This is a Validated Antibody Database (VAD) review about mouse Bace1, based on 60 published articles (read how Labome selects the articles), using Bace1 antibody in all methods. It is aimed to help Labome visitors find the most suited Bace1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Bace1 synonym: ASP2; Bace; C76936

Knockout validation
Abcam
domestic rabbit monoclonal (EPR3956)
  • immunohistochemistry knockout validation; mouse; 1:50; loading ...; fig 2e
Abcam Bace1 antibody (Abcam, ab108394) was used in immunohistochemistry knockout validation on mouse samples at 1:50 (fig 2e). J Neurosci (2019) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D10E5)
  • western blot knockout validation; mouse; loading ...; fig 5a
Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606) was used in western blot knockout validation on mouse samples (fig 5a). Sci Adv (2022) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D10E5)
  • western blot knockout validation; mouse; 1:1500; fig 1d, 5a
Cell Signaling Technology Bace1 antibody (Cell Signaling, D10E5) was used in western blot knockout validation on mouse samples at 1:1500 (fig 1d, 5a). J Biol Chem (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D10E5)
  • western blot knockout validation; mouse; fig s1a
Cell Signaling Technology Bace1 antibody (Cell Signaling, D10E5) was used in western blot knockout validation on mouse samples (fig s1a). Cell Rep (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D10E5)
  • western blot knockout validation; mouse; fig 5a
  • immunohistochemistry - frozen section; mouse; fig 5d
  • immunoprecipitation; mouse; fig 1b
  • immunoprecipitation; human; fig 2b
  • western blot; human; fig 2b
In order to study the effect of bisecting N-acetylglucosamine on beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) activity, Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606) was used in western blot knockout validation on mouse samples (fig 5a), in immunohistochemistry - frozen section on mouse samples (fig 5d), in immunoprecipitation on mouse samples (fig 1b), in immunoprecipitation on human samples (fig 2b) and in western blot on human samples (fig 2b). EMBO Mol Med (2015) ncbi
Abcam
domestic rabbit monoclonal (EPR19523)
  • western blot; human; fig 1c
Abcam Bace1 antibody (Abcam, ab183612) was used in western blot on human samples (fig 1c). Int J Mol Sci (2022) ncbi
domestic rabbit monoclonal (EPR3956)
  • western blot; mouse; 1:1000; loading ...; fig 1i
Abcam Bace1 antibody (Abcam, ab108394) was used in western blot on mouse samples at 1:1000 (fig 1i). EBioMedicine (2022) ncbi
domestic rabbit monoclonal (EPR19523)
  • western blot; rat; 1:1000; loading ...; fig 5d
Abcam Bace1 antibody (Abcam, ab183612) was used in western blot on rat samples at 1:1000 (fig 5d). Aging (Albany NY) (2021) ncbi
domestic rabbit monoclonal (EPR3956)
  • western blot; mouse; loading ...; fig 5l
Abcam Bace1 antibody (Abcam, ab108394) was used in western blot on mouse samples (fig 5l). Redox Biol (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 3d, 3e, 8e
Abcam Bace1 antibody (Abcam, ab2077) was used in western blot on mouse samples at 1:1000 (fig 3d, 3e, 8e). Aging Cell (2021) ncbi
domestic rabbit monoclonal (EPR3956)
  • western blot; mouse; fig 4b
Abcam Bace1 antibody (Cerderlane, AB-108394) was used in western blot on mouse samples (fig 4b). Alzheimers Res Ther (2021) ncbi
domestic rabbit monoclonal (EPR3956)
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 7a
  • western blot; mouse; 1:1000; loading ...; fig ev4b
Abcam Bace1 antibody (Abcam, ab108394) was used in immunohistochemistry - frozen section on mouse samples at 1:500 (fig 7a) and in western blot on mouse samples at 1:1000 (fig ev4b). EMBO Rep (2020) ncbi
domestic rabbit polyclonal
  • immunoprecipitation; human; loading ...; fig 4b
Abcam Bace1 antibody (Abcam, ab2077) was used in immunoprecipitation on human samples (fig 4b). Acta Neuropathol Commun (2019) ncbi
domestic rabbit monoclonal (EPR3956)
  • immunohistochemistry knockout validation; mouse; 1:50; loading ...; fig 2e
Abcam Bace1 antibody (Abcam, ab108394) was used in immunohistochemistry knockout validation on mouse samples at 1:50 (fig 2e). J Neurosci (2019) ncbi
domestic rabbit monoclonal (EPR3956)
  • immunohistochemistry - free floating section; mouse; loading ...; fig 1c
  • western blot; mouse; loading ...; fig 1a
Abcam Bace1 antibody (Abcam, EPR3956) was used in immunohistochemistry - free floating section on mouse samples (fig 1c) and in western blot on mouse samples (fig 1a). J Biol Chem (2019) ncbi
domestic rabbit monoclonal (EPR3956)
  • western blot; mouse; loading ...; fig 1d
Abcam Bace1 antibody (Abcam, ab108394) was used in western blot on mouse samples (fig 1d). Sci Transl Med (2018) ncbi
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 4b
Abcam Bace1 antibody (Abcam, ab2077) was used in western blot on rat samples (fig 4b). Am J Physiol Endocrinol Metab (2017) ncbi
domestic rabbit monoclonal (EPR3956)
  • western blot; mouse; 1:1000; loading ...; fig 4a
Abcam Bace1 antibody (Abcam, ab108394) was used in western blot on mouse samples at 1:1000 (fig 4a). Front Pharmacol (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 5
Abcam Bace1 antibody (Abcam, Ab2077) was used in western blot on mouse samples (fig 5). Int J Mol Med (2017) ncbi
domestic rabbit polyclonal
  • western blot; fruit fly ; 1:2000; loading ...; fig 1
Abcam Bace1 antibody (Abcam, ab2077) was used in western blot on fruit fly samples at 1:2000 (fig 1). Biol Open (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 3
In order to characterize induction of apoptosis in SH-SY5Y human neuroblastoma cells through up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling due to cholesterol overload, Abcam Bace1 antibody (Abcam, ab2077) was used in western blot on human samples (fig 3). Neuroscience (2016) ncbi
domestic rabbit monoclonal (EPR3956)
  • western blot; human; 1:2000; fig 5
Abcam Bace1 antibody (Abcam, ab108394) was used in western blot on human samples at 1:2000 (fig 5). J Pineal Res (2015) ncbi
domestic rabbit monoclonal (EPR3956)
  • western blot; mouse; 1:1000
Abcam Bace1 antibody (Epitomics, 2882?C1) was used in western blot on mouse samples at 1:1000. Proc Natl Acad Sci U S A (2015) ncbi
domestic rabbit monoclonal (EPR3956)
  • immunohistochemistry - free floating section; mouse; 1:250; fig 4
In order to test if reduction in BACE1 prevents or treats Alzheimer's disease, Abcam Bace1 antibody (Abcam, ab108394) was used in immunohistochemistry - free floating section on mouse samples at 1:250 (fig 4). Mol Neurodegener (2015) ncbi
Invitrogen
domestic rabbit recombinant (ARC0696)
  • western blot; mouse; 1:1000; loading ...; fig 6c
Invitrogen Bace1 antibody (Thermo Fisher, MA5-35126) was used in western blot on mouse samples at 1:1000 (fig 6c). Aging Dis (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 7a
Invitrogen Bace1 antibody (Invitrogen, PA1-757) was used in western blot on mouse samples (fig 7a). Acta Neuropathol Commun (2021) ncbi
mouse monoclonal (3C1C3)
  • western blot; rat; loading ...; fig 2b
Invitrogen Bace1 antibody (ThermoFisher, MA1-177) was used in western blot on rat samples (fig 2b). Molecules (2019) ncbi
mouse monoclonal (3C1C3)
  • immunocytochemistry; human; loading ...; fig 6a
Invitrogen Bace1 antibody (Thermofisher, MA1-177) was used in immunocytochemistry on human samples (fig 6a). J Alzheimers Dis (2019) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; 1:850; loading ...; fig 4e
In order to demonstrate that Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites, Invitrogen Bace1 antibody (Thermo Scientific, PA1-757) was used in immunocytochemistry on mouse samples at 1:850 (fig 4e). EMBO Rep (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 1
In order to compare the relationship between BACE1 and ubiquilin-1 in human Alzheimer's disease, APdE9 transgenic mouse brain and cell-based models, Invitrogen Bace1 antibody (Pierce, PA1-757) was used in western blot on human samples at 1:1000 (fig 1). Neurobiol Dis (2016) ncbi
domestic rabbit polyclonal
Invitrogen Bace1 antibody (Thermo Scientific, PA1?C757) was used . Biochemistry (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (A-12)
  • flow cytometry; human; loading ...; fig 6b
Santa Cruz Biotechnology Bace1 antibody (Santa Cruz Biotechnology, A-12) was used in flow cytometry on human samples (fig 6b). Cell Mol Gastroenterol Hepatol (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D10E5)
  • western blot knockout validation; mouse; loading ...; fig 5a
Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606) was used in western blot knockout validation on mouse samples (fig 5a). Sci Adv (2022) ncbi
domestic rabbit monoclonal (D10E5)
  • immunohistochemistry; mouse; 1:150; loading ...; fig e3d
Cell Signaling Technology Bace1 antibody (Cell Signaling, D10E5) was used in immunohistochemistry on mouse samples at 1:150 (fig e3d). EMBO Mol Med (2022) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; human; 1:1000; fig s7f
Cell Signaling Technology Bace1 antibody (Cell Signaling, 5606) was used in western blot on human samples at 1:1000 (fig s7f). Signal Transduct Target Ther (2021) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; loading ...; fig s5a
Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606) was used in western blot on mouse samples (fig s5a). Sci Adv (2021) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot knockout validation; mouse; 1:1500; fig 1d, 5a
Cell Signaling Technology Bace1 antibody (Cell Signaling, D10E5) was used in western blot knockout validation on mouse samples at 1:1500 (fig 1d, 5a). J Biol Chem (2021) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; 1:1000; loading ...; fig 5c
Cell Signaling Technology Bace1 antibody (CST, 5606) was used in western blot on mouse samples at 1:1000 (fig 5c). Acta Neuropathol Commun (2020) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; 1:2000; loading ...; fig 1
Cell Signaling Technology Bace1 antibody (CST, USA, D10E5) was used in western blot on mouse samples at 1:2000 (fig 1). Aging Cell (2020) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; rat; 1:1000; loading ...; fig 3a
Cell Signaling Technology Bace1 antibody (Cell Signaling, D10E5) was used in western blot on rat samples at 1:1000 (fig 3a). BMC Neurosci (2020) ncbi
domestic rabbit monoclonal (D10E5)
  • immunocytochemistry; human; 1:200; loading ...; fig 4a
  • western blot; human; 1:1000; loading ...; fig 4b
Cell Signaling Technology Bace1 antibody (Cell Signaling, 5606T) was used in immunocytochemistry on human samples at 1:200 (fig 4a) and in western blot on human samples at 1:1000 (fig 4b). Acta Neuropathol Commun (2019) ncbi
domestic rabbit monoclonal (D10E5)
Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606) was used . Cell Rep (2019) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; loading ...; fig 3e
Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606) was used in western blot on mouse samples (fig 3e). Sci Adv (2019) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; 1:1000; loading ...; fig s3b
Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606) was used in western blot on mouse samples at 1:1000 (fig s3b). J Clin Invest (2019) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; loading ...; fig 5c
Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606S) was used in western blot on mouse samples (fig 5c). Neurotherapeutics (2018) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; human; loading ...; fig 1f
Cell Signaling Technology Bace1 antibody (Cell Signaling, D10E5) was used in western blot on human samples (fig 1f). Neurodegener Dis (2018) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; human; loading ...; fig 3b
In order to characterize the stoichiometricl feature of cellular beta-secretase and its involvement in copper compartmentation, Cell Signaling Technology Bace1 antibody (Cell Signaling, D10E5) was used in western blot on human samples (fig 3b). J Biol Chem (2017) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; rat; 1:1500; loading ...; fig 6a
  • western blot; human; 1:1500; loading ...; fig 5b
Cell Signaling Technology Bace1 antibody (Cell Signaling, 5606) was used in western blot on rat samples at 1:1500 (fig 6a) and in western blot on human samples at 1:1500 (fig 5b). PLoS ONE (2017) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; hamsters; loading ...; fig 8a
In order to suggest that loss of the Wnt signaling pathway may contribute to Alzheimer's disease pathogenesis, Cell Signaling Technology Bace1 antibody (Cell signaling, 5606S) was used in western blot on hamsters samples (fig 8a). J Neurochem (2016) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; human; fig 4
Cell Signaling Technology Bace1 antibody (Cell Signaling, 5606) was used in western blot on human samples (fig 4). Sci Rep (2016) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; 1:1000; loading ...; fig ev4b
  • western blot; human; 1:1000; loading ...; fig 8
In order to describe the role of miR-132 in amyloid and TAU pathology associated with Alzheimer's disease, Cell Signaling Technology Bace1 antibody (Cell Signaling, s5606) was used in western blot on mouse samples at 1:1000 (fig ev4b) and in western blot on human samples at 1:1000 (fig 8). EMBO Mol Med (2016) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; 1:1000; fig 2
  • immunocytochemistry; human; 1:250; fig 6
  • western blot; human; 1:1000; fig 2
In order to research the modulation of beta-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1 by SEPT8, Cell Signaling Technology Bace1 antibody (Cell Signaling, 5606) was used in western blot on mouse samples at 1:1000 (fig 2), in immunocytochemistry on human samples at 1:250 (fig 6) and in western blot on human samples at 1:1000 (fig 2). J Cell Sci (2016) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; 1:2000; fig 2
In order to determine regulation of APP trafficking and processing through the endocytic adaptor protein Numb by the polarity protein Par3, Cell Signaling Technology Bace1 antibody (Cell Signaling, D10E5) was used in western blot on mouse samples at 1:2000 (fig 2). Neurobiol Dis (2016) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; fig 11a
  • western blot; hamsters; fig 11a
In order to study the activity-driven interaction between presenilin 1 and synaptotagmin 1 and links to calcium, amyloid beta, and synapse, Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, D10E5) was used in western blot on mouse samples (fig 11a) and in western blot on hamsters samples (fig 11a). BMC Biol (2016) ncbi
domestic rabbit monoclonal (D10E5)
  • immunohistochemistry; mouse; fig 7
In order to analyze chemogenetic modulation of neural activity by attenuation of beta-amyloid deposition and neurotoxicity, Cell Signaling Technology Bace1 antibody (Cell Signaling, 5606) was used in immunohistochemistry on mouse samples (fig 7). J Neurosci (2016) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; 1:250; fig 4
Cell Signaling Technology Bace1 antibody (Cell Signaling Tech, 5606S) was used in western blot on mouse samples at 1:250 (fig 4). Front Aging Neurosci (2015) ncbi
domestic rabbit monoclonal (D10E5)
  • immunoprecipitation; mouse
  • immunocytochemistry; mouse
  • western blot; mouse
In order to test if bisecting GlcNAc would stabilize BACE1 protein upon oxidative stress, Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606) was used in immunoprecipitation on mouse samples , in immunocytochemistry on mouse samples and in western blot on mouse samples . Biochem J (2016) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; fig 2a
In order to assess the efficiency and potential safety of miRNA replacement therapy for Alzheimer's disease, Cell Signaling Technology Bace1 antibody (Cell Signaling, 5606) was used in western blot on mouse samples (fig 2a). Mol Ther Nucleic Acids (2015) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot knockout validation; mouse; fig s1a
Cell Signaling Technology Bace1 antibody (Cell Signaling, D10E5) was used in western blot knockout validation on mouse samples (fig s1a). Cell Rep (2015) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; 1:1000; fig 4
In order to analyze a mouse model where human neural stem cells alleviate Alzheimer-like pathology, Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606) was used in western blot on mouse samples at 1:1000 (fig 4). Mol Neurodegener (2015) ncbi
domestic rabbit monoclonal (D10E5)
  • immunohistochemistry; mouse; loading ...; fig 4c
  • western blot; mouse; 1:1000; loading ...; fig 4a
Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606) was used in immunohistochemistry on mouse samples (fig 4c) and in western blot on mouse samples at 1:1000 (fig 4a). PLoS ONE (2015) ncbi
domestic rabbit monoclonal (D10E5)
  • immunocytochemistry; mouse; 1:500
  • immunohistochemistry; mouse; 1:400
Cell Signaling Technology Bace1 antibody (Cell signaling, 5606) was used in immunocytochemistry on mouse samples at 1:500 and in immunohistochemistry on mouse samples at 1:400. Neurobiol Aging (2015) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot knockout validation; mouse; fig 5a
  • immunohistochemistry - frozen section; mouse; fig 5d
  • immunoprecipitation; mouse; fig 1b
  • immunoprecipitation; human; fig 2b
  • western blot; human; fig 2b
In order to study the effect of bisecting N-acetylglucosamine on beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) activity, Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, 5606) was used in western blot knockout validation on mouse samples (fig 5a), in immunohistochemistry - frozen section on mouse samples (fig 5d), in immunoprecipitation on mouse samples (fig 1b), in immunoprecipitation on human samples (fig 2b) and in western blot on human samples (fig 2b). EMBO Mol Med (2015) ncbi
domestic rabbit monoclonal (D10E5)
In order to test if NHE6 expression alters amyloid precursor protein localization and processing in a stably transfected cell culture model, Cell Signaling Technology Bace1 antibody (Cell Signaling, 5606) was used . J Biol Chem (2015) ncbi
domestic rabbit monoclonal (D10E5)
  • immunohistochemistry - frozen section; mouse; 1:500
Cell Signaling Technology Bace1 antibody (Cell Signaling, D10E5) was used in immunohistochemistry - frozen section on mouse samples at 1:500. PLoS ONE (2014) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; mouse; 1:1000; fig 3
In order to investigate the contribution of IL-12/23 to disease using SAMP8 mice, Cell Signaling Technology Bace1 antibody (Cell Signaling Technology, #5606) was used in western blot on mouse samples at 1:1000 (fig 3). J Alzheimers Dis (2014) ncbi
Articles Reviewed
  1. Wuli W, Lin S, Chen S, Tannous B, Huang W, Woon P, et al. Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce β Amyloid Plaque Formation and Improve Cognition Function. Int J Mol Sci. 2022;23: pubmed publisher
  2. Singh N, Das B, Zhou J, Hu X, Yan R. Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance. Sci Adv. 2022;8:eabo3610 pubmed publisher
  3. Xu B, He Y, Liu L, Ye G, Chen L, Wang Q, et al. The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice. Aging Dis. 2022;13:1293-1310 pubmed publisher
  4. Han X, Wang C, Song L, Wang X, Tang S, Hou T, et al. KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion. EBioMedicine. 2022;78:103980 pubmed publisher
  5. Marino M, Zhou L, Rincon M, Callaerts Vegh Z, Verhaert J, Wahis J, et al. AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model. EMBO Mol Med. 2022;14:e09824 pubmed publisher
  6. Luo R, Fan Y, Yang J, Ye M, Zhang D, Guo K, et al. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. Signal Transduct Target Ther. 2021;6:325 pubmed publisher
  7. Cheng J, Dong Y, Ma J, Pan R, Liao Y, Kong X, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology. Sci Adv. 2021;7: pubmed publisher
  8. Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed publisher
  9. Sha S, Shen X, Cao Y, Qu L. Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer's disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/β-catenin pathway. Aging (Albany NY). 2021;13:15285-15306 pubmed publisher
  10. Liu Y, Cong P, Zhang T, Wang R, Wang X, Liu J, et al. Plasmalogen attenuates the development of hepatic steatosis and cognitive deficit through mechanism involving p75NTR inhibition. Redox Biol. 2021;43:102002 pubmed publisher
  11. Wang J, Liu B, Xu Y, Yang M, Wang C, Song M, et al. Activation of CREB-mediated autophagy by thioperamide ameliorates β-amyloid pathology and cognition in Alzheimer's disease. Aging Cell. 2021;20:e13333 pubmed publisher
  12. Kim W, Watanabe H, Lomoio S, Tesco G. Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo. J Biol Chem. 2021;296:100372 pubmed publisher
  13. Pons V, Lévesque P, Plante M, Rivest S. Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease. Alzheimers Res Ther. 2021;13:8 pubmed publisher
  14. Sun R, Hedl M, Abraham C. TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants. Cell Mol Gastroenterol Hepatol. 2021;11:249-272 pubmed publisher
  15. Lackie R, Marques Lopes J, Ostapchenko V, Good S, Choy W, van Oosten Hawle P, et al. Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2020;8:143 pubmed publisher
  16. Du Y, Fu M, Huang Z, Tian X, Li J, Pang Y, et al. TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer's disease. Aging Cell. 2020;19:e13113 pubmed publisher
  17. Lundgren J, Vandermeulen L, Sandebring Matton A, Ahmed S, Winblad B, Di Luca M, et al. Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain. BMC Neurosci. 2020;21:6 pubmed publisher
  18. Eede P, Obst J, Benke E, Yvon Durocher G, Richard B, Gimber N, et al. Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice. EMBO Rep. 2020;21:e48530 pubmed publisher
  19. Kirabali T, Rigotti S, Siccoli A, Liebsch F, Shobo A, Hock C, et al. The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease. Acta Neuropathol Commun. 2019;7:194 pubmed publisher
  20. Dierich M, Hartmann S, Dietrich N, Moeser P, Brede F, Johnson Chacko L, et al. β-Secretase BACE1 Is Required for Normal Cochlear Function. J Neurosci. 2019;39:9013-9027 pubmed publisher
  21. Bazzari F, Abdallah D, El Abhar H. Chenodeoxycholic Acid Ameliorates AlCl3-Induced Alzheimer's Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats. Molecules. 2019;24: pubmed publisher
  22. Zhang Q, Higginbotham J, Jeppesen D, Yang Y, Li W, McKinley E, et al. Transfer of Functional Cargo in Exomeres. Cell Rep. 2019;27:940-954.e6 pubmed publisher
  23. Pan R, Ma J, Kong X, Wang X, Li S, Qi X, et al. Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance. Sci Adv. 2019;5:eaau6328 pubmed publisher
  24. Andrew R, de Rossi P, Nguyen P, Kowalski H, Recupero A, Guerbette T, et al. Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model. J Biol Chem. 2019;294:4477-4487 pubmed publisher
  25. Beckelman B, Yang W, Kasica N, Zimmermann H, Zhou X, Keene C, et al. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019;129:820-833 pubmed publisher
  26. Hui L, Soliman M, Geiger N, Miller N, Afghah Z, Lakpa K, et al. Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis. J Alzheimers Dis. 2019;67:393-410 pubmed publisher
  27. Ou Yang M, Kurz J, Nomura T, Popovic J, Rajapaksha T, Dong H, et al. Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice. Sci Transl Med. 2018;10: pubmed publisher
  28. Huang M, Qi W, Fang S, Jiang P, Yang C, Mo Y, et al. Pigment Epithelium-Derived Factor Plays a Role in Alzheimer's Disease by Negatively Regulating Aβ42. Neurotherapeutics. 2018;15:728-741 pubmed publisher
  29. Xu S, Nigam S, Brodin L. Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein. Neurodegener Dis. 2018;18:26-37 pubmed publisher
  30. Liebsch F, Aurousseau M, Bethge T, McGuire H, Scolari S, Herrmann A, et al. Full-length cellular ?-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization. J Biol Chem. 2017;292:13258-13270 pubmed publisher
  31. Pinto S, Lamon S, Stephenson E, Kalanon M, Mikovic J, Koch L, et al. Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity. Am J Physiol Endocrinol Metab. 2017;313:E335-E343 pubmed publisher
  32. Yan L, Deng Y, Gao J, Liu Y, Li F, Shi J, et al. Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production. Front Pharmacol. 2017;8:106 pubmed publisher
  33. Roberts H, Schneider B, Brown D. α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP. PLoS ONE. 2017;12:e0171925 pubmed publisher
  34. Park T, Ryu Y, Park H, Kim J, Go J, Noh J, et al. Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. Int J Mol Med. 2017;39:21-30 pubmed publisher
  35. Ubelmann F, Burrinha T, Salavessa L, Gomes R, Ferreira C, Moreno N, et al. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep. 2017;18:102-122 pubmed publisher
  36. Tapia Rojas C, Burgos P, Inestrosa N. Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-? (A?)42 peptides. J Neurochem. 2016;139:1175-1191 pubmed publisher
  37. Yamaguchi T, Yamauchi Y, Furukawa K, Ohmi Y, Ohkawa Y, Zhang Q, et al. Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing. Sci Rep. 2016;6:34505 pubmed publisher
  38. Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher
  39. Bergkvist L, Sandin L, Kågedal K, Brorsson A. A?PP processing results in greater toxicity per amount of A?1-42 than individually expressed and secreted A?1-42 in Drosophila melanogaster. Biol Open. 2016;5:1030-9 pubmed publisher
  40. Huang Y, Lin C, Liao H, Liu C, Chen Y, Chiu W, et al. Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling. Neuroscience. 2016;328:201-9 pubmed publisher
  41. Kurkinen K, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, et al. SEPT8 modulates ?-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. J Cell Sci. 2016;129:2224-38 pubmed publisher
  42. Sun M, Asghar S, Zhang H. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. Neurobiol Dis. 2016;93:1-11 pubmed publisher
  43. Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed publisher
  44. Yuan P, Grutzendler J. Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. J Neurosci. 2016;36:632-41 pubmed publisher
  45. Hou X, Adeosun S, Zhang Q, Barlow B, Brents M, Zheng B, et al. Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's disease. Front Aging Neurosci. 2015;7:207 pubmed publisher
  46. Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen K, et al. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models. Neurobiol Dis. 2016;85:187-205 pubmed publisher
  47. Kizuka Y, Nakano M, Kitazume S, Saito T, Saido T, Taniguchi N. Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem J. 2016;473:21-30 pubmed publisher
  48. Parsi S, Smith P, Goupil C, Dorval V, Hébert S. Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease. Mol Ther Nucleic Acids. 2015;4:e256 pubmed publisher
  49. Barão S, Gärtner A, Leyva Díaz E, Demyanenko G, Munck S, Vanhoutvin T, et al. Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse. Cell Rep. 2015;12:1367-76 pubmed publisher
  50. Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed publisher
  51. Panmanee J, Nopparat C, Chavanich N, Shukla M, Mukda S, Song W, et al. Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells. J Pineal Res. 2015;59:308-20 pubmed publisher
  52. Corbett G, Gonzalez F, Pahan K. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015;112:8445-50 pubmed publisher
  53. Bhatt D, Puig K, Gorr M, Wold L, Combs C. A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain. PLoS ONE. 2015;10:e0127102 pubmed publisher
  54. Wang H, Sang N, Zhang C, Raghupathi R, Tanzi R, SAUNDERS A. Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 2015;54:2806-16 pubmed publisher
  55. Li H, Ruberu K, Muñoz S, Jenner A, Spiro A, Zhao H, et al. Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice. Neurobiol Aging. 2015;36:1820-33 pubmed publisher
  56. Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido T, et al. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med. 2015;7:175-89 pubmed publisher
  57. Sadleir K, Eimer W, Cole S, Vassar R. Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level. Mol Neurodegener. 2015;10:1 pubmed publisher
  58. Prasad H, Rao R. The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease. J Biol Chem. 2015;290:5311-27 pubmed publisher
  59. Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed publisher
  60. Tan M, Yu J, Jiang T, Zhu X, Guan H, Tan L. IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice. J Alzheimers Dis. 2014;38:633-46 pubmed publisher