This is a Validated Antibody Database (VAD) review about mouse Aurka, based on 35 published articles (read how Labome selects the articles), using Aurka antibody in all methods. It is aimed to help Labome visitors find the most suited Aurka antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Aurka synonym: AIRK1; ARK-1; AU019385; AW539821; Ark1; Aurora-A; Ayk1; IAK; IAK1; Stk6

Abcam
mouse monoclonal (35C1)
  • western blot; mouse; 1:1000; loading ...; fig 5b
In order to study the role of microRNAs in the cell cycle and differentiation, Abcam Aurka antibody (Abcam, ab13824) was used in western blot on mouse samples at 1:1000 (fig 5b). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (35C1)
  • western blot; mouse; 1:500; fig 3
In order to research the drive of early signaling and vesicle dynamics during T-cell activation by Aurora A, Abcam Aurka antibody (Abcam, a13824) was used in western blot on mouse samples at 1:500 (fig 3). Nat Commun (2016) ncbi
mouse monoclonal (35C1)
  • chromatin immunoprecipitation; human; 1:4000; fig 4
  • immunohistochemistry; human; 1:4000; fig 1
  • western blot; human; 1:4000; fig 3
Abcam Aurka antibody (Abcam, ab13824) was used in chromatin immunoprecipitation on human samples at 1:4000 (fig 4), in immunohistochemistry on human samples at 1:4000 (fig 1) and in western blot on human samples at 1:4000 (fig 3). Nat Commun (2016) ncbi
mouse monoclonal (35C1)
  • western blot; mouse; loading ...; fig 5a
In order to present the role of nuclear pore protein nup88 on anaphase-promoting complex, Abcam Aurka antibody (abcam, ab13824) was used in western blot on mouse samples (fig 5a). J Clin Invest (2016) ncbi
mouse monoclonal (35C1)
  • immunocytochemistry; human; 1:1000; loading ...; fig 2a
Abcam Aurka antibody (Abcam, ab13824) was used in immunocytochemistry on human samples at 1:1000 (fig 2a). Mol Biol Cell (2015) ncbi
mouse monoclonal (35C1)
  • western blot; human; 1:500; fig 3
In order to assess the efficacy of alisertib against glioblastoma neurosphere tumor stem-like cells in vitro and in vivo, Abcam Aurka antibody (Abcam, ab13824) was used in western blot on human samples at 1:500 (fig 3). Cancer Res (2014) ncbi
mouse monoclonal (35C1)
  • western blot; mouse
  • western blot; human
Abcam Aurka antibody (Abcam, 35C1) was used in western blot on mouse samples and in western blot on human samples . Oncogene (2015) ncbi
mouse monoclonal (35C1)
  • western blot; mouse; fig s3
Abcam Aurka antibody (abcam, ab13824) was used in western blot on mouse samples (fig s3). Cell Cycle (2014) ncbi
mouse monoclonal (35C1)
  • western blot; human; 1:1000
Abcam Aurka antibody (Abcam, ab13824) was used in western blot on human samples at 1:1000. J Biol Chem (2013) ncbi
mouse monoclonal (35C1)
  • immunocytochemistry; chicken; 1:500
Abcam Aurka antibody (Abcam, 35C1) was used in immunocytochemistry on chicken samples at 1:500. Cell Cycle (2013) ncbi
Invitrogen
mouse monoclonal (35C1)
  • western blot; human; 1:1000; fig s5
In order to analyze prevention of centrosome amplification and neoplastic progression by 14-3-3gamma, Invitrogen Aurka antibody (Invitrogen, 458900) was used in western blot on human samples at 1:1000 (fig s5). Sci Rep (2016) ncbi
mouse monoclonal (35C1)
  • western blot; human; fig 3s
In order to examine how histone H3 threonine 118 alters chromosome structure, Invitrogen Aurka antibody (Invitrogen, 45-C8900) was used in western blot on human samples (fig 3s). elife (2016) ncbi
mouse monoclonal (35C1)
  • western blot; mouse
Invitrogen Aurka antibody (Invitrogen, 35C1) was used in western blot on mouse samples . Oncotarget (2015) ncbi
GeneTex
mouse monoclonal (35C1)
  • western blot; mouse; fig 1
  • western blot; human; fig 2
GeneTex Aurka antibody (GeneTex, GTX13824) was used in western blot on mouse samples (fig 1) and in western blot on human samples (fig 2). Nat Med (2015) ncbi
mouse monoclonal (35C1)
  • immunocytochemistry; human
  • western blot; human
GeneTex Aurka antibody (GeneTex, GTX13824) was used in immunocytochemistry on human samples and in western blot on human samples . J Biol Chem (2012) ncbi
mouse monoclonal (35C1)
  • western blot; human; fig 1
GeneTex Aurka antibody (GeneTex, GTX13824) was used in western blot on human samples (fig 1). Clin Cancer Res (2010) ncbi
MilliporeSigma
mouse monoclonal (35C1)
  • immunoprecipitation; human; 1:50; loading ...; fig 1d
In order to identify Aurora kinase A as a novel Ras binding protein, MilliporeSigma Aurka antibody (Sigma, A1231) was used in immunoprecipitation on human samples at 1:50 (fig 1d). Oncotarget (2017) ncbi
mouse monoclonal (35C1)
  • western blot; chicken; fig 1
MilliporeSigma Aurka antibody (Sigma, A1231) was used in western blot on chicken samples (fig 1). PLoS Genet (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (35C1)
  • western blot; human; 1:500; loading ...; fig 6e; S6n; S6i
In order to report FOSL1 as a common transcriptional signature across mutant KRAS cancers of distinct tissue origin, Santa Cruz Biotechnology Aurka antibody (Santa Cruz, sc-56881) was used in western blot on human samples at 1:500 (fig 6e; S6n; S6i). Nat Commun (2017) ncbi
BD Biosciences
mouse monoclonal (4/IAK1)
  • western blot; mouse; 1:1000; loading ...; fig 8a
BD Biosciences Aurka antibody (BD Transduction, 610938) was used in western blot on mouse samples at 1:1000 (fig 8a). elife (2020) ncbi
mouse monoclonal (4/IAK1)
  • western blot; human; 1:1000; loading ...; fig 4d
BD Biosciences Aurka antibody (BD Biosciences, 610938) was used in western blot on human samples at 1:1000 (fig 4d). Nat Commun (2018) ncbi
mouse monoclonal (4/IAK1)
  • western blot; human; loading ...; fig 3A
BD Biosciences Aurka antibody (BD, 610939) was used in western blot on human samples (fig 3A). J Cell Biol (2016) ncbi
mouse monoclonal (4/IAK1)
  • western blot; human; 1:1000; fig 3
In order to compare regulation of a Golgi-activated pool of Src during G2 by centrosomal maturation and Aurora-A recruitment, BD Biosciences Aurka antibody (BD Biosciences, 610,938) was used in western blot on human samples at 1:1000 (fig 3). Nat Commun (2016) ncbi
mouse monoclonal (4/IAK1)
  • western blot; mouse; 1:500; fig 3
In order to characterize a novel population of binucleated mammary epithelial cells and their essential role in lactation, BD Biosciences Aurka antibody (BD, 4/IAK1) was used in western blot on mouse samples at 1:500 (fig 3). Nat Commun (2016) ncbi
mouse monoclonal (10-3.6)
  • flow cytometry; mouse; fig 3d
In order to propose that neuronal autoimmunity is a pathogenic feature of type 1 diabetes, BD Biosciences Aurka antibody (BD Biosciences, 10-3.6) was used in flow cytometry on mouse samples (fig 3d). Diabetes (2016) ncbi
mouse monoclonal (4/IAK1)
  • immunoprecipitation; mouse; fig 2e
BD Biosciences Aurka antibody (BD Biosciences, 610938) was used in immunoprecipitation on mouse samples (fig 2e). elife (2016) ncbi
mouse monoclonal (4/IAK1)
  • western blot; mouse
In order to investigate changes to AURKA signaling after treatment with erlotinib/alisertib combination therapy, BD Biosciences Aurka antibody (BD Transduction, 610939) was used in western blot on mouse samples . Front Oncol (2015) ncbi
mouse monoclonal (4/IAK1)
  • western blot; human; 1:1000; fig 1
BD Biosciences Aurka antibody (BD Biosciences, 610939) was used in western blot on human samples at 1:1000 (fig 1). Mol Biol Cell (2015) ncbi
mouse monoclonal (4/IAK1)
  • western blot; human; fig 3
BD Biosciences Aurka antibody (BD Biosciences, 610939) was used in western blot on human samples (fig 3). Oncogene (2016) ncbi
mouse monoclonal (4/IAK1)
  • western blot; human; fig 2
In order to explore how Tpr regulated chromosomal segregation, BD Biosciences Aurka antibody (BD Transduction, 610939) was used in western blot on human samples (fig 2). Cell Cycle (2015) ncbi
mouse monoclonal (4/IAK1)
  • western blot; mouse; 1:1000
BD Biosciences Aurka antibody (BD biosciences, 610938) was used in western blot on mouse samples at 1:1000. Nat Cell Biol (2015) ncbi
mouse monoclonal (4/IAK1)
  • immunocytochemistry; human
In order to elucidate the mechanism by which BI2536 induces defects in cell proliferation of non-small cell lung cancer, BD Biosciences Aurka antibody (BD, 610938) was used in immunocytochemistry on human samples . Cancer Lett (2015) ncbi
mouse monoclonal (4/IAK1)
  • immunoprecipitation; human; fig s10
BD Biosciences Aurka antibody (BD Biosciences, 610938) was used in immunoprecipitation on human samples (fig s10). Nat Commun (2014) ncbi
mouse monoclonal (4/IAK1)
  • western blot; mouse; 1:1000; fig s6
  • western blot; human; 1:1000; fig 7
BD Biosciences Aurka antibody (BD Biosciences, 610938) was used in western blot on mouse samples at 1:1000 (fig s6) and in western blot on human samples at 1:1000 (fig 7). Nat Commun (2014) ncbi
mouse monoclonal (4/IAK1)
  • western blot; human
BD Biosciences Aurka antibody (BD Pharmingen, 610938) was used in western blot on human samples . J Natl Cancer Inst (2014) ncbi
Articles Reviewed
  1. Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, et al. The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. elife. 2020;9: pubmed publisher
  2. Lin C, Kitagawa M, Tang X, Hou M, Wu J, Qu D, et al. CoA synthase regulates mitotic fidelity via CBP-mediated acetylation. Nat Commun. 2018;9:1039 pubmed publisher
  3. Otto T, Candido S, Pilarz M, Sicinska E, Bronson R, Bowden M, et al. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017;114:10660-10665 pubmed publisher
  4. Vallejo A, Perurena N, Guruceaga E, Mazur P, Martínez Canarias S, Zandueta C, et al. An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. Nat Commun. 2017;8:14294 pubmed publisher
  5. Umstead M, Xiong J, Qi Q, Du Y, Fu H. Aurora kinase A interacts with H-Ras and potentiates Ras-MAPK signaling. Oncotarget. 2017;8:28359-28372 pubmed publisher
  6. Uematsu K, Okumura F, Tonogai S, Joo Okumura A, Alemayehu D, Nishikimi A, et al. ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation. J Cell Biol. 2016;215:95-106 pubmed
  7. Mukhopadhyay A, Sehgal L, Bose A, Gulvady A, Senapati P, Thorat R, et al. 14-3-3? Prevents Centrosome Amplification and Neoplastic Progression. Sci Rep. 2016;6:26580 pubmed publisher
  8. Barretta M, Spano D, D Ambrosio C, Cervigni R, Scaloni A, Corda D, et al. Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2. Nat Commun. 2016;7:11727 pubmed publisher
  9. Rios A, Fu N, Jamieson P, Pal B, Whitehead L, Nicholas K, et al. Essential role for a novel population of binucleated mammary epithelial cells in lactation. Nat Commun. 2016;7:11400 pubmed publisher
  10. Blas Rus N, Bustos Morán E, Perez de Castro I, de Carcer G, Borroto A, Camafeita E, et al. Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun. 2016;7:11389 pubmed publisher
  11. Leeth C, Racine J, Chapman H, Arpa B, Carrillo J, Carrascal J, et al. B-lymphocytes expressing an Ig specificity recognizing the pancreatic ß-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice. Diabetes. 2016;65:1977-1987 pubmed publisher
  12. Shin J, Kim T, Kim H, Kim H, Suh M, Lee S, et al. Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells. elife. 2016;5:e10877 pubmed publisher
  13. Wike C, Graves H, Hawkins R, Gibson M, Ferdinand M, Zhang T, et al. Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis. elife. 2016;5:e11402 pubmed publisher
  14. Zheng F, Yue C, Li G, He B, Cheng W, Wang X, et al. Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nat Commun. 2016;7:10180 pubmed publisher
  15. Naylor R, Jeganathan K, Cao X, van Deursen J. Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. J Clin Invest. 2016;126:543-59 pubmed publisher
  16. Wen Q, Yang Q, Goldenson B, Malinge S, Lasho T, Schneider R, et al. Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition. Nat Med. 2015;21:1473-80 pubmed publisher
  17. Nikonova A, Deneka A, Eckman L, Kopp M, Hensley H, Egleston B, et al. Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease. Front Oncol. 2015;5:228 pubmed publisher
  18. Min M, Mevissen T, De Luca M, Komander D, Lindon C. Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages. Mol Biol Cell. 2015;26:4325-32 pubmed publisher
  19. Burgess S, Peset I, Joseph N, Cavazza T, Vernos I, Pfuhl M, et al. Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly. PLoS Genet. 2015;11:e1005345 pubmed publisher
  20. Park S, Shim J, Park H, Eum D, Park M, Mi Yi J, et al. MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28B. Oncogene. 2016;35:1292-301 pubmed publisher
  21. Kobayashi A, Hashizume C, Dowaki T, Wong R. Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A. Cell Cycle. 2015;14:1447-58 pubmed publisher
  22. Ohta S, Wood L, Toramoto I, Yagyu K, Fukagawa T, Earnshaw W. CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly. Mol Biol Cell. 2015;26:1225-37 pubmed publisher
  23. Bangs F, Schrode N, Hadjantonakis A, Anderson K. Lineage specificity of primary cilia in the mouse embryo. Nat Cell Biol. 2015;17:113-22 pubmed publisher
  24. Rizkallah R, Batsomboon P, Dudley G, Hurt M. Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins. Oncotarget. 2015;6:1446-61 pubmed
  25. Choi M, Kim W, Cheon M, Lee C, Kim J. Polo-like kinase 1 inhibitor BI2536 causes mitotic catastrophe following activation of the spindle assembly checkpoint in non-small cell lung cancer cells. Cancer Lett. 2015;357:591-601 pubmed publisher
  26. Kim M, Kim M, Lee M, Kim C, Lim D. The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis. Nat Commun. 2014;5:5370 pubmed publisher
  27. Van Brocklyn J, Wojton J, Meisen W, Kellough D, Ecsedy J, Kaur B, et al. Aurora-A inhibition offers a novel therapy effective against intracranial glioblastoma. Cancer Res. 2014;74:5364-70 pubmed publisher
  28. Vassilopoulos A, Tominaga Y, Kim H, Lahusen T, Li B, Yu H, et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene. 2015;34:3023-35 pubmed publisher
  29. Piazzolla D, Palla A, Pantoja C, Canamero M, de Castro I, Ortega S, et al. Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat Commun. 2014;5:4226 pubmed publisher
  30. Aydin I, Melamed R, Adams S, Castillo Martin M, Demir A, Bryk D, et al. FBXW7 mutations in melanoma and a new therapeutic paradigm. J Natl Cancer Inst. 2014;106:dju107 pubmed publisher
  31. d Alcontres M, Palacios J, Mejias D, Blasco M. TopoII? prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres. Cell Cycle. 2014;13:1463-81 pubmed publisher
  32. Tan E, Caro S, Potnis A, Lanza C, Slawson C. O-linked N-acetylglucosamine cycling regulates mitotic spindle organization. J Biol Chem. 2013;288:27085-99 pubmed publisher
  33. Wang Y, Dantas T, Lalor P, Dockery P, Morrison C. Promoter hijack reveals pericentrin functions in mitosis and the DNA damage response. Cell Cycle. 2013;12:635-46 pubmed publisher
  34. Pakala S, Nair V, Reddy S, Kumar R. Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization. J Biol Chem. 2012;287:40560-9 pubmed publisher
  35. Yang G, Chang B, Yang F, Guo X, Cai K, Xiao X, et al. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010;16:3171-81 pubmed publisher