34. Yi W, Gupta S, Ricker E, Manni M, Jessberger R, Chinenov Y, et al. The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity. Nat Commun. 2017;8:254 pubmed publisher
  35. Papa I, Saliba D, Ponzoni M, Bustamante S, Canete P, Gonzalez Figueroa P, et al. TFH-derived dopamine accelerates productive synapses in germinal centres. Nature. 2017;547:318-323 pubmed publisher
  36. Zamarin D, Holmgaard R, Ricca J, Plitt T, Palese P, Sharma P, et al. Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity. Nat Commun. 2017;8:14340 pubmed publisher
  37. Martínez Martín N, Maldonado P, Gasparrini F, Frederico B, Aggarwal S, Gaya M, et al. A switch from canonical to noncanonical autophagy shapes B cell responses. Science. 2017;355:641-647 pubmed publisher
  38. Mylvaganam G, Rios D, Abdelaal H, Iyer S, Tharp G, Mavigner M, et al. Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection. Proc Natl Acad Sci U S A. 2017;114:1976-1981 pubmed publisher
  39. Laidlaw B, Schmidt T, Green J, Allen C, Okada T, Cyster J. The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells. J Exp Med. 2017;214:639-649 pubmed publisher
  40. Martin Gayo E, Cronin J, Hickman T, Ouyang Z, Lindqvist M, Kolb K, et al. Circulating CXCR5+CXCR3+PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth. JCI Insight. 2017;2:e89574 pubmed publisher
  41. Fromm J, Thomas A, Wood B. Characterization and Purification of Neoplastic Cells of Nodular Lymphocyte Predominant Hodgkin Lymphoma from Lymph Nodes by Flow Cytometry and Flow Cytometric Cell Sorting. Am J Pathol. 2017;187:304-317 pubmed publisher
  42. Nish S, Zens K, Kratchmarov R, Lin W, Adams W, Chen Y, et al. CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions. J Exp Med. 2017;214:39-47 pubmed publisher
  43. Morita K, Okamura T, Inoue M, Komai T, Teruya S, Iwasaki Y, et al. Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production. Proc Natl Acad Sci U S A. 2016;113:E8131-E8140 pubmed
  44. Gil V, Bhagat G, Howell L, Zhang J, Kim C, Stengel S, et al. Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice. Dis Model Mech. 2016;9:1483-1495 pubmed
  45. Peters C, Häsler R, Wesch D, Kabelitz D. Human Vδ2 T cells are a major source of interleukin-9. Proc Natl Acad Sci U S A. 2016;113:12520-12525 pubmed
  46. Lewis G, Wehrens E, Labarta Bajo L, Streeck H, Zuniga E. TGF-? receptor maintains CD4 T helper cell identity during chronic viral infections. J Clin Invest. 2016;126:3799-3813 pubmed publisher
  47. Ladle B, Li K, Phillips M, Pucsek A, Haile A, Powell J, et al. De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation. Proc Natl Acad Sci U S A. 2016;113:10631-6 pubmed publisher
  48. Kim G, Das R, Goduni L, McClellan S, Hazlett L, Mahabeleshwar G. Kruppel-like Factor 6 Promotes Macrophage-mediated Inflammation by Suppressing B Cell Leukemia/Lymphoma 6 Expression. J Biol Chem. 2016;291:21271-21282 pubmed
  49. Leong Y, Chen Y, Ong H, Wu D, Man K, Deléage C, et al. CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol. 2016;17:1187-96 pubmed publisher
  50. Liu W, Kang S, Huang Z, Wu C, Jin H, Maine C, et al. A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. J Exp Med. 2016;213:1901-19 pubmed publisher
  51. Debliquis A, Voirin J, Harzallah I, Maurer M, Lerintiu F, Drenou B, et al. Cytomorphology and flow cytometry of brain biopsy rinse fluid enables faster and multidisciplinary diagnosis of large B-cell lymphoma of the central nervous system. Cytometry B Clin Cytom. 2018;94:182-188 pubmed publisher
  52. Lu H, Wang T, Li J, Fedele C, Liu Q, Zhang J, et al. αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor. Cancer Res. 2016;76:5163-74 pubmed publisher
  53. Locci M, Wu J, Arumemi F, Mikulski Z, Dahlberg C, Miller A, et al. Activin A programs the differentiation of human TFH cells. Nat Immunol. 2016;17:976-84 pubmed publisher
  54. Hu X, Zhou Y, Yang Y, Peng J, Song T, Xu T, et al. Identification of zinc finger protein Bcl6 as a novel regulator of early adipose commitment. Open Biol. 2016;6: pubmed publisher
  55. Yamashita K, Kawata K, Matsumiya H, Kamekura R, Jitsukawa S, Nagaya T, et al. Bob1 limits cellular frequency of T-follicular helper cells. Eur J Immunol. 2016;46:1361-70 pubmed publisher
  56. Jackson S, Jacobs H, Arkatkar T, Dam E, Scharping N, Kolhatkar N, et al. B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J Exp Med. 2016;213:733-50 pubmed publisher
  57. Zeng Q, Tao X, Huang F, Wu T, Wang J, Jiang X, et al. Overexpression of miR-155 promotes the proliferation and invasion of oral squamous carcinoma cells by regulating BCL6/cyclin D2. Int J Mol Med. 2016;37:1274-80 pubmed publisher
  58. Aloulou M, Carr E, Gador M, Bignon A, Liblau R, Fazilleau N, et al. Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells. Nat Commun. 2016;7:10579 pubmed publisher
  59. Li L, Jiang Y, Lao S, Yang B, Yu S, Zhang Y, et al. Mycobacterium tuberculosis-Specific IL-21+IFN-γ+CD4+ T Cells Are Regulated by IL-12. PLoS ONE. 2016;11:e0147356 pubmed publisher
  60. McDonald P, Read K, Baker C, Anderson A, Powell M, Ballesteros Tato A, et al. IL-7 signalling represses Bcl-6 and the TFH gene program. Nat Commun. 2016;7:10285 pubmed publisher
  61. Dupont T, Yang S, Patel J, Hatzi K, Malik A, Tam W, et al. Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma. Oncotarget. 2016;7:3520-32 pubmed publisher
  62. Cao J, Zhang X, Wang Q, Qiu G, Hou C, Wang J, et al. Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells. Cell Death Dis. 2015;6:e1984 pubmed publisher
  63. Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed publisher
  64. Black L, Srivastava R, Schoeb T, Moore R, Barnes S, KABAROWSKI J. Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone Mice. J Immunol. 2015;195:4685-98 pubmed publisher
  65. Rodda L, Bannard O, Ludewig B, Nagasawa T, Cyster J. Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells. J Immunol. 2015;195:4781-91 pubmed publisher
  66. Andersson K, Brisslert M, Cavallini N, Svensson M, Welin A, Erlandsson M, et al. Survivin co-ordinates formation of follicular T-cells acting in synergy with Bcl-6. Oncotarget. 2015;6:20043-57 pubmed
  67. Moguche A, Shafiani S, Clemons C, Larson R, Dinh C, Higdon L, et al. ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis. J Exp Med. 2015;212:715-28 pubmed publisher
  68. Hu Z, Blackman M, Kaye K, Usherwood E. Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68. J Immunol. 2015;194:2746-56 pubmed publisher
  69. Shrestha S, Yang K, Guy C, Vogel P, Neale G, Chi H. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat Immunol. 2015;16:178-87 pubmed publisher
  70. Phadnis Moghe A, Crawford R, Kaminski N. Suppression of human B cell activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin involves altered regulation of B cell lymphoma-6. Toxicol Sci. 2015;144:39-50 pubmed publisher
  71. Mylvaganam G, Velu V, Hong J, Sadagopal S, Kwa S, Basu R, et al. Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa. J Immunol. 2014;193:4527-36 pubmed publisher
  72. Kudernatsch R, Letsch A, Guerreiro M, Löbel M, Bauer S, Volk H, et al. Human bone marrow contains a subset of quiescent early memory CD8(+) T cells characterized by high CD127 expression and efflux capacity. Eur J Immunol. 2014;44:3532-42 pubmed publisher
  73. Boyoglu Barnum S, Chirkova T, Todd S, Barnum T, Gaston K, Jorquera P, et al. Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice. J Virol. 2014;88:10569-83 pubmed publisher
  74. León B, Bradley J, Lund F, Randall T, Ballesteros Tato A. FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability. Nat Commun. 2014;5:3495 pubmed publisher
  75. Oestreich K, Mohn S, Weinmann A. Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol. 2012;13:405-11 pubmed publisher
  76. Wollenberg I, Agua Doce A, Hernandez A, Almeida C, Oliveira V, Faro J, et al. Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells. J Immunol. 2011;187:4553-60 pubmed publisher
  77. Liu T, Chen S, Kuo S, Cheng A, Lin C. E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response. Mod Pathol. 2010;23:1507-17 pubmed publisher